DE69434581D1 - Immuntherapie durch rekombinanten virus - Google Patents
Immuntherapie durch rekombinanten virusInfo
- Publication number
- DE69434581D1 DE69434581D1 DE69434581T DE69434581T DE69434581D1 DE 69434581 D1 DE69434581 D1 DE 69434581D1 DE 69434581 T DE69434581 T DE 69434581T DE 69434581 T DE69434581 T DE 69434581T DE 69434581 D1 DE69434581 D1 DE 69434581D1
- Authority
- DE
- Germany
- Prior art keywords
- recombinant viruses
- viruses
- associated antigen
- immunotherapy
- recombinant virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000700605 Viruses Species 0.000 title abstract 6
- 238000009169 immunotherapy Methods 0.000 title 1
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 abstract 1
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 abstract 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 abstract 1
- 101000924345 Homo sapiens Ankyrin repeat domain-containing protein 36B Proteins 0.000 abstract 1
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 abstract 1
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 abstract 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 108090000978 Interleukin-4 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010046865 Vaccinia virus infection Diseases 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 230000002238 attenuated effect Effects 0.000 abstract 1
- 229940023860 canarypox virus HIV vaccine Drugs 0.000 abstract 1
- 102000057041 human TNF Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000007089 vaccinia Diseases 0.000 abstract 1
Classifications
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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Applications Claiming Priority (5)
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US711593A | 1993-01-21 | 1993-01-21 | |
US7115 | 1993-01-21 | ||
US184009 | 1994-01-19 | ||
US08/184,009 US5833975A (en) | 1989-03-08 | 1994-01-19 | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
PCT/US1994/000888 WO1994016716A1 (en) | 1993-01-21 | 1994-01-21 | Recombinant virus immunotherapy |
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DE69434581D1 true DE69434581D1 (de) | 2006-01-26 |
DE69434581T2 DE69434581T2 (de) | 2006-09-28 |
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DE69434581T Expired - Lifetime DE69434581T2 (de) | 1993-01-21 | 1994-01-21 | Immuntherapie durch rekombinanten virus |
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US (5) | US5833975A (de) |
EP (1) | EP0680331B1 (de) |
JP (1) | JPH09503902A (de) |
AT (1) | ATE313639T1 (de) |
AU (1) | AU684070B2 (de) |
DE (1) | DE69434581T2 (de) |
ES (1) | ES2255053T3 (de) |
WO (1) | WO1994016716A1 (de) |
Families Citing this family (240)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5505941A (en) * | 1981-12-24 | 1996-04-09 | Health Research, Inc. | Recombinant avipox virus and method to induce an immune response |
US7767449B1 (en) | 1981-12-24 | 2010-08-03 | Health Research Incorporated | Methods using modified vaccinia virus |
US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
US6699475B1 (en) * | 1987-09-02 | 2004-03-02 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
US6780407B1 (en) * | 1989-03-08 | 2004-08-24 | Aventis Pasteur | Pox virus comprising DNA sequences encoding CEA and B7 antigen |
US20030086935A1 (en) * | 1992-07-22 | 2003-05-08 | Levine Arnold J. | p53 vaccine |
US5858776A (en) * | 1993-11-03 | 1999-01-12 | Repligen Corporation | Tumor cells with increased immunogenicity and uses therefor |
US6093700A (en) | 1995-05-11 | 2000-07-25 | Thomas Jefferson University | Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF |
DE69535288T2 (de) * | 1994-05-13 | 2007-04-05 | Thomas Jefferson University | Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimieren |
WO1996010423A1 (en) * | 1994-09-30 | 1996-04-11 | Ludwig Institute For Cancer Research | COMPOSITIONS CONTAINING A p53 DERIVED PROTEIN OR PEPTIDE, AN ADJUVANT, AND INTERLEUKIN-12 AND USES THEREOF |
US6355256B1 (en) * | 1994-09-30 | 2002-03-12 | Ludwig Institute For Cancer Research | Compositions containing a p53 derived protein or peptide, an adjuvant, and interleukin-12 and uses thereof |
AU712714B2 (en) * | 1994-10-03 | 1999-11-11 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Enhanced immune response by introduction of cytokine gene and/or costimulatory molecule B7 gene in a recombinant virus expressing system |
US6045802A (en) * | 1994-10-03 | 2000-04-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Enhanced immune response to an antigen by a composition of a recombinant virus expressing the antigen with a recombinant virus expressing an immunostimulatory molecule |
ES2154738T3 (es) | 1994-10-03 | 2001-04-16 | Us Gov Health & Human Serv | Composicion que comprende un virus recombinante que expresa un antigeno y un virus recombinante que expresa una molecula inmunoestimuladora. |
US5573925A (en) * | 1994-11-28 | 1996-11-12 | The Wistar Institute Of Anatomy And Biology | P53 proteins with altered tetramerization domains |
US5721340A (en) * | 1994-11-28 | 1998-02-24 | The Wistar Institute Of Anatomy & Biology | p53 proteins with altered tetramerization domains |
