DE19943635A1 - Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften - Google Patents

Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften

Info

Publication number
DE19943635A1
DE19943635A1 DE19943635A DE19943635A DE19943635A1 DE 19943635 A1 DE19943635 A1 DE 19943635A1 DE 19943635 A DE19943635 A DE 19943635A DE 19943635 A DE19943635 A DE 19943635A DE 19943635 A1 DE19943635 A1 DE 19943635A1
Authority
DE
Germany
Prior art keywords
carbon atoms
chain
straight
branched
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19943635A
Other languages
German (de)
English (en)
Inventor
Cristina Alonso-Alija
Markus Heil
Dietmar Flubacher
Paul Naab
Josef Pernerstorfer
Johannes-Peter Stasch
Frank Wunder
Klaus Dembowsky
Elisabeth Perzborn
Elke Stahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE19943635A priority Critical patent/DE19943635A1/de
Priority to UA2002042945A priority patent/UA74346C2/uk
Priority to HK03104655.5A priority patent/HK1053638B/zh
Priority to HU0203418A priority patent/HUP0203418A3/hu
Priority to HR20020307A priority patent/HRP20020307B1/xx
Priority to BR0014179-8A priority patent/BR0014179A/pt
Priority to SI200030739T priority patent/SI1216225T1/sl
Priority to CZ20020918A priority patent/CZ302250B6/cs
Priority to TR2002/00649T priority patent/TR200200649T2/xx
Priority to EP00958516A priority patent/EP1216225B1/de
Priority to PL353790A priority patent/PL206256B1/pl
Priority to AT00958516T priority patent/ATE299134T1/de
Priority to SK338-2002A priority patent/SK287368B6/sk
Priority to US10/088,060 priority patent/US7087644B1/en
Priority to KR1020027003240A priority patent/KR100715380B1/ko
Priority to MXPA02002651A priority patent/MXPA02002651A/es
Priority to CA2387107A priority patent/CA2387107C/en
Priority to PT00958516T priority patent/PT1216225E/pt
Priority to DK00958516T priority patent/DK1216225T3/da
Priority to DE50010677T priority patent/DE50010677D1/de
Priority to IL14813400A priority patent/IL148134A0/xx
Priority to ES00958516T priority patent/ES2244466T3/es
Priority to NZ517709A priority patent/NZ517709A/en
Priority to EEP200200130A priority patent/EE05194B1/xx
Priority to AU70009/00A priority patent/AU767750B2/en
Priority to RU2002109814/15A priority patent/RU2280025C9/ru
Priority to CNB008155674A priority patent/CN100390135C/zh
Priority to JP2001523361A priority patent/JP4456312B2/ja
Priority to PCT/EP2000/008469 priority patent/WO2001019780A2/de
Priority to MYPI20004215A priority patent/MY128659A/en
Priority to TW089118552A priority patent/TWI225045B/zh
Priority to UY26332A priority patent/UY26332A1/es
Priority to CO00068921A priority patent/CO5221052A1/es
Priority to SV2000000169A priority patent/SV2002000169A/es
Priority to PE2000000945A priority patent/PE20010637A1/es
Priority to ARP000104806A priority patent/AR033346A1/es
Publication of DE19943635A1 publication Critical patent/DE19943635A1/de
Priority to CU32A priority patent/CU23105A3/es
Priority to IL148134A priority patent/IL148134A/en
Priority to ZA200201299A priority patent/ZA200201299B/en
Priority to BG106494A priority patent/BG65834B1/bg
Priority to MA26542A priority patent/MA25875A1/fr
Priority to NO20021226A priority patent/NO327998B1/no
Priority to US11/200,455 priority patent/US7517896B2/en
Priority to US12/422,763 priority patent/US7781470B2/en
Priority to JP2009274756A priority patent/JP2010077153A/ja
Priority to US12/860,933 priority patent/US20100317854A1/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE19943635A 1999-09-13 1999-09-13 Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften Withdrawn DE19943635A1 (de)

