DE69024693T2 - Gene, die ein Protein mit menschlicher MACIF-Aktivität kodieren, Expressionsvektoren mit diesen Genen, Transformantenzellen und Proteine mit menschlicher MACIF-Aktivität - Google Patents

Gene, die ein Protein mit menschlicher MACIF-Aktivität kodieren, Expressionsvektoren mit diesen Genen, Transformantenzellen und Proteine mit menschlicher MACIF-Aktivität

Info

Publication number
DE69024693T2
DE69024693T2 DE69024693T DE69024693T DE69024693T2 DE 69024693 T2 DE69024693 T2 DE 69024693T2 DE 69024693 T DE69024693 T DE 69024693T DE 69024693 T DE69024693 T DE 69024693T DE 69024693 T2 DE69024693 T2 DE 69024693T2
Authority
DE
Germany
Prior art keywords
genes
human macif
macif activity
protein
expression vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69024693T
Other languages
English (en)
Other versions
DE69024693D1 (de
Inventor
Motowo Tomita
Yuji Sugita
Toshiyuki Takemoto
Kiyoshi Furuichi
Makoto Takayama
Ko Yusakawa
Shinya Yano
Noboru Yamaji
Katsuhisa Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of DE69024693D1 publication Critical patent/DE69024693D1/de
Application granted granted Critical
Publication of DE69024693T2 publication Critical patent/DE69024693T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69024693T 1989-04-21 1990-04-19 Gene, die ein Protein mit menschlicher MACIF-Aktivität kodieren, Expressionsvektoren mit diesen Genen, Transformantenzellen und Proteine mit menschlicher MACIF-Aktivität Expired - Fee Related DE69024693T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP10308889 1989-04-21
JP17993389 1989-07-12
JP23098389 1989-09-06
JP23824689 1989-09-13
JP24781889 1989-09-21
JP28119789 1989-10-27

Publications (2)

Publication Number Publication Date
DE69024693D1 DE69024693D1 (de) 1996-02-22
DE69024693T2 true DE69024693T2 (de) 1996-07-11

Family

ID=27552152

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69024693T Expired - Fee Related DE69024693T2 (de) 1989-04-21 1990-04-19 Gene, die ein Protein mit menschlicher MACIF-Aktivität kodieren, Expressionsvektoren mit diesen Genen, Transformantenzellen und Proteine mit menschlicher MACIF-Aktivität
DE69033756T Expired - Fee Related DE69033756T2 (de) 1989-04-21 1990-04-19 Gene, die für MACIF Proteine kodieren, Expressionsvektoren mit diesem Genen, und Transformantenzellen mit diesem Proteinen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69033756T Expired - Fee Related DE69033756T2 (de) 1989-04-21 1990-04-19 Gene, die für MACIF Proteine kodieren, Expressionsvektoren mit diesem Genen, und Transformantenzellen mit diesem Proteinen

Country Status (12)

Country Link
US (1) US5532339A (de)
EP (2) EP0672683B1 (de)
JP (1) JP2828148B2 (de)
KR (1) KR0150000B1 (de)
AT (2) ATE132900T1 (de)
AU (1) AU640643B2 (de)
CA (1) CA2014948C (de)
DE (2) DE69024693T2 (de)
DK (1) DK0394035T3 (de)
ES (1) ES2084658T3 (de)
GR (1) GR3019347T3 (de)
IE (2) IE960874L (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795736A (en) * 1989-04-21 1998-08-18 Yamanouchi Pharmaceutical Co., Ltd. Genes coding for a protein having human MACIF activity, expression vectors containing said genes, transformant cells and proteins having human macif activity
US5573940A (en) * 1989-06-12 1996-11-12 Oklahoma Medical Research Foundation Cells expressing high levels of CD59
AU6015696A (en) * 1995-06-16 1997-01-15 Yamanouchi Pharmaceutical Co., Ltd. Modified polypeptide, dna encoding the same, transformant, and medicinal composition containing the polypeptide
US7166568B1 (en) 1998-02-09 2007-01-23 Oklahoma Medical Research Foundation Compositions and methods to inhibit formation of the C5b-9 complex of complement
AU6517800A (en) * 1999-08-04 2001-03-05 Amgen, Inc. Ntr3, a member of the tnf-receptor supergene family
US7439330B2 (en) 2000-05-08 2008-10-21 President And Fellows Of Harvard College Anti-glycated CD59 antibodies and uses thereof
US6835545B2 (en) 2000-05-08 2004-12-28 President And Fellows Of Harvard College Methods, products and treatments for diabetes
CN1325889A (zh) * 2000-05-26 2001-12-12 上海博德基因开发有限公司 一种新的多肽——人Kazal型抑制因子11和编码这种多肽的多核苷酸
WO2006086098A2 (en) * 2005-01-06 2006-08-17 President And Fellows Of Harvard College Mass spectrometric methods and products
AU2015202046B2 (en) * 2008-02-15 2017-06-29 Tufts University A humanized model of membrane attack complex (mac) formation on murine retina and compositions, kits and methods for treatment of macular degeneration
CA2843684A1 (en) * 2010-08-13 2012-02-16 Tufts University Compositions, kits and methods for treatment of macular degeneration using soluble membrane-independent cd59 protein
US9068006B2 (en) 2010-08-25 2015-06-30 President And Fellows Of Harvard College Glycated CD59 peptides, their preparation, and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5109113A (en) * 1986-05-02 1992-04-28 Genentech, Inc. Membrane anchor fusion polypeptides
US5179198A (en) * 1988-07-11 1993-01-12 Hidechika Okada Glycoprotein and gene coding therefor
US4935494A (en) * 1988-11-15 1990-06-19 City Of Hope C-terminal peptide and protein sequencing

Also Published As

Publication number Publication date
AU5372690A (en) 1990-11-08
ATE132900T1 (de) 1996-01-15
EP0394035B1 (de) 1996-01-10
IE74168B1 (en) 1997-07-02
EP0672683A1 (de) 1995-09-20
DE69033756D1 (de) 2001-08-02
DE69033756T2 (de) 2002-04-18
KR0150000B1 (ko) 1998-08-17
CA2014948A1 (en) 1990-10-21
US5532339A (en) 1996-07-02
AU640643B2 (en) 1993-09-02
DK0394035T3 (da) 1996-05-13
KR900016465A (ko) 1990-11-13
JP2828148B2 (ja) 1998-11-25
ES2084658T3 (es) 1996-05-16
EP0394035A3 (de) 1991-08-21
DE69024693D1 (de) 1996-02-22
IE901426L (en) 1990-10-21
ATE202570T1 (de) 2001-07-15
GR3019347T3 (en) 1996-06-30
CA2014948C (en) 2000-12-12
EP0672683B1 (de) 2001-06-27
EP0394035A2 (de) 1990-10-24
JPH03201985A (ja) 1991-09-03
IE960874L (en) 1990-10-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP

8339 Ceased/non-payment of the annual fee