WO1998015635A3 - Treatment of cancer using a recombinant poxvirus containing a nucleic acid sequence encoding a cytokine - Google Patents

Treatment of cancer using a recombinant poxvirus containing a nucleic acid sequence encoding a cytokine Download PDF

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Publication number
WO1998015635A3
WO1998015635A3 PCT/CA1997/000729 CA9700729W WO9815635A3 WO 1998015635 A3 WO1998015635 A3 WO 1998015635A3 CA 9700729 W CA9700729 W CA 9700729W WO 9815635 A3 WO9815635 A3 WO 9815635A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
cytokine
nucleic acid
virus
cancer
Prior art date
Application number
PCT/CA1997/000729
Other languages
French (fr)
Other versions
WO1998015635A2 (en
Inventor
Diane M Gajewczyk
James Tartaglia
B Cox
J Alexander
M C Bonnet
I Diaz
B Cornet
E Paoletti
Michel H Klein
Original Assignee
Connaught Lab
Virogenetics Corp
Diane M Gajewczyk
James Tartaglia
B Cox
J Alexander
M C Bonnet
I Diaz
B Cornet
E Paoletti
Michel H Klein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Connaught Lab, Virogenetics Corp, Diane M Gajewczyk, James Tartaglia, B Cox, J Alexander, M C Bonnet, I Diaz, B Cornet, E Paoletti, Michel H Klein filed Critical Connaught Lab
Priority to AU44485/97A priority Critical patent/AU4448597A/en
Publication of WO1998015635A2 publication Critical patent/WO1998015635A2/en
Publication of WO1998015635A3 publication Critical patent/WO1998015635A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Abstract

Recombinant pox virus, specifically an avipox virus, preferably a canarypox virus, having therein a nucleic acid molecule encoding a biological response modifier, specifically a cytokine or chemokine, or immunomodulating fragment thereof, in a non-essential region of the recombinant virus genome transfect cells to express the biological immune response modifier. The transfected cells are used to treat cancer by intratumor administration of by in vivo treatment of tumor cells and reintroduction of the treated tumor cells. The cells also are used, in a non-replicating form, to protect a host against tumor formation.
PCT/CA1997/000729 1996-10-04 1997-10-03 Treatment of cancer using a recombinant poxvirus containing a nucleic acid sequence encoding a cytokine WO1998015635A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU44485/97A AU4448597A (en) 1996-10-04 1997-10-03 Treatment of cancer using a recombinant poxvirus containing nucleic acid sequence encoding a cytokine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2753096P 1996-10-04 1996-10-04
US60/027,530 1996-10-04

Publications (2)

Publication Number Publication Date
WO1998015635A2 WO1998015635A2 (en) 1998-04-16
WO1998015635A3 true WO1998015635A3 (en) 1998-07-09

Family

ID=21838268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1997/000729 WO1998015635A2 (en) 1996-10-04 1997-10-03 Treatment of cancer using a recombinant poxvirus containing a nucleic acid sequence encoding a cytokine

Country Status (2)

Country Link
AU (1) AU4448597A (en)
WO (1) WO1998015635A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69926742T2 (en) 1998-04-14 2006-06-14 Sugen Inc STE20-RELATED PROTEIN KINASES
CA2412050C (en) * 2000-06-15 2011-03-22 Jeffrey Schlom A recombinant non-replicating virus expressing gm-csf and uses thereof to enhance immune responses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994016716A1 (en) * 1993-01-21 1994-08-04 Virogenetics Corporation Recombinant virus immunotherapy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994016716A1 (en) * 1993-01-21 1994-08-04 Virogenetics Corporation Recombinant virus immunotherapy

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
90TH ANNUAL MEETING OF THE AMERICAN UROLOGICAL ASSOCIATION, 23 April 1995 (1995-04-23) - 28 April 1995 (1995-04-28), LAS VEGAS, USA, XP002062562 *
91ST AANUAL MEETING OF THE AMERICAN UROLOGY ASSOCIATION, no. 5, 4 May 1996 (1996-05-04) - 9 May 1996 (1996-05-09), ORLANDO, FLORIDA, USA, XP002062560 *
91ST ANNUAL MEETING OF THE AMERICAN UROLOGY ASSOCIATION, 4 May 1996 (1996-05-04) - 9 May 1996 (1996-05-09), ORLANDO , FLORIDA,USA, XP002062561 *
BRAMSON J: "IMMUNOTHERAPY OF MURINE BREAST CANCER USING AN ADENOVIRUS VECTOR EXPRESSING INTERLEUKIN-12", PROCEEDINGS OF THE 87TH. ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, WASHINGTON, APR. 20 - 24, 1996, no. MEETING 87, 1 March 1996 (1996-03-01), AMERICAN ASSOCIATION FOR CANCER RESEARCH, pages 341, XP000574942 *
G.S. RAO ET AL: "Canary pox (ALVAC) virus mediated cytokine gene therapy induces tumor specific immunity against mouse bladder tumor", JOURNAL OF UROLOGY, vol. 155, no. 5suppl., May 1996 (1996-05-01), pages 570A *
I. PUISIEUX ET AL: "Curative and protective effects against murine tumors by iL-12 gene therapy using a canary pox virus vector", CANCER GENE THERAPY, vol. 4, no. 6 conf. suppl., November 1997 (1997-11-01), pages S53 *
M. KAWAKITA ET AL: "Canary pox (ALVAC) virus-mediated cytokinegene therapy induces tumor specific and non-specific immunity against mouse prostate tumor", JOURNAL OF UROLOGY, vol. 155, no. 5 suppl., May 1996 (1996-05-01), pages 516A *
M. KAWAKITA ET AL: "Effect of canary-pox (ALVAC) virus-mediated cytokine gene expression on prostate tumor growth", JOURNAL OF UROLOGY, vol. 153, no. 4, April 1995 (1995-04-01), pages 469A *
M. KAWAKITA ET AL: "Effect of canarypox virus (ALVAC)-mediated cytokine expression on murine prostate tumor growth", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 89, no. 6, 19 March 1997 (1997-03-19), pages 428 - 436, XP002062563 *
PAOLETTI E ET AL: "IMMUNOTHERAPEUTIC STRATEGIES FOR CANCER USING POXVIRUS VECTORS", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 690, 12 August 1993 (1993-08-12), pages 292 - 300, XP002042659 *
SEDLACEK H H: "VACCINATION FOR TREATMENT OF TUMORS: A CRITICAL COMMENT", CRITICAL REVIEWS IN ONCOGENESIS, vol. 5, no. 6, 1994, pages 555 - 587, XP000198151 *
SIXTH INTERNATIONAL CONFERENCE ON GENE THERAPY OF CANCER, 2 November 1997 (1997-11-02) - 22 November 1997 (1997-11-22), SAN DIEGO,CALIFORNIA,USA, XP002062564 *

Also Published As

Publication number Publication date
WO1998015635A2 (en) 1998-04-16
AU4448597A (en) 1998-05-05

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