ATE394391T1 - Indolderivate als histaminrezeptorantagonisten - Google Patents
Indolderivate als histaminrezeptorantagonistenInfo
- Publication number
- ATE394391T1 ATE394391T1 AT05756581T AT05756581T ATE394391T1 AT E394391 T1 ATE394391 T1 AT E394391T1 AT 05756581 T AT05756581 T AT 05756581T AT 05756581 T AT05756581 T AT 05756581T AT E394391 T1 ATE394391 T1 AT E394391T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- indole derivatives
- histamine receptor
- histamine
- indole
- Prior art date
Links
- 229940122236 Histamine receptor antagonist Drugs 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04102839 | 2004-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE394391T1 true ATE394391T1 (de) | 2008-05-15 |
Family
ID=34982342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05756581T ATE394391T1 (de) | 2004-06-21 | 2005-06-13 | Indolderivate als histaminrezeptorantagonisten |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7361682B2 (de) |
| EP (1) | EP1761519B1 (de) |
| JP (1) | JP4652404B2 (de) |
| CN (1) | CN1972926B (de) |
| AR (1) | AR049696A1 (de) |
| AT (1) | ATE394391T1 (de) |
| AU (1) | AU2005254658B2 (de) |
| BR (1) | BRPI0512335A (de) |
| CA (1) | CA2569611C (de) |
| DE (1) | DE602005006567D1 (de) |
| DK (1) | DK1761519T3 (de) |
| ES (1) | ES2306170T3 (de) |
| IL (1) | IL179737A (de) |
| MX (1) | MXPA06014810A (de) |
| MY (1) | MY139941A (de) |
| NO (1) | NO20070336L (de) |
| NZ (1) | NZ551663A (de) |
| PL (1) | PL1761519T3 (de) |
| PT (1) | PT1761519E (de) |
| RU (1) | RU2382778C2 (de) |
| TW (1) | TW200612936A (de) |
| WO (1) | WO2005123716A1 (de) |
| ZA (1) | ZA200610416B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1841734B1 (de) | 2005-01-19 | 2009-07-29 | F. Hoffmann-Roche AG | 5-aminoindol-derivate |
| EP1960383B1 (de) * | 2005-11-30 | 2010-04-28 | F. Hoffmann-la Roche AG | 5-substituierte indol-2-carbonsäureamidderivate |
| WO2007062997A1 (en) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators |
| WO2007062999A2 (en) * | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 1,5-substituted indol-2-yl amide derivatives |
| KR20090024115A (ko) | 2006-04-12 | 2009-03-06 | 에프. 호프만-라 로슈 아게 | 5-아미도-2-카복스아마이드 인돌 |
| US7432255B2 (en) | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| US7514433B2 (en) * | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| EP2684871B1 (de) | 2006-12-19 | 2016-05-04 | F. Hoffmann-La Roche AG | Heteroarylpyrrolidinyl- und Piperidinylketonderivate |
| ES2627221T3 (es) | 2006-12-28 | 2017-07-27 | Rigel Pharmaceuticals, Inc. | Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso |
| US7507736B2 (en) * | 2007-02-07 | 2009-03-24 | Hoffmann-La Roche Inc. | Indol-2-yl-piperazin-1-yl-methanone derivatives |
| US7648979B2 (en) * | 2007-02-07 | 2010-01-19 | Hoffmann-La Roche Inc. | 5-amido-(1H-indol-2-yl)-piperazin-1-yl-methanone derivatives |
| US7557108B2 (en) * | 2007-02-07 | 2009-07-07 | Hoffmann-La Roche Inc. | (Indol-4-yl) or (indol-5-yl)-piperazinylmethanones |
| EP2125720A1 (de) * | 2007-03-01 | 2009-12-02 | Janssen Pharmaceutica, N.V. | Indol- und benzothiophenverbindungen als modulatoren des histamin-h3-rezeptors |
| EP2183237A1 (de) * | 2007-07-25 | 2010-05-12 | F. Hoffmann-Roche AG | Benzofuran- und benzo[b]thiophen-2-carbonsäureamidderivate und deren verwendung als modulatoren des histamin-3-rezeptors |
| JP5327051B2 (ja) * | 2007-08-31 | 2013-10-30 | アステラス製薬株式会社 | ピペリジン誘導体 |
| BRPI0820171B8 (pt) | 2007-11-16 | 2021-05-25 | Rigel Pharmaceuticals Inc | compostos de carboxamida, sulfonamida e amina para distúrbios metabólicos, composição farmacêutica, e, uso dos mesmos |
| WO2009076631A1 (en) | 2007-12-12 | 2009-06-18 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| CN104016980B (zh) * | 2008-04-23 | 2016-12-07 | 里格尔药品股份有限公司 | 用于治疗代谢障碍的甲酰胺化合物 |
| US20100035862A1 (en) * | 2008-06-25 | 2010-02-11 | Abbott Laboratories | Novel aza-cyclic indole-2-carboxamides and methods of use thereof |
| FR2950053B1 (fr) * | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| CA2878217C (en) * | 2012-08-23 | 2016-05-17 | Suven Life Sciences Limited | Acrylamide compounds as histamine h3 receptor ligands |
| EP2722329A1 (de) * | 2012-10-18 | 2014-04-23 | F. Hoffmann-La Roche AG | Indolamidverbindungen als beta-Amyloid Inhbitoren |
