DE2759885C2 - Alkoxyiminoderivate von 7-Aminothiazolylacetamidocephalosporansäuren, ihre Herstellung und pharmazeutische Zusammensetzungen - Google Patents

Alkoxyiminoderivate von 7-Aminothiazolylacetamidocephalosporansäuren, ihre Herstellung und pharmazeutische Zusammensetzungen

Info

Publication number
DE2759885C2
DE2759885C2 DE2759885A DE2759885A DE2759885C2 DE 2759885 C2 DE2759885 C2 DE 2759885C2 DE 2759885 A DE2759885 A DE 2759885A DE 2759885 A DE2759885 A DE 2759885A DE 2759885 C2 DE2759885 C2 DE 2759885C2
Authority
DE
Germany
Prior art keywords
formula
acid
compound
hydrogenolysis
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2759885A
Other languages
German (de)
English (en)
Inventor
René Romainville Heymes
André Dr.med. Strassburg/Strasbourg Lutz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE2759885C2 publication Critical patent/DE2759885C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2759885A 1976-03-25 1977-03-25 Alkoxyiminoderivate von 7-Aminothiazolylacetamidocephalosporansäuren, ihre Herstellung und pharmazeutische Zusammensetzungen Expired DE2759885C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7608690A FR2345153A1 (fr) 1976-03-25 1976-03-25 Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
DE2759885C2 true DE2759885C2 (de) 1985-06-27

Family

ID=9170952

Family Applications (3)

Application Number Title Priority Date Filing Date
DE2759885A Expired DE2759885C2 (de) 1976-03-25 1977-03-25 Alkoxyiminoderivate von 7-Aminothiazolylacetamidocephalosporansäuren, ihre Herstellung und pharmazeutische Zusammensetzungen
DE2760156A Expired DE2760156C2 (US20080094685A1-20080424-C00004.png) 1976-03-25 1977-03-25
DE2713272A Expired DE2713272C2 (de) 1976-03-25 1977-03-25 Derivate der 7-Aminothiazolyl-acetamido-cephalosporansäure, ihre Herstellung und pharmazeutische Zusammensetzungen

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE2760156A Expired DE2760156C2 (US20080094685A1-20080424-C00004.png) 1976-03-25 1977-03-25
DE2713272A Expired DE2713272C2 (de) 1976-03-25 1977-03-25 Derivate der 7-Aminothiazolyl-acetamido-cephalosporansäure, ihre Herstellung und pharmazeutische Zusammensetzungen

Country Status (33)

Country Link
US (2) US4476122A (US20080094685A1-20080424-C00004.png)
JP (5) JPS52116492A (US20080094685A1-20080424-C00004.png)
AR (2) AR219916A1 (US20080094685A1-20080424-C00004.png)
AT (1) AT350182B (US20080094685A1-20080424-C00004.png)
AU (1) AU509857B2 (US20080094685A1-20080424-C00004.png)
BE (1) BE852860A (US20080094685A1-20080424-C00004.png)
CA (1) CA1334407C (US20080094685A1-20080424-C00004.png)
CH (2) CH622800A5 (US20080094685A1-20080424-C00004.png)
CS (1) CS209878B2 (US20080094685A1-20080424-C00004.png)
DD (2) DD130788A5 (US20080094685A1-20080424-C00004.png)
DE (3) DE2759885C2 (US20080094685A1-20080424-C00004.png)
DK (1) DK161253C (US20080094685A1-20080424-C00004.png)
ES (2) ES457115A1 (US20080094685A1-20080424-C00004.png)
FR (1) FR2345153A1 (US20080094685A1-20080424-C00004.png)
GB (1) GB1581184A (US20080094685A1-20080424-C00004.png)
GR (1) GR63125B (US20080094685A1-20080424-C00004.png)
HK (1) HK21582A (US20080094685A1-20080424-C00004.png)
HR (1) HRP931392B1 (US20080094685A1-20080424-C00004.png)
HU (1) HU173005B (US20080094685A1-20080424-C00004.png)
IE (1) IE45130B1 (US20080094685A1-20080424-C00004.png)
IL (1) IL51670A (US20080094685A1-20080424-C00004.png)
IT (1) IT1077500B (US20080094685A1-20080424-C00004.png)
LU (1) LU77014A1 (US20080094685A1-20080424-C00004.png)
MX (1) MX5129E (US20080094685A1-20080424-C00004.png)
NL (2) NL7703219A (US20080094685A1-20080424-C00004.png)
NZ (1) NZ183692A (US20080094685A1-20080424-C00004.png)
OA (1) OA05606A (US20080094685A1-20080424-C00004.png)
PL (2) PL118475B1 (US20080094685A1-20080424-C00004.png)
PT (1) PT66353B (US20080094685A1-20080424-C00004.png)
SE (1) SE439485B (US20080094685A1-20080424-C00004.png)
SU (2) SU791246A3 (US20080094685A1-20080424-C00004.png)
YU (2) YU41573B (US20080094685A1-20080424-C00004.png)
ZA (1) ZA771664B (US20080094685A1-20080424-C00004.png)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2852538A1 (de) * 1977-12-05 1979-06-07 Roussel Uclaf Neue oximderivate der 3-substituierten 7-amino-thiazolyl-acetamido-cephalosporansaeure, verfahren zu deren herstellung und die sie enthaltenden pharmazeutischen zusammensetzungen
DE2759885C2 (de) 1976-03-25 1985-06-27 Roussel-Uclaf, Paris Alkoxyiminoderivate von 7-Aminothiazolylacetamidocephalosporansäuren, ihre Herstellung und pharmazeutische Zusammensetzungen

