WO2001095919A3 - A recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses - Google Patents

A recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses Download PDF

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Publication number
WO2001095919A3
WO2001095919A3 PCT/US2001/019201 US0119201W WO0195919A3 WO 2001095919 A3 WO2001095919 A3 WO 2001095919A3 US 0119201 W US0119201 W US 0119201W WO 0195919 A3 WO0195919 A3 WO 0195919A3
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WO
WIPO (PCT)
Prior art keywords
csf
antigen
encoding
replication
enhancing
Prior art date
Application number
PCT/US2001/019201
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French (fr)
Other versions
WO2001095919A2 (en
Inventor
Jeffrey Schlom
John W Greiner
Erik Kass
Dennis Panicali
Original Assignee
Us Gov Health & Human Serv
Therion Biolog Corp
Jeffrey Schlom
John W Greiner
Erik Kass
Dennis Panicali
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Therion Biolog Corp, Jeffrey Schlom, John W Greiner, Erik Kass, Dennis Panicali filed Critical Us Gov Health & Human Serv
Priority to AU6845201A priority Critical patent/AU6845201A/en
Priority to US10/297,168 priority patent/US20040091995A1/en
Priority to AU2001268452A priority patent/AU2001268452B2/en
Priority to CA2412050A priority patent/CA2412050C/en
Priority to EP01946395A priority patent/EP1292694A2/en
Priority to JP2002510097A priority patent/JP2004507231A/en
Publication of WO2001095919A2 publication Critical patent/WO2001095919A2/en
Publication of WO2001095919A3 publication Critical patent/WO2001095919A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A61K39/001139—Colony stimulating factors [CSF]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • C07K2317/00—Immunoglobulins specific features
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
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    • C12N2740/16011—Human Immunodeficiency Virus, HIV
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Replication-defective recombinant poxvirus encoding granulocyte-macrophage colony-stimulating factor (GM-CSF) are disclosed for use in enriching an immunization site with antigen-presenting cells (APC), for enhancing an immunological response to antigen or immunlogical epitopes by functioning as a biological adjuvant, for prevention or treatment of neutropenia, and for the treatment of myeloidysplastic syndromes. Compositions comprising a replication-defective recombinant virus encoding GM-CSF alone or in combination with a recombinant virus encoding an antigen and optionally encoding an immunostimulatory molecule are disclosed for enhancing antigen-specific immunological responses, in particular enhancing tumor antigen responses for anti-tumor therapy. Methods for enriching an immunization site with APC and for enhancing immunological responses to an antigen or immunological epitope using replication-defective recombinant poxvirus encoding GM-CSF are disclosed. The superiority of the use of a replication-defective recombinant avian poxvirus encoding GM-CSF over the use of recombinant GM-CSF is described.
PCT/US2001/019201 2000-06-15 2001-06-15 A recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses WO2001095919A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU6845201A AU6845201A (en) 2000-06-15 2001-06-15 A recombinant non-replicating virus expressing GM-CSF and uses thereof to enhance immune responses
US10/297,168 US20040091995A1 (en) 2001-06-15 2001-06-15 Recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses
AU2001268452A AU2001268452B2 (en) 2000-06-15 2001-06-15 A recombinant non-replicating virus expressing GM-CSF and uses thereof to enhance immune responses
CA2412050A CA2412050C (en) 2000-06-15 2001-06-15 A recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses
EP01946395A EP1292694A2 (en) 2000-06-15 2001-06-15 A recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses
JP2002510097A JP2004507231A (en) 2000-06-15 2001-06-15 Recombinant non-replicating virus expressing GM-CSF and use thereof for enhancing an immune response

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21171700P 2000-06-15 2000-06-15
US60/211,717 2000-06-15

Publications (2)

Publication Number Publication Date
WO2001095919A2 WO2001095919A2 (en) 2001-12-20
WO2001095919A3 true WO2001095919A3 (en) 2002-11-28

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PCT/US2001/019201 WO2001095919A2 (en) 2000-06-15 2001-06-15 A recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses

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EP (1) EP1292694A2 (en)
JP (1) JP2004507231A (en)
AU (2) AU6845201A (en)
CA (1) CA2412050C (en)
WO (1) WO2001095919A2 (en)

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CA2412050C (en) 2011-03-22
CA2412050A1 (en) 2001-12-20
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