DK3253875T3 - Tau-antisense-oligomerer og anvendelser deraf - Google Patents

Tau-antisense-oligomerer og anvendelser deraf Download PDF

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Publication number
DK3253875T3
DK3253875T3 DK16706943.4T DK16706943T DK3253875T3 DK 3253875 T3 DK3253875 T3 DK 3253875T3 DK 16706943 T DK16706943 T DK 16706943T DK 3253875 T3 DK3253875 T3 DK 3253875T3
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Denmark
Prior art keywords
antisense oligomers
tau antisense
tau
oligomers
antisense
Prior art date
Application number
DK16706943.4T
Other languages
English (en)
Inventor
Richard E Olson
Peter Hagedorn
Marianne Lerbech Jensen
Niels Fisker Nielsen
Dong Li
Jeffrey M Brown
Stephen E Mercer
Angela M Cacace
Anja Mølhart Høg
Original Assignee
H Hoffmann La Roche Ag
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Publication of DK3253875T3 publication Critical patent/DK3253875T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
DK16706943.4T 2015-02-04 2016-02-04 Tau-antisense-oligomerer og anvendelser deraf DK3253875T3 (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201562112058P 2015-02-04 2015-02-04
US201562156684P 2015-05-04 2015-05-04
US201562237922P 2015-10-06 2015-10-06
US201562238941P 2015-10-08 2015-10-08
US201662279614P 2016-01-15 2016-01-15
US201662279612P 2016-01-15 2016-01-15
US201662279610P 2016-01-15 2016-01-15
PCT/US2016/016646 WO2016126995A1 (en) 2015-02-04 2016-02-04 Tau antisense oligomers and uses thereof

Publications (1)

Publication Number Publication Date
DK3253875T3 true DK3253875T3 (da) 2020-04-14

Family

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Family Applications (1)

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DK16706943.4T DK3253875T3 (da) 2015-02-04 2016-02-04 Tau-antisense-oligomerer og anvendelser deraf

Country Status (24)

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US (3) US10799523B2 (da)
EP (2) EP3253875B1 (da)
JP (1) JP2018505676A (da)
KR (1) KR20180016970A (da)
CN (1) CN107922946A (da)
AU (1) AU2016215155A1 (da)
BR (1) BR112017016663A2 (da)
CA (1) CA2975525A1 (da)
CL (1) CL2017001956A1 (da)
CO (1) CO2017009008A2 (da)
CR (1) CR20170359A (da)
DK (1) DK3253875T3 (da)
HK (1) HK1248276A1 (da)
IL (1) IL253730A0 (da)
MA (1) MA41586A (da)
MX (1) MX2017010066A (da)
PE (1) PE20171766A1 (da)
PH (1) PH12017550069A1 (da)
RU (1) RU2017127609A (da)
SG (1) SG11201706293XA (da)
TW (1) TW201641691A (da)
UY (1) UY36550A (da)
WO (1) WO2016126995A1 (da)
ZA (1) ZA201705119B (da)

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US10799523B2 (en) 2020-10-13
CL2017001956A1 (es) 2018-06-01
US20180161356A1 (en) 2018-06-14
SG11201706293XA (en) 2017-09-28
EP3653712A1 (en) 2020-05-20
BR112017016663A2 (pt) 2018-04-10
US20220143064A1 (en) 2022-05-12
AU2016215155A1 (en) 2017-08-17
UY36550A (es) 2016-08-31
ZA201705119B (en) 2020-01-29
US20160237427A1 (en) 2016-08-18
EP3253875A1 (en) 2017-12-13
IL253730A0 (en) 2017-09-28
TW201641691A (zh) 2016-12-01
CA2975525A1 (en) 2016-08-11
CR20170359A (es) 2017-11-24
RU2017127609A (ru) 2019-03-04
MX2017010066A (es) 2017-11-01
EP3653712B1 (en) 2022-11-30
CO2017009008A2 (es) 2017-11-21
CN107922946A (zh) 2018-04-17
EP3253875B1 (en) 2020-01-08
HK1248276A1 (zh) 2018-10-12
JP2018505676A (ja) 2018-03-01
WO2016126995A1 (en) 2016-08-11
MA41586A (fr) 2017-12-13
US11077132B2 (en) 2021-08-03
PH12017550069A1 (en) 2018-02-05
PE20171766A1 (es) 2017-12-21
KR20180016970A (ko) 2018-02-20

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