Priority Applications (46)

Application Number Priority Date Filing Date Title
DE19943635A DE19943635A1 (de) 1999-09-13 1999-09-13 Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
AU70009/00A AU767750B2 (en) 1999-09-13 2000-08-31 Novel derivatives of dicarboxylic acid having pharmaceutical properties
EEP200200130A EE05194B1 (et) 1999-09-13 2000-08-31 Farmatseutiliste omadustega aminodikarbokslhappe derivaadid
HU0203418A HUP0203418A3 (en) 1999-09-13 2000-08-31 Novel derivatives of dicarboxylic acid having pharmaceutical properties
HR20020307A HRP20020307B1 (hr) 1999-09-13 2000-08-31 Novi derivati aminodikarboksilnih kiselina koji imaju farmaceutska svojstva
BR0014179-8A BR0014179A (pt) 1999-09-13 2000-08-31 Modernos derivados de ácido aminodicarboxìlico com propriedades farmacêuticas
SI200030739T SI1216225T1 (sl) 1999-09-13 2000-08-31 Novi derivati aminodikarboksilne kisline s farmacevtskimi lastnostmi
CZ20020918A CZ302250B6 (cs) 1999-09-13 2000-08-31 Deriváty aminoalkankarboxylové kyseliny s farmaceutickými vlastnostmi, zpusob jejich výroby, léciva tyto látky obsahující a jejich použití
TR2002/00649T TR200200649T2 (tr) 1999-09-13 2000-08-31 Farmasötik özelliklere sahip olan yeni aminodikarboksilik asit türevleri
EP00958516A EP1216225B1 (de) 1999-09-13 2000-08-31 Neuartige aminodicarbonsäurederivate mit pharmazeutischen eigenschaften
PL353790A PL206256B1 (pl) 1999-09-13 2000-08-31 Pochodne kwasów aminodikarboksylowych, sposób ich wytwarzania, ich zastosowanie i leki je zawierające oraz związki pośrednie
AT00958516T ATE299134T1 (de) 1999-09-13 2000-08-31 Neuartige aminodicarbonsäurederivate mit pharmazeutischen eigenschaften
SK338-2002A SK287368B6 (sk) 1999-09-13 2000-08-31 Deriváty aminodikarboxylovej kyseliny s farmaceutickými vlastnosťami, spôsob ich výroby, liečivá tieto zlúčeniny obsahujúce a ich použitie
HK03104655.5A HK1053638B (zh) 1999-09-13 2000-08-31 具有药理活性的二羧酸衍生物
KR1020027003240A KR100715380B1 (ko) 1999-09-13 2000-08-31 약학적 특성을 갖는 신규한 디카르복실산 유도체
MXPA02002651A MXPA02002651A (es) 1999-09-13 2000-08-31 Nuevos derivados de acido aminodicarboxilico con propiedades farmaceuticas.
CA2387107A CA2387107C (en) 1999-09-13 2000-08-31 Derivatives of dicarboxylic acid having pharmaceutical properties
PT00958516T PT1216225E (pt) 1999-09-13 2000-08-31 Novos derivados de acido aminodicarboxilico com propriedade farmaceuticas
DK00958516T DK1216225T3 (da) 1999-09-13 2000-08-31 Nye aminodicarboxylsyrederivater med farmaceutiske egenskaber
DE50010677T DE50010677D1 (de) 1999-09-13 2000-08-31 Neuartige aminodicarbonsäurederivate mit pharmazeutischen eigenschaften
IL14813400A IL148134A0 (en) 1999-09-13 2000-08-31 Novel derivatives of dicarboxylic acid having pharmaceutical properties
ES00958516T ES2244466T3 (es) 1999-09-13 2000-08-31 Derivados de acido aminodicarboxilico nuevos con propiedades farmaceuticas.
NZ517709A NZ517709A (en) 1999-09-13 2000-08-31 Novel derivatives of dicarboxylic acid having pharmaceutical properties
