|
US4618577A
(en)
*
|
1983-02-09 |
1986-10-21 |
The Regents Of The University Of California |
Human-human hybridoma, CLNH5
|
|
CA1247538A
(en)
*
|
1982-05-21 |
1988-12-28 |
Mark C. Glassy |
Human-human hybridomas for solid tumors
|
|
US4939240A
(en)
*
|
1983-03-04 |
1990-07-03 |
Health Research, Inc. |
Monoclonal antibodies to human breast carcinoma cells and their use in diagnosis and therapy
|
|
DE3483054D1
(de)
*
|
1983-03-04 |
1990-10-04 |
Health Research Inc |
Monoklonale antikoerper gegen humane brustkarzinomzellen und ihre verwendung in der diagnose und therapie.
|
|
US4613576A
(en)
*
|
1983-03-09 |
1986-09-23 |
Sloan-Kettering Institute For Cancer Research |
Human monoclonal antibodies to cancer cells
|
|
US4693966A
(en)
*
|
1983-03-11 |
1987-09-15 |
Sloan-Kettering Institute For Cancer Research |
Human monoclonal antibodies from lymphocytes of patients with malignant melanoma
|
|
GB2140030A
(en)
*
|
1983-04-08 |
1984-11-21 |
Kureha Chemical Ind Co Ltd |
Monoclonal antibody to human urinary bladder cancer
|
|
EP0162070A1
(en)
*
|
1983-11-25 |
1985-11-27 |
The University Of Melbourne |
Cell line and monoclonal antibody
|
|
NZ210867A
(en)
*
|
1984-01-31 |
1989-01-06 |
Litton Bionetics Inc |
Tumour-specific monoclonal antibodies, production thereof and use
|
|
US4886745A
(en)
*
|
1984-03-30 |
1989-12-12 |
Syntex Inc. |
Monoclonal antibody specific for human basal cell surface antigen
|
|
ES8802196A1
(es)
*
|
1984-03-30 |
1988-04-16 |
Syntex Inc |
Metodo para determinar la presion de un estado maligno en tejidos.
|
|
JPS6133125A
(ja)
*
|
1984-07-25 |
1986-02-17 |
Morinaga & Co Ltd |
ヒト単クロ−ン性抗肺ガン細胞抗体
|
|
US4761377A
(en)
*
|
1984-10-15 |
1988-08-02 |
The Regents Of The University Of California |
Human-human hybrid cell lines that produce antibodies against antigenic determinants on cancer cells
|
|
JPS61130300A
(ja)
*
|
1984-11-27 |
1986-06-18 |
ザ ボ−ド オブ トラステイ−ズ オブ ザ レランド スタンフオ−ド ジユニア ユニバ−シテイ |
ヒトモノクロ−ナル抗体
|
|
US5106746A
(en)
*
|
1985-05-22 |
1992-04-21 |
E. I. Du Pont De Nemours And Company |
Process for the in vitro immunization of human splenocytes against tumor associated antigens
|
|
US5776093A
(en)
|
1985-07-05 |
1998-07-07 |
Immunomedics, Inc. |
Method for imaging and treating organs and tissues
|
|
JPH0655680B2
(ja)
*
|
1985-10-26 |
1994-07-27 |
萩原 義秀 |
悪性腫瘍用ヒトモノクロナル抗体複合剤
|
|
EP0222360A3
(en)
*
|
1985-11-12 |
1989-03-15 |
Biotherapeutics Inc. |
A method of producing a patient-specific cytotoxic reagent and composition
|
|
JPH0767388B2
(ja)
*
|
1986-01-13 |
1995-07-26 |
三菱化学株式会社 |
抗体産生細胞株の樹立方法
|
|
US5434076A
(en)
*
|
1989-12-18 |
1995-07-18 |
Board Of Regents, The University Of Texas System |
Tumor-specific, cell surface-binding monoclonal antibodies
|
|
US5281710A
(en)
*
|
1990-08-01 |
1994-01-25 |
