DE77670T1 - Humanes immuninterferon. - Google Patents
Humanes immuninterferon.Info
- Publication number
- DE77670T1 DE77670T1 DE198282305521T DE82305521T DE77670T1 DE 77670 T1 DE77670 T1 DE 77670T1 DE 198282305521 T DE198282305521 T DE 198282305521T DE 82305521 T DE82305521 T DE 82305521T DE 77670 T1 DE77670 T1 DE 77670T1
- Authority
- DE
- Germany
- Prior art keywords
- polypeptide
- microorganism
- cell culture
- amino acid
- dna sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920001184 polypeptide Polymers 0.000 claims abstract 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 17
- 238000000034 method Methods 0.000 claims abstract 6
- 239000013604 expression vector Substances 0.000 claims abstract 4
- 108010050904 Interferons Proteins 0.000 claims abstract 3
- 102000014150 Interferons Human genes 0.000 claims abstract 3
- 229940079322 interferon Drugs 0.000 claims abstract 3
- 238000004113 cell culture Methods 0.000 claims 8
- 244000005700 microbiome Species 0.000 claims 8
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 150000001413 amino acids Chemical group 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000001131 transforming effect Effects 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/811—Interferon
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/142—Interferon
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (1)
- 8.2305521 .5Patentansprüche1. Eine Stoffzusammensetzung, bestehend im wesentlichen aus einem Polypeptide umfassend die Aminosäuresequenz von reifem menschlichem Immuninterferon.2. Das Polypeptid nach Anspruch 1, unbegleitet von assoziierter, natürlicher Glycosylierung.3. Das Polypeptid nach Anspruch 1, gegebenenfalls die Aminosäure Methionin enthaltend, die an den N-Terminus der normalerweise ersten Aminosäure des genannten Interferons gebunden ist .4. Das Polypeptid nach Anspruch 1, gegebenenfalls enthaltend ein abspaltbares Konjugat oder Signalprotein, das an den N-Terminus der normalerweise ersten Aminosäure des genannten Interferons gebunden ist.5. Eine DNA-Sequenz, umfassend eine Sequenzkodierung des PoIypeptids nach Anspruch 1, 3 oder 4.6. Die DNA-Sequenz nach Anspruch 5,arbeitsfähig verbunden mit einer DNA-Sequenz, die fähig ist, die Expression eines Polypeptids nach Anspruch 1, 3 oder 4 zu bewirken.7. Ein replizierbarer Expressionsvektor, der fähig ist, in einem transfonnanten Mikroorganismus oder einer transformanten Zellkultur ein Polypeptid nach einem der Ansprüche 1, 3 oder 4 zu exprimieren.8. Ein Mikroorganismus oder eine Zellkultur, der (die) mit dem Vektor nach Anspruch 7 transformiert ist.9. Die Zellkultur nach Anspruch 8, erhalten durch Transformierung der COS-7-Linie von Affennierenfibroblasten.10. Ein Mikroorganismus nach Anspruch 8, erhalten durch Transformieren eines E. coli-Stammes.11. Ein Mikroorganismus nach Anspruch 8, erhalten durch Transformierung eines Hefestammes.12. Ein Plasmid,ausgewählt aus der Gruppe_, bestehend aus plFN-y-trp 48, pSV-^-69, und pPGK-IFN-^13. Ein Mikroorganismus oder eine Zellkultur, transformiert mit jedem der Plasmide nach Anspruch 12.14. Eine Stoffzusammensetzung, umfassend eine therapeutisch wirksame Fraktion eines Polypeptides, die im wesentlichen aus der Aminosäuresequenz von reifem menschlichem Immuninterferon besteht.15. Ein ZeI1kulturextrakt, umfassend mehr als etwa 90 % reines Polypeptidjbestehend im wesentlichen aus der Aminosäuresequenz von reifem Immuninterferon nach Anspruch 1,2,3 oder 4.16. Eine Zusammensetzung, umfassend eine therapeutisch wirksame Menge eines reifen menschlichen Immun interferons nach Anspruch 1, 3 oder 4, geeignet für pharmazeutische Verabreichung.17. Die Zusammensetzung nach Anspruch 16, geeignet für parenterale Verabreichung.18. Eine Kultur von transformanten Zellen, die fähig sind, menschliches Immuninterferon in reifer Form zu erzeugen.19. Die Verwendung eines reifen menschlichen Immuninterferons nach Anspruch 1, 3 oder 4 für die Antitumor-, Antivirus- oder Immunosuppressionsbehandlung oder für die Herstellung von pharmazeutischen Zusammensetzungen, die für eine solche Behandlung von Nutzen sind.20. Ein Verfahren,umfassend die Exprimierung eines für menschliches Immuninterferon kodierenden Gens in reifer Form in einer