ATE387202T1 - Pyrrolidinderivate als histaminrezeptor-liganden - Google Patents
Pyrrolidinderivate als histaminrezeptor-ligandenInfo
- Publication number
- ATE387202T1 ATE387202T1 AT05802453T AT05802453T ATE387202T1 AT E387202 T1 ATE387202 T1 AT E387202T1 AT 05802453 T AT05802453 T AT 05802453T AT 05802453 T AT05802453 T AT 05802453T AT E387202 T1 ATE387202 T1 AT E387202T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor ligands
- histamine receptor
- pyrrolidine derivatives
- pyrrolidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0423005A GB0423005D0 (en) | 2004-10-15 | 2004-10-15 | Novel compounds |
| GB0508441A GB0508441D0 (en) | 2004-10-15 | 2005-04-26 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE387202T1 true ATE387202T1 (de) | 2008-03-15 |
Family
ID=35583486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05802453T ATE387202T1 (de) | 2004-10-15 | 2005-10-13 | Pyrrolidinderivate als histaminrezeptor-liganden |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080045506A1 (de) |
| EP (1) | EP1802307B1 (de) |
| JP (1) | JP2008516922A (de) |
| AR (1) | AR051391A1 (de) |
| AT (1) | ATE387202T1 (de) |
| DE (1) | DE602005005080T2 (de) |
| DK (1) | DK1802307T3 (de) |
| ES (1) | ES2303280T3 (de) |
| HR (1) | HRP20080227T3 (de) |
| PL (1) | PL1802307T3 (de) |
| PT (1) | PT1802307E (de) |
| SI (1) | SI1802307T1 (de) |
| WO (1) | WO2006040192A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0324159D0 (en) | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| CN103382174A (zh) | 2006-06-23 | 2013-11-06 | 雅培制药有限公司 | 作为组胺h3受体调节物的环丙胺衍生物 |
| TW200902007A (en) * | 2007-05-25 | 2009-01-16 | Astrazeneca Ab | Spirocyclopropyl piperidine derivatives |
| PT2195293E (pt) | 2007-08-22 | 2014-01-21 | Astrazeneca Ab | Derivados da ciclopropilamida |
| PE20091199A1 (es) | 2007-09-06 | 2009-09-12 | Glaxo Group Ltd | Derivado de piperazina que tiene afinidad por el receptor de histamina h3 |
| MX2010008700A (es) | 2008-02-22 | 2010-08-30 | Hoffmann La Roche | Moduladores de beta-amiloide. |
| WO2009135842A1 (en) | 2008-05-08 | 2009-11-12 | Evotec Neurosciences Gmbh | Azetidines and cyclobutanes as histamine h3 receptor antagonists |
| WO2009143153A1 (en) * | 2008-05-23 | 2009-11-26 | Janssen Pharmaceutica Nv | Substituted pyrrolidine amides as modulators of the histamine h3 receptor |
| ES2421920T3 (es) * | 2008-08-06 | 2013-09-06 | Pfizer Ltd | Compuestos de diazepina y diazocano como agonistas de MC4 |
| AU2009301210B2 (en) | 2008-10-09 | 2014-05-15 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| MX2011004954A (es) | 2008-11-10 | 2011-05-30 | Hoffmann La Roche | Moduladores heterociclicos de gamma-secretasa. |
| US20100130477A1 (en) * | 2008-11-25 | 2010-05-27 | Astrazeneca Ab | Spirocyclobutyl Piperidine Derivatives |
| US8912176B2 (en) | 2009-02-02 | 2014-12-16 | Evotec Ag | Azetidines as histamine H3 receptor antagonists |
| TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| WO2011016559A1 (ja) * | 2009-08-07 | 2011-02-10 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| RU2012136148A (ru) | 2010-02-18 | 2014-03-27 | Астразенека Аб | Новая кристаллическая форма производного циклопропилбензамида |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| EP2647377A1 (de) | 2012-04-06 | 2013-10-09 | Sanofi | Verwendung eines H3-Rezeptorantagonisten zur Behandlung von Morbus Alzheimer |
| CN116615417B (zh) * | 2022-03-31 | 2024-05-14 | 广州必贝特医药股份有限公司 | 1,4-二杂环基取代芳环或芳杂环类化合物及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000029984A (ko) * | 1996-08-14 | 2000-05-25 | 사라 엔 람베쓰 | 치환된피리미딘유도체및이의약학적용도 |
| DE10034338C2 (de) * | 2000-07-14 | 2002-06-20 | Forschungszentrum Juelich Gmbh | Mehrpoliges kaskadierendes Quardrupel-Bandpaßfilter auf der Basis dielektrischer Dual-Mode-Resonatoren |