The Scripps Research Institute |
Dynemicin analogs: synthesis, methods of preparation and use
|
|
JPH04346792A
(ja)
*
|
1991-05-22 |
1992-12-02 |
Hagiwara Yoshihide |
抗癌ヒトモノクローナル抗体のアミノ酸配列及びそれをコードするdna塩基配列
|
|
EP0528663B1
(en)
*
|
1991-08-16 |
1997-10-29 |
Kabushiki Kaisha Toshiba |
Monoclonal antibody to a synaptophysin
|
|
PT1004315E
(pt)
|
1997-08-15 |
2008-07-09 |
Chugai Pharmaceutical Co Ltd |
Profilácticos e/ou medicamentos contendo anticorpos neutralizantes anti-receptor de il-6 para reduzir a excreção de proteínas urinárias no lúpus eritematoso sistémico
|
|
CA2382587A1
(en)
|
1999-08-23 |
2001-03-01 |
Chugai Seiyaku Kabushiki Kaisha |
Hm1.24 antigen expression potentiators
|
|
BR0014667A
(pt)
|
1999-10-01 |
2002-07-02 |
Chugai Pharmaceutical Co Ltd |
Prevenção e tratamento de doenças relacionadas à coagulação sanguìnea
|
|
JP3986439B2
(ja)
|
2001-02-07 |
2007-10-03 |
中外製薬株式会社 |
造血器腫瘍の治療剤
|
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
|
CN101721362B
(zh)
|
2002-02-14 |
2018-07-03 |
中外制药株式会社 |
包含抗体的溶液制剂
|
|
WO2004019966A1
(ja)
|
2002-08-27 |
2004-03-11 |
Chugai Seiyaku Kabushiki Kaisha |
タンパク質溶液製剤の安定化方法
|
|
WO2004024752A1
(ja)
|
2002-09-11 |
2004-03-25 |
Chugai Seiyaku Kabushiki Kaisha |
タンパク質精製方法
|
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
|
ATE474921T1
(de)
|
2003-06-18 |
2010-08-15 |
Chugai Pharmaceutical Co Ltd |
Fucosetransporter
|
|
JP4643450B2
(ja)
|
2003-08-08 |
2011-03-02 |
株式会社ペルセウスプロテオミクス |
癌高発現遺伝子
|
|
CA2548185A1
(en)
|
2003-12-03 |
2005-06-16 |
Chugai Seiyaku Kabushiki Kaisha |
Expression systems using mammalian .beta.-actin promoter
|
|
WO2005056605A1
(ja)
|
2003-12-12 |
2005-06-23 |
Chugai Seiyaku Kabushiki Kaisha |
3量体以上の受容体を認識する改変抗体
|
|
PT1674111E
(pt)
|
2004-07-09 |
2010-12-15 |
Chugai Pharmaceutical Co Ltd |
Anticorpo anti-glipicano 3
|
|
EP2208783A1
(en)
|
2004-12-22 |
2010-07-21 |
Chugai Seiyaku Kabushiki Kaisha |
Method of producing an antibody using a cell in which the function of fucose transporter is inhibited
|
|
WO2006106905A1
(ja)
|
2005-03-31 |
2006-10-12 |
Chugai Seiyaku Kabushiki Kaisha |
会合制御によるポリペプチド製造方法
|
|
US8945543B2
(en)
|
2005-06-10 |
2015-02-03 |
Chugai Seiyaku Kabushiki Kaisha |
Stabilizer for protein preparation comprising meglumine and use thereof
|
|
RU2446826C2
(ru)
|
2005-10-14 |
2012-04-10 |
Фукуока Юниверсити |
Агенты для подавления повреждения трансплантированных островков после трансплантации островков
|
|
WO2007055378A1
(ja)
|
2005-11-14 |
2007-05-18 |
Cell Signals Inc. |
調節性t細胞の機能異常に基づく疾患の治療方法及び予防方法
|
|
AR057582A1
(es)
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
|
WO2007061029A1
(ja)
|
2005-11-25 |
2007-05-31 |
Keio University |
前立腺癌治療剤
|
|
CN101370521A
(zh)
|
2006-01-27 |
2009-02-18 |
学校法人庆应义塾 |
伴有脉络膜血管生成的疾病的治疗药
|
|
US9670269B2
(en)
|
2006-03-31 |
