CS248705B2 - Production method of the activator of the human tissue plasminogen - Google Patents

Production method of the activator of the human tissue plasminogen Download PDF

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Publication number
CS248705B2
CS248705B2 CS833187A CS318783A CS248705B2 CS 248705 B2 CS248705 B2 CS 248705B2 CS 833187 A CS833187 A CS 833187A CS 318783 A CS318783 A CS 318783A CS 248705 B2 CS248705 B2 CS 248705B2
Authority
CS
Czechoslovakia
Prior art keywords
plasminogen activator
tissue plasminogen
cells
dna
activator
Prior art date
Application number
CS833187A
Other languages
Czech (cs)
English (en)
Inventor
David V Goeddel
William J Kohr
Diane Pennica
Gordon A Vehar
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27409206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS248705(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/483,052 external-priority patent/US4766075A/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CS248705B2 publication Critical patent/CS248705B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C12N9/003—Dihydrofolate reductase [DHFR] (1.5.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CS833187A 1982-05-05 1983-05-05 Production method of the activator of the human tissue plasminogen CS248705B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37486082A 1982-05-05 1982-05-05
US39800382A 1982-07-14 1982-07-14
US06/483,052 US4766075A (en) 1982-07-14 1983-04-07 Human tissue plasminogen activator

Publications (1)

Publication Number Publication Date
CS248705B2 true CS248705B2 (en) 1987-02-12

Family

ID=27409206

Family Applications (1)

Application Number Title Priority Date Filing Date
CS833187A CS248705B2 (en) 1982-05-05 1983-05-05 Production method of the activator of the human tissue plasminogen

Country Status (26)

Country Link
EP (1) EP0093619B2 (bg)
JP (2) JPH0216981A (bg)
AR (1) AR241654A1 (bg)
BG (1) BG60253B1 (bg)
BR (1) BR8302318A (bg)
CA (1) CA1293211C (bg)
CS (1) CS248705B2 (bg)
CY (1) CY1341A (bg)
DD (1) DD210303A5 (bg)
DE (3) DE93619T1 (bg)
DK (1) DK174236B1 (bg)
ES (1) ES8501629A1 (bg)
FR (1) FR2526443B1 (bg)
GB (1) GB2119804B (bg)
GR (1) GR79202B (bg)
HK (1) HK88586A (bg)
IE (1) IE54975B1 (bg)
IL (1) IL68561A (bg)
KE (1) KE3647A (bg)
MY (1) MY8700119A (bg)
NO (2) NO831575L (bg)
OA (1) OA07419A (bg)
PL (1) PL152438B1 (bg)
PT (1) PT76636B (bg)
RO (1) RO90639B (bg)
ZW (1) ZW10483A1 (bg)

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NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
JPS5852634B2 (ja) * 1980-12-05 1983-11-24 株式会社林原生物化学研究所 ウロキナ−ゼの製造法
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
GT198302091A (es) * 1982-05-05 1984-10-25 Activador de plasminogeno de tejido humano a),b),c).

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PT76636B (en) 1986-01-10
FR2526443A1 (fr) 1983-11-10
PL241805A1 (en) 1984-07-30
BG60253B2 (bg) 1994-03-24
ZW10483A1 (en) 1983-09-21
IE831024L (en) 1983-11-05
IL68561A (en) 1991-01-31
GB8312221D0 (en) 1983-06-08
GB2119804B (en) 1986-02-26
EP0093619B2 (en) 1996-09-18
OA07419A (fr) 1984-11-30
GB2119804A (en) 1983-11-23
JPH0448440B2 (bg) 1992-08-06
EP0093619A1 (en) 1983-11-09
DE93619T1 (de) 1987-08-13
CY1341A (en) 1987-01-16
RO90639A (ro) 1987-01-30
BR8302318A (pt) 1984-01-10
DE3380567D1 (en) 1989-10-19
AU1414283A (en) 1983-11-10
DE3316297A1 (de) 1983-11-17
CA1293211C (en) 1991-12-17
JPH05137583A (ja) 1993-06-01
NO831575L (no) 1983-11-07
KE3647A (en) 1986-07-25
FR2526443B1 (fr) 1985-12-06
PT76636A (en) 1983-06-01
AR241654A1 (es) 1992-10-30
ES522085A0 (es) 1984-12-16
DK198883D0 (da) 1983-05-04
RO90639B (ro) 1987-01-31
DK198883A (da) 1983-12-20
NO852065L (no) 1983-11-07
ES8501629A1 (es) 1984-12-16
EP0093619B1 (en) 1989-09-13
JP2564444B2 (ja) 1996-12-18
HK88586A (en) 1986-11-28
GR79202B (bg) 1984-10-22
BG60253B1 (bg) 1994-03-24
DK174236B1 (da) 2002-10-07
PL152438B1 (en) 1990-12-31
JPH0216981A (ja) 1990-01-19
DE3316297C2 (bg) 1989-09-21
DD210303A5 (de) 1984-06-06
MY8700119A (en) 1987-12-31
IL68561A0 (en) 1983-09-30
AU563031B2 (en) 1987-06-25
IE54975B1 (en) 1990-04-11

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