MX2007003104A - Nuevos derivados de ftalazinona, como inhibidores de cinasa aurora-a. - Google Patents
Nuevos derivados de ftalazinona, como inhibidores de cinasa aurora-a.Info
- Publication number
- MX2007003104A MX2007003104A MX2007003104A MX2007003104A MX2007003104A MX 2007003104 A MX2007003104 A MX 2007003104A MX 2007003104 A MX2007003104 A MX 2007003104A MX 2007003104 A MX2007003104 A MX 2007003104A MX 2007003104 A MX2007003104 A MX 2007003104A
- Authority
- MX
- Mexico
- Prior art keywords
- aurora
- kinase inhibitors
- phthalazinone derivatives
- novel phthalazinone
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Son objetos de la presente invencion los compuestos de la formula (I) sus sales, formas enantiomericas, diaestereoisomeros y racematos farmaceuticamente aceptables, la obtencion de los compuestos recien mencionados, los medicamentos que los contienen y su fabricacion, asi como el uso de los compuestos recien mencionados para el control o prevencion de enfermedades, tales como el cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04022755 | 2004-09-24 | ||
PCT/EP2005/010311 WO2006032518A1 (en) | 2004-09-24 | 2005-09-23 | Novel phthalazinone derivatives, as aurora-a kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007003104A true MX2007003104A (es) | 2007-06-07 |
Family
ID=34926696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007003104A MX2007003104A (es) | 2004-09-24 | 2005-09-23 | Nuevos derivados de ftalazinona, como inhibidores de cinasa aurora-a. |
Country Status (16)
Country | Link |
---|---|
US (1) | US7226923B2 (es) |
EP (1) | EP1794148B1 (es) |
JP (1) | JP2008514564A (es) |
KR (1) | KR100907202B1 (es) |
CN (1) | CN101027290B (es) |
AR (1) | AR050948A1 (es) |
AT (1) | ATE428708T1 (es) |
AU (1) | AU2005287458A1 (es) |
BR (1) | BRPI0515885A (es) |
CA (1) | CA2580198A1 (es) |
DE (1) | DE602005013985D1 (es) |
ES (1) | ES2323885T3 (es) |
MX (1) | MX2007003104A (es) |
RU (1) | RU2397166C2 (es) |
TW (1) | TW200624431A (es) |
WO (1) | WO2006032518A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8153630B2 (en) | 2004-11-17 | 2012-04-10 | Miikana Therapeutics, Inc. | Kinase inhibitors |
KR101487027B1 (ko) | 2005-09-30 | 2015-01-28 | 미카나 테라퓨틱스, 인크. | 치환된 피라졸 화합물 |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
BRPI0708850A2 (pt) * | 2006-03-20 | 2011-06-21 | Hoffmann La Roche | derivados de ftalazinona pirazol, sua produção e uso como agentes farmacêuticos |
WO2007107469A1 (en) * | 2006-03-20 | 2007-09-27 | F. Hoffmann-La Roche Ag | Methods of inhibiting btk and syk protein kinases |
US9162953B2 (en) * | 2006-07-05 | 2015-10-20 | Centre Nationale De Recherche Scientifique | Iron-copper co-catalyzed process for carbon-carbon or carbon-heteroatom bonding |
GB0619342D0 (en) * | 2006-09-30 | 2006-11-08 | Vernalis R&D Ltd | New chemical compounds |
MX2009003793A (es) | 2006-10-09 | 2009-12-14 | Takeda Pharmaceutical | Inhibidores de cinasa. |
DE102008000872A1 (de) | 2007-04-11 | 2008-11-13 | Basf Se | Fungizide Pyridazine, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Schadpilzen sowie sie enthaltende Mittel |
EP2688565A1 (en) | 2011-03-23 | 2014-01-29 | Semorex Technologies Ltd. | Treatment of proliferative disorders with a chemiluminescent agent |
EA028156B9 (ru) | 2011-05-10 | 2018-01-31 | Джилид Сайэнс, Инк. | Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов |
TWI478908B (zh) | 2011-07-01 | 2015-04-01 | Gilead Sciences Inc | 作為離子通道調節劑之稠合雜環化合物 |
NO3175985T3 (es) | 2011-07-01 | 2018-04-28 | ||
JP6545148B2 (ja) | 2013-03-13 | 2019-07-17 | フラットリー ディスカバリー ラブ,エルエルシー | ピリダジノン化合物及び嚢胞性線維症の治療のための方法 |
BR112016014006A2 (pt) | 2013-12-18 | 2017-08-08 | Monsanto Technology Llc | Processos para a diazotização de 2,5-dicloroanilinas |
WO2016130460A2 (en) * | 2015-02-09 | 2016-08-18 | The Johns Hopkins University | Phthalazinone pyrazole derivatives for treating retinal degenerative disease |
US9957267B2 (en) | 2015-07-01 | 2018-05-01 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
RU2674761C2 (ru) * | 2016-12-21 | 2018-12-13 | федеральное государственное бюджетное образовательное учреждение высшего образования "Тольяттинский государственный университет" | Способ получения анилина и катализатор для него |
EP3658560A4 (en) | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | SOMATOSTAT IN MODULATORS AND USES THEREOF |
CN108250150B (zh) * | 2018-03-15 | 2020-12-29 | 兰州大学 | 一种肽嗪酮化合物及其制备方法与应用 |
CN111039940B (zh) * | 2019-12-31 | 2022-10-21 | 北京鑫开元医药科技有限公司 | 一种Aurora A激酶抑制剂、制备方法、药物组合物及其用途 |
CN113773263B (zh) * | 2020-06-10 | 2023-09-19 | 兰州大学 | 一种4-胺取代酞嗪酮极光激酶b抑制剂及其制备与应用 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700823A (en) | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
CN1141633A (zh) | 1994-02-23 | 1997-01-29 | 辉瑞大药厂 | 4-杂环取代的喹唑啉衍生物、它们的制备方法以及用作抗癌剂 |
JP3944241B2 (ja) | 1995-12-18 | 2007-07-11 | スージェン・インコーポレーテッド | Aur―1および/またはaur―2関連疾患の診断および処置 |
US6716575B2 (en) | 1995-12-18 | 2004-04-06 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
ITMI981671A1 (it) | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
US6180629B1 (en) * | 1998-08-14 | 2001-01-30 | Cell Pathways, Inc. | [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia |
UA71945C2 (en) | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
KR20080015482A (ko) | 1999-02-10 | 2008-02-19 | 아스트라제네카 아베 | 혈관형성 억제제로서의 퀴나졸린 유도체 |
WO2001021594A1 (en) | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline compounds and pharmaceutical compositions containing them |
CN1391562A (zh) | 1999-09-21 | 2003-01-15 | 阿斯特拉曾尼卡有限公司 | 用作药物的喹唑啉衍生物 |
GB9922171D0 (en) | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
GB9922173D0 (en) | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
WO2001055116A2 (en) | 2000-01-28 | 2001-08-02 | Astrazeneca Ab | Quinoline derivatives and their use as aurora 2 kinase inhibitors |
US7160889B2 (en) | 2000-04-07 | 2007-01-09 | Astrazeneca Ab | Quinazoline compounds |
DE60128709T2 (de) | 2000-09-15 | 2007-12-27 | Vertex Pharmaceuticals Inc., Cambridge | Triazol-verbindungen als protein-kinase-inhibitoren |
KR100947185B1 (ko) | 2000-12-21 | 2010-03-15 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 억제제로서 유용한 피라졸 화합물 및 이를 포함하는 조성물 |
DE60214703T2 (de) | 2001-06-01 | 2007-09-13 | Vertex Pharmaceuticals Inc., Cambridge | Thiazolverbindungen, die sich als inhibitoren von proteinkinasen eignen |
WO2003015785A1 (en) | 2001-08-15 | 2003-02-27 | Icos Corporation | 2h-phthalazin-1-ones and methods for use thereof |
DK1463506T3 (da) | 2001-12-24 | 2010-01-11 | Astrazeneca Ab | Substituerede quinazolin-derivater som inhibitorer af aurora-kinaser |