Mikroorganismusoder Zellkultur.21. Ein Verfahren,umfassend die Bildung eines Polypeptids nach Anspruch 1, 3 oder 4 in einer Mikroorganismus- oder Zellkultur.22. Ein Verfahren zur Herstellung eines Polypeptides nach Anspruch 1, 3 oder 4, umfassend das Bewirken einer Kultur eines Mikroorganismus oder einer Zellkultur, der (die) mit einem replizierbaren Expressionsvektor transformiert ist, zu wachsen und die Produktion des genannten Polypeptids zu bewirken,und das Gewinnen des genannten Polypeptids.23. Ein Verfahren zur Herstellung eines Expressionsvektors nach Anspruch 7} umfassend den Aufbau einer ersten DNA-Sequenz,die für das genannte (in Anspruch 7 definierte) Polypeptid kodiert, und das arbeitsfähige Binden der genannten ersten DNA-Sequenz mit einer zweiten DNA-Sequenz, die fähig ist, die Exprimierung der ersten DNA-Sequenz zu bewirken.24. Ein Produkt des Verfahrens nach Anspruch 20, 21, 22 oder 23,25. Eine Stoffzusammensetzung·, umfassend reifes menschliches Immuninterferon, das im wesentlichen frei von anderen Proteinen menschlichen Ursprungs ist.26. Ein im wesentlichen reines Polypeptid, dessen Aminosäuresequenz im wesentlichen der beiliegenden Fig. 5 entspricht.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31248981A | 1981-10-19 | 1981-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE77670T1 true DE77670T1 (de) | 1987-09-03 |
Family
ID=23211703
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE198282305521T Pending DE77670T1 (de) | 1981-10-19 | 1982-10-18 | Humanes immuninterferon. |
DE8282305521T Expired DE3279788D1 (en) | 1981-10-19 | 1982-10-18 | Human immune interferon |
DE1993175065 Active DE19375065I2 (de) | 1981-10-19 | 1982-10-18 | Humanes Immuninterferon. |
DE19823238554 Granted DE3238554A1 (de) | 1981-10-19 | 1982-10-18 | Human-immuninterferon |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8282305521T Expired DE3279788D1 (en) | 1981-10-19 | 1982-10-18 | Human immune interferon |
DE1993175065 Active DE19375065I2 (de) | 1981-10-19 | 1982-10-18 | Humanes Immuninterferon. |
DE19823238554 Granted DE3238554A1 (de) | 1981-10-19 | 1982-10-18 | Human-immuninterferon |
Country Status (43)
Country | Link |
---|---|
US (4) | US4762791A (de) |
EP (1) | EP0077670B1 (de) |
JP (3) | JPS5890514A (de) |
KR (1) | KR840001837A (de) |
AT (1) | ATE44289T1 (de) |
AU (1) | AU561343B2 (de) |
BG (2) | BG42527A3 (de) |
BR (1) | BR8206068A (de) |
CA (1) | CA1341590C (de) |
CH (1) | CH663619A5 (de) |
CZ (1) | CZ282154B6 (de) |
DD (1) | DD208822A5 (de) |
DE (4) | DE77670T1 (de) |
DK (1) | DK163187C (de) |
DZ (1) | DZ467A1 (de) |
ES (1) | ES8402351A1 (de) |
FI (1) | FI86559C (de) |
FR (1) | FR2514783B1 (de) |
GB (1) | GB2107718B (de) |
GR (1) | GR78391B (de) |
GT (1) | GT198277746A (de) |
HK (1) | HK66289A (de) |
HU (1) | HU202287B (de) |
IE (1) | IE54371B1 (de) |
IL (1) | IL66992A (de) |
IT (1) | IT1153265B (de) |
LU (1) | LU88327I2 (de) |
MX (2) | MX166499B (de) |
MY (1) | MY102546A (de) |
NL (1) | NL930040I2 (de) |
NO (2) | NO164177C (de) |
NZ (1) | NZ202190A (de) |
OA (1) | OA07233A (de) |
PH (1) | PH26963A (de) |
PL (1) | PL153202B1 (de) |
PT (1) | PT75696B (de) |
RO (1) | RO89534A (de) |
RU (3) | RU2056460C1 (de) |
SG (1) | SG76988G (de) |
SK (1) | SK279535B6 (de) |
YU (1) | YU45871B (de) |
ZA (1) | ZA827569B (de) |
ZW (1) | ZW22282A1 (de) |
Families Citing this family (188)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
ZW18282A1 (en) * | 1981-08-31 | 1983-03-23 | Genentech Inc | Preparation of polypeptides in vertebrate cell culture |
JPS58146281A (ja) * | 1981-10-19 | 1983-08-31 | Suntory Ltd | 酵母細胞の形質転換法 |
AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
JPS62223191A (ja) * | 1981-12-24 | 1987-10-01 | Asahi Chem Ind Co Ltd | 新規な生理活性ペプチドの製法 |
JPS58110548A (ja) * | 1981-12-24 | 1983-07-01 | Asahi Chem Ind Co Ltd | 新規な生理活性ペプチド |
GB8406910D0 (en) * | 1984-03-16 | 1984-04-18 | Biogen Nv | Gamma interferon |
EP0088540A3 (de) * | 1982-02-22 | 1984-10-17 | Biogen, Inc. | DNS-Sequenzen, Rekombinante DNS-Moleküle und Verfahren zur Herstellung von dem immunen menschlichen Interferon ähnlichen Polypeptiden |
US5004689A (en) * | 1982-02-22 | 1991-04-02 | Biogen, Massachusetts | DNA sequences, recombinant DNA molecules and processes for producing human gamma interferon-like polypeptides in high yields |