UA2002042945A UA74346C2 (uk) 1999-09-13 2000-08-31 Похідні амінодикарбонових кислот, їх застосування та лікарський засіб
US10/088,060 US7087644B1 (en) 1999-09-13 2000-08-31 Derivatives of dicarboxylic acid having pharmaceutical properties
RU2002109814/15A RU2280025C9 (ru) 1999-09-13 2000-08-31 Новые производные аминодикарбоновых кислот, обладающие фармацевтическими свойствами
CNB008155674A CN100390135C (zh) 1999-09-13 2000-08-31 具有药理活性的二羧酸衍生物
JP2001523361A JP4456312B2 (ja) 1999-09-13 2000-08-31 製薬学的性質を有する新規なアミノジカルボン酸誘導体
PCT/EP2000/008469 WO2001019780A2 (de) 1999-09-13 2000-08-31 Neuartige aminodicarbonsäurederivate mit pharmazeutischen eigenschaften
MYPI20004215A MY128659A (en) 1999-09-13 2000-09-11 Novel aminodicarboxylic acid derivatives having pharmaceutical properties
TW089118552A TWI225045B (en) 1999-09-13 2000-09-11 Novel aminodicarboxylic acid derivatives having pharmaceutical properties
UY26332A UY26332A1 (es) 1999-09-13 2000-09-11 Nuevos derivados del ácido aminodicarboxílico con propiedades farmacéuticas.
SV2000000169A SV2002000169A (es) 1999-09-13 2000-09-12 Nuevos derivados del acido aminodicarboxilico con propiedades farmaceuticas ref. lea 33878-sv
CO00068921A CO5221052A1 (es) 1999-09-13 2000-09-12 Nuevos derivados del acido aminocarboxilo farmaceuticas
PE2000000945A PE20010637A1 (es) 1999-09-13 2000-09-13 Derivados del acido aminodicarboxilico como estimulantes de la guanilato ciclasa
ARP000104806A AR033346A1 (es) 1999-09-13 2000-09-13 Acido aminoalcano carboxilicos, un procedimiento para su preparacion, intermediarios, y el uso de los mismos para la manufactura de un medicamento
IL148134A IL148134A (en) 1999-09-13 2002-02-13 History of dicarboxylic acid with pharmacological properties
CU32A CU23105A3 (es) 1999-09-13 2002-02-13 DERIVADOS NOVEDOSOS DEL áCIDO AMINODICARBOXILICO CON PROPIEDADES FARMACéUTICAS
ZA200201299A ZA200201299B (en) 1999-09-13 2002-02-15 Novel derivatives or dicarboxylic acid having pharmaceutical properties.
BG106494A BG65834B1 (bg) 1999-09-13 2002-03-07 Производни на аминокарбоксилни киселини с фармацевтични свойства
MA26542A MA25875A1 (fr) 1999-09-13 2002-03-11 Nouveaux derives de l'acide aminodicarboxylique presentant des proprietes pharmaceutiques.
NO20021226A NO327998B1 (no) 1999-09-13 2002-03-12 Nye derivater av dikarboksylsyre, fremgangsmate for fremstilling derav, mellomprodukter, medikament inneholdende minst en slik forbindelse samt anvendelser av forbindelsene
US11/200,455 US7517896B2 (en) 1999-09-13 2005-08-08 Aminodicarboxylic acid derivatives having pharmaceutical properties
US12/422,763 US7781470B2 (en) 1999-09-13 2009-04-13 Aminodicarboxylic acid derivatives having pharmaceutical properties
JP2009274756A JP2010077153A (ja) 1999-09-13 2009-12-02 製薬学的性質を有する新規なアミノジカルボン酸誘導体
US12/860,933 US20100317854A1 (en) 1999-09-13 2010-08-23 Novel aminodicarboxylic acid derivatives having pharmaceutical properties

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