NO177499C - Insulin-forstadier, DNA-sekvenser, replikerbare ekspresjonsvektorer og vertsceller - Google Patents

Insulin-forstadier, DNA-sekvenser, replikerbare ekspresjonsvektorer og vertsceller

Info

Publication number
NO177499C
NO177499C NO905470A NO905470A NO177499C NO 177499 C NO177499 C NO 177499C NO 905470 A NO905470 A NO 905470A NO 905470 A NO905470 A NO 905470A NO 177499 C NO177499 C NO 177499C
Authority
NO
Norway
Prior art keywords
insulin
amino acid
acid residues
precursors
replicable expression
Prior art date
Application number
NO905470A
Other languages
English (en)
Norwegian (no)
Other versions
NO905470L (no
NO905470D0 (no
NO177499B (no
Inventor
Ib Jonassen
Ib Groth Clausen
Ejner Bech Jensen
Allan Svendsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO905470D0 publication Critical patent/NO905470D0/no
Publication of NO905470L publication Critical patent/NO905470L/no
Publication of NO177499B publication Critical patent/NO177499B/no
Publication of NO177499C publication Critical patent/NO177499C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
NO905470A 1988-06-20 1990-12-19 Insulin-forstadier, DNA-sekvenser, replikerbare ekspresjonsvektorer og vertsceller NO177499C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK336188A DK336188D0 (da) 1988-06-20 1988-06-20 Propeptider
PCT/DK1989/000152 WO1989012647A1 (en) 1988-06-20 1989-06-19 Insulin precursors

Publications (4)

Publication Number Publication Date
NO905470D0 NO905470D0 (no) 1990-12-19
NO905470L NO905470L (no) 1991-02-18
NO177499B NO177499B (no) 1995-06-19
NO177499C true NO177499C (no) 1995-09-27

Family

ID=8122004

Family Applications (1)

Application Number Title Priority Date Filing Date
NO905470A NO177499C (no) 1988-06-20 1990-12-19 Insulin-forstadier, DNA-sekvenser, replikerbare ekspresjonsvektorer og vertsceller

Country Status (17)

Country Link
US (2) US5202415A (de)
EP (1) EP0347845B1 (de)
JP (1) JP2766999B2 (de)
KR (1) KR0140238B1 (de)
AT (1) ATE93239T1 (de)
AU (1) AU618612B2 (de)
CA (1) CA1337976C (de)
DE (1) DE68908491T2 (de)
DK (1) DK336188D0 (de)
ES (1) ES2059627T3 (de)
FI (1) FI102294B (de)
IE (1) IE64303B1 (de)
NO (1) NO177499C (de)
NZ (1) NZ229615A (de)
PT (1) PT90897B (de)
WO (1) WO1989012647A1 (de)
ZA (1) ZA894639B (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
US6001604A (en) * 1993-12-29 1999-12-14 Bio-Technology General Corp. Refolding of proinsulins without addition of reducing agents
KR0150565B1 (ko) * 1995-02-15 1998-08-17 김정재 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
KR100253916B1 (ko) * 1997-12-29 2000-05-01 김충환 사람 인슐린 전구체의 제조방법
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6777207B2 (en) 1999-12-29 2004-08-17 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
US7378390B2 (en) 1999-12-29 2008-05-27 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
US6521738B2 (en) 1999-12-29 2003-02-18 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
WO2001049870A1 (en) 1999-12-29 2001-07-12 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
KR100449454B1 (ko) * 2000-10-02 2004-09-21 이현철 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터
KR20030005204A (ko) * 2000-12-25 2003-01-17 가부시키가이샤 시세이도 교감신경 활성화 향료 조성물
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
WO2002079251A2 (en) * 2001-04-02 2002-10-10 Novo Nordisk A/S Method for making human insulin precursors
US7105314B2 (en) 2001-04-02 2006-09-12 Novo Nordisk A/S Method for making human insulin precursors
ATE443082T1 (de) * 2001-04-02 2009-10-15 Novo Nordisk As Insulinvorstufen und verfahren zu deren herstellung
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828297B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
AU2002316807A1 (en) * 2001-06-08 2002-12-23 Novo Nordisk A/S Method for making insulin precursors and insulin precursor analogs
US20030040601A1 (en) * 2001-06-08 2003-02-27 Ivan Diers Method for making insulin precursors and insulin analog precursors
US7196059B2 (en) * 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7601688B2 (en) * 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
WO2004085472A1 (en) * 2003-03-27 2004-10-07 Novo Nordisk A/S Method for making human insulin precursors and human insulin
CN1836047B (zh) 2003-06-17 2010-12-22 赛姆生物系统遗传公司 在植物中生产胰岛素的方法
CA2580313C (en) * 2004-07-19 2016-03-15 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof
KR101699370B1 (ko) 2006-09-22 2017-02-14 노보 노르디스크 에이/에스 프로테아제 내성 인슐린 유사체
CN101939023B (zh) * 2007-10-16 2016-08-03 百康有限公司 可经口给药的固体药物组合物及其方法
WO2010149772A1 (en) 2009-06-26 2010-12-29 Novo Nordisk A/S Preparation comprising insulin, nicotinamide and an amino acid
CN103249427A (zh) 2010-12-14 2013-08-14 诺沃—诺迪斯克有限公司 速效胰岛素联合长效胰岛素
RU2013130374A (ru) 2010-12-14 2015-01-20 Ново Нордиск А/С Препарат, содержащий инсулин, никотинамид и аминокислоту
WO2013186138A1 (en) 2012-06-14 2013-12-19 Novo Nordisk A/S Preparation comprising insulin, nicotinamide and arginine
EP4086279A4 (de) 2019-12-30 2024-08-07 Gan & Lee Pharmaceuticals Co Ltd Insulinderivat
AU2020418207A1 (en) 2019-12-30 2022-08-25 Gan & Lee Pharmaceuticals Co., Ltd. Long-acting GLP-1 compound
CN118574842A (zh) 2022-01-28 2024-08-30 甘李药业股份有限公司 酰化胰岛素

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO81951B (ro) * 1980-03-27 1984-02-28 Eli Lilly And Company Procedeu de preparare a unui precursor de insulina
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
US5015575A (en) * 1983-04-07 1991-05-14 Chiron Corporation Hybrid DNA synthesis of insulin
DE3327928A1 (de) * 1983-08-03 1985-02-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten
DK58285D0 (da) * 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
DK437786D0 (da) * 1986-09-12 1986-09-12 Nordisk Gentofte Insulinprecursorer
KR900701842A (ko) * 1988-07-20 1990-12-04 헨리 브뢰늄 인간 인슐린 동족체와 그를 포함하는 제제
KR910700262A (ko) * 1988-12-23 1991-03-14 안네 제케르 사람 인슐린 유사체

Also Published As

Publication number Publication date
ES2059627T3 (es) 1994-11-16
AU3860089A (en) 1990-01-12
FI102294B1 (fi) 1998-11-13
EP0347845A2 (de) 1989-12-27
FI102294B (fi) 1998-11-13
KR900701841A (ko) 1990-12-04
US5202415A (en) 1993-04-13
PT90897A (pt) 1989-12-29
PT90897B (pt) 1995-03-31
ZA894639B (en) 1991-12-24
CA1337976C (en) 1996-01-23
EP0347845B1 (de) 1993-08-18
FI906285A0 (fi) 1990-12-19
DK336188D0 (da) 1988-06-20
KR0140238B1 (en) 1998-07-01
EP0347845A3 (de) 1991-07-03
DE68908491D1 (de) 1993-09-23
ATE93239T1 (de) 1993-09-15
NO905470L (no) 1991-02-18
NZ229615A (en) 1991-03-26
NO905470D0 (no) 1990-12-19
IE891976L (en) 1989-12-20
NO177499B (no) 1995-06-19
WO1989012647A1 (en) 1989-12-28
IE64303B1 (en) 1995-07-26
JP2766999B2 (ja) 1998-06-18
JPH03505206A (ja) 1991-11-14
AU618612B2 (en) 1992-01-02
US5324641A (en) 1994-06-28
DE68908491T2 (de) 1994-01-20

Similar Documents

Publication Publication Date Title
NO177499C (no) Insulin-forstadier, DNA-sekvenser, replikerbare ekspresjonsvektorer og vertsceller
NO174351C (no) Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten
NO885659D0 (no) Mycobakterielle rekombinanter og peptider.
SG49097A1 (en) Nucleotide sequences coding for a protein with urease activity
ES2009238A6 (es) Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas.
AU5945086A (en) Hybrid polypeptides by recombinant dna technology
CY2028A (en) Peptides having a brady kinine-inhibiting activity
NO924234D0 (no) Variant cd44-overflateproteiner, dna-sekvenser som koder for proteinene, antistoffer mot proteinene, samt anvendelser av proteinene i diagnose og terapi
DE69334350D1 (de) P- Selectin Ligandenprotein
AU8258591A (en) Human mk gene and protein sequence
DK301090A (da) Insulinprecursorer
ES2007110A6 (es) Un metodo para la preparacion de precursores de insulina.
TH38358A (th) ลำดับกรดนิวคลีอิคและกรดอะมิโนที่เกี่ยวข้องกับHelicobacter pylori สำหรับการวินิจฉัยและรักษา