AU601959B2 - GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use - Google Patents

GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use

Info

Publication number
AU601959B2
AU601959B2 AU66756/86A AU6675686A AU601959B2 AU 601959 B2 AU601959 B2 AU 601959B2 AU 66756/86 A AU66756/86 A AU 66756/86A AU 6675686 A AU6675686 A AU 6675686A AU 601959 B2 AU601959 B2 AU 601959B2
Authority
AU
Australia
Prior art keywords
proteins
derivatives
preparation
type
csf protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU66756/86A
Other versions
AU6675686A (en
Inventor
Paul Habermann
Hubert Mullner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU6675686A publication Critical patent/AU6675686A/en
Application granted granted Critical
Publication of AU601959B2 publication Critical patent/AU601959B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Abstract

CSF proteins which are biologically active are obtained by expression of a gene coding for human granulocyte macrophage colony stimulating factor (CSF) in bacteria. Biologically active derivatives with a modified amino acid sequence are obtained by altering the natural or synthetic gene structure.
AU66756/86A 1985-12-21 1986-12-19 GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use Ceased AU601959B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3545568 1985-12-21
DE19853545568 DE3545568A1 (en) 1985-12-21 1985-12-21 GM-CSF-PROTEIN, ITS DERIVATIVES, PRODUCTION OF SUCH PROTEINS AND THEIR USE

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU62683/90A Division AU637139B2 (en) 1985-12-21 1990-09-19 Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use

Publications (2)

Publication Number Publication Date
AU6675686A AU6675686A (en) 1987-06-25
AU601959B2 true AU601959B2 (en) 1990-09-27

Family

ID=6289242

Family Applications (2)

Application Number Title Priority Date Filing Date
AU66756/86A Ceased AU601959B2 (en) 1985-12-21 1986-12-19 GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use
AU62683/90A Ceased AU637139B2 (en) 1985-12-21 1990-09-19 Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU62683/90A Ceased AU637139B2 (en) 1985-12-21 1990-09-19 Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use

Country Status (17)

Country Link
EP (1) EP0228018B1 (en)
JP (1) JP2575367B2 (en)
KR (1) KR940005585B1 (en)
AT (1) ATE71144T1 (en)
AU (2) AU601959B2 (en)
CA (1) CA1341197C (en)
DE (2) DE3545568A1 (en)
DK (1) DK170346B1 (en)
ES (1) ES2055686T3 (en)
FI (1) FI91168C (en)
GR (1) GR3003999T3 (en)
HU (1) HU202584B (en)
IE (1) IE59779B1 (en)
IL (1) IL81020A (en)
NO (1) NO177270C (en)
PT (1) PT83972B (en)
ZA (1) ZA869557B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5078996A (en) * 1985-08-16 1992-01-07 Immunex Corporation Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor
AU606585B2 (en) * 1985-10-03 1991-02-14 Biogen, Inc. Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells
DE3712985A1 (en) * 1987-04-16 1988-11-03 Hoechst Ag BIFUNCTIONAL PROTEINS
US5359035A (en) * 1985-12-21 1994-10-25 Hoechst Aktiengesellschaft Bifunctional proteins including interleukin-2 (IL-2) and granuloctyte macrophage colony stimulating factor (GM-CSF)
JP2583770B2 (en) * 1986-09-17 1997-02-19 大塚製薬株式会社 gene
JPS6420097A (en) * 1987-03-02 1989-01-24 Sumitomo Chemical Co Human granulocyte-macrophage colony stimulating factor
PT87133B (en) * 1987-04-02 1992-07-31 Amrad Corp Ltd METHOD OF PURIFICATION OF THE LEUKEMIA INHIBITOR FACTOR (LIF) AND PHARMACEUTICAL COMPOSITIONS CONTAINING POLIPEPTIDES WITH LIF ACTIVITY
AU609128B2 (en) * 1987-04-02 1991-04-26 Amrad Operations Pty. Limited Leukaemia-inhibitory factor
AU602097B2 (en) * 1987-06-25 1990-09-27 Immunex Corporation Bovine granulocyte-macrophage colony stimulating factor
IL88344A (en) * 1987-11-12 1994-06-24 Schering Corp Acceleration of bone formation with gm-csf
GB2212159B (en) * 1987-11-13 1992-01-22 British Bio Technology Synthetic gene for human granulocyte/macrophage colony stimulating factor.
JPH03503897A (en) * 1988-04-21 1991-08-29 メドベット・サイエンス・プロプライアテリー・リミテッド Human GM-CSF variants
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
AU632372B2 (en) * 1989-08-22 1992-12-24 Immunex Corporation Fusion proteins comprising gm-csf and il-3
NZ236819A (en) * 1990-02-03 1993-07-27 Max Planck Gesellschaft Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions
US5270181A (en) * 1991-02-06 1993-12-14 Genetics Institute, Inc. Peptide and protein fusions to thioredoxin and thioredoxin-like molecules
WO1997012054A1 (en) * 1995-09-28 1997-04-03 Otsuka Pharmaceutical Co., Ltd. Neutrophil chemotactic lymphokine, and drug and kit for the diagnosis of drug hypersensitive granulocytopenia containing the same
KR100448021B1 (en) * 2001-12-28 2004-09-08 크레아젠 주식회사 Transgenic Escherichia coli transformed with pGM-CSF vector expressing recombinant mouse granulocyte-macrophage colony stimulating factor and method for mass production of the recombinant protein
US9132146B2 (en) 2009-12-23 2015-09-15 Gradalis, Inc. Furin-knockdown and GM-CSF-augmented (FANG) cancer vaccine
US9157084B2 (en) 2009-12-23 2015-10-13 Gradalis, Inc. Furin-knockdown bi-functional RNA

