MX2009002010A - Derivados de heteroarilo como inhibidores de la proteina cinasa. - Google Patents

Derivados de heteroarilo como inhibidores de la proteina cinasa.

Info

Publication number
MX2009002010A
MX2009002010A MX2009002010A MX2009002010A MX2009002010A MX 2009002010 A MX2009002010 A MX 2009002010A MX 2009002010 A MX2009002010 A MX 2009002010A MX 2009002010 A MX2009002010 A MX 2009002010A MX 2009002010 A MX2009002010 A MX 2009002010A
Authority
MX
Mexico
Prior art keywords
protein kinase
kinase inhibitors
heteroaryl derivatives
compounds
mentioned compounds
Prior art date
Application number
MX2009002010A
Other languages
English (en)
Inventor
Stefan Scheiblich
Konrad Honold
Wolfgang Schaefer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009002010A publication Critical patent/MX2009002010A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se relaciona con los compuestos de la fórmula I sus sales farmacéuticamente aceptables, formas enantioméricas, diastereoisómeros y racetamos, la preparación de los compuestos mencionados anteriormente, medicamentos que los contienen y su manufactura, así como el uso de los compuestos mencionados anteriormente en el control o prevención de enfermedades, tal como cáncer.
MX2009002010A 2006-09-06 2007-09-04 Derivados de heteroarilo como inhibidores de la proteina cinasa. MX2009002010A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06018627 2006-09-06
PCT/EP2007/007691 WO2008028617A1 (en) 2006-09-06 2007-09-04 Heteroaryl derivatives as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2009002010A true MX2009002010A (es) 2009-03-05

Family

ID=37668072

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002010A MX2009002010A (es) 2006-09-06 2007-09-04 Derivados de heteroarilo como inhibidores de la proteina cinasa.

Country Status (11)

Country Link
US (1) US8067599B2 (es)
EP (1) EP2064213A1 (es)
JP (1) JP2010502660A (es)
KR (1) KR101104666B1 (es)
CN (1) CN101511828A (es)
AU (1) AU2007294149A1 (es)
BR (1) BRPI0716477A2 (es)
CA (1) CA2662031A1 (es)
IL (1) IL196554A0 (es)
MX (1) MX2009002010A (es)
WO (1) WO2008028617A1 (es)

