CZ277728B6 - Biologically usable preparation containing as an active component methyl hydroxyprogesterone acetate and process for preparing thereof - Google Patents
Biologically usable preparation containing as an active component methyl hydroxyprogesterone acetate and process for preparing thereof Download PDFInfo
- Publication number
- CZ277728B6 CZ277728B6 CS85784A CS78485A CZ277728B6 CZ 277728 B6 CZ277728 B6 CZ 277728B6 CS 85784 A CS85784 A CS 85784A CS 78485 A CS78485 A CS 78485A CZ 277728 B6 CZ277728 B6 CZ 277728B6
- Authority
- CZ
- Czechia
- Prior art keywords
- map
- polymer
- mixture
- swellable
- pvp
- Prior art date
Links
- NNRCINHMAXRRNU-HXTGIOSGSA-N CC(O)=O.C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(C)(O)[C@H](C(=O)C)[C@@]1(C)CC2 Chemical compound CC(O)=O.C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(C)(O)[C@H](C(=O)C)[C@@]1(C)CC2 NNRCINHMAXRRNU-HXTGIOSGSA-N 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 229920000642 polymer Polymers 0.000 claims abstract description 74
- 239000000203 mixture Substances 0.000 claims abstract description 50
- 238000002844 melting Methods 0.000 claims abstract description 16
- 230000008018 melting Effects 0.000 claims abstract description 16
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 54
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 54
- 238000000034 method Methods 0.000 claims description 26
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 8
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims description 8
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 4
- 229920003169 water-soluble polymer Polymers 0.000 claims description 4
- MZVHNXXTLCWLEU-VHDNCQQFSA-N (8s,9s,10r,13s,14s,17s)-17-acetyl-1-hydroxy-1,10,13-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydro-2h-cyclopenta[a]phenanthren-3-one Chemical compound C1CC2=CC(=O)CC(C)(O)[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 MZVHNXXTLCWLEU-VHDNCQQFSA-N 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- 230000008961 swelling Effects 0.000 abstract description 22
- 238000000227 grinding Methods 0.000 abstract description 18
- 238000010438 heat treatment Methods 0.000 abstract description 15
- 229920003176 water-insoluble polymer Polymers 0.000 abstract description 9
- 238000001035 drying Methods 0.000 abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 50
- 238000004090 dissolution Methods 0.000 description 18
- 239000003814 drug Substances 0.000 description 12
- 229940079593 drug Drugs 0.000 description 12
- 239000000243 solution Substances 0.000 description 12
- 239000000843 powder Substances 0.000 description 11
- 238000005280 amorphization Methods 0.000 description 10
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- 241000282472 Canis lupus familiaris Species 0.000 description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 229920002959 polymer blend Polymers 0.000 description 8
- 238000002156 mixing Methods 0.000 description 7
- 239000007909 solid dosage form Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 239000006069 physical mixture Substances 0.000 description 5