| JPWO2003062234A1 (ja) * | 2002-01-23 | 2005-05-19 | 山之内製薬株式会社 | キノキサリン化合物 |
| CA2504272A1 (en) * | 2002-10-23 | 2004-05-06 | Janssen Pharmaceutica, N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
| AR044045A1 (es) * | 2003-04-23 | 2005-08-24 | Glaxo Group Ltd | Compuesto de piperidincarbonilpiperazina, composicion farmaceutica que lo comprende, su uso para la elaboracion de un medicamento y procedimiento para su preparacion |
-
2005
- 2005-10-13 PT PT05802453T patent/PT1802307E/pt unknown
- 2005-10-13 AT AT05802453T patent/ATE387202T1/de not_active IP Right Cessation
- 2005-10-13 WO PCT/EP2005/011371 patent/WO2006040192A1/en active IP Right Grant
- 2005-10-13 PL PL05802453T patent/PL1802307T3/pl unknown
- 2005-10-13 EP EP05802453A patent/EP1802307B1/de active Active
- 2005-10-13 JP JP2007536122A patent/JP2008516922A/ja not_active Withdrawn
- 2005-10-13 ES ES05802453T patent/ES2303280T3/es active Active
- 2005-10-13 US US11/576,968 patent/US20080045506A1/en not_active Abandoned
- 2005-10-13 DE DE602005005080T patent/DE602005005080T2/de active Active
- 2005-10-13 DK DK05802453T patent/DK1802307T3/da active
- 2005-10-13 AR ARP050104299A patent/AR051391A1/es unknown
- 2005-10-13 SI SI200530241T patent/SI1802307T1/sl unknown
-
2008
- 2008-05-23 HR HR20080227T patent/HRP20080227T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2303280T3 (es) | 2008-08-01 |
| EP1802307A1 (de) | 2007-07-04 |
| PT1802307E (pt) | 2008-06-06 |
| HRP20080227T3 (en) | 2008-06-30 |
| DE602005005080T2 (de) | 2009-02-26 |
| PL1802307T3 (pl) | 2008-07-31 |
| EP1802307B1 (de) | 2008-02-27 |
| US20080045506A1 (en) | 2008-02-21 |
| DE602005005080D1 (de) | 2008-04-10 |
| WO2006040192A1 (en) | 2006-04-20 |
| SI1802307T1 (sl) | 2008-08-31 |
| AR051391A1 (es) | 2007-01-10 |
| JP2008516922A (ja) | 2008-05-22 |
| DK1802307T3 (da) | 2008-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE387202T1 (de) | Pyrrolidinderivate als histaminrezeptor-liganden | |
| IL180548A0 (en) | Piperidine derivatives as histamine h3 receptor ligands | |
| ATE394391T1 (de) | Indolderivate als histaminrezeptorantagonisten | |
| ATE400271T1 (de) | Aryl-pyridinderivate als 11-beta-hsd1-hemmer | |
| ATE520671T1 (de) | Pyrimidin-harnstoff-derivate als kinase-hemmer | |
| ATE420076T1 (de) | Indozolonderivate als 11b-hsd1-inhibitoren | |
| DE602005026391D1 (de) | Chinazolinonderivate als parp-hemmer | |
| DE602005015962D1 (de) | Indolylderivate als liver-x-rezeptormodulatoren | |
| DE602006015607D1 (de) | Thiazol-4-carboxamid-derivate als mglur5-antagonisten | |
| IS8578A (is) | 3- karbamoýl - 2- pýridón afleiður | |
| ATE394399T1 (de) | Tetrahydropyridoindolderivate | |
| ATE383361T1 (de) | Pyrrazolopyrimidinderivate | |
| DE602004015724D1 (de) | Diazepinoindolderivate als kinaseinhibitoren | |
| ATE383857T1 (de) | Als histamin-3-rezeptorliganden einsetzbare naphthalene-derivate | |
| DE602004024420D1 (de) | Chinazolinderivate als antitumormittel | |
| DE602004018629D1 (de) | 3-(1-naphthyl)-2-cyanopropansäurederivate als östrogen rezeptor liganden | |
| DK1828154T3 (da) | Phenylpiperazinmethanonderivater | |
| ATE425167T1 (de) | Neue pyridothienopyrimidinderivate | |
| ATE404542T1 (de) | 4-phenylpyrimidin-2-carbonitrilderivate | |
| BRPI0509256A (pt) | derivados de pirrolidina-3,4-dicarboxamida | |
| DE602006003666D1 (de) | Indol-3-ylcarbonylpiperidinbenzimidazolderivate als v1a-rezeptorantagonisten | |
| ATE377008T1 (de) | Imidazolderivate als glutamatrezeptorantagonisten | |
| DE112005002826A5 (de) | Ausgleichseinheit | |
| NO20070299L (no) | Novel heterocyclic compounds | |
| ATE365731T1 (de) | 4-amino-5-cyanopyrimidinderivate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1802307 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |