BG60253B1 - Човешки тъканен плазминогенен активатор - Google Patents

Човешки тъканен плазминогенен активатор

Info

Publication number
BG60253B1
BG60253B1 BG060834A BG6083483A BG60253B1 BG 60253 B1 BG60253 B1 BG 60253B1 BG 060834 A BG060834 A BG 060834A BG 6083483 A BG6083483 A BG 6083483A BG 60253 B1 BG60253 B1 BG 60253B1
Authority
BG
Bulgaria
Prior art keywords
human tissue
activator
plasminogenic
plasminogenic activator
human
Prior art date
Application number
BG060834A
Other languages
English (en)
Other versions
BG60253B2 (bg
Inventor
David Goeddel
William Kohr
Diane Pennica
Gordon Vehar
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27409206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG60253(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/483,052 external-priority patent/US4766075A/en
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of BG60253B2 publication Critical patent/BG60253B2/bg
Publication of BG60253B1 publication Critical patent/BG60253B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Активаторът намира приложение в медицината за профилактика и лечение на пациенти с различни сърдечно-съдови неразположения и заболявания. Полученият чрез рекомбинантни клетки-приемници деглюколизиран човешки такънен плазминогенен активатор е високопречистен. 15 претенции, 14 фигури
BG060834A 1982-05-05 1983-05-05 Човешки тъканен плазминогенен активатор BG60253B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37486082A 1982-05-05 1982-05-05
US39800382A 1982-07-14 1982-07-14
US06/483,052 US4766075A (en) 1982-07-14 1983-04-07 Human tissue plasminogen activator

Publications (2)

Publication Number Publication Date
BG60253B2 BG60253B2 (bg) 1994-03-24
BG60253B1 true BG60253B1 (bg) 1994-03-24

Family

ID=27409206

Family Applications (1)

Application Number Title Priority Date Filing Date
BG060834A BG60253B1 (bg) 1982-05-05 1983-05-05 Човешки тъканен плазминогенен активатор

Country Status (26)

Country Link
EP (1) EP0093619B2 (bg)
JP (2) JPH0216981A (bg)
AR (1) AR241654A1 (bg)
BG (1) BG60253B1 (bg)
BR (1) BR8302318A (bg)
CA (1) CA1293211C (bg)
CS (1) CS248705B2 (bg)
CY (1) CY1341A (bg)
DD (1) DD210303A5 (bg)
DE (3) DE93619T1 (bg)
DK (1) DK174236B1 (bg)
ES (1) ES8501629A1 (bg)
FR (1) FR2526443B1 (bg)
GB (1) GB2119804B (bg)
GR (1) GR79202B (bg)
HK (1) HK88586A (bg)
IE (1) IE54975B1 (bg)
IL (1) IL68561A (bg)
KE (1) KE3647A (bg)
MY (1) MY8700119A (bg)
NO (2) NO831575L (bg)
OA (1) OA07419A (bg)
PL (1) PL152438B1 (bg)
PT (1) PT76636B (bg)
RO (1) RO90639B (bg)
ZW (1) ZW10483A1 (bg)

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IL43343A (en) * 1972-10-24 1976-03-31 Lilly Co Eli Production of plasminogen activator
FR2252842B1 (bg) * 1973-12-03 1977-11-04 Fabre Sa Pierre
FR2310133A2 (fr) * 1975-05-05 1976-12-03 Fabre Sa Pierre Nouveau medicament comportant un activateur du plasminogene perfectionne
US4245051A (en) * 1978-03-30 1981-01-13 Rockefeller University Human serum plasminogen activator
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
ES494343A0 (es) * 1979-07-27 1981-10-01 Procedimiento de obtencion de un activador del plasminogeno
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
AR241654A1 (es) * 1982-05-05 1992-10-30 Genentech Inc Procedimiento para producir activador de plasminogeno de tejido humano.
SU1662352A3 (ru) * 1982-05-05 1991-07-07 Генентек, Инк (Фирма) Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа

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DE3316297C2 (bg) 1989-09-21
MY8700119A (en) 1987-12-31
ZW10483A1 (en) 1983-09-21
GB2119804B (en) 1986-02-26
OA07419A (fr) 1984-11-30
KE3647A (en) 1986-07-25
BG60253B2 (bg) 1994-03-24
PL241805A1 (en) 1984-07-30
AU1414283A (en) 1983-11-10
JPH0216981A (ja) 1990-01-19
DE3316297A1 (de) 1983-11-17
DE3380567D1 (en) 1989-10-19
AU563031B2 (en) 1987-06-25
NO852065L (no) 1983-11-07
ES522085A0 (es) 1984-12-16
IE831024L (en) 1983-11-05
IL68561A0 (en) 1983-09-30
CA1293211C (en) 1991-12-17
DD210303A5 (de) 1984-06-06
DK198883D0 (da) 1983-05-04
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IL68561A (en) 1991-01-31
CS248705B2 (en) 1987-02-12
EP0093619B1 (en) 1989-09-13
FR2526443A1 (fr) 1983-11-10
DK174236B1 (da) 2002-10-07
EP0093619A1 (en) 1983-11-09
ES8501629A1 (es) 1984-12-16
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AR241654A1 (es) 1992-10-30
GR79202B (bg) 1984-10-22
JPH05137583A (ja) 1993-06-01
GB8312221D0 (en) 1983-06-08
RO90639A (ro) 1987-01-30
EP0093619B2 (en) 1996-09-18
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JP2564444B2 (ja) 1996-12-18
PT76636A (en) 1983-06-01
RO90639B (ro) 1987-01-31
HK88586A (en) 1986-11-28
PL152438B1 (en) 1990-12-31
PT76636B (en) 1986-01-10
DK198883A (da) 1983-12-20
FR2526443B1 (fr) 1985-12-06
JPH0448440B2 (bg) 1992-08-06
CY1341A (en) 1987-01-16
NO831575L (no) 1983-11-07
IE54975B1 (en) 1990-04-11

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