US6432677B1 (en) | 1982-03-08 | 2002-08-13 | Genentech, Inc. | Non-human animal interferons |
IE54592B1 (en) * | 1982-03-08 | 1989-12-06 | Genentech Inc | Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby |
US5827694A (en) * | 1982-03-08 | 1998-10-27 | Genentech, Inc. | DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides |
IL68100A0 (en) * | 1982-03-24 | 1983-06-15 | Takeda Chemical Industries Ltd | Novel dna and use thereof |
US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
JPH0787797B2 (ja) * | 1982-05-20 | 1995-09-27 | サントリー株式会社 | ヒト・ガンマ・インタ−フエロン様ポリペプチドの製造法 |
AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
AU571460B2 (en) * | 1982-09-27 | 1988-04-21 | Cancer Institute Of Japanese Foundation For Cancer Research | Alpha interferon dna, recombinant plasmid, engineered organism and alpha interferon polypeptide |
AU575301B2 (en) * | 1982-10-08 | 1988-07-28 | Juridical Foundation, Japanese Foundation For Cancer Research | Novel vector |
US4966843A (en) * | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
US5831023A (en) * | 1982-11-01 | 1998-11-03 | Genentech, Inc. | Recombinant animal interferon polypeptides |
WO1984002129A1 (en) * | 1982-11-22 | 1984-06-07 | Takeda Chemical Industries Ltd | Human immune interferon protein and process for its preparation |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
GR79124B (de) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
US4599197A (en) * | 1982-12-22 | 1986-07-08 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
JPH0740925B2 (ja) * | 1983-03-14 | 1995-05-10 | 協和醗酵工業株式会社 | 新規ヒトインタ−フエロン−γポリペプチド |
US7198919B1 (en) * | 1983-04-25 | 2007-04-03 | Genentech, Inc. | Use of alpha factor sequences in yeast expression systems |
ZA843275B (en) * | 1983-05-05 | 1984-12-24 | Hoffmann La Roche | Novel vectors for interferon expression |
DK265384A (da) * | 1983-06-01 | 1984-12-02 | Hoffmann La Roche | Polypeptider med interferonaktivitet |
JP2551746B2 (ja) * | 1983-07-19 | 1996-11-06 | サントリー株式会社 | 改良プラスミドベクタ−およびその利用 |
JPS6034919A (ja) * | 1983-08-04 | 1985-02-22 | Green Cross Corp:The | ガンマ・インタ−フェロン組成物 |
EP0133767B1 (de) * | 1983-08-04 | 1991-04-03 | The Green Cross Corporation | Gamma-Interferonzusammensetzung |
IL72773A0 (en) * | 1983-08-29 | 1984-11-30 | Meloy Lab | Production of immune interferon and its mrna |
US4476049A (en) * | 1983-09-20 | 1984-10-09 | Hoffmann-La Roche Inc. | Method for the extraction of immune interferon |
US4681930A (en) * | 1983-09-20 | 1987-07-21 | Hoffmann-La Roche Inc. | Immune interferon and a method for its extraction and purification |
US4604284A (en) * | 1983-09-20 | 1986-08-05 | Hoffmann-La Roche Inc. | Homogeneous immune interferon fragment |
ZA846554B (en) * | 1983-09-20 | 1985-04-24 | Hoffmann La Roche | Immune interferon and method for its purification |
JPS6079000A (ja) * | 1983-10-04 | 1985-05-04 | Takeda Chem Ind Ltd | ヒトγ型インタ−フエロン単量体の製造法 |
JPH0788398B2 (ja) * | 1983-10-17 | 1995-09-27 | サントリー株式会社 | 新規生理活性ポリペプチドおよびその製造法 |
GB8328820D0 (en) * | 1983-10-28 | 1983-11-30 | Searle & Co | Synthetic human gamma interferon gene |
FR2556365B1 (fr) * | 1983-12-09 | 1987-07-31 | Transgene Sa | Vecteurs de clonage et d'expression de l'interferon-g, bacteries transformees et procede de preparation de l'interferon-g |
KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
US4855238A (en) * | 1983-12-16 | 1989-08-08 | Genentech, Inc. | Recombinant gamma interferons having enhanced stability and methods therefor |
MX9203641A (es) * | 1983-12-16 | 1992-07-01 | Genentech Inc | Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion. |
JPS60145098A (ja) * | 1984-01-09 | 1985-07-31 | Suntory Ltd | 糖付加ポリペプチドの製造法 |
WO1985004420A1 (en) * | 1984-03-29 | 1985-10-10 | Takeda Chemical Industries, Ltd. | Novel dna and its use |
DE3414831A1 (de) * | 1984-04-19 | 1985-10-31 | Hoechst Ag, 6230 Frankfurt | Herstellung von polypeptiden mit human-gammainterferon-aktivitaet |
GB8414354D0 (en) * | 1984-06-05 | 1984-07-11 | Biogen Nv | Purifying protein |
WO1985005618A1 (en) * | 1984-06-06 | 1985-12-19 | Takeda Chemical Industries, Ltd. | Process for preparing interferon derivative |
IL75302A0 (en) * | 1984-06-06 | 1985-09-29 | Takeda Chemical Industries Ltd | Novel polypeptide and production thereof |
CA1302320C (en) * | 1984-06-11 | 1992-06-02 | Hideo Niwa | Expression of human cromosomal interferon-_ in animal cells |
JPS60262594A (ja) * | 1984-06-11 | 1985-12-25 | Kanegafuchi Chem Ind Co Ltd | ヒトインタ−フエロン−γ |
GB8414911D0 (en) * | 1984-06-12 | 1984-07-18 | Searle & Co | Producing human gamma interferon |
JPS6124599A (ja) * | 1984-07-11 | 1986-02-03 | Kyowa Hakko Kogyo Co Ltd | 新規ヒトインタ−フエロン−rポリペプチド誘導体 |
GB2164650A (en) * | 1984-09-25 | 1986-03-26 | Fujisawa Pharmaceutical Co | Process for production of y-interferon |
US4946674A (en) * | 1984-10-05 | 1990-08-07 | Bioferon Biochemische Substanzen Gmbh & Co. | Process for treatment of rheumatic diseases |
JPS6188875A (ja) * | 1984-10-05 | 1986-05-07 | Kanegafuchi Chem Ind Co Ltd | ヒトインタ−フエロン−γ |
DE3436638C2 (de) * | 1984-10-05 | 1992-10-08 | Bioferon biochemische Substanzen GmbH & Co, 7958 Laupheim | Verwendung von Interferon-gamma (IFN-gamma) enthaltenden Präparationen zur Behandlung rheumatischer Erkrankungen |
ATE66375T1 (de) * | 1984-10-05 | 1991-09-15 | Bioferon Biochem Substanz | Verwendung von interferon-gamma (ifn-gamma) enthaltenden praeparationen zur systemischen behandlung von verschiedenen erkrankungen des menschen in niedriger dosierung. |
IL76591A0 (en) * | 1984-10-05 | 1986-02-28 | Bioferon Biochem Substanz | Pharmaceutical compositions containing ifn-ypsilon and processes for the preparation thereof |
JPS61108397A (ja) * | 1984-10-31 | 1986-05-27 | Green Cross Corp:The | インタ−フエロン−γ蛋白質の製造法 |
AU598455B2 (en) * | 1984-12-27 | 1990-06-28 | Suntory Limited | Method for purifying an interferon |
JPS6156195A (ja) * | 1985-03-01 | 1986-03-20 | Asahi Chem Ind Co Ltd | 新規生理活性ペプチド |
GB8508340D0 (en) * | 1985-03-29 | 1985-05-09 | Creighton T E | Production of protein |
EP0225887B1 (de) * | 1985-04-08 | 1994-06-08 | Amgen Inc. | Verfahren und hybridpromotor zur steuerung der exogenen gentranskription |
US4873312A (en) * | 1985-04-25 | 1989-10-10 | Amgen | Method for purifying interferon and composition of matter produced thereby |
FR2583429B1 (fr) * | 1985-06-18 | 1989-11-03 | Transgene Sa | Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u |
US4845196A (en) * | 1985-06-24 | 1989-07-04 | G. D. Searle & Co. | Modified interferon gammas |
US5104795A (en) * | 1985-11-13 | 1992-04-14 | Zoma Corporation | Shortened phosphoglycerate kinase promoter |
JPS63501767A (ja) * | 1985-11-13 | 1988-07-21 | ゾマ、コーポレーション | 短縮化されたホスホグリセリン酸キナ−ゼプロモ−タ− |
EP0237019A3 (de) * | 1986-03-14 | 1988-03-09 | Toray Industries, Inc. | Konjugiertes Interferon und dessen Herstellung unter Verwendung eines rekombinanten Gens |
US5198343A (en) * | 1986-08-05 | 1993-03-30 | Transgene, S.A. | Method for expressing a heterologous protein in a dapD- mutant of E. coli and the strain obtained |
US6238889B1 (en) * | 1986-12-16 | 2001-05-29 | Dsm N.V. | Molecular cloning and expression of the Pro8 isoform of human IL-3 |
US4939088A (en) * | 1987-02-18 | 1990-07-03 | Meloy Laboratories Inc. | Sustained production of recombinant gamma interferon using an Epstein-Barr virus replicon |
US4944941A (en) * | 1987-08-07 | 1990-07-31 | Genentech, Inc. | Methods and compositions for the treatment of lung conditions |
US6384194B1 (en) * | 1987-12-16 | 2002-05-07 | Dsm N.V. | Expression and purification of human interleukin-3 and muteins thereof |
US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
IL90021A0 (en) * | 1988-04-25 | 1989-12-15 | Phillips Petroleum Co | Process for the production of interferon |
US5198212A (en) * | 1988-10-31 | 1993-03-30 | University Of Lousville Research Foundation Incorporated | Method and compositions for treatment of trauma-associated sepsis with gamma interferon |
US20020168750A1 (en) * | 1988-12-23 | 2002-11-14 | James Rasmussen | Enzymatically active recombinant glucocerebrosidase |
US5236838A (en) * | 1988-12-23 | 1993-08-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
US6451600B1 (en) * | 1989-12-22 | 2002-09-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
US5196191A (en) * | 1989-03-17 | 1993-03-23 | Genentech, Inc. | Temporal gamma-interferon administration for allergies |
US5112605A (en) * | 1989-03-17 | 1992-05-12 | Genentech, Inc. | Temporal gamma-interferon administration for allergies |
