AU637139B2 - Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use - Google Patents

Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use

Info

Publication number
AU637139B2
AU637139B2 AU62683/90A AU6268390A AU637139B2 AU 637139 B2 AU637139 B2 AU 637139B2 AU 62683/90 A AU62683/90 A AU 62683/90A AU 6268390 A AU6268390 A AU 6268390A AU 637139 B2 AU637139 B2 AU 637139B2
Authority
AU
Australia
Prior art keywords
proteins
derivatives
preparation
type
csf protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU62683/90A
Other versions
AU6268390A (en
Inventor
Paul Habermann
Hubert Mullner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU6268390A publication Critical patent/AU6268390A/en
Application granted granted Critical
Publication of AU637139B2 publication Critical patent/AU637139B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

CSF proteins which are biologically active are obtained by expression of a gene coding for human granulocyte macrophage colony stimulating factor (CSF) in bacteria. Biologically active derivatives with a modified amino acid sequence are obtained by altering the natural or synthetic gene structure.
AU62683/90A 1985-12-21 1990-09-19 Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use Ceased AU637139B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853545568 DE3545568A1 (en) 1985-12-21 1985-12-21 GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE
DE3545568 1985-12-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU66756/86A Division AU601959B2 (en) 1985-12-21 1986-12-19 GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use

Publications (2)

Publication Number Publication Date
AU6268390A AU6268390A (en) 1990-12-13
AU637139B2 true AU637139B2 (en) 1993-05-20

Family

ID=6289242

Family Applications (2)

Application Number Title Priority Date Filing Date
AU66756/86A Ceased AU601959B2 (en) 1985-12-21 1986-12-19 GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use
AU62683/90A Ceased AU637139B2 (en) 1985-12-21 1990-09-19 Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU66756/86A Ceased AU601959B2 (en) 1985-12-21 1986-12-19 GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use

Country Status (17)

Country Link
EP (1) EP0228018B1 (en)
JP (1) JP2575367B2 (en)
KR (1) KR940005585B1 (en)
AT (1) ATE71144T1 (en)
AU (2) AU601959B2 (en)
CA (1) CA1341197C (en)
DE (2) DE3545568A1 (en)
DK (1) DK170346B1 (en)
ES (1) ES2055686T3 (en)
FI (1) FI91168C (en)
GR (1) GR3003999T3 (en)
HU (1) HU202584B (en)
IE (1) IE59779B1 (en)
IL (1) IL81020A (en)
NO (1) NO177270C (en)
PT (1) PT83972B (en)
ZA (1) ZA869557B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5078996A (en) * 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
AU606585B2 (en) * 1985-10-03 1991-02-14 Biogen, Inc. Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells
DE3712985A1 (en) * 1987-04-16 1988-11-03 Hoechst Ag BIFUNCTIONAL PROTEINS
US5359035A (en) * 1985-12-21 1994-10-25 Hoechst Aktiengesellschaft Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)
JP2583770B2 (en) * 1986-09-17 1997-02-19 大塚製薬株式会社 gene
JPS6420097A (en) * 1987-03-02 1989-01-24 Sumitomo Chemical Co Human granulocyte-macrophage colony stimulating factor
AU609128B2 (en) * 1987-04-02 1991-04-26 Amrad Operations Pty. Limited Leukaemia-inhibitory factor
PT87133B (en) * 1987-04-02 1992-07-31 Amrad Corp Ltd METHOD OF PURIFICATION OF THE LEUKEMIA INHIBITOR FACTOR (LIF) AND PHARMACEUTICAL COMPOSITIONS CONTAINING POLIPEPTIDES WITH LIF ACTIVITY
DE3853590T2 (en) * 1987-06-25 1996-01-04 Immunex Corp CATTLE GRANULOCYT MACROPHAGE COLONY STIMULATING FACTOR.
IL88344A (en) * 1987-11-12 1994-06-24 Schering Corp Acceleration of bone formation with gm-csf
GB2212159B (en) * 1987-11-13 1992-01-22 British Bio Technology Synthetic gene for human granulocyte/macrophage colony stimulating factor.
AU615550B2 (en) * 1988-04-21 1991-10-03 Medvet Science Pty. Ltd. Human gm-csf variants
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
ES2055445T3 (en) * 1989-08-22 1994-08-16 Immunex Corp FUSION PROTEINS INCLUDING GM-CSF AND IL-3.
NZ236819A (en) * 1990-02-03 1993-07-27 Max Planck Gesellschaft Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions
US5270181A (en) * 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
US6060258A (en) * 1995-09-28 2000-05-09 Otsuka Pharmaceutical Co., Ltd. Neutrophil chemotactic lymphokine, and method for the diagnosis of drug hypersensitive granulocytopenia using the same
KR100448021B1 (en) * 2001-12-28 2004-09-08 크레아젠 주식회사 Transgenic Escherichia coli transformed with pGM-CSF vector expressing recombinant mouse granulocyte-macrophage colony stimulating factor and method for mass production of the recombinant protein
CA2785258A1 (en) 2009-12-23 2011-06-30 Gradalis, Inc. Furin-knockdown and gm-csf-augmented (fang) cancer vaccine
WO2011079070A1 (en) 2009-12-23 2011-06-30 Gradalis, Inc. Furin-knockdown bi-functional rna

