ATE257516T1 - Nukleotidsequenzen, die für ein protein mit ureaseaktivität kodieren - Google Patents

Nukleotidsequenzen, die für ein protein mit ureaseaktivität kodieren

Info

Publication number
ATE257516T1
ATE257516T1 AT94110776T AT94110776T ATE257516T1 AT E257516 T1 ATE257516 T1 AT E257516T1 AT 94110776 T AT94110776 T AT 94110776T AT 94110776 T AT94110776 T AT 94110776T AT E257516 T1 ATE257516 T1 AT E257516T1
Authority
AT
Austria
Prior art keywords
protein
nucleotide sequences
urease activity
sequences coding
urease
Prior art date
Application number
AT94110776T
Other languages
English (en)
Inventor
Agnes Labigne
Original Assignee
Pasteur Institut
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Inst Nat Sante Rech Med filed Critical Pasteur Institut
Application granted granted Critical
Publication of ATE257516T1 publication Critical patent/ATE257516T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
AT94110776T 1988-10-06 1989-10-06 Nukleotidsequenzen, die für ein protein mit ureaseaktivität kodieren ATE257516T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8813135A FR2637612B1 (fr) 1988-10-06 1988-10-06 Sequences de nucleotides codant pour une proteine a activite ureasique

Publications (1)

Publication Number Publication Date
ATE257516T1 true ATE257516T1 (de) 2004-01-15

Family

ID=9370758

Family Applications (2)

Application Number Title Priority Date Filing Date
AT89402764T ATE118821T1 (de) 1988-10-06 1989-10-06 Nukleotidesequenzen, die ein protein mit ureareaktivität kodieren.
AT94110776T ATE257516T1 (de) 1988-10-06 1989-10-06 Nukleotidsequenzen, die für ein protein mit ureaseaktivität kodieren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT89402764T ATE118821T1 (de) 1988-10-06 1989-10-06 Nukleotidesequenzen, die ein protein mit ureareaktivität kodieren.

Country Status (9)

Country Link
US (5) US5695931A (de)
EP (2) EP0367644B1 (de)
JP (3) JP2628767B2 (de)
AT (2) ATE118821T1 (de)
DE (2) DE68929510T2 (de)
ES (2) ES2214479T3 (de)
FR (1) FR2637612B1 (de)
SG (1) SG49097A1 (de)
WO (1) WO1990004030A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2637612B1 (fr) * 1988-10-06 1993-09-10 Pasteur Institut Sequences de nucleotides codant pour une proteine a activite ureasique
GB8928625D0 (en) * 1989-12-19 1990-02-21 3I Res Expl Ltd H.pylori dna probes
IE76730B1 (en) * 1990-07-30 1997-11-05 Abbott Laboraties Method and product for the treatment of gastric disease
JPH04169539A (ja) * 1990-11-01 1992-06-17 Imuno Japan:Kk 消化器疾患治療・予防剤およびその製造方法
FR2682122B1 (fr) * 1991-10-03 1995-06-09 Pasteur Institut Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
US5928865A (en) * 1992-03-02 1999-07-27 Chiron S.P.A. Compositions comprising isolated Helicobacter pylori CagI polynucleotides and method of preparation thereof
WO1993018150A1 (en) 1992-03-02 1993-09-16 Biocine S.P.A. Helicobacter pylori proteins useful for vaccines and diagnostics
US6130059A (en) * 1992-03-02 2000-10-10 Covacci; Antonello Helicobacter pylori proteins useful for vaccines and diagnostics
US7141244B1 (en) 1992-03-02 2006-11-28 Chiron Srl Helicobacter pylori proteins useful for vaccines and diagnostics
IT1262895B (it) * 1992-03-02 1996-07-22 Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico.
MX9301706A (es) * 1992-04-13 1994-05-31 Oravax Inc Composicion de vacuna para el tratamiento de la infeccion por helicobacter.
US6290962B1 (en) * 1992-11-03 2001-09-18 Oravax, Inc. Urease-based vaccine and treatment for helicobacter infection
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
EP0698104B1 (de) * 1993-05-14 1997-10-01 CHAN, Voon Loong Hippurikasegen
US5843460A (en) * 1993-05-19 1998-12-01 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides
WO1995014093A1 (en) 1993-05-19 1995-05-26 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions and nucleic acid sequences encoding said polypeptides
GB9313437D0 (en) * 1993-06-30 1993-08-11 Smith Andrew W Pathogenicity sequences in helicobacter pylori
US6406703B1 (en) 1993-07-27 2002-06-18 Csl Limited Treatment of H. pylori associated gastroduodenal disease
DE69432929T2 (de) * 1993-07-27 2004-04-15 Csl Ltd., Parkville Behandlung eines durch helicobakter verursachten gastroduodenalen krankheit
FR2719998B1 (fr) * 1994-04-08 1996-09-27 Pasteur Merieux Serums Vacc Composition immunisante anti-hélicobacter pylori à base de catalase.
AUPM612494A0 (en) * 1994-06-08 1994-06-30 Csl Limited Treatment or prevention of helicobacter infection
GB2290710B (en) * 1994-06-29 1998-03-25 Reckitt & Colmann Prod Ltd Protease from helicobacter pylori for use in vaccines/therapeutic compositions
US6468765B1 (en) 1995-04-21 2002-10-22 Human Genome Sciences, Inc. Selected Haemophilus influenzae Rd polynucleotides and polypeptides
GB2307987A (en) * 1995-12-06 1997-06-11 Univ Manchester Epitopes of the urease of Helicobacter pylori as dignostic agents; pharmaceuticals comprising such epitopes or the antibodies thereto
WO1997025429A1 (en) 1996-01-04 1997-07-17 Rican Limited Helicobacter pylori bacterioferritin
WO1997038110A2 (en) * 1996-04-05 1997-10-16 Kieta Holding S.A. Compositions and methods relating to drug discovery and detection and treatment of gastrointestinal diseases
US6248551B1 (en) * 1997-03-28 2001-06-19 Institut Pasteur Helicobacter aliphatic amidase AmiE polypeptides, and DNA sequences encoding those polypeptides
JP3430853B2 (ja) * 1997-04-11 2003-07-28 株式会社ゲン・コーポレーション 胃炎、胃潰瘍および十二指腸潰瘍の予防剤並びに治療剤
EP1105159A2 (de) 1998-06-19 2001-06-13 Mérieux Oravax Lt und ct in verfahren zur parenteralen immunisierung gegen helicobacter-infektionen
US6190667B1 (en) * 1998-06-30 2001-02-20 Institut Pasteur Methods of inhibiting Helicobacter pylori
TWI237695B (en) * 1999-12-14 2005-08-11 Joy Biomedical Corp Helicobacter pylori antigens in blood
US7556807B2 (en) 2001-02-20 2009-07-07 Kane Biotech, Inc. Signal peptides, nucleic acid molecules and methods for treatment of caries
US7597895B2 (en) * 2001-02-20 2009-10-06 The Governing Council Of The University Of Toronto Signal peptides, nucleic acid molecules and methods for treatment of caries
DK1530482T3 (da) 2002-07-18 2014-01-20 Helix Biopharma Corp Brug af urease til at hæmme vækst af cancerceller
JP2012508586A (ja) 2008-11-14 2012-04-12 ジェン−プローブ・インコーポレーテッド カンピロバクター属（Ｃａｍｐｙｌｏｂａｃｔｅｒ）核酸を検出するための組成物、キットおよび方法
EP2984170A4 (de) 2013-04-08 2016-11-30 Helix Biopharma Corp Verwendung von antikörper-urease-konjugaten für diagnostische und therapeutische zwecke
WO2016018465A1 (en) * 2014-07-30 2016-02-04 Medtronic, Inc. Urease purification from jack beans or other organisms
RU2689689C2 (ru) 2015-01-23 2019-05-28 Хеликс Байофарма Корпорейшн Конъюгаты антитело-уреаза для терапевтических целей

