DD107670B3 - Verfahren zur herstellung von (3.4-dihydroxy-n-)3-(4-hydroxyphenyl)-1-methyl-n-propyl/-beta-phenethyl-amin - Google Patents

Verfahren zur herstellung von (3.4-dihydroxy-n-)3-(4-hydroxyphenyl)-1-methyl-n-propyl/-beta-phenethyl-amin Download PDF

Info

Publication number
DD107670B3
DD107670B3 DD73170118A DD17011873A DD107670B3 DD 107670 B3 DD107670 B3 DD 107670B3 DD 73170118 A DD73170118 A DD 73170118A DD 17011873 A DD17011873 A DD 17011873A DD 107670 B3 DD107670 B3 DD 107670B3
Authority
DD
German Democratic Republic
Prior art keywords
compound
amine
propyl
methyl
heart
Prior art date
Application number
DD73170118A
Other languages
German (de)
English (en)
Other versions
DD107670A5 (de
Inventor
Ronald R Tuttle
Jack Mills
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22918877&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD107670(B3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD107670A5 publication Critical patent/DD107670A5/xx
Publication of DD107670B3 publication Critical patent/DD107670B3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD73170118A 1972-04-12 1973-04-12 Verfahren zur herstellung von (3.4-dihydroxy-n-)3-(4-hydroxyphenyl)-1-methyl-n-propyl/-beta-phenethyl-amin DD107670B3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24346672A 1972-04-12 1972-04-12

Publications (2)

Publication Number Publication Date
DD107670A5 DD107670A5 (de) 1974-08-12
DD107670B3 true DD107670B3 (de) 1988-04-06

Family

ID=22918877

Family Applications (1)

Application Number Title Priority Date Filing Date
DD73170118A DD107670B3 (de) 1972-04-12 1973-04-12 Verfahren zur herstellung von (3.4-dihydroxy-n-)3-(4-hydroxyphenyl)-1-methyl-n-propyl/-beta-phenethyl-amin

Country Status (31)

Country Link
JP (2) JPS5825656B2 (it)
KR (1) KR790000113B1 (it)
AR (1) AR203822A1 (it)
AT (1) AT323719B (it)
AU (1) AU472734B2 (it)
BE (1) BE798051A (it)
BG (1) BG23001A3 (it)
CA (1) CA1018188A (it)
CH (2) CH569691A5 (it)
CS (2) CS190406B2 (it)
CY (1) CY963A (it)
DD (1) DD107670B3 (it)
DE (1) DE2317710C2 (it)
DK (1) DK142750C (it)
ES (1) ES413639A1 (it)
FR (1) FR2182947B1 (it)
GB (1) GB1392674A (it)
HK (1) HK50178A (it)
HU (2) HU167597B (it)
IE (1) IE37511B1 (it)
IL (1) IL42016A (it)
KE (1) KE2870A (it)
MY (1) MY7800381A (it)
NL (1) NL174459C (it)
PH (1) PH11041A (it)
PL (2) PL90695B1 (it)
RO (2) RO70892A (it)
SE (1) SE399064B (it)
SU (1) SU496719A3 (it)
YU (2) YU36483B (it)
ZA (1) ZA732136B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH585693A5 (it) * 1974-02-08 1977-03-15 Ciba Geigy Ag
US4342692A (en) * 1980-10-20 1982-08-03 Usv Pharmaceutical Corporation Pyrrolidines
FI822585L (fi) * 1981-07-22 1983-01-23 Syntex Inc Kardiovaskulaersystem reglerande och antihypertensiva substituerade pyrrolidiner
JPS6061523A (ja) * 1983-09-16 1985-04-09 Shionogi & Co Ltd 経口用ドブタミン製剤
ZA881076B (en) * 1987-02-24 1989-10-25 Lilly Co Eli Dobutamine salts
JPH0383364U (it) * 1989-12-18 1991-08-23
EP0613879A4 (en) * 1991-05-20 1995-05-03 Tsumura & Co PHELLODENDRIN ANALOGS AND TYPE IV ALLERGY SUPPRESSOR CONTAINING THEM AS ACTIVE INGREDIENTS.
EP0620208B1 (en) * 1993-04-13 1997-07-09 Duphar International Research B.V Production of dobutamine compounds
ATE155125T1 (de) * 1993-04-13 1997-07-15 Duphar Int Res Herstellung von dobutamin verbindungen
US7642290B2 (en) 2002-10-03 2010-01-05 Novaremed Limited Compounds for use in the treatment of autoimmune diseases, immuno-allergical diseases and organ or tissue transplantation rejection
WO2005092305A2 (en) * 2004-03-26 2005-10-06 New Era Biotech Ltd Compounds for treating aids and other diseases
GB0804213D0 (en) 2008-03-06 2008-04-16 New Era Biotech Ltd A method of printing or preventing pain
SG10201506978UA (en) 2009-07-31 2015-10-29 Cognition Therapeutics Inc Inhibitors Of Cognitive Decline
US8802734B2 (en) 2009-09-09 2014-08-12 Novaremed Limited Method of treating or preventing pain
WO2013029057A2 (en) * 2011-08-25 2013-02-28 Cognition Therapeutics, Inc. Compositions and methods for treating neurodegenerative disease
CA2938212C (en) 2014-01-31 2023-03-14 Cognition Therapeutics, Inc. Isoindoline compositions and methods for treating neurodegenerative disease
BR112019023851A2 (pt) 2017-05-15 2020-08-18 Cognition Therapeutics, Inc. compostos, suas composições farmacêuticas e métodos para tratamento de doenças neurodegenerativas
CN114524734B (zh) * 2021-12-27 2024-04-26 嘉实（湖南）医药科技有限公司 一种盐酸多巴酚丁胺的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2276619A (en) * 1942-03-17 N-phentlaliphatic-dihtoroxyphentnl