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4008485A (en) * 1984-03-21 1985-09-26 Research Corporation Technologies, Inc. Recombinant DNA molecules
AU5196386A (en) * 1984-11-20 1986-06-18 Schering Biotech Corporation cDNA clones coding for polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity
AU6549386A (en) * 1985-10-03 1987-04-24 Biogen, Inc. Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
SE8300693L (en) * 1983-02-09 1984-08-10 Sven Lofdahl SET TO MAKE AND ISOLATE PROTEINS AND POLYPEPTIDES, AND A HYBRID VECTOR FOR THIS
IL71991A (en) * 1983-06-06 1994-05-30 Genentech Inc Preparation of mature human IGF and EGF via prokaryotic recombinant DNA technology
AU599572B2 (en) * 1984-07-06 1990-07-26 Novartis Ag Lymphokine production and purification
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
ZA856108B (en) * 1984-10-29 1986-10-29 Immunex Corp Cloning of human granulocyte-macrophage colony simulating factor gene
DE3636903A1 (en) * 1985-12-21 1987-07-02 Hoechst Ag FUSION PROTEINS WITH EUKARYOTIC BALLASTES
DE3541856A1 (en) * 1985-11-27 1987-06-04 Hoechst Ag EUKARYOTIC FUSION PROTEINS, THEIR PRODUCTION AND USE, AND MEANS FOR CARRYING OUT THE PROCESS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4008485A (en) * 1984-03-21 1985-09-26 Research Corporation Technologies, Inc. Recombinant DNA molecules
AU5196386A (en) * 1984-11-20 1986-06-18 Schering Biotech Corporation cDNA clones coding for polypeptides exhibiting human granulocyte macrophage and eosinophil cellular growth factor activity
AU6549386A (en) * 1985-10-03 1987-04-24 Biogen, Inc. Human granulocyte-macrophage colony stimulating factor-like polypeptides and processes for producing them in high yields in microbial cells

Also Published As

Publication number Publication date
DK170346B1 (en) 1995-08-07
FI91168C (en) 1994-05-25
PT83972A (en) 1987-01-01
AU637139B2 (en) 1993-05-20
EP0228018B1 (en) 1992-01-02
IE59779B1 (en) 1994-04-06
DE3683267D1 (en) 1992-02-13
HU202584B (en) 1991-03-28
EP0228018A3 (en) 1987-12-02
IL81020A (en) 1995-11-27
AU6675686A (en) 1987-06-25
NO177270B (en) 1995-05-08
ES2055686T3 (en) 1994-09-01
JPS62164695A (en) 1987-07-21
DE3545568A1 (en) 1987-07-16
DK619086D0 (en) 1986-12-19
NO865191L (en) 1987-06-22
DK619086A (en) 1987-06-22
FI865186A0 (en) 1986-12-18
KR940005585B1 (en) 1994-06-21
ATE71144T1 (en) 1992-01-15
FI865186A (en) 1987-06-22
PT83972B (en) 1989-07-31
IL81020A0 (en) 1987-03-31
NO865191D0 (en) 1986-12-19
HUT44615A (en) 1988-03-28
FI91168B (en) 1994-02-15
CA1341197C (en) 2001-03-06
JP2575367B2 (en) 1997-01-22
EP0228018A2 (en) 1987-07-08
NO177270C (en) 1995-08-16
KR870006188A (en) 1987-07-09
ZA869557B (en) 1987-10-28
GR3003999T3 (en) 1993-03-16
AU6268390A (en) 1990-12-13
IE863335L (en) 1987-06-21

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