ATE93239T1 - Insulinvorlaeufer, deren herstellung und dnasequenzen, expressionsvehikel und primer und ein prozess zur herstellung von humaninsulin und analoge. - Google Patents
Insulinvorlaeufer, deren herstellung und dnasequenzen, expressionsvehikel und primer und ein prozess zur herstellung von humaninsulin und analoge.Info
- Publication number
- ATE93239T1 ATE93239T1 AT89111221T AT89111221T ATE93239T1 AT E93239 T1 ATE93239 T1 AT E93239T1 AT 89111221 T AT89111221 T AT 89111221T AT 89111221 T AT89111221 T AT 89111221T AT E93239 T1 ATE93239 T1 AT E93239T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin
- amino acid
- production
- precursors
- acid residues
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 11
- 102000004877 Insulin Human genes 0.000 title abstract 5
- 108090001061 Insulin Proteins 0.000 title abstract 5
- 229940125396 insulin Drugs 0.000 title abstract 5
- 239000002243 precursor Substances 0.000 title abstract 5
- 101000976075 Homo sapiens Insulin Proteins 0.000 title abstract 4
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 230000014509 gene expression Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 2
- 238000000034 method Methods 0.000 title 1
- 230000008569 process Effects 0.000 title 1
- 125000000539 amino acid group Chemical group 0.000 abstract 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK336188A DK336188D0 (da) | 1988-06-20 | 1988-06-20 | Propeptider |
| EP89111221A EP0347845B1 (de) | 1988-06-20 | 1989-06-20 | Insulinvorläufer, deren Herstellung und DNA-Sequenzen, Expressionsvehikel und Primer und ein Prozess zur Herstellung von Humaninsulin und Analoge |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE93239T1 true ATE93239T1 (de) | 1993-09-15 |
Family
ID=8122004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89111221T ATE93239T1 (de) | 1988-06-20 | 1989-06-20 | Insulinvorlaeufer, deren herstellung und dnasequenzen, expressionsvehikel und primer und ein prozess zur herstellung von humaninsulin und analoge. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5202415A (de) |
| EP (1) | EP0347845B1 (de) |
| JP (1) | JP2766999B2 (de) |
| KR (1) | KR0140238B1 (de) |
| AT (1) | ATE93239T1 (de) |
| AU (1) | AU618612B2 (de) |
| CA (1) | CA1337976C (de) |
| DE (1) | DE68908491T2 (de) |
| DK (1) | DK336188D0 (de) |
| ES (1) | ES2059627T3 (de) |
| FI (1) | FI102294B1 (de) |
| IE (1) | IE64303B1 (de) |
| NO (1) | NO177499C (de) |
| NZ (1) | NZ229615A (de) |
| PT (1) | PT90897B (de) |
| WO (1) | WO1989012647A1 (de) |
| ZA (1) | ZA894639B (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK105489D0 (da) * | 1989-03-03 | 1989-03-03 | Novo Nordisk As | Polypeptid |
| DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
| DK72793D0 (da) * | 1993-06-21 | 1993-06-21 | Novo Nordisk As | Nyt produkt |
| US6001604A (en) * | 1993-12-29 | 1999-12-14 | Bio-Technology General Corp. | Refolding of proinsulins without addition of reducing agents |
| KR0150565B1 (ko) * | 1995-02-15 | 1998-08-17 | 김정재 | 유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법 |
| GB9513967D0 (en) * | 1995-07-08 | 1995-09-06 | Univ Leicester | Insulin |
| KR100253916B1 (ko) * | 1997-12-29 | 2000-05-01 | 김충환 | 사람 인슐린 전구체의 제조방법 |
| US7169889B1 (en) | 1999-06-19 | 2007-01-30 | Biocon Limited | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin |
| US6521738B2 (en) | 1999-12-29 | 2003-02-18 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogs |
| BR0016860A (pt) | 1999-12-29 | 2002-10-01 | Novo Nordisk As | Precursor da insulina ou análogo de precursor de insulina, sequência de polinucleotìdeo, vetor de expressão, célula hospedeira, e, processos para fabricar um precursor da insulina ou análogo de precursor de insulina, e, insulina ou um análogo de insulina |
| US7378390B2 (en) | 1999-12-29 | 2008-05-27 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
| US6777207B2 (en) | 1999-12-29 | 2004-08-17 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast |
| KR100449454B1 (ko) * | 2000-10-02 | 2004-09-21 | 이현철 | 단일사슬 인슐린 유도체의 유전자를 포함하는 당뇨병치료용 벡터 |