AU5355790A (en) * | 1989-04-19 | 1990-11-16 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
DE4009268A1 (de) * | 1990-03-22 | 1991-09-26 | Consortium Elektrochem Ind | Sekretion von hirudinderivaten |
US5281520A (en) * | 1990-09-12 | 1994-01-25 | Zymogenetics, Inc. | Method for producing acyloxyacyl hydrolase |
JPH05506247A (ja) * | 1990-09-27 | 1993-09-16 | シェリング・コーポレーション | ヒトγインターフェロンのアンタゴニスト |
EP0487298A3 (en) * | 1990-11-21 | 1992-12-16 | Schering Corporation | Human gamma interferon antagonist/agonist screen |
AU1268192A (en) * | 1991-01-04 | 1992-08-17 | Board Of Regents, The University Of Texas System | Cloning and expression of tissue transglutaminases |
AU1337092A (en) * | 1991-01-29 | 1992-08-27 | Brigham And Women's Hospital | A cdna encoding the type i iodothyronine 5' deiodinase |
US5272078A (en) * | 1991-01-29 | 1993-12-21 | Brigham And Women's Hospital | CDNA encoding the type I iodothyronine 5'deiodinase |
US6180602B1 (en) | 1992-08-04 | 2001-01-30 | Sagami Chemical Research Center | Human novel cDNA, TGF-beta superfamily protein encoded thereby and the use of immunosuppressive agent |
WO1994003599A1 (en) * | 1992-08-04 | 1994-02-17 | Sagami Chemical Research Center | HUMAN cDNA AND PROTEIN WHICH SAID cDNA CODES FOR |
WO1994010296A1 (en) * | 1992-11-03 | 1994-05-11 | Oklahoma Medical Research Foundation | Transglutaminase gene |
US6558661B1 (en) * | 1992-12-29 | 2003-05-06 | Genentech, Inc. | Treatment of inflammatory bowel disease with IFN-γ inhibitors |
AU690583B2 (en) | 1993-09-15 | 1998-04-30 | Novartis Vaccines And Diagnostics, Inc. | Recombinant alphavirus vectors |
JP4383530B2 (ja) | 1996-04-05 | 2009-12-16 | ノバルティス バクシンズ アンド ダイアグノスティックス, インコーポレーテッド | 細胞巨大分子合成の阻害が減少したアルファウイルスベクター |
WO1998012332A1 (en) | 1996-09-17 | 1998-03-26 | Chiron Corporation | Compositions and methods for treating intracellular diseases |
US20020168634A1 (en) * | 1999-05-05 | 2002-11-14 | Christine Marie Debouck | Methods for identifiying genes essential to the growth of an organism |
US6753165B1 (en) * | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
DE69838552T2 (de) | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
US7153943B2 (en) * | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
ATE410181T1 (de) | 1998-04-02 | 2008-10-15 | Genentech Inc | Verwendung von intereferon gamma zur behandlung von herzhypertrophie |
US6602705B1 (en) | 1998-12-31 | 2003-08-05 | Chiron Corporation | Expression of HIV polypeptides and production of virus-like particles |
US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
CN1309423C (zh) | 1999-11-12 | 2007-04-11 | 马克西根控股公司 | 干扰素γ偶联物 |
HUP0203409A3 (en) | 1999-11-12 | 2005-06-28 | Maxygen Holdings Ltd Redwood C | Interferon gamma conjugates |
EP2213743A1 (de) | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Albuminfusionsproteine |
IL152804A0 (en) * | 2000-05-16 | 2003-06-24 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
KR20040007413A (ko) * | 2000-11-03 | 2004-01-24 | 바이오메디신즈 인코포레이티드 | 단기 및 장기 약물 약량측정 방법 |
EP1351707B9 (de) * | 2001-01-09 | 2012-01-25 | Baylor Research Institute | Verfahren zur behandlung von autoimmunerkrankungen bei einem probanden und diagnostische in-vitro-assays |
US6958388B2 (en) | 2001-04-06 | 2005-10-25 | Maxygen, Aps | Interferon gamma polypeptide variants |
US7038015B2 (en) | 2001-04-06 | 2006-05-02 | Maxygen Holdings, Ltd. | Interferon gamma polypeptide variants |
EP2292772A1 (de) | 2001-07-05 | 2011-03-09 | Novartis Vaccines and Diagnostics, Inc. | HIV Impfung mit für ein HIV Polypeptid kodierender DNS und einem HIV Polypeptid |
CA2634992C (en) | 2001-07-05 | 2012-10-16 | Novartis Vaccines And Diagnostics, Inc. | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
KR100991644B1 (ko) * | 2001-08-17 | 2010-11-02 | 콜리 파마슈티칼 게엠베하 | 활성이 개량된 조합 모티프 면역자극성 올리고뉴클레오티드 |
US20050002900A1 (en) * | 2001-11-06 | 2005-01-06 | Grace Wong | Method of treating estrogen responsive breast cancer |
WO2003039455A2 (en) * | 2001-11-06 | 2003-05-15 | Applied Research Systems Ars Holding N.V. | Methods of treating endometreosis |
CN100438870C (zh) * | 2001-11-09 | 2008-12-03 | 精达制药公司 | ω干扰素在制备治疗温血动物对象中病毒性疾病的药物中的用途 |