CA2210294C (en) * | 1995-01-13 | 2003-11-11 | Virogenetics Corporation | Immunogenic compositions containing recombinant attenuated poxviruses expressing htlv antigens |
US6001349A (en) * | 1995-02-22 | 1999-12-14 | Therion Biologics Corporation | Generation of human cytotoxic T-cells specific for carcinoma self-associated antigens and uses thereof |
WO1996040880A1 (en) * | 1995-06-07 | 1996-12-19 | Syntro Corporation | Recombinant fowlpox viruses and uses thereof |
WO1997000085A1 (en) * | 1995-06-19 | 1997-01-03 | University Of Medicine & Dentistry Of New Jersey | Gene therapy of solid tumors with interferons alone or with other immuno-effector proteins |
US6165460A (en) * | 1995-07-10 | 2000-12-26 | Therion Biologics Corporation | Generation of immune responses to prostate-specific antigen (PSA) |
US5763415A (en) * | 1995-08-03 | 1998-06-09 | John Hopkins University School Of Medicine | Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer |
US5847083A (en) * | 1996-08-21 | 1998-12-08 | The Wistar Institute Of Anatomy And Biology | Modified p53 constructs which enhance DNA binding |
US6344445B1 (en) | 1995-10-19 | 2002-02-05 | Cantab Pharmaceutical Research Limited | Herpes virus vectors and their uses |
JP2000505650A (ja) * | 1996-02-08 | 2000-05-16 | アメリカ合衆国 | 樹状突起細胞を形質転換し、そしてt細胞を活性化するための方法及び組成物 |
US6734014B1 (en) | 1996-02-08 | 2004-05-11 | The United States Of America As Represented By The Department Of Health And Human Services | Methods and compositions for transforming dendritic cells and activating T cells |
US20010036928A1 (en) * | 1996-04-22 | 2001-11-01 | Chamberlain Ronald S. | Heterologous boosting immunizations |
US5922685A (en) * | 1996-06-05 | 1999-07-13 | Powderject Vaccines, Inc. | IL-12 gene therapy of tumors |
US5837231A (en) * | 1996-06-27 | 1998-11-17 | Regents Of The University Of Minnesota | GM-CSF administration for the treatment and prevention of recurrence of brain tumors |
AU3514197A (en) | 1996-07-03 | 1998-01-21 | Genetics Institute Inc. | Protease fmh-1, an ice/ced-like protease |
CA2261989C (en) * | 1996-07-25 | 2008-09-30 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
AU4448597A (en) * | 1996-10-04 | 1998-05-05 | Connaught Laboratories Limited | Treatment of cancer using a recombinant poxvirus containing nucleic acid sequence encoding a cytokine |
WO1998017814A2 (en) * | 1996-10-18 | 1998-04-30 | Valentis Inc. | Gene expression and delivery systems and uses |
JP2001503257A (ja) * | 1996-10-18 | 2001-03-13 | バレンティス・インコーポレーテッド | Il―12遺伝子発現および送達系および使用 |
AU727308B2 (en) * | 1997-02-24 | 2000-12-07 | Dana-Farber Cancer Institute | Recombinant pox virus for immunization against muc1 tumor-associated antigen |
TW586934B (en) * | 1997-05-19 | 2004-05-11 | Sumitomo Pharma | Immunopotentiating composition |
CN1106846C (zh) | 1997-08-21 | 2003-04-30 | 宝酒造株式会社 | 抗癌症剂 |
US6517843B1 (en) | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
US7780962B2 (en) | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
AU2005237176C1 (en) * | 1997-10-09 | 2009-09-24 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
US7470426B1 (en) | 1997-10-09 | 2008-12-30 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
IL135507A0 (en) * | 1997-10-09 | 2001-05-20 | Pro Virus Inc | Treatment of neoplasms with viruses |
US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
US20070048860A1 (en) * | 1997-10-10 | 2007-03-01 | The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services | Carcinoembryonic antigen (CEA) peptides |
CA2307316C (en) | 1997-10-24 | 2010-12-21 | University Of Utah Research Foundation | Kcnq2 and kcnq3-potassium channel genes which are mutated in benign familial neonatal convulsions (bfnc) and other epilepsies |
US6224882B1 (en) | 1997-11-07 | 2001-05-01 | Protein Science Corp. | Insect cells or fractions as adjuvant for antigens |
FR2772047B1 (fr) * | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
AU1606799A (en) * | 1997-12-09 | 1999-06-28 | Virogenetics Corporation | Recombinant vaccinia constructs expressing feline il-2, compositions and methodsof use thereof |
CZ298364B6 (cs) | 1998-02-05 | 2007-09-05 | Smithkline Beecham Biologicals S. A. | Deriváty antigenu asociovaných s nádory z MAGE rodiny a sekvence nukleových kyselin kodující tyto deriváty, jejich použití pro prípravu fúzních proteinu a prostredku pro vakcinaci |
AU767880B2 (en) * | 1998-03-16 | 2003-11-27 | Introgen Therapeutics, Inc. | Multigene vectors |
CA2340596A1 (en) * | 1998-08-26 | 2000-03-09 | Bavarian Nordic Research Institute A/S | Guanylate binding protein (gbp-1) as inhibitor of cell proliferation and molecular marker for the determination of the stage of cellular differentiation |
AUPP700798A0 (en) * | 1998-11-09 | 1998-12-03 | Australian National University, The | Recombinant viral constructs and methods relating thereto |
GB2370572B (en) * | 1998-11-18 | 2003-05-07 | Oxford Biomedica Ltd | Use of a professional antigen presenting cell |
US7148035B1 (en) | 1998-11-18 | 2006-12-12 | Oxford Biomedica (Uk) Limited | Polypeptide |