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU595262B2 (en) * 1985-11-27 1990-03-29 Hoechst Aktiengesellschaft Eukaryotic fusion proteins, the preparation and use thereof and means for carrying out the process
AU599943B2 (en) * 1985-12-21 1990-08-02 Hoechst Aktiengesellschaft Fusion proteins with a eukaryotic ballast portion

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
SE8300693L (en) * 1983-02-09 1984-08-10 Sven Lofdahl SET TO MAKE AND ISOLATE PROTEINS AND POLYPEPTIDES, AND A HYBRID VECTOR FOR THIS
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of mature human IGF and EGF via prokaryotic recombinant DNA technology
AU594014B2 (en) * 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
IE930961L (en) * 1984-07-06 1986-01-06 Sandoz Ag Lymphokine production and purification
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
ZA856108B (en) * 1984-10-29 1986-10-29 Immunex Corp Cloning of human granulocyte-macrophage colony simulating factor gene
ATE82321T1 (en) * 1984-11-20 1992-11-15 Schering Biotech Corp CDNA CLONES ENCODING PEPTIDES WITH HUMAN GRANULOCYTE, MACROPHAGE AND EOSINOPHIL CELL GROWTH FACTOR ACTIVITIES.
AU606585B2 (en) * 1985-10-03 1991-02-14 Biogen, Inc. Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU595262B2 (en) * 1985-11-27 1990-03-29 Hoechst Aktiengesellschaft Eukaryotic fusion proteins, the preparation and use thereof and means for carrying out the process
AU599943B2 (en) * 1985-12-21 1990-08-02 Hoechst Aktiengesellschaft Fusion proteins with a eukaryotic ballast portion

Also Published As

Publication number Publication date
HUT44615A (en) 1988-03-28
JPS62164695A (en) 1987-07-21
HU202584B (en) 1991-03-28
IL81020A (en) 1995-11-27
FI865186A0 (en) 1986-12-18
DK619086A (en) 1987-06-22
DK170346B1 (en) 1995-08-07
PT83972B (en) 1989-07-31
JP2575367B2 (en) 1997-01-22
IL81020A0 (en) 1987-03-31
GR3003999T3 (en) 1993-03-16
EP0228018A2 (en) 1987-07-08
CA1341197C (en) 2001-03-06
AU601959B2 (en) 1990-09-27
NO865191D0 (en) 1986-12-19
ATE71144T1 (en) 1992-01-15
KR940005585B1 (en) 1994-06-21
ZA869557B (en) 1987-10-28
NO177270C (en) 1995-08-16
FI865186A (en) 1987-06-22
AU6675686A (en) 1987-06-25
IE59779B1 (en) 1994-04-06
FI91168B (en) 1994-02-15
KR870006188A (en) 1987-07-09
NO177270B (en) 1995-05-08
AU6268390A (en) 1990-12-13
EP0228018B1 (en) 1992-01-02
PT83972A (en) 1987-01-01
DK619086D0 (en) 1986-12-19
FI91168C (en) 1994-05-25
ES2055686T3 (en) 1994-09-01
EP0228018A3 (en) 1987-12-02
NO865191L (en) 1987-06-22
DE3683267D1 (en) 1992-02-13
IE863335L (en) 1987-06-21
DE3545568A1 (en) 1987-07-16

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