CY1122986T1 - Παραγωγα 1,2,4-οξαδιαζολιου ως ανοσοτροποποιητες - Google Patents
Παραγωγα 1,2,4-οξαδιαζολιου ως ανοσοτροποποιητεςInfo
- Publication number
- CY1122986T1 CY1122986T1 CY20201100394T CY201100394T CY1122986T1 CY 1122986 T1 CY1122986 T1 CY 1122986T1 CY 20201100394 T CY20201100394 T CY 20201100394T CY 201100394 T CY201100394 T CY 201100394T CY 1122986 T1 CY1122986 T1 CY 1122986T1
- Authority
- CY
- Cyprus
- Prior art keywords
- oxadiazole derivatives
- immune modulators
- derivatives
- relates
- therapeutic agents
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Η παρούσα εφεύρεση αφορά ενώσεις 1,2,4-οξαδιαζολίου και 1,2,4-θειαδιαζολίου ως θεραπευτικούς παράγοντες ικανούς να αναστέλλουν το μονοπάτι σηματοδότησης προγραμματισμένου κυτταρικού θανάτου 1 (PD1). Η εφεύρεση αφορά επίσης παράγωγα των θεραπευτικών παραγόντων. Η εφεύρεση περιλαμβάνει επίσης τη χρήση των εν λόγω θεραπευτικών παραγόντων παραγώγων για την αγωγή διαταραχών μέσω ανοσοενίσχυσης που περιλαμβάνει αναστολή του ανοσοκατασταλτικού σήματος που επάγεται δια PD-1, PD-L1 ή PD-L2 και θεραπείες με τη χρήση αυτών.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN4011CH2013 | 2013-09-06 | ||
PCT/IB2014/064279 WO2015033299A1 (en) | 2013-09-06 | 2014-09-05 | 1,2,4-oxadiazole derivatives as immunomodulators |
EP14790320.7A EP3041827B1 (en) | 2013-09-06 | 2014-09-05 | 1,2,4-oxadiazole derivatives as immunomodulators |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122986T1 true CY1122986T1 (el) | 2021-10-29 |
Family
ID=51830558
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY181100745T CY1120899T1 (el) | 2013-09-06 | 2018-07-17 | Παραγωγα 1,2,4-οξαδιαζολιου ως ανοσοτροποποιητες |
CY20201100394T CY1122986T1 (el) | 2013-09-06 | 2020-04-29 | Παραγωγα 1,2,4-οξαδιαζολιου ως ανοσοτροποποιητες |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY181100745T CY1120899T1 (el) | 2013-09-06 | 2018-07-17 | Παραγωγα 1,2,4-οξαδιαζολιου ως ανοσοτροποποιητες |
Country Status (28)
Country | Link |
---|---|
US (8) | US20150073024A1 (el) |
EP (2) | EP3041827B1 (el) |
JP (1) | JP6521977B2 (el) |
KR (1) | KR102362277B1 (el) |
CN (2) | CN105814028B (el) |
AU (4) | AU2014316682B2 (el) |
BR (1) | BR112016004889B1 (el) |
CA (1) | CA2922607C (el) |
CU (1) | CU24362B1 (el) |
CY (2) | CY1120899T1 (el) |
DK (2) | DK3363790T3 (el) |
EA (1) | EA030155B1 (el) |
ES (2) | ES2675027T3 (el) |
HR (2) | HRP20181052T1 (el) |
HU (2) | HUE038169T2 (el) |
IL (3) | IL244314A (el) |
LT (2) | LT3041827T (el) |
MX (1) | MX365218B (el) |
MY (1) | MY186438A (el) |
PH (1) | PH12016500406B1 (el) |
PL (2) | PL3041827T3 (el) |
PT (2) | PT3041827T (el) |
RS (2) | RS60317B1 (el) |
SG (1) | SG11201601682RA (el) |
SI (2) | SI3363790T1 (el) |
TR (1) | TR201809838T4 (el) |
WO (1) | WO2015033299A1 (el) |
ZA (1) | ZA201602193B (el) |
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RU2666730C2 (ru) | 2012-12-07 | 2018-09-12 | Кемосентрикс, Инк. | Диазольные лактамы |
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PL3041827T3 (pl) | 2013-09-06 | 2018-09-28 | Aurigene Discovery Tech Limited | Pochodne 1,2,4-oksadiazolu jako immunomodulatory |
PL3041828T3 (pl) | 2013-09-06 | 2018-10-31 | Aurigene Discovery Technologies Limited | Pochodne 1,3,4-oksadiazolu i 1,3,4-tiadiazolu jako immunomodulatory |
SG11201706902SA (en) * | 2015-03-10 | 2017-09-28 | Aurigene Discovery Tech Ltd | 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
AU2016230793B2 (en) | 2015-03-10 | 2021-03-25 | Aurigene Discovery Technologies Limited | 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
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CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
PL3394033T3 (pl) | 2015-12-22 | 2021-05-31 | Incyte Corporation | Związki heterocykliczne jako immunomodulatory |
DK3402503T3 (da) | 2016-01-13 | 2020-12-21 | Acerta Pharma Bv | Terapeutiske kombinationer af et antifolat og en btk-hæmmer |
JP2019510832A (ja) | 2016-04-07 | 2019-04-18 | ケモセントリクス,インコーポレーテッド | Pd−1阻害剤又はpd−l1阻害剤と組み合わせてccr1アンタゴニストを投与することによる腫瘍負荷の低減 |
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MA45116A (fr) * | 2016-05-26 | 2021-06-02 | Incyte Corp | Composés hétérocycliques comme immunomodulateurs |
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MA46045A (fr) | 2016-08-29 | 2021-04-28 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
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IL265921B1 (en) | 2016-10-14 | 2024-01-01 | Prec Biosciences Inc | Transgenic meganonucleases specific for recognition sequences in the hepatitis B virus genome |
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