JP5448283B2 (ja) | 1998-11-19 | 2014-03-19 | ジョージタウン・ユニバーシティ | 全身性ウイルス/リガンド遺伝子送達システムおよび遺伝子治療 |
US20050063950A1 (en) * | 1998-11-19 | 2005-03-24 | Georgetown University | Systemic viral/ligand gene delivery system and gene therapy |
DE19905501B4 (de) | 1999-02-10 | 2005-05-19 | MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie | Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels |
EP1390046A4 (de) | 1999-04-15 | 2005-04-20 | Wellstat Biologics Corp | Behandlung von neoplasmen mit viren |
CA2375189C (en) * | 1999-05-28 | 2010-02-09 | The Government Of The United States Of America | A combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector |
US6497883B1 (en) | 1999-06-10 | 2002-12-24 | Merial | Porcine circovirus recombinant poxvirus vaccine |
FR2796396A1 (fr) * | 1999-07-16 | 2001-01-19 | Merial Sas | Gene de calicivirus felin et vaccin recombine les incorporant |
US6541458B1 (en) | 1999-07-16 | 2003-04-01 | Merial | Feline calicivirus genes and vaccines in particular recombinant vaccines |
FR2796397B1 (fr) * | 1999-07-16 | 2006-09-01 | Merial Sas | Genes de calicivirus felin et vaccins notamment vaccins recombines |
WO2001023404A1 (en) * | 1999-09-30 | 2001-04-05 | Genaissance Pharmaceuticals, Inc. | Drug target isogenes: polymorphisms in the interleukin-4 gene |
WO2001030847A1 (en) | 1999-10-22 | 2001-05-03 | Aventis Pasteur Limited | Modified gp100 and uses thereof |
US7115712B1 (en) * | 1999-12-02 | 2006-10-03 | Maxygen, Inc. | Cytokine polypeptides |
ES2170622B1 (es) * | 1999-12-03 | 2004-05-16 | Consejo Superior De Investigaciones Cientificas | Clones y vectores infectivos derivados de coronavirus y sus aplicaciones. |
DE60038048T2 (de) * | 1999-12-21 | 2009-07-09 | Merial | Mindestens ein cryptosporidium parvum-antigen und mindestens ein antigen eines anderen darmkrankheitserregers enthaltende zusammensetzungen und impfstoffe |
AU5810201A (en) | 2000-05-10 | 2001-11-20 | Aventis Pasteur | Immunogenic polypeptides encoded by mage minigenes and uses thereof |
CA2412050C (en) * | 2000-06-15 | 2011-03-22 | Jeffrey Schlom | A recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses |
US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
US20110091428A1 (en) * | 2000-07-31 | 2011-04-21 | New York Medical College | Compositions of adult organ stem cells and uses thereof |
US7547674B2 (en) | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
US20020098167A1 (en) * | 2000-07-31 | 2002-07-25 | Piero Anversa | Methods and compositions for the repair and/or regeneration of damaged myocardium |
US7862810B2 (en) * | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
US6892140B1 (en) * | 2000-11-27 | 2005-05-10 | Enteron, Inc. | Immunogenic cancer peptides and uses thereof |
US20030049651A1 (en) * | 2001-03-05 | 2003-03-13 | Mount Sinai Hospital | Tumor associated proteins |
WO2002072852A2 (en) * | 2001-03-08 | 2002-09-19 | Akzo Nobel N.V. | Leporipox-based vector vaccines |
GB0109515D0 (en) * | 2001-04-17 | 2001-06-06 | Neg Micon As | A method for transporting a set of large longitudinal items, a package system to be used by the method and use of such a package system |
US20020193295A1 (en) * | 2001-05-04 | 2002-12-19 | Emanuel Calenoff | Immunogenic peptides and uses thereof |
US20030148973A1 (en) * | 2001-05-23 | 2003-08-07 | Peter Emtage | MAGE-A1 peptides for treating or preventing cancer |
EP1281767A3 (de) * | 2001-07-31 | 2003-05-28 | Aladar A. Szalay | Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren |
US20030113919A1 (en) * | 2001-08-17 | 2003-06-19 | Aventis Pasteur, Ltd. | Immunogenic targets for melanoma |
EP2172552A3 (de) | 2001-10-11 | 2010-07-21 | Merck Sharp & Dohme Corp. | Rekombinante Nukleinsäuren beinhaltend Regionen von AD6 |
EP1308517A1 (de) * | 2001-10-31 | 2003-05-07 | Aventis Pharmacueticals Products Inc. | Vektoren für die Expression von mehrere Transgenen |
CA2466413C (en) * | 2001-12-04 | 2014-11-04 | Bavarian Nordic A/S | Flavivirus ns1 subunit vaccine |
WO2003050268A2 (en) * | 2001-12-12 | 2003-06-19 | Aventis Pasteur Limited | Enhancement of the immune response using cd36-binding domain |
EP1496939B1 (de) * | 2002-04-09 | 2007-08-15 | Sanofi Pasteur Limited | Modifizierte cea nucleinsäure und expressionsvektoren |
AU2004280608B2 (en) * | 2002-04-09 | 2012-04-05 | Sanofi Pasteur, Inc. | Modified CEA/B7 vector |
EP1369491A1 (de) | 2002-06-05 | 2003-12-10 | Aladar A. Szalay | Lichtemittierende Mikroorganismen und Zellen für die Diagnose und Therapie von Krankheiten assoziiert mit Wunden oder entzündetem Gewebe |
WO2004005463A2 (en) * | 2002-07-03 | 2004-01-15 | Aventis Pasteur Inc. | Tumor antigens bfa4 and bcy1 for prevention and/or treatment of cancer |
ATE504653T1 (de) | 2002-08-07 | 2011-04-15 | Bavarian Nordic As | Vaccinia virus wirtspektrum gene zur erhöhung des titers von avipoxviren |
EP2269619A1 (de) * | 2002-08-12 | 2011-01-05 | Jennerex Biotherapeutics ULC | Verfahren und Zusammensetzungen in Bezug auf Pockenviren und Krebs |
KR101044538B1 (ko) * | 2002-09-05 | 2011-06-27 | 버베리안 노딕 에이/에스 | 무혈청 조건하에서 일차세포의 배양 및 바이러스의 증식방법 |