| US20030054015A1 (en) * | 2000-12-25 | 2003-03-20 | Shinichiro Haze | Sympathetic-activating perfume composition |
| US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
| US6867183B2 (en) * | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| ES2333942T3 (es) * | 2001-04-02 | 2010-03-03 | Novo Nordisk A/S | Precursores de insulina y proceso para su preparacion. |
| US7105314B2 (en) | 2001-04-02 | 2006-09-12 | Novo Nordisk A/S | Method for making human insulin precursors |
| WO2002079251A2 (en) * | 2001-04-02 | 2002-10-10 | Novo Nordisk A/S | Method for making human insulin precursors |
| US6835802B2 (en) * | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
| US6713452B2 (en) * | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US7713932B2 (en) * | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
| US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US6828305B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| US20030040601A1 (en) * | 2001-06-08 | 2003-02-27 | Ivan Diers | Method for making insulin precursors and insulin analog precursors |
| WO2002100887A2 (en) * | 2001-06-08 | 2002-12-19 | Novo Nordisk A/S | Method for making insulin precursors and insulin precursor analogs |
| US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
| US6913903B2 (en) * | 2001-09-07 | 2005-07-05 | Nobex Corporation | Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US7166571B2 (en) * | 2001-09-07 | 2007-01-23 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
| AU2003236521A1 (en) * | 2002-06-13 | 2003-12-31 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
| WO2004085472A1 (en) * | 2003-03-27 | 2004-10-07 | Novo Nordisk A/S | Method for making human insulin precursors and human insulin |
| EP1633876B1 (de) | 2003-06-17 | 2008-08-20 | SemBioSys Genetics Inc. | Verfahren zur insulinproduktion in pflanzen |
| RU2527893C2 (ru) | 2004-07-19 | 2014-09-10 | Биокон Лимитед | Инсулин-олигомерные конъюгаты, их препараты и применения |
| US9018161B2 (en) | 2006-09-22 | 2015-04-28 | Novo Nordisk A/S | Protease resistant insulin analogues |
| BRPI0818004B8 (pt) * | 2007-10-16 | 2021-05-25 | Biocon Ltd | composição farmacêutica sólida administrável por via oral e o processo da mesma. |
| RU2533217C3 (ru) | 2009-06-26 | 2020-12-21 | Ново Нордиск А/С | Препарат, содержащий инсулин, никотинамид и аминокислоту |
| CN103249427A (zh) | 2010-12-14 | 2013-08-14 | 诺沃—诺迪斯克有限公司 | 速效胰岛素联合长效胰岛素 |
| MX2013006174A (es) | 2010-12-14 | 2013-07-15 | Novo Nordisk As | Preparacion que comprende insulina, nicotinamida y un aminoacido. |
| WO2013186138A1 (en) | 2012-06-14 | 2013-12-19 | Novo Nordisk A/S | Preparation comprising insulin, nicotinamide and arginine |
| WO2021136293A1 (zh) | 2019-12-30 | 2021-07-08 | 甘李药业股份有限公司 | 胰岛素衍生物 |
| JP2023510218A (ja) | 2019-12-30 | 2023-03-13 | ガン アンド リー ファーマスゥーティカルズ カンパニー リミテッド | 長時間作用型ｇｌｐ－１化合物 |
| EP4471053A1 (de) | 2022-01-28 | 2024-12-04 | Gan & Lee Pharmaceuticals Co., Ltd. | Acyliertes insulin |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU76881A (en) * | 1980-03-27 | 1984-04-30 | Lilly Co Eli | Process for obtaining insulin precursors |
| US4430266A (en) * | 1980-11-28 | 1984-02-07 | Eli Lilly And Company | Process for producing an insulin precursor |
| US5015575A (en) * | 1983-04-07 | 1991-05-14 | Chiron Corporation | Hybrid DNA synthesis of insulin |
| DE3327928A1 (de) * | 1983-08-03 | 1985-02-21 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten |
| DK58285D0 (da) * | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| DK347086D0 (da) * | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
| US4946828A (en) * | 1985-03-12 | 1990-08-07 | Novo Nordisk A/S | Novel insulin peptides |
| DK129385A (da) * | 1985-03-22 | 1986-09-23 | Novo Industri As | Peptider og fremstilling deraf |
| DK437786D0 (da) * | 1986-09-12 | 1986-09-12 | Nordisk Gentofte | Insulinprecursorer |
| US5149777A (en) * | 1988-07-20 | 1992-09-22 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
| JPH04502465A (ja) * | 1988-12-23 | 1992-05-07 | ノボ ノルディスク アクティーゼルスカブ | ヒトインシュリン類似物質 |
-