JP2005517648A (ja) * | 2001-12-07 | 2005-06-16 | インターミューン インコーポレイテッド | 肝炎ウイルス感染症を治療するための組成物および方法 |
EP2261250B1 (de) | 2001-12-21 | 2015-07-01 | Human Genome Sciences, Inc. | GCSF-Albumin Fusionsproteine |
US6790641B2 (en) | 2002-05-01 | 2004-09-14 | Cell Genesys, Inc. | Lentiviral vector particles resistant to complement inactivation |
CA2491178A1 (en) | 2002-07-03 | 2004-01-15 | Maxygen Holdings Ltd. | Full-length interferon gamma polypeptide variants |
US7229614B2 (en) * | 2002-07-03 | 2007-06-12 | The Brigham And Women's Hospital, Inc. | Interferon gamma in the detection and treatment of angiomyolipomas |
US7335743B2 (en) * | 2002-10-16 | 2008-02-26 | Amgen Inc. | Human anti-IFN-γ neutralizing antibodies as selective IFN-γ pathway inhibitors |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
CA2545603A1 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto |
BRPI0507159A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos em feixe de quatro hélices humanos modificados e seus usos |
EP1814583A2 (de) | 2004-11-01 | 2007-08-08 | Novartis Vaccines and Diagnostics, Inc. | Kombinationswege zur erzeugung von immunantworten |
EP2364995A1 (de) | 2004-12-23 | 2011-09-14 | Molmed SpA | Konjugatprodukt |
KR20070100346A (ko) | 2005-01-05 | 2007-10-10 | 바이오겐 아이덱 엠에이 인코포레이티드 | 크립토 결합 분자 |
KR101380570B1 (ko) * | 2005-01-27 | 2014-04-01 | 노비뮨 에스 에이 | 인간 항-인터페론 감마 항체 및 이것의 사용 방법 |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US20100196336A1 (en) | 2006-05-23 | 2010-08-05 | Dongsu Park | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
CA2651855C (en) | 2006-05-30 | 2011-08-02 | Intarcia Therapeutics, Inc. | Two-piece, internal-channel osmotic delivery system flow modulator |
US7682356B2 (en) | 2006-08-09 | 2010-03-23 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies for use therein |
EP2102355B1 (de) | 2006-12-14 | 2016-03-02 | Bolder Biotechnology, Inc. | Proteine und peptide mit langer wirkung sowie verfahren zu ihrer herstellung und verwendung |
CN105688191A (zh) | 2007-04-23 | 2016-06-22 | 精达制药公司 | 促胰岛素释放肽的混悬制剂及其应用 |
CN101675071B (zh) * | 2007-05-02 | 2014-06-18 | Ambrx公司 | 经修饰干扰素β多肽和其用途 |
AU2008331866A1 (en) * | 2007-11-28 | 2009-06-11 | Smart Tube, Inc. | Devices, systems and methods for the collection, stimulation, stabilization, and analysis of a biological sample |
NZ602170A (en) | 2008-02-08 | 2014-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
EP2240155B1 (de) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Vorrichtungen, formulierungen und verfahren zur freisetzung mehrerer wirkstoffe |
EP2248903A1 (de) | 2009-04-29 | 2010-11-10 | Universitat Autònoma De Barcelona | Verfahren und Reagenzien zum effizienten und gezielten Gentransfer in Monozyten und Makrophagen |
US8298561B2 (en) | 2009-09-28 | 2012-10-30 | Intarcia Therapeutics, Inc. | Rapid establishment and/or termination of substantial steady-state drug delivery |
MX2013000301A (es) | 2010-07-09 | 2013-05-09 | Biogen Idec Hemophilia Inc | Factores quimericos de coagulacion. |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
RU2446172C1 (ru) * | 2011-03-24 | 2012-03-27 | Общество С Ограниченной Ответственностью "Фармапарк" | Способ получения зрелого интерферона альфа-2 человека с использованием дрожжей saccharomyces cerevisiae и штамм-продуцент интерферона альфа-2 человека (варианты) |
EA023379B1 (ru) * | 2011-06-21 | 2016-05-31 | Общество С Ограниченной Ответственностью "Фарма Ген" | ШТАММ ESCHERICHIA COLI BL21(DE3)-pIE-GAMMA И СПОСОБ ПОЛУЧЕНИЯ ПРЕПАРАТА НАТИВНОГО РЕКОМБИНАНТНОГО ИНТЕРФЕРОНА ГАММА ЧЕЛОВЕКА |
US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
WO2013024156A2 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of anti-hcv-entry factor antibodies and interferons for the treatment and the prevention of hcv infection |
WO2013024158A1 (en) | 2011-08-17 | 2013-02-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations of protein kinase inhibitors and interferons or of protein kinase inhibitors and direct acting antivirals for the treatment and the prevention of hcv infection |
WO2013106577A2 (en) | 2012-01-10 | 2013-07-18 | Biogen Idec Ma Inc. | Enhancement of transport of therapeutic molecules across the blood brain barrier |
US20140350087A9 (en) | 2012-03-22 | 2014-11-27 | Halozyme, Inc. | Oncovector Nucleic Acid Molecules and Methods of Use |
