DE68908491T2 - Insulinvorläufer, deren Herstellung und DNA-Sequenzen, Expressionsvehikel und Primer und ein Prozess zur Herstellung von Humaninsulin und Analoge. - Google Patents

Insulinvorläufer, deren Herstellung und DNA-Sequenzen, Expressionsvehikel und Primer und ein Prozess zur Herstellung von Humaninsulin und Analoge.

Info

Publication number
DE68908491T2
DE68908491T2 DE89111221T DE68908491T DE68908491T2 DE 68908491 T2 DE68908491 T2 DE 68908491T2 DE 89111221 T DE89111221 T DE 89111221T DE 68908491 T DE68908491 T DE 68908491T DE 68908491 T2 DE68908491 T2 DE 68908491T2
Authority
DE
Germany
Prior art keywords
insulin
amino acid
production
precursors
acid residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89111221T
Other languages
English (en)
Other versions
DE68908491D1 (de
Inventor
Ib Jonassen
Ib Groth Clausen
Ejner Bech Jensen
Allan Svendsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of DE68908491D1 publication Critical patent/DE68908491D1/de
Publication of DE68908491T2 publication Critical patent/DE68908491T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE89111221T 1988-06-20 1989-06-20 Insulinvorläufer, deren Herstellung und DNA-Sequenzen, Expressionsvehikel und Primer und ein Prozess zur Herstellung von Humaninsulin und Analoge. Expired - Lifetime DE68908491T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK336188A DK336188D0 (da) 1988-06-20 1988-06-20 Propeptider

Publications (2)

Publication Number Publication Date
DE68908491D1 DE68908491D1 (de) 1993-09-23
DE68908491T2 true DE68908491T2 (de) 1994-01-20

Family

ID=8122004

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89111221T Expired - Lifetime DE68908491T2 (de) 1988-06-20 1989-06-20 Insulinvorläufer, deren Herstellung und DNA-Sequenzen, Expressionsvehikel und Primer und ein Prozess zur Herstellung von Humaninsulin und Analoge.

Country Status (17)

Country Link
US (2) US5202415A (de)
EP (1) EP0347845B1 (de)
JP (1) JP2766999B2 (de)
KR (1) KR0140238B1 (de)
AT (1) ATE93239T1 (de)
AU (1) AU618612B2 (de)
CA (1) CA1337976C (de)
DE (1) DE68908491T2 (de)
DK (1) DK336188D0 (de)
ES (1) ES2059627T3 (de)
FI (1) FI102294B (de)
IE (1) IE64303B1 (de)
NO (1) NO177499C (de)
NZ (1) NZ229615A (de)
PT (1) PT90897B (de)
WO (1) WO1989012647A1 (de)
ZA (1) ZA894639B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
KR100253916B1 (ko) * 1997-12-29 2000-05-01 김충환 사람 인슐린 전구체의 제조방법
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6777207B2 (en) 1999-12-29 2004-08-17 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
US6521738B2 (en) 1999-12-29 2003-02-18 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
DE60044728D1 (de) 1999-12-29 2010-09-02 Novo Nordisk As VERFAHREN ZUR HERSTELLUNG VON INSULINVORLäUFERN UND ANALOGEN VON INSULINVORLÄUFERN MIT VERBESSERTER FERMENTATIONSAUSBEUTE IN HEFE
US7378390B2 (en) 1999-12-29 2008-05-27 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
WO2002051428A1 (fr) * 2000-12-25 2002-07-04 Shiseido Company, Ltd. Composition de parfum stimulant le systeme sympathique
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7105314B2 (en) 2001-04-02 2006-09-12 Novo Nordisk A/S Method for making human insulin precursors
DE60233722D1 (de) * 2001-04-02 2009-10-29 Novo Nordisk As Insulinvorstufen und verfahren zu deren herstellung
WO2002079251A2 (en) * 2001-04-02 2002-10-10 Novo Nordisk A/S Method for making human insulin precursors
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) * 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US20030040601A1 (en) * 2001-06-08 2003-02-27 Ivan Diers Method for making insulin precursors and insulin analog precursors
AU2002316807A1 (en) * 2001-06-08 2002-12-23 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
AU2003236521A1 (en) * 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
WO2004085472A1 (en) * 2003-03-27 2004-10-07 Novo Nordisk A/S Method for making human insulin precursors and human insulin
DE602004015980D1 (de) 2003-06-17 2008-10-02 Sembiosys Genetics Inc Verfahren zur insulinproduktion in pflanzen
CA2580313C (en) * 2004-07-19 2016-03-15 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
ES2601839T3 (es) 2006-09-22 2017-02-16 Novo Nordisk A/S Análogos de insulina resistentes a proteasas
JP5868594B2 (ja) * 2007-10-16 2016-02-24 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ 経口投与可能な固形医薬組成物及びそのプロセス
ES2440289T3 (es) 2009-06-26 2014-01-28 Novo Nordisk A/S Preparación que comprende insulina, nicotinamida y arginina
EP2651432A1 (de) 2010-12-14 2013-10-23 Novo Nordisk A/S Schnellwirkendes insulin in verbindung mit langwirkendem insulin
RU2013130374A (ru) 2010-12-14 2015-01-20 Ново Нордиск А/С Препарат, содержащий инсулин, никотинамид и аминокислоту
WO2013186138A1 (en) 2012-06-14 2013-12-19 Novo Nordisk A/S Preparation comprising insulin, nicotinamide and arginine
KR20220119731A (ko) 2019-12-30 2022-08-30 간 앤 리 파마슈티칼스 컴퍼니, 리미티드 장기 지속형 glp-1 화합물
MX2022008130A (es) 2019-12-30 2022-10-03 Gan & Lee Pharmaceuticals Co Ltd Derivado de insulina.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL127843B1 (en) * 1980-03-27 1983-11-30 Lilly Co Eli Process for preparing insulin precursor
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
US5015575A (en) * 1983-04-07 1991-05-14 Chiron Corporation Hybrid DNA synthesis of insulin
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
KR900701842A (ko) * 1988-07-20 1990-12-04 헨리 브뢰늄 인간 인슐린 동족체와 그를 포함하는 제제
KR910700262A (ko) * 1988-12-23 1991-03-14 안네 제케르 사람 인슐린 유사체

Also Published As

Publication number Publication date
KR0140238B1 (en) 1998-07-01
NO905470D0 (no) 1990-12-19
DK336188D0 (da) 1988-06-20
FI102294B1 (fi) 1998-11-13
JPH03505206A (ja) 1991-11-14
FI102294B (fi) 1998-11-13
PT90897A (pt) 1989-12-29
NZ229615A (en) 1991-03-26
NO177499B (no) 1995-06-19
ES2059627T3 (es) 1994-11-16
EP0347845A2 (de) 1989-12-27
US5324641A (en) 1994-06-28
KR900701841A (ko) 1990-12-04
CA1337976C (en) 1996-01-23
PT90897B (pt) 1995-03-31
AU3860089A (en) 1990-01-12
ATE93239T1 (de) 1993-09-15
WO1989012647A1 (en) 1989-12-28
ZA894639B (en) 1991-12-24
IE891976L (en) 1989-12-20
US5202415A (en) 1993-04-13
EP0347845A3 (de) 1991-07-03
EP0347845B1 (de) 1993-08-18
JP2766999B2 (ja) 1998-06-18
AU618612B2 (en) 1992-01-02
NO905470L (no) 1991-02-18
DE68908491D1 (de) 1993-09-23
NO177499C (no) 1995-09-27
FI906285A0 (fi) 1990-12-19
IE64303B1 (en) 1995-07-26

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