DE93619T1 - Plasminogenaktivator fuer menschliches gewebe, diesen aktivator enthaltende pharmazeutische zusammensetzungen, verfahren zur herstellung des aktivators sowie dna und transformierte zellzwischenprodukte hierfuer. - Google Patents

Plasminogenaktivator fuer menschliches gewebe, diesen aktivator enthaltende pharmazeutische zusammensetzungen, verfahren zur herstellung des aktivators sowie dna und transformierte zellzwischenprodukte hierfuer.

Info

Publication number
DE93619T1
DE93619T1 DE198383302501T DE83302501T DE93619T1 DE 93619 T1 DE93619 T1 DE 93619T1 DE 198383302501 T DE198383302501 T DE 198383302501T DE 83302501 T DE83302501 T DE 83302501T DE 93619 T1 DE93619 T1 DE 93619T1
Authority
DE
Germany
Prior art keywords
activator
plasminogenactivator
dna
producing
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198383302501T
Other languages
English (en)
Inventor
David Vannorman Hillsborough California 94010 Us Goeddel
William Jack San Mateo California 94403 Us Kohr
Diane Foster City California 94404 Us Pennica
Gordon Allen San Carlos California 94070 Us Vehar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27409206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE93619(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/483,052 external-priority patent/US4766075A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DE93619T1 publication Critical patent/DE93619T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE198383302501T 1982-05-05 1983-05-04 Plasminogenaktivator fuer menschliches gewebe, diesen aktivator enthaltende pharmazeutische zusammensetzungen, verfahren zur herstellung des aktivators sowie dna und transformierte zellzwischenprodukte hierfuer. Pending DE93619T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37486082A 1982-05-05 1982-05-05
US39800382A 1982-07-14 1982-07-14
US06/483,052 US4766075A (en) 1982-07-14 1983-04-07 Human tissue plasminogen activator

Publications (1)

Publication Number Publication Date
DE93619T1 true DE93619T1 (de) 1987-08-13

Family

ID=27409206

Family Applications (3)

Application Number Title Priority Date Filing Date
DE198383302501T Pending DE93619T1 (de) 1982-05-05 1983-05-04 Plasminogenaktivator fuer menschliches gewebe, diesen aktivator enthaltende pharmazeutische zusammensetzungen, verfahren zur herstellung des aktivators sowie dna und transformierte zellzwischenprodukte hierfuer.
DE8383302501T Expired DE3380567D1 (en) 1982-05-05 1983-05-04 Human tissue plasminogen activator, pharmaceutical compositions containing it, processes for making it, and dna and transformed cell intermediates therefor
DE19833316297 Granted DE3316297A1 (de) 1982-05-05 1983-05-04 Humangewebe-plasminogen-aktivator

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE8383302501T Expired DE3380567D1 (en) 1982-05-05 1983-05-04 Human tissue plasminogen activator, pharmaceutical compositions containing it, processes for making it, and dna and transformed cell intermediates therefor
DE19833316297 Granted DE3316297A1 (de) 1982-05-05 1983-05-04 Humangewebe-plasminogen-aktivator

Country Status (26)

Country Link
EP (1) EP0093619B2 (de)
JP (2) JPH0216981A (de)
AR (1) AR241654A1 (de)
BG (1) BG60253B2 (de)
BR (1) BR8302318A (de)
CA (1) CA1293211C (de)
CS (1) CS248705B2 (de)
CY (1) CY1341A (de)
DD (1) DD210303A5 (de)
DE (3) DE93619T1 (de)
DK (1) DK174236B1 (de)
ES (1) ES522085A0 (de)
FR (1) FR2526443B1 (de)
GB (1) GB2119804B (de)
GR (1) GR79202B (de)
HK (1) HK88586A (de)
IE (1) IE54975B1 (de)
IL (1) IL68561A (de)
KE (1) KE3647A (de)
MY (1) MY8700119A (de)
NO (2) NO831575L (de)
OA (1) OA07419A (de)
PL (1) PL152438B1 (de)
PT (1) PT76636B (de)
RO (1) RO90639B (de)
ZW (1) ZW10483A1 (de)

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DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
CA1154671A (fr) * 1979-07-27 1983-10-04 Lucien D. D'hinterland Separation d'un activateur tissulaire du plasminogene
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
GT198302091A (es) * 1982-05-05 1984-10-25 Activador de plasminogeno de tejido humano a),b),c).
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof

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GB2119804B (en) 1986-02-26
AU1414283A (en) 1983-11-10
BG60253B1 (bg) 1994-03-24
EP0093619B1 (de) 1989-09-13
AR241654A1 (es) 1992-10-30
GR79202B (de) 1984-10-22
CY1341A (en) 1987-01-16
PT76636B (en) 1986-01-10
RO90639B (ro) 1987-01-31
ZW10483A1 (en) 1983-09-21
ES8501629A1 (es) 1984-12-16
RO90639A (ro) 1987-01-30
ES522085A0 (es) 1984-12-16
IL68561A (en) 1991-01-31
JPH0448440B2 (de) 1992-08-06
DE3316297C2 (de) 1989-09-21
JPH0216981A (ja) 1990-01-19
CA1293211C (en) 1991-12-17
PL241805A1 (en) 1984-07-30
OA07419A (fr) 1984-11-30
JPH05137583A (ja) 1993-06-01
DK198883A (da) 1983-12-20
FR2526443B1 (fr) 1985-12-06
JP2564444B2 (ja) 1996-12-18
NO831575L (no) 1983-11-07
GB2119804A (en) 1983-11-23
PT76636A (en) 1983-06-01
NO852065L (no) 1983-11-07
PL152438B1 (en) 1990-12-31
AU563031B2 (en) 1987-06-25
BR8302318A (pt) 1984-01-10
MY8700119A (en) 1987-12-31
DK174236B1 (da) 2002-10-07
HK88586A (en) 1986-11-28
IL68561A0 (en) 1983-09-30
EP0093619B2 (de) 1996-09-18
FR2526443A1 (fr) 1983-11-10
DE3316297A1 (de) 1983-11-17
BG60253B2 (bg) 1994-03-24
GB8312221D0 (en) 1983-06-08
DE3380567D1 (en) 1989-10-19
IE831024L (en) 1983-11-05
CS248705B2 (en) 1987-02-12
EP0093619A1 (de) 1983-11-09
IE54975B1 (en) 1990-04-11
DK198883D0 (da) 1983-05-04
KE3647A (en) 1986-07-25
DD210303A5 (de) 1984-06-06

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