US9732144B2 (en) | 2012-07-05 | 2017-08-15 | Ohio State Innovation Foundation | Infectious bursal disease (IBDV) vaccine compositions |
WO2014033266A1 (en) | 2012-08-31 | 2014-03-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-sr-bi antibodies for the inhibition of hepatitis c virus infection |
AU2014228938B2 (en) | 2013-03-15 | 2019-05-02 | Bioverativ Therapeutics Inc. | Factor IX polypeptide formulations |
EP2940128A1 (de) | 2014-04-30 | 2015-11-04 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Adenovirus mit einem albuminbindenden Teil |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
DK3253875T3 (da) | 2015-02-04 | 2020-04-14 | H Hoffmann La Roche Ag | Tau-antisense-oligomerer og anvendelser deraf |
EP3954993A1 (de) | 2015-02-04 | 2022-02-16 | Bristol-Myers Squibb Company | Verfahren zur auswahl therapeutischer moleküle |
US11091543B2 (en) | 2015-05-07 | 2021-08-17 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
IL302519A (en) | 2015-05-07 | 2023-07-01 | Novimmune Sa | Methods and preparations for diagnosis and treatment of disorders in patients with high levels of chemokine C.-X.-C. Ligand 9 and other biomarkers |
CA2987766A1 (en) | 2015-06-03 | 2016-12-08 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
CN108348593B (zh) | 2015-08-31 | 2022-08-16 | 泰克诺瓦克斯股份有限公司 | 基于人呼吸道合胞病毒(hrsv)病毒样颗粒(vlps)的疫苗 |
JP7250520B2 (ja) | 2016-04-13 | 2023-04-03 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | 組換えアルテリウイルスレプリコン系およびその使用 |
MX2018014016A (es) | 2016-05-16 | 2019-08-01 | Intarcia Therapeutics Inc | Polipéptidos selectivos del receptor de glucagón y métodos para utilizarlos. |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
CA3040264A1 (en) | 2016-10-17 | 2018-04-26 | Synthetic Genomics, Inc. | Recombinant virus replicon systems and uses thereof |
WO2018106615A2 (en) | 2016-12-05 | 2018-06-14 | Synthetic Genomics, Inc. | Compositions and methods for enhancing gene expression |
WO2018129058A1 (en) | 2017-01-03 | 2018-07-12 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug |
US11672877B2 (en) | 2017-08-23 | 2023-06-13 | Wayne State University | In vivo immunoimaging of interferon-gamma |
EA202091516A1 (ru) | 2017-12-19 | 2020-11-03 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Способы и композиции для индукции иммунного ответа против вируса гепатита b (hbv) |
US11389531B2 (en) | 2017-12-19 | 2022-07-19 | Janssen Sciences Ireland Unlimited Company | Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines |
EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
AU2019210189A1 (en) | 2018-01-19 | 2020-08-06 | Janssen Pharmaceuticals, Inc. | Induce and enhance immune responses using recombinant replicon systems |
AU2021237818A1 (en) | 2020-03-19 | 2022-09-29 | Trizell Ltd. | Temperature-responsive virus storage system |
JP2023519709A (ja) | 2020-03-30 | 2023-05-12 | トライゼル リミテッド | がんを治療するための組成物及び方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4332892A (en) * | 1979-01-15 | 1982-06-01 | President And Fellows Of Harvard College | Protein synthesis |
JPS5598118A (en) * | 1979-01-18 | 1980-07-25 | Hayashibara Takeshi | Preparation of type-2 interferon and drug containing the same |
AU538665B2 (en) * | 1979-10-30 | 1984-08-23 | Juridical Foundation, Japanese Foundation For Cancer Research | Human interferon dna |
IL58765A (en) * | 1979-11-21 | 1986-09-30 | Yeda Res & Dev | Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta |
GB2068970B (en) * | 1980-02-06 | 1983-06-22 | Searle & Co | Recombinant dna technique for the preparation of a protein resembling human interferon |
DE3005897A1 (de) * | 1980-02-16 | 1981-09-03 | Hoechst Ag, 6000 Frankfurt | Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus |
US4338397A (en) * | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
US4460685A (en) * | 1980-05-29 | 1984-07-17 | New York University | Method of enhancing the production of human γ Interferon |
FI64813C (fi) * | 1980-12-31 | 1984-01-10 | Ilkka Antero Palva | Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer |
IL65475A0 (en) * | 1981-04-17 | 1982-07-30 | Meloy Lab | Production of immune interferon and its mrna |
US4376821A (en) * | 1981-04-17 | 1983-03-15 | Meloy Laboratories, Inc. | Production of human IFN-gamma (immune) interferon |
AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
-
1982
- 1982-10-14 AU AU89352/82A patent/AU561343B2/en not_active Expired
- 1982-10-15 ZA ZA827569A patent/ZA827569B/xx unknown
- 1982-10-15 IL IL66992A patent/IL66992A/xx not_active IP Right Cessation
- 1982-10-15 FI FI823528A patent/FI86559C/fi not_active IP Right Cessation
- 1982-10-15 ZW ZW222/82A patent/ZW22282A1/xx unknown
- 1982-10-15 NZ NZ202190A patent/NZ202190A/en unknown
- 1982-10-15 PH PH27993A patent/PH26963A/en unknown
- 1982-10-16 KR KR1019820004666A patent/KR840001837A/ko unknown
- 1982-10-17 DZ DZ826687A patent/DZ467A1/fr active
- 1982-10-18 DE DE198282305521T patent/DE77670T1/de active Pending
- 1982-10-18 GB GB08229661A patent/GB2107718B/en not_active Expired
- 1982-10-18 RO RO82108819A patent/RO89534A/ro unknown
- 1982-10-18 BG BG058326A patent/BG42527A3/xx unknown
- 1982-10-18 MX MX194810A patent/MX166499B/es unknown
- 1982-10-18 DD DD82244081A patent/DD208822A5/de unknown
- 1982-10-18 AT AT82305521T patent/ATE44289T1/de active
- 1982-10-18 YU YU233582A patent/YU45871B/sh unknown
- 1982-10-18 BR BR8206068A patent/BR8206068A/pt unknown
- 1982-10-18 ES ES516620A patent/ES8402351A1/es not_active Expired
- 1982-10-18 GR GR69556A patent/GR78391B/el unknown
- 1982-10-18 IT IT23795/82A patent/IT1153265B/it active
- 1982-10-18 DK DK460882A patent/DK163187C/da active
- 1982-10-18 CA CA004136713A patent/CA1341590C/en not_active Expired - Fee Related
- 1982-10-18 IE IE2517/82A patent/IE54371B1/en not_active IP Right Cessation
- 1982-10-18 JP JP57182681A patent/JPS5890514A/ja active Granted
- 1982-10-18 NO NO823467A patent/NO164177C/no not_active IP Right Cessation
- 1982-10-18 SK SK7389-82A patent/SK279535B6/sk unknown
- 1982-10-18 DE DE8282305521T patent/DE3279788D1/de not_active Expired
- 1982-10-18 CZ CS827389A patent/CZ282154B6/cs unknown
- 1982-10-18 DE DE1993175065 patent/DE19375065I2/de active Active
- 1982-10-18 CH CH6057/82A patent/CH663619A5/de not_active IP Right Cessation
- 1982-10-18 FR FR8217405A patent/FR2514783B1/fr not_active Expired
- 1982-10-18 DE DE19823238554 patent/DE3238554A1/de active Granted
- 1982-10-18 BG BG076612A patent/BG44877A3/xx unknown
- 1982-10-18 PT PT75696A patent/PT75696B/pt unknown
- 1982-10-18 EP EP82305521A patent/EP0077670B1/de not_active Expired
- 1982-10-19 HU HU823305A patent/HU202287B/hu unknown
- 1982-10-19 GT GT198277746A patent/GT198277746A/es unknown
- 1982-10-19 PL PL1982238671A patent/PL153202B1/pl unknown
- 1982-10-19 RU SU823507549A patent/RU2056460C1/ru active
- 1982-10-19 OA OA57825A patent/OA07233A/xx unknown
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1985
- 1985-06-20 US US06/746,813 patent/US4762791A/en not_active Expired - Lifetime
- 1985-09-11 US US06/774,838 patent/US4727138A/en not_active Expired - Lifetime
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1986
- 1986-11-11 JP JP61268482A patent/JP2515308B2/ja not_active Expired - Lifetime
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1987
- 1987-08-04 US US07/081,420 patent/US4925793A/en not_active Expired - Lifetime
- 1987-09-04 US US07/094,477 patent/US4929554A/en not_active Expired - Lifetime
- 1987-09-19 MY MYPI87001768A patent/MY102546A/en unknown
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1988
- 1988-04-08 RU SU884355518A patent/RU2092561C1/ru active
- 1988-04-28 RU SU4355606A patent/RU2107728C1/ru active
- 1988-11-17 SG SG769/88A patent/SG76988G/en unknown
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1989
- 1989-08-17 HK HK662/89A patent/HK66289A/xx not_active IP Right Cessation
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1990
- 1990-10-17 JP JP2278835A patent/JPH07106144B2/ja not_active Expired - Lifetime
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1992
- 1992-10-21 MX MX9206041A patent/MX9206041A/es not_active Application Discontinuation
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1993
- 1993-05-27 NL NL930040C patent/NL930040I2/nl unknown
- 1993-06-24 LU LU88327C patent/LU88327I2/fr unknown
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1994
- 1994-12-20 NO NO1994025C patent/NO1994025I1/no unknown
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