BR0306982A (pt) * | 2002-01-17 | 2004-10-26 | Neurogen Corp | Composto ou um sal deste farmaceuticamente aceitável, composição farmacêutica, métodos para reduzir a condutância de cálcio de um receptor da capsaicina celular, para inibir a ligação de ligando vanilóide a um receptor da capsaicina in vitro e em um paciente, para tratar uma condição responsiva à modulação do receptor da capsaicina em um paciente, para tratar a dor em um paciente, para tratar coceira em um paciente, para tratar tosse ou soluço em um paciente, promover a perda de peso em um paciente obeso, e para determinar a presença ou ausência de receptor da capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto |
AU2003220299A1 (en) | 2002-03-15 | 2003-09-29 | Vertex Pharmaceuticals, Inc. | Azinylaminoazoles as inhibitors of protein kinases |
WO2003078426A1 (en) | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Azolylaminoazine as inhibitors of protein kinases |
DE60332604D1 (de) | 2002-03-15 | 2010-07-01 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
ATE365733T1 (de) | 2002-03-15 | 2007-07-15 | Vertex Pharma | Zusammensetzungen brauchbar als protein-kinase- inhibitoren |
MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
EP1554269A1 (en) | 2002-07-09 | 2005-07-20 | Vertex Pharmaceuticals Incorporated | Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities |
-
2005
- 2005-09-21 TW TW094132585A patent/TW200624431A/zh unknown
- 2005-09-21 AR ARP050103956A patent/AR050948A1/es unknown
- 2005-09-23 BR BRPI0515885-0A patent/BRPI0515885A/pt not_active IP Right Cessation
- 2005-09-23 AT AT05785230T patent/ATE428708T1/de active
- 2005-09-23 US US11/233,311 patent/US7226923B2/en not_active Expired - Fee Related
- 2005-09-23 DE DE602005013985T patent/DE602005013985D1/de active Active
- 2005-09-23 RU RU2007115161/04A patent/RU2397166C2/ru not_active IP Right Cessation
- 2005-09-23 JP JP2007532843A patent/JP2008514564A/ja active Pending
- 2005-09-23 CN CN2005800319622A patent/CN101027290B/zh not_active Expired - Fee Related
- 2005-09-23 KR KR1020077006776A patent/KR100907202B1/ko not_active IP Right Cessation
- 2005-09-23 WO PCT/EP2005/010311 patent/WO2006032518A1/en active Application Filing
- 2005-09-23 CA CA002580198A patent/CA2580198A1/en not_active Abandoned
- 2005-09-23 ES ES05785230T patent/ES2323885T3/es active Active
- 2005-09-23 MX MX2007003104A patent/MX2007003104A/es active IP Right Grant
- 2005-09-23 AU AU2005287458A patent/AU2005287458A1/en not_active Abandoned
- 2005-09-23 EP EP05785230A patent/EP1794148B1/en not_active Not-in-force
Also Published As
Publication number | Publication date |
---|---|
KR20070046193A (ko) | 2007-05-02 |
CN101027290A (zh) | 2007-08-29 |
KR100907202B1 (ko) | 2009-07-10 |
RU2397166C2 (ru) | 2010-08-20 |
ATE428708T1 (de) | 2009-05-15 |
JP2008514564A (ja) | 2008-05-08 |
AR050948A1 (es) | 2006-12-06 |
ES2323885T3 (es) | 2009-07-27 |
TW200624431A (en) | 2006-07-16 |
US20060089359A1 (en) | 2006-04-27 |
EP1794148A1 (en) | 2007-06-13 |
EP1794148B1 (en) | 2009-04-15 |
WO2006032518A1 (en) | 2006-03-30 |
BRPI0515885A (pt) | 2008-08-12 |
AU2005287458A1 (en) | 2006-03-30 |
CA2580198A1 (en) | 2006-03-30 |
DE602005013985D1 (de) | 2009-05-28 |
RU2007115161A (ru) | 2008-11-10 |
US7226923B2 (en) | 2007-06-05 |
CN101027290B (zh) | 2010-05-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |