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Priority claimed from GB888805070Aexternal-prioritypatent/GB8805070D0/en
Priority claimed from GB888825258Aexternal-prioritypatent/GB8825258D0/en
Application filed by Kocher Theodor Inst, Sandoz LtdfiledCriticalKocher Theodor Inst
Publication of MY103637ApublicationCriticalpatent/MY103637A/en
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Abstract
BIOLOGICALLY ACTIVE, PURE NEUTROPHIL-ACTIVATING FACTOR (NAF) IS ISOLATED FROM HUMAN MONOCYTES OR AFTER EXPRESSION OF A SYNTHETIC NAF GENE IN E.COLI. IT HAS THE FOLLOWING AMINO ACID SEQUENCE:SER-ALA-LYS-GLU-LEU-ARG-CYS-GLN-CYS-ILE-LYS-THR-TYR-SER-LYS-PRO-PHE-HIS-PRO-LYS-PHE-ILE-LYS-GLU-LEU-ARG-VAL-ILE-GLU-SER-GLY-PRO-HIS-CYS-ALA-ASN-THR-GLU-ILE-ILE-VAL-LYS-LEU-SER-ASP-GLY-ARG-GLU-LEU-CYS-LEU-ASP-PRO-LYS-GLU-ASN-TRP-VAL-GLN-ARG-VAL-VAL-GLU-LYS-PHE-LEU-LYS-ARGALA-GLU-ASN-SER.THERE ARE THREE FURTHER MINOR VARIANTS WITH LONGER AND SHORTER SEQUENCES. NATURAL AND SYNTHETIC NAF HAVE IDENTICAL STRUCTURE AND BIOLOGICAL PROPERTIES.
Dna sequences coding for proteins having the biological activity of husi-type i inhibitors,biotechnological methods for the preparation of said proteins and pharmaceutical compositions containing said proteins
PLASMID VECTOR EXPRESSION IN BACILLUS USEFUL FOR THE CLONING OF THE STRUCTURAL GENE THAT CODES FOR THE HUMAN GROWTH HORMONE AND PROCEDURE FOR THE PRODUCTION OF SAID HORMONE