CY1110127T1 - Υποκατεστημενες 1-προπιολυλο-πιπεραζινες με χημικη συγγενεια για τον υποδοχεα mglur5 για τη θεραπεια καταστασεων πονου - Google Patents

Υποκατεστημενες 1-προπιολυλο-πιπεραζινες με χημικη συγγενεια για τον υποδοχεα mglur5 για τη θεραπεια καταστασεων πονου

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Publication number
CY1110127T1
CY1110127T1 CY20101100485T CY101100485T CY1110127T1 CY 1110127 T1 CY1110127 T1 CY 1110127T1 CY 20101100485 T CY20101100485 T CY 20101100485T CY 101100485 T CY101100485 T CY 101100485T CY 1110127 T1 CY1110127 T1 CY 1110127T1
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CY
Cyprus
Prior art keywords
substituted
piperazines
propyloyl
treatment
chemical affinity
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CY20101100485T
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English (en)
Inventor
Sven Kühnert
Stefan Oberbörsch
Michael Haurand
Ruth Jostock
Klaus Schiene
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Grünenthal GmbH
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Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1110127T1 publication Critical patent/CY1110127T1/el

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P25/36—Opioid-abuse
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

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  • Health & Medical Sciences (AREA)
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Abstract

Η παρούσα εφεύρεση αφορά υποκατεστημένες 1-προπιολυλο-πιπεραζίνες σύμφωνα με τον τύπο (Ι), μεθόδους για την παρασκευή τους, φάρμακα που περιέχουν τις ενώσεις αυτές καθώς και τη χρησιμοποίησή τους για την παρασκευή φαρμάκων. (Ι), όπου Χ στέκει για N ή C-R2 και η αντιστοιχεί σε μία τιμή μεταξύ 0-8.
CY20101100485T 2004-07-05 2010-06-03 Υποκατεστημενες 1-προπιολυλο-πιπεραζινες με χημικη συγγενεια για τον υποδοχεα mglur5 για τη θεραπεια καταστασεων πονου CY1110127T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004032567A DE102004032567A1 (de) 2004-07-05 2004-07-05 Substituierte 1-Propiolyl-piperazine
EP05756539A EP1765816B1 (de) 2004-07-05 2005-07-05 Substituierte 1-propinoyl-piperazine mit affinität für den mglur5 rezeptor zur behandlung von schmerzzuständen

Publications (1)

Publication Number Publication Date
CY1110127T1 true CY1110127T1 (el) 2015-01-14

Family

ID=34971564

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CY20101100485T CY1110127T1 (el) 2004-07-05 2010-06-03 Υποκατεστημενες 1-προπιολυλο-πιπεραζινες με χημικη συγγενεια για τον υποδοχεα mglur5 για τη θεραπεια καταστασεων πονου

Country Status (13)

Country Link
US (1) US7300939B2 (el)
EP (1) EP1765816B1 (el)
JP (1) JP5022218B2 (el)
AT (1) ATE460413T1 (el)
CA (1) CA2572685A1 (el)
CY (1) CY1110127T1 (el)
DE (2) DE102004032567A1 (el)
DK (1) DK1765816T3 (el)
ES (1) ES2342473T3 (el)
PL (1) PL1765816T3 (el)
PT (1) PT1765816E (el)
SI (1) SI1765816T1 (el)
WO (1) WO2006002981A1 (el)

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US7531529B2 (en) * 2003-06-05 2009-05-12 Roche Palo Alto Llc Imidazole derivatives
KR101032834B1 (ko) * 2003-10-15 2011-05-06 스미또모 가가꾸 가부시키가이샤 1,2,4-티아디아졸 화합물 및 그를 함유하는 유해 생물 방제조성물
NZ551253A (en) 2004-06-01 2010-07-30 Hoffmann La Roche Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as MGLU5 receptor antagonists
US8631130B2 (en) 2005-03-16 2014-01-14 Adaptive Computing Enterprises, Inc. Reserving resources in an on-demand compute environment from a local compute environment
DE102005023784A1 (de) * 2005-05-19 2006-11-30 Grünenthal GmbH Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
DE102005062986A1 (de) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
DE102005062990A1 (de) 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte Thiazole und ihre Verwendung zur Herstellung von Arzneimitteln
DE102005062991A1 (de) * 2005-12-28 2007-07-05 Grünenthal GmbH Substituierte Thiazole und ihre Verwendung zur Herstellung von Arzneimitteln
GB0602335D0 (en) * 2006-02-07 2006-03-15 Remynd Nv Thiadiazole Derivatives For The Treatment Of Neurodegenerative Diseases
US8541406B2 (en) 2006-02-07 2013-09-24 Nv Remynd Thiadiazole derivatives for the treatment of neurodegenerative diseases
GB0623258D0 (en) 2006-11-22 2007-01-03 Remynd Nv Thiadiazole derivatives for the treatment of neuro-degenerative diseases
EP2134687A1 (en) * 2007-03-09 2009-12-23 AstraZeneca AB Piperazine and piperidine mglur5 potentiators
AU2008271051C1 (en) 2007-06-29 2012-10-04 Acucela Inc. Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders
US20100144756A1 (en) * 2007-07-13 2010-06-10 Bolea Christelle Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors
EP2387567B1 (en) 2009-01-14 2014-06-11 The Salk Institute for Biological Studies Compounds that protect against amyloid diseases
UY32940A (es) * 2009-10-27 2011-05-31 Bayer Cropscience Ag Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas
JP5972367B2 (ja) * 2011-07-01 2016-08-17 リマインド・ナムローゼ・フエンノートシャップＲｅｍｙｎｄ Ｎｖ 神経変性疾患の治療に有用な１，２，４−チアジアゾール−５−イルピペラジン誘導体
ES2573299T3 (es) 2011-08-17 2016-06-07 Remynd Nv Derivados de piperazina tiazol útiles en el tratamiento de tauopatías tales como la enfermedad de Alzheimer
CN105837503A (zh) * 2016-05-12 2016-08-10 蚌埠中实化学技术有限公司 一种6-溴喹啉的制备方法
CN107325284B (zh) * 2017-07-02 2020-01-14 苏州大学 一种超支化聚苯基三唑甲酸酯及其制备方法与应用

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JPS56120669A (en) * 1980-02-27 1981-09-22 Res Inst For Prod Dev Allophanoylpiperazine compound and analgesic agent containing the same as active constituent
EP0552418A1 (en) * 1992-01-13 1993-07-28 Takeda Chemical Industries, Ltd. N-substituted-3-iodopropiolamide, production and use thereof
AUPQ386899A0 (en) * 1999-11-04 1999-11-25 Fujisawa Pharmaceutical Co., Ltd. Peptide compounds
WO2003093236A1 (en) * 2002-05-02 2003-11-13 Euro-Celtique, S.A. 1-(pyrid-2-yl)-piperazine compounds as metabotropic glutamate receptor inhibitor
US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain

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EP1765816A1 (de) 2007-03-28
PL1765816T3 (pl) 2010-08-31
WO2006002981A1 (de) 2006-01-12
US20070112011A1 (en) 2007-05-17
EP1765816B1 (de) 2010-03-10
JP2008505149A (ja) 2008-02-21
DK1765816T3 (da) 2010-06-14
DE502005009201D1 (de) 2010-04-22
JP5022218B2 (ja) 2012-09-12
US7300939B2 (en) 2007-11-27
ES2342473T3 (es) 2010-07-07
PT1765816E (pt) 2010-06-14
SI1765816T1 (sl) 2010-07-30
DE102004032567A1 (de) 2006-03-02
CA2572685A1 (en) 2006-01-12
ATE460413T1 (de) 2010-03-15

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