US20040223949A1 (en) * | 2002-10-22 | 2004-11-11 | Sunnybrook And Women's College Health Sciences Center Aventis Pasteur, Ltd. | Vaccines using high-dose cytokines |
ES2347239T3 (es) | 2002-12-02 | 2010-10-27 | Amgen Fremont Inc. | Anticuerpos dirigidos al factor de necrosis tumoral y usos de los mismos. |
AU2003296974A1 (en) * | 2002-12-13 | 2004-07-14 | Aventis Pasteur, Inc. | Production of alvac on avian embryonic stem cells |
WO2004058157A2 (en) * | 2002-12-16 | 2004-07-15 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
CA2510309C (en) * | 2002-12-16 | 2014-09-16 | Liyange P. Perera | Recombinant vaccine viruses expressing il-15 and methods of using the same |
US20040156828A1 (en) * | 2003-01-07 | 2004-08-12 | Ruian Xu | Adeno-associated virus mediated B7.1 vaccination synergizes with angiostatin to eradicate disseminated liver metastatic cancers |
EP1606419A1 (de) | 2003-03-18 | 2005-12-21 | Quantum Genetics Ireland Limited | Systeme und methoden zur erhohung der milchproduktion in tieren |
US20060160090A1 (en) * | 2003-04-11 | 2006-07-20 | Macina Robert A | Composition splice variants and methods relating to cancer specific genes and proteins |
US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
US8207314B2 (en) * | 2003-05-16 | 2012-06-26 | Sanofi Pasteur Limited | Tumor antigens for prevention and/or treatment of cancer |
US8105615B2 (en) * | 2003-06-06 | 2012-01-31 | Agennix Incorporated | Lactoferrin as an adjuvant in cancer vaccines |
DE602004018927D1 (de) * | 2003-06-18 | 2009-02-26 | Genelux Corp | Modifizierte rekombinante vacciniaviren, verwendungen davon |
WO2005049794A2 (en) | 2003-11-13 | 2005-06-02 | University Of Georgia Research Foundation, Inc. | Methods of characterizing infectious bursal disease virus |
ATE510928T1 (de) | 2004-02-19 | 2011-06-15 | Univ Alberta | Leptinpromotor-polymorphismen und verwendungen davon |
US20050281782A1 (en) * | 2004-06-21 | 2005-12-22 | Howard Kaufman | Novel recombinant poxvirus composition and uses thereof |
US7998733B2 (en) * | 2004-10-05 | 2011-08-16 | Merial Limited | Chimeric vectors |
WO2006113927A2 (en) * | 2005-04-20 | 2006-10-26 | University Of Washington | Immunogenic vaccinia peptides and methods of using same |
ES2343270T3 (es) | 2005-04-25 | 2010-07-27 | Merial Ltd. | Vacunas contra el virus nipah. |
EP2570423B1 (de) | 2005-06-17 | 2023-05-03 | MSD Italia S.r.l. | Nukleinsäureimpfstoff für Hepatitis-C-Virus |
CN100333793C (zh) * | 2005-06-28 | 2007-08-29 | 崔栋 | 二倍体细胞狂犬疫苗及纯化狂犬疫苗,剂型冻干及水针 |
US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
US8980246B2 (en) | 2005-09-07 | 2015-03-17 | Sillajen Biotherapeutics, Inc. | Oncolytic vaccinia virus cancer therapy |
CA2621982C (en) * | 2005-09-07 | 2017-11-28 | Jennerex Biotherapeutics Ulc | Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses |
US7771995B2 (en) | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
EP3147296A1 (de) | 2005-11-14 | 2017-03-29 | Merial, Inc. | Gentherapie für nierenversagen |
JP5138601B2 (ja) * | 2005-11-21 | 2013-02-06 | サノフィ パストゥール リミテッド | 組換えウイルス安定化製剤 |
US7870822B2 (en) * | 2006-01-19 | 2011-01-18 | Ecolab Usa Inc. | Method and system for recapturing and reusing unreacted antimicrobial solutions in spray applications |
US7913477B2 (en) * | 2006-01-27 | 2011-03-29 | William Anthony Harper | Insert registration in packets |
US20090060947A1 (en) * | 2006-05-19 | 2009-03-05 | Sanofi Pasteur, Inc. | Immunological compositions |
US7862821B2 (en) | 2006-06-01 | 2011-01-04 | Merial Limited | Recombinant vaccine against bluetongue virus |
CA2654324A1 (en) | 2006-06-02 | 2007-12-13 | International Aids Vaccine Initiative | Hiv-1 clade a consensus sequences, antigens, and transgenes |
TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
EP2426142A3 (de) | 2006-10-16 | 2012-06-13 | Genelux Corporation | Modifizierte Impfstoffvirusstämme zur Verwendung in einem Diagnose- und Therapieverfahren |
US8202967B2 (en) | 2006-10-27 | 2012-06-19 | Boehringer Ingelheim Vetmedica, Inc. | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
KR20080084528A (ko) * | 2007-03-15 | 2008-09-19 | 제네렉스 바이오테라퓨틱스 인크. | 종양살상형 백시니아 바이러스 암 치료 |
WO2008156655A2 (en) * | 2007-06-15 | 2008-12-24 | Genelux Corporation | Vaccinia virus vectors encoding a sodium-dependent transporter protein for imaging and/or treatment of tumors |
EP2173368A1 (de) * | 2007-07-18 | 2010-04-14 | Genelux Corporation | Verwendung eines chemotherapeutischen mittels zur herstellung eines medikaments zur behandlung oder linderung einer mit einer onkolytischen virentherapie verbundenen unerwünschten nebenwirkung |
AU2008323719B2 (en) * | 2007-11-09 | 2013-04-04 | New York Medical College | Methods for the repair and/or regeneration of damaged myocardium using variants of hepatocyte growth factor |
NZ584199A (en) | 2007-11-19 | 2012-07-27 | Transgene Sa | Poxviral oncolytic vectors comprising a defective 14l and/or f4l gene |
US9687515B2 (en) | 2007-11-19 | 2017-06-27 | Transgene S.A. | Poxviral oncolytic vectors |
CN102257134B (zh) | 2008-02-12 | 2014-03-05 | 赛诺菲巴斯德有限公司 | 使用离子交换和凝胶过滤色谱进行痘病毒纯化的方法 |
ES2760004T3 (es) | 2008-05-08 | 2020-05-12 | Boehringer Ingelheim Animal Health Usa Inc | Vacuna contra Leishmania utilizando un inmunnógeno salival de mosca de la arena |
WO2009139921A2 (en) * | 2008-05-16 | 2009-11-19 | Genelux Corporation | Microorganisms for preventing and treating neoplasms accompanying cellular therapy |
EP3156069B8 (de) | 2008-06-20 | 2020-10-21 | Duke University | Zusammensetzungen, verfahren und kits zur auslösung einer immunreaktion |
WO2010017083A1 (en) * | 2008-08-04 | 2010-02-11 | Wayne State University | Methods of treating cancer with cd11b antibodies |
US8691502B2 (en) | 2008-10-31 | 2014-04-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
MX2011006922A (es) | 2008-12-24 | 2012-06-12 | Netherlands Vaccine Inst | Polipeptidos de neumolisina (ply) modificada a partir de streptococcus pneumonia. |
US8394385B2 (en) | 2009-03-13 | 2013-03-12 | Bavarian Nordic A/S | Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines |
EP2413962A1 (de) | 2009-03-30 | 2012-02-08 | Mount Sinai School of Medicine | Impfstoffe gegen das grippevirus und ihre verwendungen |
CN102428099B (zh) | 2009-04-03 | 2016-03-16 | 梅里亚有限公司 | 运载新城疫病毒的禽疫苗 |
KR102019728B1 (ko) | 2009-04-17 | 2019-09-09 | 글로브이뮨 | 암에 대한 병용 면역요법 조성물 및 방법 |
EP2424999A1 (de) | 2009-04-30 | 2012-03-07 | Centre Hospitalier Universitaire Vaudois Lausanne (CHUV) | Modifizierte immunisierungsvektoren |
TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
ES2848650T3 (es) | 2009-09-14 | 2021-08-11 | Sillajen Biotherapeutics Inc | Terapia combinada contra el cáncer con virus vaccinia oncolítico |
CA2792537A1 (en) | 2010-03-30 | 2011-10-06 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
BR112012029633A8 (pt) | 2010-05-21 | 2017-12-05 | Ah Usa 42 Llc | Vetores do parapoxvírus contendo antígeno do vírus da raiva. |
KR20130020963A (ko) | 2010-07-20 | 2013-03-04 | 에이에이치 유에스에이 42 엘엘씨 | 파라폭스바이러스 벡터 |
US9109007B2 (en) | 2010-08-18 | 2015-08-18 | Purdue Pharma L.P. | MHC-I restricted epitopes containing non-natural amino acid residues |
MX344103B (es) | 2010-08-31 | 2016-12-05 | Merial Ltd | Vacunas de virus herpes vectorizado con virus de enfermedad de newcastle. |
AR083533A1 (es) | 2010-10-22 | 2013-03-06 | Boehringer Ingelheim Vetmed | Proteinas de hemaglutinina 5 (h5) para el tratamiento y prevencion de las infecciones de gripe |
WO2012090073A2 (en) | 2010-12-30 | 2012-07-05 | The Netherlands Cancer Institute | Methods and compositions for predicting chemotherapy sensitivity |
CN103429258B (zh) | 2011-01-04 | 2016-03-09 | 新罗杰公司 | 通过施用溶瘤痘苗病毒生成针对肿瘤抗原的抗体和生成肿瘤特异性补体依赖性细胞毒性 |
EP2668201A2 (de) | 2011-01-28 | 2013-12-04 | Sanofi Pasteur SA | Immunologische zusammensetzungen mit hiv-gp41-polypeptidderivaten |
KR20200044990A (ko) | 2011-03-21 | 2020-04-29 | 알티뮨 인크. | 급속 및 지속적 면역학적제제-치료제 |
EP2694678A2 (de) | 2011-04-04 | 2014-02-12 | Netherland Cancer Institute | Verfahren und zusammensetzungen zur vorhersage der resistenz gegenüber einer antikrebsbehandlung |
AU2012240240A1 (en) | 2011-04-04 | 2013-05-09 | Netherlands Cancer Institute | Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors |
JP6415977B2 (ja) | 2011-04-15 | 2018-10-31 | ジェネラックス・コーポレイションGenelux Corporation | 弱毒化ワクシニアウイルスのクローン株およびその使用方法 |
US9216213B2 (en) | 2011-04-20 | 2015-12-22 | Merial, Inc. | Adjuvanted rabies vaccine with improved viscosity profile |
CN103945864A (zh) | 2011-04-25 | 2014-07-23 | 先进生物学实验室股份有限公司 | 截短的hiv包膜蛋白(env)、其相关方法和组合物 |
US9669085B2 (en) | 2011-06-01 | 2017-06-06 | Merial Inc. | Needle-free administration of PRRSV vaccines |
SG2014008411A (en) | 2011-08-08 | 2014-03-28 | Curelab Oncology Inc | Methods and compositions relating to p62 for the treatment and prophylaxis of cancer |
CN103841963B (zh) | 2011-08-12 | 2018-04-24 | 梅里亚股份有限公司 | 用于生物产品特别是疫苗的真空辅助保存 |
AR088028A1 (es) | 2011-08-15 | 2014-05-07 | Boehringer Ingelheim Vetmed | Proteinas h5, de h5n1 para un uso medicinal |
WO2013033092A2 (en) | 2011-09-03 | 2013-03-07 | Boehringer Ingelheim Vetmedica Gmbh | Streptococcus suis pilus antigens |
EP2758075B1 (de) | 2011-09-20 | 2023-05-03 | Icahn School of Medicine at Mount Sinai | Influenzavirus-impfstoffe und verwendungen davon |
EP2788021B1 (de) | 2011-12-09 | 2017-01-18 | Bavarian Nordic A/S | Pockenvirus-vektor zur expression von bakteriellen antigen, welche mit tetanus toxin fragment c verbunden sind |
WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
WO2013138522A2 (en) | 2012-03-16 | 2013-09-19 | Genelux Corporation | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
WO2013138776A1 (en) | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
WO2013158265A1 (en) | 2012-04-20 | 2013-10-24 | Genelux Corporation | Imaging methods for oncolytic virus therapy |
US10111946B2 (en) | 2012-06-22 | 2018-10-30 | Bavarian Nordic A/S | Poxviral vectors for low antibody response after a first priming immunization |
EA201891945A3 (ru) | 2012-08-01 | 2019-05-31 | Бавариан Нордик А/С | Вакцина рекомбинантного модифицированного вируса осповакцины анкара (mva) респираторно-синцитиального вируса (rsv) |
JP2016508133A (ja) | 2012-12-18 | 2016-03-17 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン及びその使用 |
WO2014127825A1 (en) | 2013-02-21 | 2014-08-28 | Boehringer Ingelheim Vetmedica Gmbh | H5 proteins of h5n1 influenza virus for use as a medicament |