- 238000007707 calorimetry Methods 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 239000007884 disintegrant Substances 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 238000003801 milling Methods 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- LGDAGYXJBDILKZ-UHFFFAOYSA-N [2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1$l^{6},2-benzothiazin-4-yl] 2,2-dimethylpropanoate Chemical compound CC(C)(C)C(=O)OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 LGDAGYXJBDILKZ-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 229940097362 cyclodextrins Drugs 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000004570 mortar (masonry) Substances 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 238000000825 ultraviolet detection Methods 0.000 description 2
- YREOLPGEVLLKMB-UHFFFAOYSA-N 3-methylpyridin-1-ium-2-amine bromide hydrate Chemical compound O.[Br-].Cc1ccc[nH+]c1N YREOLPGEVLLKMB-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000000113 differential scanning calorimetry Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229960002985 medroxyprogesterone acetate Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000008184 oral solid dosage form Substances 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000001757 thermogravimetry curve Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848403360A GB8403360D0 (en) | 1984-02-08 | 1984-02-08 | Pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS78485A3 CS78485A3 (en) | 1992-11-18 |
| CZ277728B6 true CZ277728B6 (en) | 1993-04-14 |
Family
ID=10556300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS85784A CZ277728B6 (en) | 1984-02-08 | 1985-02-05 | Biologically usable preparation containing as an active component methyl hydroxyprogesterone acetate and process for preparing thereof |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US4632828A (en, 2012) |
| JP (1) | JPS60181017A (en, 2012) |
| KR (1) | KR930009897B1 (en, 2012) |
| AT (1) | AT388869B (en, 2012) |
| AU (1) | AU577351B2 (en, 2012) |
| BE (1) | BE901664A (en, 2012) |
| BG (1) | BG60524B2 (en, 2012) |
| CA (1) | CA1240928A (en, 2012) |
| CH (1) | CH664693A5 (en, 2012) |
| CZ (1) | CZ277728B6 (en, 2012) |
| DE (1) | DE3503679A1 (en, 2012) |
| DK (1) | DK164149C (en, 2012) |
| ES (3) | ES8607984A1 (en, 2012) |
| FI (1) | FI84230C (en, 2012) |
| FR (1) | FR2559065B1 (en, 2012) |
| GB (2) | GB8403360D0 (en, 2012) |
| GR (1) | GR850312B (en, 2012) |
| HK (1) | HK94290A (en, 2012) |
| HU (1) | HU194050B (en, 2012) |
| IE (1) | IE58230B1 (en, 2012) |
| IL (1) | IL74241A (en, 2012) |
| IT (1) | IT1209615B (en, 2012) |
| NL (1) | NL192780C (en, 2012) |
| NO (1) | NO170568C (en, 2012) |
| NZ (1) | NZ211058A (en, 2012) |
| PT (1) | PT79933B (en, 2012) |
| SE (2) | SE8500553L (en, 2012) |
| SG (1) | SG80390G (en, 2012) |
| SK (1) | SK278084B6 (en, 2012) |
| SU (1) | SU1605926A3 (en, 2012) |
| UA (1) | UA6028A1 (en, 2012) |
| ZA (1) | ZA85943B (en, 2012) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7084587A (en) * | 1986-04-01 | 1987-10-20 | Upjohn Company, The | Methylprednisolone/sodium carboxymethyl starch tablet composition |
| US5019562A (en) * | 1988-01-19 | 1991-05-28 | The Trustees Of The University Of Pennsylvania/Childrens Hospital Corporation | Growth inhibiting agent and the use thereof |
| GB8806367D0 (en) * | 1988-03-17 | 1988-04-13 | Erba Carlo Spa | Siloxane matrices with internal non-uniform drug distribution |
| IE60458B1 (en) * | 1989-10-26 | 1994-07-13 | Elan Corp Plc | Enhanced bioavailability adsorbates |
| HU222501B1 (hu) * | 1991-06-28 | 2003-07-28 | Endorecherche Inc. | MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására |
| RU2138525C1 (ru) * | 1993-10-25 | 1999-09-27 | Байер Аг | Композиция с биологической активностью и водное средство защиты растений |