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785086A (en) * 1985-01-17 1988-11-15 Integrated Genetics, Inc. Test for Campylobacter
ES8706823A1 (es) * 1985-03-28 1987-06-16 Cetus Corp Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra
CA1274757A (en) * 1985-05-17 1990-10-02 Barry James Marshall Compositions and methods for the detection of urease for the diagnosis of campylobacter pyloridis infection
WO1987001119A1 (en) * 1985-08-16 1987-02-26 Gregory Murray Winn Monoclonal antibodies reactive against campylobacter pyloridis
US4837017A (en) * 1987-03-12 1989-06-06 Leveen Harry H Urease antigen product and process
US4882271A (en) * 1988-03-10 1989-11-21 Baylor College Of Medicine Process for preparation of high molecular weight cell-associated protein of campylobacter pylori and use for serological detection of campylobacter pylori infection
WO1989009407A1 (en) * 1988-03-23 1989-10-05 Julie Claire Dent Detection of campylobacter pylori urease antibodies and reagent therefor
FR2637612B1 (fr) * 1988-10-06 1993-09-10 Pasteur Institut Sequences de nucleotides codant pour une proteine a activite ureasique
NZ307017A (en) * 1995-04-28 1999-07-29 Oravax Inc Vaccine containing multimeric complexes of helicobacter urease, composition of antigen (from gastroduodenal pathogen) and antibiotic, antisecretory agent, and/or bismuth salt

Also Published As

Publication number Publication date
JPH09117286A (ja) 1997-05-06
US6146634A (en) 2000-11-14
WO1990004030A1 (fr) 1990-04-19
SG49097A1 (en) 1998-05-18
DE68929510D1 (de) 2004-02-12
ES2068907T3 (es) 1995-05-01
DE68921287T2 (de) 1995-06-22
ATE118821T1 (de) 1995-03-15
US5695931A (en) 1997-12-09
DE68921287D1 (de) 1995-03-30
JP2628767B2 (ja) 1997-07-09
FR2637612B1 (fr) 1993-09-10
EP0367644B1 (de) 1995-02-22
JPH03501928A (ja) 1991-05-09
EP0649906B1 (de) 2004-01-07
JP2974966B2 (ja) 1999-11-10
ES2214479T3 (es) 2004-09-16
JPH08196283A (ja) 1996-08-06
EP0367644A1 (de) 1990-05-09
US5811237A (en) 1998-09-22
JP3375470B2 (ja) 2003-02-10
DE68929510T2 (de) 2004-11-18
US5849295A (en) 1998-12-15
FR2637612A1 (fr) 1990-04-13
US5837472A (en) 1998-11-17
EP0649906A1 (de) 1995-04-26

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