EP2968514A1 (de) | 2013-03-12 | 2016-01-20 | Merial, Inc. | Mittels reverser genetik hergestellte impfstoffzusammensetzungen gegen schmallenberg-virus und verfahren zur verwendung davon |
WO2014140938A2 (en) | 2013-03-14 | 2014-09-18 | Centre Hospitalier Universitaire Vaudois | Immunological methods |
US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
WO2015048115A1 (en) | 2013-09-25 | 2015-04-02 | Zoetis Llc | Pcv2b divergent vaccine composition and methods of use |
WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
WO2015085147A1 (en) | 2013-12-05 | 2015-06-11 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
CA2934073A1 (en) | 2013-12-20 | 2015-06-25 | The Broad Institute, Inc. | Combination therapy with neoantigen vaccine |
AU2015241107B2 (en) | 2014-04-03 | 2019-10-03 | Boehringer Ingelheim Animal Health USA Inc. | Porcine epidemic diarrhea virus vaccine |
NZ731659A (en) | 2014-11-03 | 2018-10-26 | Merial Inc | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
EP3234193B1 (de) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Molekulare biomarker für krebsimmuntherapie |
EP3757211A1 (de) | 2014-12-19 | 2020-12-30 | The Broad Institute, Inc. | Verfahren zur profilierung des t-zell-rezeptor-repertoirs |
JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
CA2977660A1 (en) | 2015-02-25 | 2016-09-15 | Memorial Sloan-Kettering Cancer Center | Use of inactivated nonreplicating modified vaccinia virus ankara (mva) as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors |
WO2016145150A2 (en) | 2015-03-11 | 2016-09-15 | The Broad Institute Inc. | Selective treatment of prmt5 dependent cancer |
CA2982896A1 (en) | 2015-04-17 | 2016-10-20 | Memorial Sloan Kettering Cancer Center | Use of modified vaccinia ankara virus (mva) or mva with a deletion of virulence factor e8 as immunotherapeutic agent against solid tumors |
US10441644B2 (en) | 2015-05-05 | 2019-10-15 | The Regents Of The University Of California | H3.3 CTL peptides and uses thereof |
AU2016258984B2 (en) | 2015-05-05 | 2020-11-19 | The Regents Of The University Of California | H3.3 CTL peptides and uses thereof |
RU2020132040A (ru) | 2015-05-20 | 2020-10-12 | Те Брод Инститьют Инк. | Общие неоантигены |
KR20160140075A (ko) * | 2015-05-29 | 2016-12-07 | 코오롱생명과학 주식회사 | 폭스바이러스 유래 프로모터 및 이를 포함하는 벡터 |
TW202241500A (zh) | 2015-06-09 | 2022-11-01 | 美商博德研究所有限公司 | 用於贅瘤疫苗之調配物及其製備方法 |
PL3313864T3 (pl) | 2015-06-23 | 2022-01-03 | Boehringer Ingelheim Animal Health USA Inc. | Rekombinowane wektory wirusowe zawierające drugorzędne białko prrsv oraz sposoby ich wytwarzania i zastosowania |
ES2778649T3 (es) | 2015-08-31 | 2020-08-11 | Boehringer Ingelheim Vetmedica Gmbh | Vacunas pestivirales para temblores congénitos |
MX2018003173A (es) | 2015-09-16 | 2018-05-17 | Boehringer Ingelheim Vetmedica Inc | Vacunas de salmonella choleraesuis-salmonella typhimurium. |
WO2017147212A1 (en) | 2016-02-22 | 2017-08-31 | The Regents Of The University Of California | Compositions and methods for imaging cell populations |
MX2018010204A (es) | 2016-02-25 | 2019-05-06 | Memorial Sloan Kettering Cancer Center | Virus de la vaccinia atenuada competentes para replicacion con la supresion de timidina quinasa con y sin la expresion del flt3l o gm-csf humanos para inmunoterapia del cancer. |
MX2018010231A (es) | 2016-02-25 | 2019-06-06 | Memorial Sloan Kettering Cancer Center | Mva recombinante o mvadele3l que expresa el flt3l humano y uso de los mismos como agentes inmunoterapéuticos contra tumores sólidos. |
WO2017184590A1 (en) | 2016-04-18 | 2017-10-26 | The Broad Institute Inc. | Improved hla epitope prediction |
EP3471767A4 (de) | 2016-06-15 | 2020-01-15 | Icahn School of Medicine at Mount Sinai | Influenzavirus-hämagglutinin-proteine und verwendungen davon |
TW201823467A (zh) | 2016-09-20 | 2018-07-01 | 德商百靈佳殷格翰維美迪加股份有限公司 | 犬腺病毒載體 |
AR109540A1 (es) | 2016-09-20 | 2018-12-19 | Boehringer Ingelheim Vetmedica Gmbh | Moléculas promotoras para expresar antígenos virales |
EP3515480A1 (de) | 2016-09-20 | 2019-07-31 | Boehringer Ingelheim Vetmedica GmbH | Neuer schweinegrippenimpfstoff |
CN109715204B (zh) | 2016-09-20 | 2023-08-22 | 勃林格殷格翰动物保健有限公司 | 新的ehv插入位点orf70 |
WO2018083154A1 (en) | 2016-11-03 | 2018-05-11 | Boehringer Ingelheim Vetmedica Gmbh | Vaccine against porcine parvovirus |
MY191895A (en) | 2016-11-03 | 2022-07-18 | Boehringer Ingelheim Vetmedica Gmbh | Vaccine against porcine parvovirus and porcine reproductive and respiratory syndrome virus and methods of production thereof |
WO2018140391A1 (en) | 2017-01-24 | 2018-08-02 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
JP2020506915A (ja) | 2017-01-30 | 2020-03-05 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | ブタコロナウイルスワクチン |
ES2965475T3 (es) | 2017-02-12 | 2024-04-15 | Biontech Us Inc | Métodos y composiciones basados en HLA y usos de los mismos |
EP3606555A4 (de) | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | Neuraminidase-antikörper gegen influenza-b-virus und verwendungen davon |
CN111107872A (zh) | 2017-05-12 | 2020-05-05 | 纪念斯隆-凯特林癌症中心 | 有用于癌症免疫疗法的牛痘病毒突变体 |
CN107012245B (zh) * | 2017-05-12 | 2023-05-12 | 兰州海关技术中心 | 一种检测菜豆晕疫病菌实时荧光pcr试剂盒及其检测方法 |
WO2019014144A1 (en) | 2017-07-12 | 2019-01-17 | Boehringer Ingelheim Vetmedica, Inc. | IMMUNOGENIC COMPOSITIONS BASED ON SENECAVIRUS TYPE A AND CORRESPONDING METHODS |
CA3072553A1 (en) | 2017-09-23 | 2019-03-28 | Boehringer Ingelheim Vetmedica Gmbh | Paramyxoviridae expression system |
WO2019092027A1 (en) | 2017-11-09 | 2019-05-16 | Boehringer Ingelheim Vetmedica Gmbh | Sapelovirus immunogenic compositions and uses thereof |
EP3717000A1 (de) | 2017-12-01 | 2020-10-07 | Gerd Sutter | Immunmodulierter replikationseffizienter vacciniavirusstamm |
WO2019126186A1 (en) | 2017-12-18 | 2019-06-27 | Neon Therapeutics, Inc. | Neoantigens and uses thereof |
AU2019223768A1 (en) | 2018-02-23 | 2020-08-27 | Boehringer Ingelheim Animal Health USA Inc. | Recombinant viral vector systems expressing exogenous feline paramyxovirus genes and vaccines made therefrom |
CA3091960A1 (en) | 2018-03-19 | 2019-09-26 | Boehringer Ingelheim Vetmedica Gmbh | New ehv insertion site ul43 |
AR115002A1 (es) | 2018-03-19 | 2020-11-18 | Boehringer Ingelheim Vetmedica Gmbh | Ehv con ul18 y/o ul8 inactivados |
JP7162072B2 (ja) | 2018-03-26 | 2022-10-27 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 免疫原性組成物を製造する方法 |
CN112867506A (zh) | 2018-09-20 | 2021-05-28 | 勃林格殷格翰动物保健有限公司 | 抗猪流行性腹泻的鼻内载体疫苗 |
EP3852797A1 (de) | 2018-09-20 | 2021-07-28 | Boehringer Ingelheim Vetmedica GmbH | Modifiziertes pedv-spike-protein |
WO2020072700A1 (en) | 2018-10-02 | 2020-04-09 | Dana-Farber Cancer Institute, Inc. | Hla single allele lines |
US20220062394A1 (en) | 2018-12-17 | 2022-03-03 | The Broad Institute, Inc. | Methods for identifying neoantigens |
MX2021007556A (es) | 2018-12-21 | 2021-09-10 | Biontech Us Inc | Método y sistemas de predicción de epítopos específicos de hla de clase ii y caracterización de células t cd4+. |
AU2019412516A1 (en) * | 2018-12-28 | 2021-07-15 | Transgene | M2-defective poxvirus |
EP4100420A1 (de) | 2020-02-06 | 2022-12-14 | Boehringer Ingelheim Vetmedica GmbH | Polypeptide zur detektion von anti-rhabdovirus-antikörpern |
WO2022076977A1 (en) | 2020-10-05 | 2022-04-14 | Boehringer Ingelheim Animal Health USA Inc. | Fusion protein comprising circoviridae capsid protein, and chimeric virus-like particles composed thereof |
WO2022076979A1 (en) | 2020-10-05 | 2022-04-14 | Boehringer Ingelheim Vetmedica Gmbh | Fusion protein useful for vaccination against rotavirus |
CN117083081A (zh) | 2020-12-14 | 2023-11-17 | 百欧恩泰美国公司 | 用于癌症免疫疗法的组织特异性抗原 |
US20240050555A1 (en) | 2022-04-05 | 2024-02-15 | Boehringer Ingelheim Vetmedica Gmbh | Immunogenic composition useful for vaccination against rotavirus |
WO2024011250A1 (en) | 2022-07-08 | 2024-01-11 | Viromissile, Inc. | Oncolytic vaccinia viruses and recombinant viruses and methods of use thereof |
WO2024015892A1 (en) | 2022-07-13 | 2024-01-18 | The Broad Institute, Inc. | Hla-ii immunopeptidome methods and systems for antigen discovery |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK489481A (da) * | 1980-11-10 | 1982-05-11 | Searle & Co | Plasmidvektor og frmgangsmaade til fremstilling deraf |
US5378457A (en) * | 1981-12-24 | 1995-01-03 | Virogenetics Corporation | Interferon sensitive recombinant poxvirus vaccine |
US4603112A (en) * | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
US4769330A (en) * | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
US5110587A (en) * | 1981-12-24 | 1992-05-05 | Health Research, Incorporated | Immunogenic composition comprising synthetically modified vaccinia virus |
US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
US4722848A (en) * | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
US5364773A (en) * | 1991-03-07 | 1994-11-15 | Virogenetics Corporation | Genetically engineered vaccine strain |
US5174993A (en) * | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
US4663281A (en) * | 1984-03-22 | 1987-05-05 | Mass Institute Of Technology | Enhanced production of proteinaceous materials in eucaryotic cells |
FR2563434B1 (fr) * | 1984-04-25 | 1986-07-25 | Transgene Sa | Vaccin contre la rage et procede pour sa preparation |
US4736866A (en) * | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
US4738846A (en) * | 1984-08-30 | 1988-04-19 | The Salk Institute For Biological Studies | Vaccine for vesicular stomatitis virus |
WO1986005806A1 (en) * | 1985-03-29 | 1986-10-09 | National Research Development Corporation | Infectious bronchitis virus spike protein |
FR2583429B1 (fr) * | 1985-06-18 | 1989-11-03 | Transgene Sa | Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u |
AU607399B2 (en) * | 1985-09-09 | 1991-03-07 | Cetus Corporation | Infectious recombinant virus vaccine for feline leukemia |
AU602875B2 (en) * | 1985-12-18 | 1990-11-01 | British Technology Group Limited | Newcastle disease virus gene clones |
US5141742A (en) * | 1986-02-07 | 1992-08-25 | Oncogen | Vaccines against melanoma |
EP0275300B1 (de) * | 1986-08-01 | 1996-01-03 | Commonwealth Scientific And Industrial Research Organisation | Rekombinanter impfstoff |