Also Published As

Publication number Publication date
FR2182947B1 (it) 1976-07-02
CS190448B2 (en) 1979-05-31
MY7800381A (en) 1978-12-31
YU36483B (en) 1984-02-29
JPS6221343B2 (it) 1987-05-12
DD107670A5 (de) 1974-08-12
NL7305097A (it) 1973-10-16
NL174459C (nl) 1984-06-18
HU167597B (it) 1975-11-28
JPS497237A (it) 1974-01-22
JPS5825656B2 (ja) 1983-05-28
AR203822A1 (es) 1975-10-31
FR2182947A1 (it) 1973-12-14
AU472734B2 (en) 1976-06-03
ZA732136B (en) 1974-03-27
GB1392674A (en) 1975-04-30
CH580563A5 (it) 1976-10-15
PH11041A (en) 1977-10-25
NL174459B (nl) 1984-01-16
RO70892A (ro) 1982-02-26
HK50178A (en) 1978-09-15
IL42016A (en) 1976-05-31
PL90695B1 (it) 1977-01-31
DK142750C (da) 1981-08-17
YU37113B (en) 1984-08-31
DE2317710A1 (de) 1973-10-18
IL42016A0 (en) 1973-06-29
YU321279A (en) 1983-04-27
JPS58131945A (ja) 1983-08-06
IE37511B1 (en) 1977-08-03
KE2870A (en) 1978-09-01
CA1018188A (en) 1977-09-27
BG23001A3 (it) 1977-05-20
ES413639A1 (es) 1976-01-16
BE798051A (fr) 1973-10-11
DK142750B (da) 1981-01-12
CS190406B2 (en) 1979-05-31
SU496719A3 (ru) 1975-12-25
DE2317710C2 (de) 1983-08-04
SE399064B (sv) 1978-01-30
AT323719B (de) 1975-07-25
KR790000113B1 (en) 1979-03-20
AU5438573A (en) 1974-10-17
PL94207B1 (it) 1977-07-30
CH569691A5 (it) 1975-11-28
CY963A (en) 1978-12-22
HU166213B (it) 1975-02-28
RO65105A (ro) 1980-01-15
YU97673A (en) 1982-02-25