Families Citing this family (36)

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GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
FR2367756B1 (fr) * 1976-04-12 1985-07-05 Fujisawa Pharmaceutical Co Derives 2-alcoxyamino-2-(amino-1,3-thiazolyl) acetiques et leur utilisation
DK162391C (da) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
JPS53101393A (en) 1977-02-17 1978-09-04 Takeda Chem Ind Ltd Cephalosporin derivatives and process for their preparation
JPS6011714B2 (ja) 1977-02-17 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
JPS53103493A (en) 1977-02-18 1978-09-08 Takeda Chem Ind Ltd Cephalosporin derivatives and process for their preparation
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
FR2421907A1 (fr) * 1978-04-07 1979-11-02 Roussel Uclaf Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE2945248A1 (de) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co Cephem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende antibakterielle pharmazeutische mittel
JPS5579393A (en) * 1978-12-11 1980-06-14 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
JPS55133385A (en) * 1979-04-03 1980-10-17 Fujisawa Pharmaceut Co Ltd Novel cephem compound, its preparation, and remedy and preventive against microbism
US4331666A (en) * 1979-05-11 1982-05-25 Farmitalia Carlo Erba S.P.A. 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid
IL61458A0 (en) * 1979-12-07 1980-12-31 Erba Farmitalia N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
FR2479229B1 (fr) * 1980-03-26 1986-01-17 Clin Midy Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives
DE3177090D1 (en) * 1980-12-31 1989-09-28 Fujisawa Pharmaceutical Co 7-acylaminocephalosporanic acid derivatives and processes for the preparation thereof
JPS57163386A (en) * 1981-08-13 1982-10-07 Takeda Chem Ind Ltd Cephalosporin derivative and its production
US4576938A (en) * 1981-12-08 1986-03-18 Tanabe Seiyaku Co., Ltd. Cephalosporin compound and process for preparing the same
JPS60215690A (ja) * 1984-04-09 1985-10-29 Meiji Seika Kaisha Ltd セフアロスポリン化合物及びそれを有効成分とする抗菌剤
JPS60178891A (ja) * 1984-02-24 1985-09-12 Kureha Chem Ind Co Ltd セファロスポリン誘導体及び該誘導体を含有する医薬
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4874856A (en) * 1985-06-24 1989-10-17 Bristol-Myers Company 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
GB8819104D0 (en) * 1988-08-11 1988-09-14 Beecham Group Plc Novel compounds
JPH01265093A (ja) * 1988-10-12 1989-10-23 Sankyo Co Ltd 経口用セフアロスポリン化合物
US5261314A (en) * 1988-12-05 1993-11-16 Hirotaka Manufacturing Co., Ltd. Directional control valve for pneumatic cylinder
KR940000112B1 (ko) * 1990-07-05 1994-01-05 주식회사 대웅제약 신규의 3-치환 세펨화합물 및 그의 제조방법
WO2013109205A1 (en) 2012-01-18 2013-07-25 Mahmut Bilgic Pharmaceutical tablet formulations comprising cefetamet
CN108586491B (zh) * 2017-12-26 2021-03-02 山东裕欣药业有限公司 一种盐酸头孢他美酯的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2439880A1 (de) * 1973-08-21 1975-04-03 Glaxo Lab Ltd Antibiotika und verfahren zu ihrer herstellung
DE2461478A1 (de) * 1973-12-25 1976-02-26 Takeda Chemical Industries Ltd Neue 7-(thiazolin-4-yl-acetamido)- cephalosporinderivate, verfahren zur herstellung derselben und diese enthaltende pharmazeutische mittel
DE2713272A1 (de) 1976-03-25 1977-10-06 Roussel Uclaf Derivate der 7-aminothiazolyl-acetamido-cephalosporansaeure, ihr herstellungsverfahren sowie pharmazeutische zusammensetzungen
DE2556736C2 (de) * 1974-12-19 1982-02-11 Takeda Chemical Industries, Ltd., Osaka Cephemverbindungen und sie enthaltende Arzneimittel

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US4024137A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
US4298606A (en) * 1974-12-19 1981-11-03 Takeda Chemical Industries, Ltd. Thiazolylacetamido compounds
DE2760123C2 (de) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2439880A1 (de) * 1973-08-21 1975-04-03 Glaxo Lab Ltd Antibiotika und verfahren zu ihrer herstellung
DE2461478A1 (de) * 1973-12-25 1976-02-26 Takeda Chemical Industries Ltd Neue 7-(thiazolin-4-yl-acetamido)- cephalosporinderivate, verfahren zur herstellung derselben und diese enthaltende pharmazeutische mittel
DE2556736C2 (de) * 1974-12-19 1982-02-11 Takeda Chemical Industries, Ltd., Osaka Cephemverbindungen und sie enthaltende Arzneimittel
DE2713272A1 (de) 1976-03-25 1977-10-06 Roussel Uclaf Derivate der 7-aminothiazolyl-acetamido-cephalosporansaeure, ihr herstellungsverfahren sowie pharmazeutische zusammensetzungen
DE2759885C2 (de) 1976-03-25 1985-06-27 Roussel-Uclaf, Paris Alkoxyiminoderivate von 7-Aminothiazolylacetamidocephalosporansäuren, ihre Herstellung und pharmazeutische Zusammensetzungen

Non-Patent Citations (1)

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Title
Fortschritte der Antimikrobiellen und Antineoplastischen Chemotherapie, Bd. 1, München 1982, Futuramed Verlag, S. 17-22

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2759885C2 (de) 1976-03-25 1985-06-27 Roussel-Uclaf, Paris Alkoxyiminoderivate von 7-Aminothiazolylacetamidocephalosporansäuren, ihre Herstellung und pharmazeutische Zusammensetzungen
DE2760156C2 (US20080094685A1-20080424-C00004.png) * 1976-03-25 1987-08-27 Roussel-Uclaf, Paris, Fr
DE2852538A1 (de) * 1977-12-05 1979-06-07 Roussel Uclaf Neue oximderivate der 3-substituierten 7-amino-thiazolyl-acetamido-cephalosporansaeure, verfahren zu deren herstellung und die sie enthaltenden pharmazeutischen zusammensetzungen

Also Published As

Publication number Publication date
LU77014A1 (US20080094685A1-20080424-C00004.png) 1977-10-03
ES469116A1 (es) 1978-11-16
YU41573B (en) 1987-10-31
NL8004943A (nl) 1980-11-28
OA05606A (fr) 1981-04-30
IL51670A (en) 1981-07-31
US4476122A (en) 1984-10-09
FR2345153A1 (fr) 1977-10-21
BE852860A (fr) 1977-09-26
YU43087B (en) 1989-02-28
PT66353B (fr) 1979-01-18
DE2760156C2 (US20080094685A1-20080424-C00004.png) 1987-08-27
AT350182B (de) 1979-05-10
AU509857B2 (en) 1980-05-29
JPH0257072B2 (US20080094685A1-20080424-C00004.png) 1990-12-03
US4396618A (en) 1983-08-02
NL7703219A (nl) 1977-09-27
IT1077500B (it) 1985-05-04
IE45130B1 (en) 1982-06-30
ES457115A1 (es) 1978-08-16
PL124945B1 (en) 1983-03-31
GB1581184A (en) 1980-12-10
GR63125B (en) 1979-09-17
SE7702909L (sv) 1977-09-26
ATA211177A (de) 1978-10-15
JPS58192890A (ja) 1983-11-10
JPS52116492A (en) 1977-09-29
JPS62174084A (ja) 1987-07-30
IE45130L (en) 1977-09-25
JPS638116B2 (US20080094685A1-20080424-C00004.png) 1988-02-19
FR2345153B1 (US20080094685A1-20080424-C00004.png) 1979-10-05
DD134526A5 (de) 1979-03-07
PT66353A (fr) 1977-04-01
CH622800A5 (US20080094685A1-20080424-C00004.png) 1981-04-30
PL196886A1 (pl) 1979-07-16
IL51670A0 (en) 1977-05-31
AU2360877A (en) 1978-09-28
HRP931392B1 (en) 1996-04-30
DE2713272C2 (de) 1983-01-20
DK161253B (da) 1991-06-17
SU791246A3 (ru) 1980-12-23
NZ183692A (en) 1979-10-25
CH623590A5 (US20080094685A1-20080424-C00004.png) 1981-06-15
AR220333A1 (es) 1980-10-31
JPS6229436B2 (US20080094685A1-20080424-C00004.png) 1987-06-25
JPH0322849B2 (US20080094685A1-20080424-C00004.png) 1991-03-27
SU795482A3 (ru) 1981-01-07
DK129477A (da) 1977-09-26
YU189382A (en) 1983-01-21
JPS568392A (en) 1981-01-28
ZA771664B (en) 1978-04-26
SE439485B (sv) 1985-06-17
CA1334407C (fr) 1995-02-14
MX5129E (es) 1983-03-25
CS209878B2 (en) 1981-12-31
DD130788A5 (de) 1978-05-03
AR219916A1 (es) 1980-09-30
DE2713272A1 (de) 1977-10-06
HK21582A (en) 1982-05-28
JPS62174018A (ja) 1987-07-30
PL118475B1 (en) 1981-10-31
HU173005B (hu) 1979-01-28
YU72577A (en) 1983-10-31
DK161253C (da) 1991-12-09

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