ATE495168T1 - Heteroarylsubstituierte imidazolderivate als glutamatrezeptorantagonisten - Google Patents
Heteroarylsubstituierte imidazolderivate als glutamatrezeptorantagonistenInfo
- Publication number
- ATE495168T1 ATE495168T1 AT04739649T AT04739649T ATE495168T1 AT E495168 T1 ATE495168 T1 AT E495168T1 AT 04739649 T AT04739649 T AT 04739649T AT 04739649 T AT04739649 T AT 04739649T AT E495168 T1 ATE495168 T1 AT E495168T1
- Authority
- AT
- Austria
- Prior art keywords
- glutama
- heteroaryl
- receptor antagonists
- imidazole derivatives
- substituted imidazole
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03012290 | 2003-06-12 | ||
| PCT/EP2004/006111 WO2004111040A1 (en) | 2003-06-12 | 2004-06-07 | Heteroaryl-substituted imdazole derivatives as glutamate receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE495168T1 true ATE495168T1 (de) | 2011-01-15 |
Family
ID=33495606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04739649T ATE495168T1 (de) | 2003-06-12 | 2004-06-07 | Heteroarylsubstituierte imidazolderivate als glutamatrezeptorantagonisten |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7241760B2 (de) |
| EP (1) | EP1670784B1 (de) |
| JP (1) | JP4395512B2 (de) |
| KR (1) | KR100717914B1 (de) |
| CN (1) | CN100462363C (de) |
| AR (1) | AR044657A1 (de) |
| AT (1) | ATE495168T1 (de) |
| AU (1) | AU2004247368B2 (de) |
| BR (1) | BRPI0411350A (de) |
| CA (1) | CA2527587C (de) |
| CL (1) | CL2004001430A1 (de) |
| CO (1) | CO5660263A2 (de) |
| DE (1) | DE602004031030D1 (de) |
| ES (1) | ES2358512T3 (de) |
| HK (1) | HK1093071A1 (de) |
| IL (1) | IL172080A (de) |
| MX (1) | MXPA05013233A (de) |
| MY (1) | MY140206A (de) |
| NO (1) | NO332175B1 (de) |
| NZ (1) | NZ543638A (de) |
| RU (1) | RU2327697C2 (de) |
| TW (1) | TWI336700B (de) |
| WO (1) | WO2004111040A1 (de) |
| ZA (1) | ZA200509908B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7452909B2 (en) * | 2003-09-04 | 2008-11-18 | Hoffman-La Roche Inc. | Imidazole derivatives |
| MX2007011483A (es) * | 2005-03-23 | 2007-10-12 | Hoffmann La Roche | Derivados de acetilenil-pirazolo-pirimidina como antagonistas de glutamato metabotropico 2. |
| CA2623721C (en) | 2005-09-27 | 2014-05-13 | F. Hoffmann-La Roche Ag | Oxadiazolyl pyrazolo-pyrimidines as mglur2 antagonists |
| DE102006011574A1 (de) * | 2006-03-10 | 2007-10-31 | Grünenthal GmbH | Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln |
| WO2009024491A1 (en) * | 2007-08-20 | 2009-02-26 | F. Hoffmann-La Roche Ag | Use of mglur5 antagonists for the treatment of gerd |
| US8334287B2 (en) * | 2009-07-17 | 2012-12-18 | Hoffmann-La Roche Inc. | Imidazoles |
| US9447099B2 (en) | 2011-10-04 | 2016-09-20 | Hoffmann-La Roche Inc. | Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine |
| CN114746408A (zh) * | 2019-12-02 | 2022-07-12 | 豪夫迈·罗氏有限公司 | 炔基-(杂芳基)-甲酰胺hcn1抑制剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5354867A (en) * | 1988-12-06 | 1994-10-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| US6774138B2 (en) * | 1999-08-31 | 2004-08-10 | Merck & Co., Inc. | Thiazolyl(pyridyl)ethyne compounds |
| JP4815083B2 (ja) * | 1999-08-31 | 2011-11-16 | メルク・シャープ・エンド・ドーム・コーポレイション | 複素環化合物およびそれの使用方法 |
| ES2346513T3 (es) * | 2000-07-24 | 2010-10-18 | Krenitsky Pharmaceuticals, Inc. | 5-alquinil pirimidinas sustituidas que tienen actividad neurotrofica. |
| DE10040683C2 (de) * | 2000-08-19 | 2002-06-27 | Hinderer & Muehlich Kg | Verfahren zum Positionieren einer Patrize an einer Gegendruckwalze einer Prägestation |
| WO2002046166A1 (en) * | 2000-12-04 | 2002-06-13 | F. Hoffmann-La Roche Ag | Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists |
-
2004
- 2004-06-07 ES ES04739649T patent/ES2358512T3/es not_active Expired - Lifetime
- 2004-06-07 DE DE602004031030T patent/DE602004031030D1/de not_active Expired - Lifetime