Similar Documents

Publication Publication Date Title
DE2317710C2 (de) 3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methyl-n-propyl]-β-phenethylamin und dessen Säureadditionssalze, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2106209C3 (de) p-substituierte Phenoxypropanolamine, Verfahren zu deren Herstellung und Arzneimittel auf deren Basis AB Hässle, Mölndal (Schweden)
DE1294955B (de) 1-(o-Allylphenoxy)- und 1-(p-Allyl-phenoxy)-2-hydroxy-3-isopropylaminopropan und Verfahren zu deren Herstellung
DE1275069B (de) 1-(3', 5'-Dihydroxyphenyl)-1-hydroxy-2-isopropylaminoalkane und Verfahren zu ihrer Herstellung
DE1468092B2 (de) Aminopropoxy-derivate des tetrahydronaphthalins und des indans, deren saeureadditionssalze, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate
AT321888B (de) Verfahren zur herstellung von neuen sulfamidensowie deren saeureadditionssalzen
DE2656088A1 (de) Neues benzylalkoholderivat und verfahren zu seiner herstellung
DE1915230C3 (de) Hydroxyphenylalkylaminderivate, Verfahren zu deren Herstellung und Arzneimittel auf deren Basis
DE2501122B2 (de) Amidoximderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2304414C3 (de) 1-[3-(trifluormethyl)phenyl]-2-[(cyanoalkyl)amino]-propane, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE2062055C3 (de) Propanolamin-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE1593924C3 (de) 6-Guanidomethyl-1,4-benzodioxan und dessen pharmakologisch nichtgiftige Säureadditionssalze sowie Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE2810482C2 (de) 1-Phenyl-2- eckige Klammer auf (N-alkyl)-amino eckige Klammer zu -propan-1,3-diole, Verfahren zur Herstellung derselben und solche enthaltende Arzneimittel
AT256816B (de) Verfahren zur Herstellung von neuen substituierten 1-Phenyl-2-aminoalkanolen und deren Säureadditionssalzen
DE2738131A1 (de) Aminoketone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
AT228786B (de) Verfahren zur Herstellung des neuen (-)-Enantiomeren des 1-(p-Hydroxyphenyl)-2-(α-methyl- γ-phenyl-propylamino)-propanols-(1) und seiner Säureadditionssalze
DE2427208A1 (de) Triazole und deren salze, verfahren zu deren herstellung und sie enthaltende arzneimittel
AT371102B (de) Verfahren zur herstellung neuer optisch aktiver phenethanolamine und der pharmazeutisch unbedenklichen salze hiervon
DE1518444C (de) erythro alpha Phenyl beta amino propanole, Verfahren zu ihrer Herstellung und solche Verbindungen enthaltende Arz neimittel
DE1812770C (de) Saureadditionssalze des Racemats des 1 (3,4 Dihydroxyphenyl) 2 tert butyl aminobutanols (1) und dessen optischem 1R,2S Isomer
AT268247B (de) Verfahren zur Herstellung von neuen 1-Isopropylamino-2-hydroxy-3-(alkenylphenoxy)-propanen und deren Salzen
AT371101B (de) Verfahren zur herstellung neuer optisch aktiver phenethanolamine und der pharmazeutisch unbedenklichen salze hiervon
AT223595B (de) Verfahren zur Herstellung der neuen optischen Antipoden desjenigen der je zwei möglichen α- und β-erythro-Razemate von 1-(4'-Hydroxyphenyl)-2-(1"-methyl-2"-phenoxyäthylamino)-propanol-(1), dessen Hydrochlorid die geringste Löslichkeit in Wasser aufweist
DE2754148A1 (de) Substituierte aminoaethanole, verfahren zu ihrer herstellung und ihre verwendung als arzneistoffe
AT333264B (de) Verfahren zur herstellung des neuen 3-(4-biphenylyl)-3-methyl-propionsaurenitrils