2017-06-06 |
Chugai Seiyaku Kabushiki Kaisha |
Methods of modifying antibodies for purification of bispecific antibodies
|
|
WO2007114319A1
(ja)
|
2006-03-31 |
2007-10-11 |
Chugai Seiyaku Kabushiki Kaisha |
抗体の血中動態を制御する方法
|
|
JP5242382B2
(ja)
|
2006-04-14 |
2013-07-24 |
株式会社医学生物学研究所 |
エフェクター機能を有するポリペプチド変異体
|
|
JP5043008B2
(ja)
|
2006-06-08 |
2012-10-10 |
中外製薬株式会社 |
炎症性疾患の予防または治療剤
|
|
US20100040600A1
(en)
|
2006-06-14 |
2010-02-18 |
Chugai Seiyaku Kabushiki Kaisha |
Agents for Promoting the Growth of Hematopoietic Stem Cells
|
|
EP2048230A4
(en)
|
2006-07-13 |
2010-01-20 |
Chugai Pharmaceutical Co Ltd |
Cell death inducer
|
|
WO2008010556A1
(fr)
|
2006-07-21 |
2008-01-24 |
Chugai Seiyaku Kabushiki Kaisha |
Médicament agissant contre une maladie rénale
|
|
ATE465179T1
(de)
|
2006-07-24 |
2010-05-15 |
Pasteur Institut |
Antikörper, antikörperfragmente und scfv die an posttranslational modifizierte neurotrophine binden
|
|
EP2050466B1
(en)
|
2006-08-14 |
2015-10-28 |
Chugai Seiyaku Kabushiki Kaisha |
Diagnosis and treatment of cancer using anti-desmoglein-3 antibodies
|
|
JPWO2008032833A1
(ja)
|
2006-09-14 |
2010-01-28 |
株式会社医学生物学研究所 |
Adcc活性を増強させた抗体及びその製造方法
|
|
MX2009003738A
(es)
|
2006-10-12 |
2009-07-17 |
Forerunner Pharma Res Co Ltd |
Diagnóstico y tratamiento de cáncer usando anticuerpo anti-ereg.
|
|
EP3040347A3
(en)
|
2006-10-20 |
2016-09-21 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient
|
|
EP2123676A4
(en)
|
2007-01-05 |
2011-01-05 |
Univ Tokyo |
DIAGNOSIS AND TREATMENT OF CANCER USING ANTI-PRG-3 ANTIBODIES
|
|
CN101951953A
(zh)
|
2007-02-27 |
2011-01-19 |
株式会社未来创药研究所 |
含抗grp78抗体作为有效成分的药物组合物
|
|
US8722858B2
(en)
|
2007-06-25 |
2014-05-13 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-Prominin-1 antibody having ADCC activity or CDC activity
|
|
EP3246045B1
(en)
|
2007-07-26 |
2025-09-03 |
Osaka University |
Therapeutic agents for ocular inflammatory disease comprising interleukin 6 receptor inhibitor as active ingredient
|
|
EP3127921A1
(en)
|
2007-09-26 |
2017-02-08 |
Chugai Seiyaku Kabushiki Kaisha |
Method of modifying isoelectric point of antibody via amino acid substition in cdr
|
|
JP5264752B2
(ja)
|
2007-10-02 |
2013-08-14 |
中外製薬株式会社 |
インターロイキン6受容体阻害剤を有効成分とする移植片対宿主病治療剤
|
|
WO2009054435A1
(ja)
|
2007-10-24 |
2009-04-30 |
Otsuka Chemical Co., Ltd. |
増強されたエフェクター機能を有するポリペプチド
|
|
WO2009063970A1
(ja)
|
2007-11-14 |
2009-05-22 |
Forerunner Pharma Research Co., Ltd. |
抗gpr49抗体を用いる癌の診断および治療
|
|
KR101568051B1
(ko)
|
2007-11-15 |
2015-11-10 |
추가이 세이야쿠 가부시키가이샤 |
Anexelekto에 결합하는 단일클론항체, 및 그의 이용
|
|
WO2009072598A1
(ja)
|
2007-12-05 |
2009-06-11 |
Chugai Seiyaku Kabushiki Kaisha |
掻痒症治療剤
|
|
TWI548418B
(zh)
|
2007-12-05 |
2016-09-11 |
Chugai Pharmaceutical Co Ltd |
Anti-NR10 / IL-31RA antibody and its use
|
|
WO2009075344A1
(ja)
|
2007-12-12 |
2009-06-18 |
Japan As Represented By Director General Of Agency Of National Cancer Center |
M-csf受容体を分子標的とするmll白血病及びmoz白血病治療剤、およびその利用
|
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
|
EP2241578B1
(en)
|
2008-01-11 |
2016-04-20 |
The University of Tokyo |
Anti-cldn6 antibody
|
|
EP2708559B1
(en)
|
2008-04-11 |
2018-03-28 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
|
EP2116261A1
(en)
|
2008-05-07 |
2009-11-11 |
Institut Pasteur |
Sub-region of a plasmodium protein with improved vaccine potential and medical uses thereof
|
|
EP2283862B1
(en)
|
2008-06-02 |
2018-08-08 |
The University of Tokyo |
Combination treatment of cancer comprising anti-mfg-e8 antibody
|
|
CN104906581A
(zh)
|
2008-06-05 |
2015-09-16 |
国立研究开发法人国立癌症研究中心 |
神经浸润抑制剂
|
|
US8575314B2
(en)
|
2008-06-20 |
2013-11-05 |
National University Corporation Okayama University |
Antibody against oxidized LDL/β2GPI complex and use of the same
|
|
CN102395603A
(zh)
|
2008-12-26 |
2012-03-28 |
国立大学法人东京大学 |
使用抗lgr7抗体的癌症的诊断和治疗
|
|
JP2010210772A
(ja)
|
2009-03-13 |
2010-09-24 |
Dainippon Screen Mfg Co Ltd |
液晶表示装置の製造方法
|
|
US8455249B2
(en)
|
2009-05-01 |
2013-06-04 |
The University Of Tokyo |
Highly effective anti-cadherin antibody for induction of antibody-dependent cellular cytotoxicity in vivo
|
|
EP2436397B1
(en)
|
2009-05-29 |
2017-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical composition containing antagonist of egf family ligand as component
|
|
NZ598127A
(en)
|
2009-07-31 |
2014-03-28 |
Shin Maeda |
Cancer metastasis inhibitor
|
|
TW201118166A
(en)
|
2009-09-24 |
2011-06-01 |
Chugai Pharmaceutical Co Ltd |
HLA class I-recognizing antibodies
|
|
AR080428A1
(es)
|
2010-01-20 |
2012-04-11 |
Chugai Pharmaceutical Co Ltd |
Formulaciones liquidas estabilizadas contentivas de anticuerpos
|
|
BR112012020116B8
(pt)
|
2010-02-10 |
2023-01-10 |
Perseus Proteomics Inc |
Anticorpo anti-p-caderina marcado com metal radioativo, agente terapêutico contra o câncer e agente de diagnóstico de câncer que compreendem o dito anticorpo, hibridoma, bem como usos do mesmo para produzir um agente terapêutico contra o câncer e um agente de diagnóstico de câncer
|
|
EP2540827A4
(en)
|
2010-02-26 |
2013-09-04 |
Chugai Pharmaceutical Co Ltd |
ANTI-ICAM3 ANTIBODY AND ITS USE
|
|
TWI667257B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
|
JP6051049B2
(ja)
|
2010-05-28 |
2016-12-21 |
中外製薬株式会社 |
抗腫瘍t細胞応答増強剤
|
|
CA2816021A1
(en)
|
2010-10-25 |
2012-05-10 |
Regents Of The University Of Minnesota |
Therapeutic composition for treatment of glioblastoma
|
|
PT2634194T
(pt)
|
2010-10-29 |
2018-10-19 |
Perseus Proteomics Inc |
Anticorpos anti-cdh3 possuidores de elevada capacidade de internalização
|
|
WO2013012022A1
(ja)
|
2011-07-19 |
2013-01-24 |
中外製薬株式会社 |
アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
|
|
EP2749572A4
(en)
|
2011-08-23 |
2015-04-01 |
Chugai Pharmaceutical Co Ltd |
NEW ANTI-DDR1 ANTIBODY WITH ANTITUMORACTIVITY
|
|
TW201817744A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
|
EP2772268B8
(en)
|
2011-10-28 |
2020-01-08 |
Chugai Seiyaku Kabushiki Kaisha |
Cancer stem cell-specific molecule
|
|
WO2013065708A1
(ja)
|
2011-10-31 |
2013-05-10 |
中外製薬株式会社 |
重鎖と軽鎖の会合が制御された抗原結合分子
|
|
WO2013150623A1
(ja)
|
2012-04-04 |
2013-10-10 |
株式会社ペルセウスプロテオミクス |
抗cdh3(p-カドヘリン)抗体の薬剤コンジュゲート
|
|
EP2876160B1
(en)
|
2012-07-06 |
2020-05-13 |
Kyoto Prefectural Public University Corporation |
Differentiation marker for and differentiation control for ocular cells
|
|
ES2643571T3
(es)
|
2012-09-27 |
2017-11-23 |
Chugai Seiyaku Kabushiki Kaisha |
Gen de fusión FGFR3 y fármaco que se dirige al mismo
|
|
EP3009518B1
(en)
|
2013-06-11 |
2020-08-12 |
National Center of Neurology and Psychiatry |
Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy
|
|
NZ722057A
(en)
|
2013-12-27 |
2022-10-28 |
Chugai Pharmaceutical Co Ltd |
Method for purifying antibody having low isoelectric point
|
|
EP3087986B1
(en)
|
2013-12-27 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Fgfr gatekeeper mutant gene and drug targeting same
|
|
EP3185004A4
(en)
|
2014-08-20 |
2018-05-30 |
Chugai Seiyaku Kabushiki Kaisha |
Method for measuring viscosity of protein solution
|
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
|
ES2967627T3
(es)
|
2015-02-27 |
2024-05-03 |
Chugai Pharmaceutical Co Ltd |
Composición para tratar enfermedades relacionadas con IL-6
|
|
AU2018240938A1
(en)
|
2017-03-24 |
2019-10-10 |
Zenyaku Kogyo Co., Ltd. |
Anti-IgM/B cell surface antigen bispecific antibody
|
|
WO2019078344A1
(ja)
|
2017-10-20 |
2019-04-25 |
学校法人兵庫医科大学 |
抗il-6受容体抗体を含有する術後の癒着を抑制するための医薬組成物
|
|
TWI822728B
(zh)
|
2018-01-31 |
2023-11-21 |
加藤元一 |
含有il-6抑制劑的哮喘治療劑
|
|
KR20210134705A
(ko)
|
2019-02-28 |
2021-11-10 |
각코우호우진 쥰텐도 |
절단형의 변이형 Calreticulin에 결합하는 항체, 및 골수 증식성 종양의 진단, 예방 또는 치료약
|
|
US20220204608A1
(en)
|
2019-04-17 |
2022-06-30 |
Hiroshima University |
Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination
|
|
US20220227887A1
(en)
|
2019-06-11 |
2022-07-21 |
Ono Pharmaceutical Co., Ltd. |
Immunosuppressant
|
|
CN115379858A
(zh)
|
2020-04-06 |
2022-11-22 |
光爱科技公司 |
用于杀死肿瘤细胞的医药品
|
|
AU2021315210A1
(en)
|
2020-07-28 |
2023-03-09 |
Chugai Seiyaku Kabushiki Kaisha |
Prefilled syringe formulation with needle with needle shield containing novel modified antibody
|
|
MX2023002374A
(es)
|
2020-08-27 |
2023-03-23 |
Juntendo Educational Found |
Anticuerpo biespecifico anti-calr-cd3 mutante escindido y composicion farmaceutica.
|
|
IL305793A
(en)
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