- 2004-06-07 BR BRPI0411350-0A patent/BRPI0411350A/pt not_active IP Right Cessation
- 2004-06-07 AT AT04739649T patent/ATE495168T1/de active
- 2004-06-07 AU AU2004247368A patent/AU2004247368B2/en not_active Ceased
- 2004-06-07 EP EP04739649A patent/EP1670784B1/de not_active Expired - Lifetime
- 2004-06-07 WO PCT/EP2004/006111 patent/WO2004111040A1/en active IP Right Grant
- 2004-06-07 JP JP2006515286A patent/JP4395512B2/ja not_active Expired - Fee Related
- 2004-06-07 KR KR1020057023885A patent/KR100717914B1/ko not_active IP Right Cessation
- 2004-06-07 CN CNB2004800158698A patent/CN100462363C/zh not_active Expired - Fee Related
- 2004-06-07 CA CA2527587A patent/CA2527587C/en not_active Expired - Fee Related
- 2004-06-07 RU RU2006100106/04A patent/RU2327697C2/ru not_active IP Right Cessation
- 2004-06-07 NZ NZ543638A patent/NZ543638A/en not_active IP Right Cessation
- 2004-06-07 MX MXPA05013233A patent/MXPA05013233A/es active IP Right Grant
- 2004-06-09 CL CL200401430A patent/CL2004001430A1/es unknown
- 2004-06-09 TW TW093116555A patent/TWI336700B/zh not_active IP Right Cessation
- 2004-06-10 MY MYPI20042241A patent/MY140206A/en unknown
- 2004-06-10 AR ARP040102004A patent/AR044657A1/es active IP Right Grant
- 2004-06-12 US US10/866,255 patent/US7241760B2/en not_active Expired - Fee Related
-
2005
- 2005-11-21 IL IL172080A patent/IL172080A/en not_active IP Right Cessation
- 2005-12-05 CO CO05123374A patent/CO5660263A2/es active IP Right Grant
- 2005-12-05 NO NO20055758A patent/NO332175B1/no not_active IP Right Cessation
- 2005-12-06 ZA ZA200509908A patent/ZA200509908B/xx unknown
-
2006
- 2006-12-18 HK HK06113875.7A patent/HK1093071A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE384053T1 (de) | Triazolderivate als tachykininrezeptor- antagonisten | |
| CY2017032I2 (el) | Παραγωγα (θειο)καρβαμοϋλ-κυκλοεξανιου ως ανταγωνιστες των υποδοχεων d3/d2 | |
| ATE394391T1 (de) | Indolderivate als histaminrezeptorantagonisten | |
| ATE461191T1 (de) | N-substituierte 2-oxodihydropyridinderivate als npy antagonisten | |
| ATE518834T1 (de) | 2,3,4,9-tetrahydro-1h-carbazol-derivative als crth2-rezeptorantagonisten | |
| DK1951660T3 (da) | Histamin-3-receptorantagonister | |
| DE602006015607D1 (de) | Thiazol-4-carboxamid-derivate als mglur5-antagonisten | |
| ATE387202T1 (de) | Pyrrolidinderivate als histaminrezeptor-liganden | |
| HK1093070A1 (en) | Imidazole derivatives as glutamate receptor antagonists | |
| DE60320529D1 (de) | Chinolinderivate als npy antagonisten | |
| ATE427299T1 (de) | Indol-2-carboxamidin-derivate als antagonisten der nmda-rezeptoren | |
| ATE555111T1 (de) | Chinuclidinol-derivate als muscarinrezeptor- antagonisten | |
| DE602006004768D1 (de) | Carboxamid derivate als muskarin rezeptor antagonisten | |
| DE60316411D1 (de) | Thiazolderivate als npy-rezeptorantagonisten | |
| ATE414078T1 (de) | Indol-3-ylcarbonylpiperidinbenzimidazolderivate als v1a-rezeptorantagonisten | |
| NO20055758D0 (no) | Heteroarylsubstituerte imidazolderivater som glutamatreseptorantagonister | |
| DE60305058D1 (de) | Imidazoquinoline derivate als adenosine a3 rezeptor liganden | |
| ATE488519T1 (de) | Indol-3-ylcarbonylazaspiroderivate als vasopressinrezeptorantagonisten | |
| ATE427945T1 (de) | Imidazolderivate | |
| ATE425161T1 (de) | Mercaptoimidazole als ccr2-rezeptorantagonisten | |
| DE60336672D1 (de) | Harnstoffderivate als IL-8-Rezeptorantagonisten | |
| ATE411989T1 (de) | Mercaptoimidazole als ccr2-rezeptorantagonisten | |
| ATE528291T1 (de) | Cyclopropylderivate als nk3 rezeptor-antagonisten | |
| DE602004008447D1 (de) | 7-(ä1,4üdioxan-2-yl)-benzothiazol derivative als adenosin-rezeptoren liganden | |
| ATE398620T1 (de) | Spirokondensierte indolinderivate als pestizide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1670784 Country of ref document: EP |