| KR101551313B1 (ko) * | 2014-07-28 | 2015-09-09 | 충남대학교산학협력단 | 신규한 인덴 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 망막 질환의 예방 또는 치료용 약학적 조성물 |
| CN106065008B (zh) * | 2016-06-16 | 2018-06-05 | 黑龙江中医药大学 | 一种具有改善睡眠作用的吲哚-2-酰胺类化合物及其应用 |
| BR112019016775A2 (pt) | 2017-02-17 | 2020-03-31 | Trevena, Inc. | Compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 7 membros, métodos de uso e produção dos mesmos |
| KR20190129867A (ko) | 2017-02-17 | 2019-11-20 | 트레베나, 인코포레이티드. | 5-원 아자-헤테로고리 함유 델타-오피오이드 수용체 조절 화합물, 및 그의 사용 및 제조 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2705095B1 (fr) * | 1993-05-12 | 1995-06-23 | Adir | Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| EP0978512A1 (de) * | 1998-07-29 | 2000-02-09 | Societe Civile Bioprojet | Aryloxy- (oder Arylthio)alkylamine ohne Imidazolring als Histamin-H3-Antagonisten und deren therapeutische Anwendung |
| ES2325477T3 (es) * | 2000-03-31 | 2009-09-07 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indoles sustituidos por fenilo como antagonistas del receptor de histamina h3. |
| HU227197B1 (en) * | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| JP4544820B2 (ja) * | 2001-03-09 | 2010-09-15 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 複素環化合物 |
| US6673829B2 (en) * | 2001-09-14 | 2004-01-06 | Novo Nordisk A/S | Aminoazetidine,-pyrrolidine and -piperidine derivatives |
| AU2003243709B2 (en) * | 2002-06-24 | 2007-01-18 | Schering Corporation | Indole derivatives useful as histamine H3 antagonists |
-
2005
- 2005-06-13 CN CN2005800204455A patent/CN1972926B/zh not_active Expired - Fee Related
- 2005-06-13 ES ES05756581T patent/ES2306170T3/es active Active
- 2005-06-13 PL PL05756581T patent/PL1761519T3/pl unknown
- 2005-06-13 CA CA2569611A patent/CA2569611C/en not_active Expired - Fee Related
- 2005-06-13 AU AU2005254658A patent/AU2005254658B2/en not_active Ceased
- 2005-06-13 JP JP2007517135A patent/JP4652404B2/ja not_active Expired - Fee Related
- 2005-06-13 PT PT05756581T patent/PT1761519E/pt unknown
- 2005-06-13 MX MXPA06014810A patent/MXPA06014810A/es active IP Right Grant
- 2005-06-13 EP EP05756581A patent/EP1761519B1/de active Active
- 2005-06-13 DE DE602005006567T patent/DE602005006567D1/de active Active
- 2005-06-13 NZ NZ551663A patent/NZ551663A/en unknown
- 2005-06-13 DK DK05756581T patent/DK1761519T3/da active
- 2005-06-13 BR BRPI0512335-6A patent/BRPI0512335A/pt not_active IP Right Cessation
- 2005-06-13 RU RU2007102224/04A patent/RU2382778C2/ru not_active IP Right Cessation
- 2005-06-13 AT AT05756581T patent/ATE394391T1/de active
- 2005-06-13 WO PCT/EP2005/006303 patent/WO2005123716A1/en active IP Right Grant
- 2005-06-17 AR ARP050102510A patent/AR049696A1/es not_active Application Discontinuation
- 2005-06-20 TW TW094120464A patent/TW200612936A/zh unknown
- 2005-06-20 US US11/157,093 patent/US7361682B2/en not_active Expired - Fee Related
- 2005-06-20 MY MYPI20052800A patent/MY139941A/en unknown
-
2006
- 2006-11-30 IL IL179737A patent/IL179737A/en not_active IP Right Cessation
- 2006-12-12 ZA ZA200610416A patent/ZA200610416B/xx unknown
-
2007
- 2007-01-18 NO NO20070336A patent/NO20070336L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1761519B1 (de) | 2008-05-07 |
| ES2306170T3 (es) | 2008-11-01 |
| CN1972926B (zh) | 2011-02-16 |
| TW200612936A (en) | 2006-05-01 |
| DE602005006567D1 (de) | 2008-06-19 |
| RU2382778C2 (ru) | 2010-02-27 |
| ZA200610416B (en) | 2008-09-25 |
| DK1761519T3 (da) | 2008-07-21 |
| US7361682B2 (en) | 2008-04-22 |
| JP2008503511A (ja) | 2008-02-07 |
| MXPA06014810A (es) | 2007-02-12 |
| US20050282864A1 (en) | 2005-12-22 |
| PL1761519T3 (pl) | 2008-09-30 |
| AU2005254658B2 (en) | 2011-06-16 |
| PT1761519E (pt) | 2008-07-02 |
| CA2569611C (en) | 2012-12-11 |
| AU2005254658A1 (en) | 2005-12-29 |
| WO2005123716A1 (en) | 2005-12-29 |
| RU2007102224A (ru) | 2008-07-27 |
| IL179737A0 (en) | 2007-05-15 |
| CN1972926A (zh) | 2007-05-30 |
| JP4652404B2 (ja) | 2011-03-16 |
| BRPI0512335A (pt) | 2008-03-04 |
| EP1761519A1 (de) | 2007-03-14 |
| NZ551663A (en) | 2009-09-25 |
| IL179737A (en) | 2011-12-29 |
| NO20070336L (no) | 2007-02-13 |
| CA2569611A1 (en) | 2005-12-29 |
| AR049696A1 (es) | 2006-08-30 |
| MY139941A (en) | 2009-11-30 |
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