| US5547948A (en) * | 1995-01-17 | 1996-08-20 | American Home Products Corporation | Controlled release of steroids from sugar coatings |
| US5759577A (en) * | 1995-01-17 | 1998-06-02 | American Home Products Corporation | Controlled release of steroids from sugar coatings |
| UA65607C2 (uk) | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
| DE19847252B4 (de) * | 1998-10-02 | 2004-02-12 | Jenapharm Gmbh & Co. Kg | Bukkal applizierbare bioadhäsive Systeme mit zeitlich gesteuerter Wirkstofffreisetzung enthaltend Testosteronester und fakultativ zusätzlich Testosteron |
| AU2669700A (en) * | 1999-02-24 | 2000-09-14 | Akzo Nobel N.V. | Pharmaceutical compositions containing a crystalline form of the progestagen-(17alpha)-17-hydroxy-11-methylene-19-nor-pregna- 4,15-dien-20-yn-3-one (org 30659) and lactose |
| US20020132839A1 (en) * | 2000-06-22 | 2002-09-19 | Ganter Sabina Maria | Tablet formulations comprising valsartan |
| AUPS244002A0 (en) * | 2002-05-20 | 2002-06-13 | John Kohnke Products Pty Ltd | Agent delivery system |
| DE10247037A1 (de) * | 2002-10-09 | 2004-04-22 | Abbott Gmbh & Co. Kg | Herstellung von festen Dosierungsformen unter Verwendung eines vernetzten nichtthermoplastischen Trägers |
| JP2005094910A (ja) * | 2003-09-17 | 2005-04-07 | Aruze Corp | モータ停止制御装置 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3545439A (en) * | 1968-01-04 | 1970-12-08 | Upjohn Co | Medicated devices and methods |
| AU454482B2 (en) * | 1970-11-05 | 1974-10-15 | Alza Corporation | Drug-delivery system |
| DE2200778B2 (de) * | 1971-01-13 | 1974-04-18 | Sandoz Ag, Basel (Schweiz) | Verwendung von hochmolekularem, unlöslichem, quervernetztem Polyvinylpyrrolidon als Sprengmittel in festen Arzneiformen |
| DE2362785A1 (de) * | 1973-12-18 | 1975-06-26 | Atmos Fritzsching & Co Gmbh | Verfahren zum haltbarmachen von kristallsuspensionen |
| US4038389A (en) * | 1975-05-07 | 1977-07-26 | The Upjohn Company | Medroxyprogesterone acetate compositions |
| SE439586B (sv) * | 1975-09-05 | 1985-06-24 | Kanebo Ltd | Sett att framstella ett stabilt farmaceutiskt torrpreparat av ett alkalimetallsalt av dehydroepiandrosteronsulfat |
| DE2634004B2 (de) * | 1976-07-29 | 1978-08-10 | Bernhard Dr. 8000 Muenchen Lippold | Verfahren zur Beschleunigung der Auflösung und Verbesserung der Löslichkeit von schlechtlöslichen zur peroralen Verabreichung bestimmten Arzneistoffen |
| US4115563A (en) * | 1977-03-14 | 1978-09-19 | Sterling Drug Inc. | Pharmaceutical steroid formulation |
| CA1098443A (en) * | 1977-05-20 | 1981-03-31 | Namassivaya Doddi | Absorbable p-dioxanone polymer-drug compositions |
| SE431821B (sv) * | 1979-01-29 | 1984-03-05 | Perstorp Ab | Lagringsstabilt, prostaglandininnehallande medicinskt preparat |
| GB2042888B (en) * | 1979-03-05 | 1983-09-28 | Teijin Ltd | Preparation for administration to the mucosa of the oral or nasal cavity |
| GB2067900B (en) * | 1980-01-25 | 1983-06-22 | Ddsa Pharmaceuticals Ltd | Medicinal tablets |
| DE3006635A1 (de) * | 1980-02-22 | 1981-08-27 | Basf Ag, 6700 Ludwigshafen | Verwendung von mikronisiertem vernetztem, unloeslichem polyvinylpyrrolidon zur stabilisierung von suspensionen |
| DE3045135A1 (de) * | 1980-11-29 | 1982-06-09 | Sandoz-Patent-GmbH, 7850 Lörrach | Pharmazeutische kompositionen enthaltende bioabbaubare polymere |
| IL61721A (en) * | 1980-12-16 | 1984-03-30 | Blank Izhak | Nitroglycerin preparations |
| DE3125178A1 (de) * | 1981-06-26 | 1983-01-13 | Gödecke AG, 1000 Berlin | Verfahren zur zeitlichen steuerung der freisetzung von wirkstoffen aus wirkstoffzubereitungen, insbesondere arzneimittelzubereitungen |
| DE3270785D1 (en) * | 1981-10-29 | 1986-05-28 | Bayer Ag | Process for preparing solid fast-releasing drug formulations of dihydropyridines |
| DE3205399A1 (de) * | 1982-02-16 | 1983-08-25 | Bayer Ag, 5090 Leverkusen | Feste, schnellfreisetzende arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung |
| EP0084190A3 (en) * | 1981-12-08 | 1984-11-28 | Fisons Plc | Medicinal composition, package and method of making the composition |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| GB2138286B (en) * | 1983-04-19 | 1986-10-08 | Dr Christopher Harry Mortimer | Pharmaceutical composition for the treatment of hair loss |
-
1984
- 1984-02-08 GB GB848403360A patent/GB8403360D0/en active Pending
-
1985
- 1985-01-25 ES ES539874A patent/ES8607984A1/es not_active Expired
- 1985-02-04 DE DE19853503679 patent/DE3503679A1/de active Granted
- 1985-02-04 AT AT0031685A patent/AT388869B/de not_active IP Right Cessation
- 1985-02-04 IE IE26185A patent/IE58230B1/en not_active IP Right Cessation
- 1985-02-04 FI FI850455A patent/FI84230C/fi not_active IP Right Cessation
- 1985-02-04 IL IL74241A patent/IL74241A/xx not_active IP Right Cessation
- 1985-02-04 CH CH494/85A patent/CH664693A5/de not_active IP Right Cessation
- 1985-02-04 GR GR850312A patent/GR850312B/el not_active IP Right Cessation
- 1985-02-05 FR FR8501562A patent/FR2559065B1/fr not_active Expired
- 1985-02-05 CZ CS85784A patent/CZ277728B6/cs not_active IP Right Cessation
- 1985-02-05 SK SK784-85A patent/SK278084B6/sk unknown
- 1985-02-05 IT IT8519385A patent/IT1209615B/it active
- 1985-02-05 NZ NZ211058A patent/NZ211058A/xx unknown
- 1985-02-06 SE SE8500553D patent/SE8500553L/xx not_active Application Discontinuation
- 1985-02-06 SE SE8500553A patent/SE462547B/sv not_active IP Right Cessation
- 1985-02-06 GB GB08503033A patent/GB2153677B/en not_active Expired
- 1985-02-06 NL NL8500323A patent/NL192780C/nl not_active IP Right Cessation
- 1985-02-06 SU SU853848424A patent/SU1605926A3/ru active
- 1985-02-06 AU AU38488/85A patent/AU577351B2/en not_active Expired
- 1985-02-06 US US06/698,784 patent/US4632828A/en not_active Expired - Lifetime
- 1985-02-06 JP JP60020188A patent/JPS60181017A/ja active Granted
- 1985-02-06 PT PT79933A patent/PT79933B/pt unknown
- 1985-02-06 UA UA3848424A patent/UA6028A1/uk unknown
- 1985-02-06 BE BE0/214458A patent/BE901664A/fr not_active IP Right Cessation
- 1985-02-07 HU HU85469A patent/HU194050B/hu unknown
- 1985-02-07 DK DK057085A patent/DK164149C/da not_active IP Right Cessation
- 1985-02-07 ZA ZA85943A patent/ZA85943B/xx unknown
- 1985-02-07 NO NO850477A patent/NO170568C/no not_active IP Right Cessation
- 1985-02-07 CA CA000473748A patent/CA1240928A/en not_active Expired
- 1985-02-08 KR KR1019850000786A patent/KR930009897B1/ko not_active Expired - Lifetime
- 1985-12-31 ES ES550614A patent/ES8703278A1/es not_active Expired
- 1985-12-31 ES ES550613A patent/ES8703277A1/es not_active Expired
-
1990
- 1990-10-03 SG SG803/90A patent/SG80390G/en unknown
- 1990-11-15 HK HK942/90A patent/HK94290A/xx not_active IP Right Cessation
-
1994
- 1994-02-22 BG BG098519A patent/BG60524B2/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MK4A | Patent expired |
Effective date: 20050205 |