1988
- 1988-06-20 DK DK336188A patent/DK336188D0/da not_active Application Discontinuation
-
1989
- 1989-06-19 JP JP1507202A patent/JP2766999B2/ja not_active Expired - Fee Related
- 1989-06-19 PT PT90897A patent/PT90897B/pt not_active IP Right Cessation
- 1989-06-19 CA CA000603208A patent/CA1337976C/en not_active Expired - Fee Related
- 1989-06-19 ZA ZA894639A patent/ZA894639B/xx unknown
- 1989-06-19 IE IE197689A patent/IE64303B1/en not_active IP Right Cessation
- 1989-06-19 AU AU38600/89A patent/AU618612B2/en not_active Ceased
- 1989-06-19 WO PCT/DK1989/000152 patent/WO1989012647A1/en not_active Ceased
- 1989-06-19 US US07/623,739 patent/US5202415A/en not_active Expired - Lifetime
- 1989-06-20 ES ES89111221T patent/ES2059627T3/es not_active Expired - Lifetime
- 1989-06-20 AT AT89111221T patent/ATE93239T1/de not_active IP Right Cessation
- 1989-06-20 DE DE89111221T patent/DE68908491T2/de not_active Expired - Lifetime
- 1989-06-20 NZ NZ229615A patent/NZ229615A/en unknown
- 1989-06-20 EP EP89111221A patent/EP0347845B1/de not_active Expired - Lifetime
-
1990
- 1990-02-20 KR KR90700348A patent/KR0140238B1/ko not_active Expired - Fee Related
- 1990-12-19 FI FI906285A patent/FI102294B1/fi not_active IP Right Cessation
- 1990-12-19 NO NO905470A patent/NO177499C/no unknown
-
1992
- 1992-09-23 US US07/952,696 patent/US5324641A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI102294B (fi) | 1998-11-13 |
| NO905470D0 (no) | 1990-12-19 |
| PT90897B (pt) | 1995-03-31 |
| NZ229615A (en) | 1991-03-26 |
| JPH03505206A (ja) | 1991-11-14 |
| EP0347845A3 (de) | 1991-07-03 |
| NO177499B (no) | 1995-06-19 |
| EP0347845B1 (de) | 1993-08-18 |
| NO905470L (no) | 1991-02-18 |
| PT90897A (pt) | 1989-12-29 |
| WO1989012647A1 (en) | 1989-12-28 |
| FI102294B1 (fi) | 1998-11-13 |
| DE68908491D1 (de) | 1993-09-23 |
| KR900701841A (ko) | 1990-12-04 |
| CA1337976C (en) | 1996-01-23 |
| US5324641A (en) | 1994-06-28 |
| DE68908491T2 (de) | 1994-01-20 |
| IE64303B1 (en) | 1995-07-26 |
| JP2766999B2 (ja) | 1998-06-18 |
| IE891976L (en) | 1989-12-20 |
| AU618612B2 (en) | 1992-01-02 |
| ZA894639B (en) | 1991-12-24 |
| FI906285A0 (fi) | 1990-12-19 |
| DK336188D0 (da) | 1988-06-20 |
| ES2059627T3 (es) | 1994-11-16 |
| US5202415A (en) | 1993-04-13 |
| EP0347845A2 (de) | 1989-12-27 |
| NO177499C (no) | 1995-09-27 |
| KR0140238B1 (en) | 1998-07-01 |
| AU3860089A (en) | 1990-01-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE93239T1 (de) | Insulinvorlaeufer, deren herstellung und dnasequenzen, expressionsvehikel und primer und ein prozess zur herstellung von humaninsulin und analoge. | |
| NO174351C (no) | Fremgangsmåte for fremstilling av human insulinforlöper samt DNA-sekvens og vektor til anvendelse av fremgangsmåten | |
| ATE257516T1 (de) | Nukleotidsequenzen, die für ein protein mit ureaseaktivität kodieren | |
| DE69124939D1 (de) | Rekombinante DNS-Sequenzen kodierend für Enzyme frei von Feedback Inhibition, Plasmide diese Sequenzen enthaltend, transformierte Mikroorganismen nützlich für Produktion von aromatischen Aminosäuren, und deren Verfahren zur Herstellung durch Fermentation | |
| AU1672388A (en) | Expression of human proapolipoprotein a-i | |
| BR9712348B1 (pt) | vetor de expressão, célula de bactéria ou levedura transformada ou transfectada, processo para produzir um polipeptídeo homólogo de fgf, composição farmacêutica, e, processos para estimular ex vivo células progenitoras de miócitos ou miócitos | |
| ES2009238A6 (es) | Metodo para producir proteinas de mycobacterium tuberculosis y peptidos antigenicos de las mismas. | |
| DK1396542T3 (da) | P-selectin ligand protein | |
| EP0374044A3 (de) | TGF béta 1/béta2: ein chimärer transformierender Wachstumsfaktor | |
| CA2169631A1 (en) | A novel homeobox factor which stimulates insulin expression in pancreatic islet cells | |
| DK301090A (da) | Insulinprecursorer | |
| DK0828004T3 (da) | Proteindisulfidisomerase-gen afledt af stamme af methylotrof gær | |
| DK238585A (da) | Peptider og fremstilling deraf |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |