ATE428708T1 - Neue phthalazinonderivate als aurora-a- kinaseinhibitoren - Google Patents

Neue phthalazinonderivate als aurora-a- kinaseinhibitoren

Info

Publication number
ATE428708T1
ATE428708T1 AT05785230T AT05785230T ATE428708T1 AT E428708 T1 ATE428708 T1 AT E428708T1 AT 05785230 T AT05785230 T AT 05785230T AT 05785230 T AT05785230 T AT 05785230T AT E428708 T1 ATE428708 T1 AT E428708T1
Authority
AT
Austria
Prior art keywords
aurora
new
kinase inhibitors
phthalazinone derivatives
phthalazinone
Prior art date
Application number
AT05785230T
Other languages
English (en)
Inventor
Edward Boyd
Frederick Brookfield
Guy Georges
Bernhard Goller
Sabine Huensch
Petra Rueger
Matthias Rueth
Stefan Scheiblich
Christine Schuell
Der Saal Wolfgang Von
Justin Warne
Stefan Weigand
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE428708T1 publication Critical patent/ATE428708T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05785230T 2004-09-24 2005-09-23 Neue phthalazinonderivate als aurora-a- kinaseinhibitoren ATE428708T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04022755 2004-09-24
PCT/EP2005/010311 WO2006032518A1 (en) 2004-09-24 2005-09-23 Novel phthalazinone derivatives, as aurora-a kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE428708T1 true ATE428708T1 (de) 2009-05-15

Family

ID=34926696

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05785230T ATE428708T1 (de) 2004-09-24 2005-09-23 Neue phthalazinonderivate als aurora-a- kinaseinhibitoren

Country Status (16)

Country Link
US (1) US7226923B2 (de)
EP (1) EP1794148B1 (de)
JP (1) JP2008514564A (de)
KR (1) KR100907202B1 (de)
CN (1) CN101027290B (de)
AR (1) AR050948A1 (de)
AT (1) ATE428708T1 (de)
AU (1) AU2005287458A1 (de)
BR (1) BRPI0515885A (de)
CA (1) CA2580198A1 (de)
DE (1) DE602005013985D1 (de)
ES (1) ES2323885T3 (de)
MX (1) MX2007003104A (de)
RU (1) RU2397166C2 (de)
TW (1) TW200624431A (de)
WO (1) WO2006032518A1 (de)

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US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
CA2645728A1 (en) * 2006-03-20 2007-09-27 Edward Boyd (Deceased) Phthalazinone pyrazole derivatives, their manufacture and use as pharmaceutical agents
CA2645583A1 (en) * 2006-03-20 2007-09-27 F. Hoffman-La Roche Ag Methods of inhibiting btk and syk protein kinases
US9162953B2 (en) * 2006-07-05 2015-10-20 Centre Nationale De Recherche Scientifique Iron-copper co-catalyzed process for carbon-carbon or carbon-heteroatom bonding
GB0619342D0 (en) * 2006-09-30 2006-11-08 Vernalis R&D Ltd New chemical compounds
SG158147A1 (en) 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
DE102008000872A1 (de) 2007-04-11 2008-11-13 Basf Se Fungizide Pyridazine, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Schadpilzen sowie sie enthaltende Mittel
WO2012127441A1 (en) 2011-03-23 2012-09-27 Semorex Technologies Ltd. Treatment of proliferative disorders with a chemiluminescent agent
AU2012253653A1 (en) 2011-05-10 2013-05-02 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
NO3175985T3 (de) 2011-07-01 2018-04-28
TWI622583B (zh) 2011-07-01 2018-05-01 基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
CN105307655B (zh) 2013-03-13 2019-05-03 弗拉特利发现实验室有限责任公司 哒嗪酮化合物及其用于制备治疗囊肿状纤维化的药物的应用
CN105873900B (zh) 2013-12-18 2018-11-30 孟山都技术公司 用于使2,5-二氯苯胺重氮化的方法
WO2016130460A2 (en) * 2015-02-09 2016-08-18 The Johns Hopkins University Phthalazinone pyrazole derivatives for treating retinal degenerative disease
HK1255034A1 (zh) 2015-07-01 2019-08-02 Crinetics Pharmaceuticals, Inc. 生长抑素调节剂及其用途
RU2674761C2 (ru) * 2016-12-21 2018-12-13 федеральное государственное бюджетное образовательное учреждение высшего образования "Тольяттинский государственный университет" Способ получения анилина и катализатор для него
EP3658560A4 (de) 2017-07-25 2021-01-06 Crinetics Pharmaceuticals, Inc. Somatostatinmodulatoren und verwendungen davon
CN108250150B (zh) * 2018-03-15 2020-12-29 兰州大学 一种肽嗪酮化合物及其制备方法与应用
CN111039940B (zh) * 2019-12-31 2022-10-21 北京鑫开元医药科技有限公司 一种Aurora A激酶抑制剂、制备方法、药物组合物及其用途
CN113773263B (zh) * 2020-06-10 2023-09-19 兰州大学 一种4-胺取代酞嗪酮极光激酶b抑制剂及其制备与应用

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PT868519E (pt) 1995-12-18 2006-05-31 Sugen Inc Diagnostico e tratamento de disturbios relacionados com aur-1 e/ou aur-2
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9707800D0 (en) 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
ITMI981671A1 (it) 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
US6180629B1 (en) * 1998-08-14 2001-01-30 Cell Pathways, Inc. [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
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JP2003520855A (ja) 2000-01-28 2003-07-08 アストラゼネカ アクチボラグ 化学的化合物
US7160889B2 (en) 2000-04-07 2007-01-09 Astrazeneca Ab Quinazoline compounds
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EP1345925B1 (de) 2000-12-21 2006-05-17 Vertex Pharmaceuticals Incorporated Pyrazolverbindungen als proteinkinasehemmer
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KR101029281B1 (ko) * 2001-12-24 2011-04-18 아스트라제네카 아베 오로라 키나제의 억제제로서 치환된 퀴나졸린 유도체
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EP1485381B8 (de) 2002-03-15 2010-05-12 Vertex Pharmaceuticals Incorporated Azolylaminoazine als inhibitoren von proteinkinasen
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EP1485100B1 (de) 2002-03-15 2010-05-05 Vertex Pharmaceuticals Incorporated Azolylaminoazine als proteinkinasehemmer
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EP1554269A1 (de) 2002-07-09 2005-07-20 Vertex Pharmaceuticals Incorporated Imidazole, oxazole und thiazole mit proteinkinasehemmenden wirkungen

Also Published As

Publication number Publication date
RU2397166C2 (ru) 2010-08-20
MX2007003104A (es) 2007-06-07
WO2006032518A1 (en) 2006-03-30
TW200624431A (en) 2006-07-16
EP1794148B1 (de) 2009-04-15
AR050948A1 (es) 2006-12-06
KR20070046193A (ko) 2007-05-02
ES2323885T3 (es) 2009-07-27
EP1794148A1 (de) 2007-06-13
DE602005013985D1 (de) 2009-05-28
BRPI0515885A (pt) 2008-08-12
RU2007115161A (ru) 2008-11-10
CN101027290B (zh) 2010-05-12
US20060089359A1 (en) 2006-04-27
JP2008514564A (ja) 2008-05-08
US7226923B2 (en) 2007-06-05
AU2005287458A1 (en) 2006-03-30
KR100907202B1 (ko) 2009-07-10
CA2580198A1 (en) 2006-03-30
CN101027290A (zh) 2007-08-29

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