DE19819846B4 - Multivalente Antikörper-Konstrukte - Google Patents

Multivalente Antikörper-Konstrukte Download PDF

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Publication number
DE19819846B4
DE19819846B4 DE19819846.9A DE19819846A DE19819846B4 DE 19819846 B4 DE19819846 B4 DE 19819846B4 DE 19819846 A DE19819846 A DE 19819846A DE 19819846 B4 DE19819846 B4 DE 19819846B4
Authority
DE
Germany
Prior art keywords
antibody
peptide linker
antibody construct
variable domains
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE19819846.9A
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German (de)
English (en)
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DE19819846A1 (de
Inventor
Melvyn Little
Sergej Kipriyanov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Krebsforschungszentrum DKFZ
Original Assignee
Deutsches Krebsforschungszentrum DKFZ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7866613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19819846(B4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Deutsches Krebsforschungszentrum DKFZ filed Critical Deutsches Krebsforschungszentrum DKFZ
Priority to DE19819846.9A priority Critical patent/DE19819846B4/de
Priority to AT99932626T priority patent/ATE377027T1/de
Priority to US09/674,794 priority patent/US7129330B1/en
Priority to DE59914538T priority patent/DE59914538D1/de
Priority to CA2331641A priority patent/CA2331641C/en
Priority to JP2000547118A priority patent/JP4431277B2/ja
Priority to EP99932626A priority patent/EP1078004B1/de
Priority to PCT/DE1999/001350 priority patent/WO1999057150A2/de
Priority to ES99932626T priority patent/ES2296395T3/es
Priority to DK99932626T priority patent/DK1078004T3/da
Priority to AU48960/99A priority patent/AU4896099A/en
Publication of DE19819846A1 publication Critical patent/DE19819846A1/de
Priority to US11/546,262 priority patent/US7507796B2/en
Priority to US12/367,219 priority patent/US8148496B2/en
Publication of DE19819846B4 publication Critical patent/DE19819846B4/de
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE19819846.9A 1998-05-05 1998-05-05 Multivalente Antikörper-Konstrukte Expired - Lifetime DE19819846B4 (de)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DE19819846.9A DE19819846B4 (de) 1998-05-05 1998-05-05 Multivalente Antikörper-Konstrukte
ES99932626T ES2296395T3 (es) 1998-05-05 1999-05-05 Construcciones de anticuerpos tetravalentes.
AU48960/99A AU4896099A (en) 1998-05-05 1999-05-05 Multivalent antibody constructs
DE59914538T DE59914538D1 (de) 1998-05-05 1999-05-05 Tetravalente Antikörperkonstrukte
CA2331641A CA2331641C (en) 1998-05-05 1999-05-05 Multivalent antibody constructs
JP2000547118A JP4431277B2 (ja) 1998-05-05 1999-05-05 多価抗体構築物
EP99932626A EP1078004B1 (de) 1998-05-05 1999-05-05 Tetravalente Antikörperkonstrukte
PCT/DE1999/001350 WO1999057150A2 (de) 1998-05-05 1999-05-05 Multivalente antikörper-konstrukte
AT99932626T ATE377027T1 (de) 1998-05-05 1999-05-05 Tetravalente antikörperkonstrukte
DK99932626T DK1078004T3 (da) 1998-05-05 1999-05-05 Tetravalente antistof-konstrukter
US09/674,794 US7129330B1 (en) 1998-05-05 1999-05-05 Multivalent antibody constructs
US11/546,262 US7507796B2 (en) 1998-05-05 2006-10-10 Multivalent antibody constructs
US12/367,219 US8148496B2 (en) 1998-05-05 2009-02-06 Multivalent antibody constructs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19819846.9A DE19819846B4 (de) 1998-05-05 1998-05-05 Multivalente Antikörper-Konstrukte

Publications (2)

Publication Number Publication Date
DE19819846A1 DE19819846A1 (de) 1999-11-11
DE19819846B4 true DE19819846B4 (de) 2016-11-24

Family

ID=7866613

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19819846.9A Expired - Lifetime DE19819846B4 (de) 1998-05-05 1998-05-05 Multivalente Antikörper-Konstrukte
DE59914538T Expired - Lifetime DE59914538D1 (de) 1998-05-05 1999-05-05 Tetravalente Antikörperkonstrukte

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59914538T Expired - Lifetime DE59914538D1 (de) 1998-05-05 1999-05-05 Tetravalente Antikörperkonstrukte

Country Status (10)

Country Link
US (3) US7129330B1 (https=)
EP (1) EP1078004B1 (https=)
JP (1) JP4431277B2 (https=)
AT (1) ATE377027T1 (https=)
AU (1) AU4896099A (https=)
CA (1) CA2331641C (https=)
DE (2) DE19819846B4 (https=)
DK (1) DK1078004T3 (https=)
ES (1) ES2296395T3 (https=)
WO (1) WO1999057150A2 (https=)

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US20100099853A1 (en) 2010-04-22
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DE19819846A1 (de) 1999-11-11
DE59914538D1 (de) 2007-12-13
DK1078004T3 (da) 2008-02-25
CA2331641A1 (en) 1999-11-11
US8148496B2 (en) 2012-04-03
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AU4896099A (en) 1999-11-23
WO1999057150A3 (de) 2000-06-22
US20070031436A1 (en) 2007-02-08
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JP4431277B2 (ja) 2010-03-10

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