WO1988002027A1 (en) * | 1986-09-08 | 1988-03-24 | Applied Biotechnology, Inc. | Genetically engineered vaccines for mycobacteria |
WO1988002022A1 (en) * | 1986-09-22 | 1988-03-24 | Commonwealth Scientific And Industrial Research Or | Recombinant poxviruses |
FR2604183B1 (fr) * | 1986-09-23 | 1988-12-30 | Transgene Sa | Sequence d'adn, vecteurs, virus recombinants et procede mettant en oeuvre des virus de la vaccine recombinants capables de se multiplier dans les cellules cho |
EP0261940A3 (de) * | 1986-09-23 | 1989-07-05 | Applied Biotechnology, Inc. | Pseudorabies-Impfstoffe und DNS-Vektoren zur Rekombination mit Poxviren |
AU605567B2 (en) * | 1987-03-11 | 1991-01-17 | Nippon Zeon Co., Ltd. | Recombinant avipoxvirus |
WO1989001973A2 (en) * | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Recombinant pox virus for immunization against tumor-associated antigens |
GB8724885D0 (en) * | 1987-10-23 | 1987-11-25 | Binns M M | Fowlpox virus promotors |
FR2632863B2 (fr) * | 1987-10-29 | 1990-08-31 | Transgene Sa | Virus du fowlpox recombinant et vaccins derives de ces virus |
CA1341245C (en) * | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
ATE115187T1 (de) * | 1988-02-12 | 1994-12-15 | Commw Scient Ind Res Org | Poxvirus-vektoren. |
JPH01218590A (ja) * | 1988-02-29 | 1989-08-31 | Toa Nenryo Kogyo Kk | 組換ワクチニアウイルスを用いたリンダペスト(牛疫)ウイルスワクチン |
JPH03504196A (ja) * | 1988-03-18 | 1991-09-19 | アメリカ合衆国 | 新規組換えワクチニアウイルス発現ベクター及びその選択方法 |
DE3813093A1 (de) * | 1988-04-19 | 1989-11-09 | Immuno Ag | Rekombinantes plasmid, verfahren zum herstellen eines rekombinanten avipoxvirus, rekombinantes avipoxvirus und dessen verwendung |
DE3819008C1 (de) * | 1988-06-03 | 1989-12-21 | Veit Transpo Gmbh, 8910 Landsberg, De | |
JPH03505523A (ja) * | 1988-06-10 | 1991-12-05 | アプライド・バイオテクノロジー・インコーポレーテッド | 組換え痘瘡ウイルスの選択方法 |
GB2220941B (en) * | 1988-06-24 | 1991-09-11 | Nat Res Dev | Fowlpox virus non-essential regions |
ES2035533T3 (es) * | 1988-07-29 | 1993-04-16 | Akzo N.V. | Procedimiento para la preparacion de un catalizador presulfurado; procedimiento para la preparacion de un catalizador sulfurado y uso de dicho catalizador. |
GB2222165B (en) * | 1988-08-20 | 1992-06-17 | Animal Health Inst | Recombinant capripoxvirus |
CH682669A5 (fr) * | 1989-03-08 | 1993-10-29 | Health Research Inc | Virus recombinant modifié pour exprimer un produit de gènes chez un hôte, procédés et vaccin correspondants. |
US5225336A (en) * | 1989-03-08 | 1993-07-06 | Health Research Incorporated | Recombinant poxvirus host range selection system |
US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
GB8907468D0 (en) * | 1989-04-03 | 1989-05-17 | Smith Geoffrey L | Vaccinia vectors,vaccinia genes and expression products thereof |
AU634773B2 (en) * | 1989-05-08 | 1993-03-04 | Basil Arif | Spheroidin dna isolate and recombinant entomopoxvirus expression vectors |
IE71643B1 (en) * | 1990-11-20 | 1997-02-26 | Virogenetics Corp | A recombinant poxviral vaccine for canine distemper |
EP0575491B1 (de) * | 1991-03-07 | 2003-08-13 | Virogenetics Corporation | Gentechnologisch hergestellter stamm für impfstoffe |
WO1992019266A1 (en) * | 1991-05-06 | 1992-11-12 | The United States Of America, As Represented By The Department Of Health And Human Services | Recombinant virus expressing carcinoembryonic antigen and methods of use thereof |
ATE241696T1 (de) * | 1991-06-14 | 2003-06-15 | Virogenetics Corp | Rekombinanter hiv-spezifischer impfstoff aus poxviru |
FR2710536B1 (fr) * | 1993-09-29 | 1995-12-22 | Transgene Sa | Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire. |
-
1994
- 1994-01-19 US US08/184,009 patent/US5833975A/en not_active Expired - Lifetime
- 1994-01-21 JP JP6517281A patent/JPH09503902A/ja active Pending
- 1994-01-21 DE DE69434581T patent/DE69434581T2/de not_active Expired - Lifetime
- 1994-01-21 WO PCT/US1994/000888 patent/WO1994016716A1/en active IP Right Grant
- 1994-01-21 ES ES94908635T patent/ES2255053T3/es not_active Expired - Lifetime
- 1994-01-21 AT AT94908635T patent/ATE313639T1/de active
- 1994-01-21 AU AU61652/94A patent/AU684070B2/en not_active Expired
- 1994-01-21 EP EP94908635A patent/EP0680331B1/de not_active Expired - Lifetime
-
1995
- 1995-06-02 US US08/458,356 patent/US5942235A/en not_active Expired - Lifetime
- 1995-06-02 US US08/460,736 patent/US6265189B1/en not_active Expired - Lifetime
-
2000
- 2000-03-24 US US09/535,370 patent/US6537594B1/en not_active Expired - Fee Related
-
2002
- 2002-10-09 US US10/267,384 patent/US20030198623A1/en not_active Abandoned
Also Published As
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US5833975A (en) | 1998-11-10 |
ES2255053T3 (es) | 2006-06-16 |
DE69434581T2 (de) | 2006-09-28 |
EP0680331A4 (de) | 1997-12-03 |
AU6165294A (en) | 1994-08-15 |
ATE313639T1 (de) | 2006-01-15 |
US6265189B1 (en) | 2001-07-24 |
US20030198623A1 (en) | 2003-10-23 |
JPH09503902A (ja) | 1997-04-22 |
EP0680331A1 (de) | 1995-11-08 |
US6537594B1 (en) | 2003-03-25 |
EP0680331B1 (de) | 2005-12-21 |
AU684070B2 (en) | 1997-12-04 |
US5942235A (en) | 1999-08-24 |
WO1994016716A1 (en) | 1994-08-04 |
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