CY1112903T1 - Ενωσεις 3,4-διυποκατεστημενου 1η-πυραζολιου και χρηση αυτων ως ρυθμιστες κινασων που εξαρτωνται απο κυκλινη (cdk) και κινασης-3 συνθασης γλυκογονου (gsκ-3) - Google Patents

Ενωσεις 3,4-διυποκατεστημενου 1η-πυραζολιου και χρηση αυτων ως ρυθμιστες κινασων που εξαρτωνται απο κυκλινη (cdk) και κινασης-3 συνθασης γλυκογονου (gsκ-3)

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Publication number
CY1112903T1
CY1112903T1 CY20121100595T CY121100595T CY1112903T1 CY 1112903 T1 CY1112903 T1 CY 1112903T1 CY 20121100595 T CY20121100595 T CY 20121100595T CY 121100595 T CY121100595 T CY 121100595T CY 1112903 T1 CY1112903 T1 CY 1112903T1
Authority
CY
Cyprus
Prior art keywords
cylinder
compounds
cycline
cdk
differential
Prior art date
Application number
CY20121100595T
Other languages
Greek (el)
English (en)
Inventor
Valerio Berdini
Michael Alistair O'brien
Maria Grazia Carr
Theresa Rachel Early
AdrianL GILL
Gary Trewartha
Alison Jo-Anne Woolford
Andrew James Woodhead
Paul Graham Wyatt
Original Assignee
Astex Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0317127.9A external-priority patent/GB0317127D0/en
Application filed by Astex Therapeutics Limited filed Critical Astex Therapeutics Limited
Publication of CY1112903T1 publication Critical patent/CY1112903T1/el

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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