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CN101511828A (zh) 2006-09-06 2009-08-19 霍夫曼-拉罗奇有限公司 作为蛋白激酶抑制剂的杂芳基衍生物
WO2008144253A1 (en) * 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
US20110003809A1 (en) * 2008-02-29 2011-01-06 Array Biopharma Inc. Imidazo [4,5-b] pyridine derivatives used as raf inhibitors
AU2009222144A1 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Pyrazole [3, 4-b] pyridine Raf inhibitors
WO2009111280A1 (en) 2008-02-29 2009-09-11 Array Biopharma Inc. N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer
CL2009000447A1 (es) 2008-02-29 2010-01-04 Array Biopharma Inc Y Genentech Inc Compuestos derivados de (1h-pirrolo{2,3-b}piridin-5-il)-sulfonamido-benzamida sustituida; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer, a travez de la inhibicion de raf.
KR100970670B1 (ko) 2008-04-22 2010-07-15 계명대학교 산학협력단 세포증식 억제제로서 유용한 벤즈아미드 유도체 및 그제조방법
FR2941948B1 (fr) 2009-02-12 2013-04-05 Nova Decision Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
US20120157451A1 (en) 2009-08-28 2012-06-21 Genentech, Inc Raf inhibitor compounds and methods of use thereof
JP2013503187A (ja) 2009-08-28 2013-01-31 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害化合物およびその使用方法
JP2013503193A (ja) 2009-08-28 2013-01-31 ジェネンテック， インコーポレイテッド Ｒａｆ阻害剤化合物およびその使用方法
WO2011025968A1 (en) 2009-08-28 2011-03-03 Array Biopharma Inc. 1h-pyrazolo [ 3, 4-b] pyridine compounds for inhibiting raf kinase
CN102712646A (zh) 2009-08-28 2012-10-03 阵列生物制药公司 Raf抑制剂化合物及其使用方法
JP2013503189A (ja) 2009-08-28 2013-01-31 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害化合物およびその使用方法
US8883819B2 (en) * 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
FR2984325A1 (fr) * 2011-12-14 2013-06-21 Sanofi Sa Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique
US10138235B2 (en) 2011-12-14 2018-11-27 Sanofi Pyrazolopyridine derivatives, preparation process therefor and therapeutic use thereof
SI2797888T1 (sl) 2011-12-31 2017-01-31 BeiGene, Ltd. Mourant Ozannes Corporate Services (Cayman) Limited Zlite triciklične spojine kot inhibitorji kinaze raf
CN102659778A (zh) * 2012-03-22 2012-09-12 盛世泰科生物医药技术(苏州)有限公司 6-氨基-2-甲基-3H-咪唑并[4,5-b]吡啶的合成新工艺
FR3000493A1 (fr) * 2012-12-28 2014-07-04 Oribase Pharma Nouveaux inhibiteurs de proteines kinases
FR3000492B1 (fr) * 2012-12-28 2015-09-11 Oribase Pharma Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
FR3000494B1 (fr) * 2012-12-28 2015-08-21 Oribase Pharma Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
WO2014134391A1 (en) 2013-02-28 2014-09-04 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
JP6380862B2 (ja) 2013-06-28 2018-08-29 ベイジーン リミテッド 複数種類のキナーゼの阻害剤としての縮合三環式アミド系化合物
KR102272606B1 (ko) 2013-06-28 2021-07-05 베이진 엘티디 Raf 키나아제 및/또는 raf 키나아제 이량체 저해제로서 융합 트리시클릭 우레아 화합물
AU2016247768B2 (en) * 2015-04-17 2019-03-07 Corteva Agriscience Llc Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
US20200247794A1 (en) * 2015-10-22 2020-08-06 Mangosuthu University Of Technology Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of cyp17a1 and cyp19a1
NZ753358A (en) 2016-10-12 2022-07-29 Corteva Agriscience Llc Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
TWI758313B (zh) 2016-10-12 2022-03-21 美商陶氏農業科學公司 一種用於製備(1r,3r)-及(1s,3s)-2,2-二鹵基-3-(經取代之苯基)環丙烷甲酸的方法
CN111757883B (zh) * 2018-02-23 2024-02-13 弗劳恩霍夫应用研究促进协会 用于治疗牙周疾病和相关疾病的细菌谷氨酰胺酰环化酶的新抑制剂

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US6849713B2 (en) * 2000-06-27 2005-02-01 Genelabs Technologies, Inc. Compounds possessing antibacterial, antifungal or antitumor activity
TWI276631B (en) 2002-09-12 2007-03-21 Avanir Pharmaceuticals Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation
GB0330043D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
EP1833829A2 (en) * 2004-12-23 2007-09-19 F. Hoffmann-Roche AG Benzamide substituted imidazo- and pyrrolo-pyridines as protein kinase inhibitors
CN101830899A (zh) * 2004-12-23 2010-09-15 霍夫曼-拉罗奇有限公司 杂环氨基甲酸酯衍生物,它们的制备及作为药剂的应用
JP2009502843A (ja) * 2005-07-29 2009-01-29 エフ．ホフマン−ラ ロシュ アーゲー アザベンズイミダゾール誘導体、それらの製造、及び抗癌剤としての使用
CN101511828A (zh) 2006-09-06 2009-08-19 霍夫曼-拉罗奇有限公司 作为蛋白激酶抑制剂的杂芳基衍生物

Also Published As

Publication number Publication date
BRPI0716477A2 (pt) 2014-03-18
CN101511828A (zh) 2009-08-19
KR101104666B1 (ko) 2012-01-13
AU2007294149A1 (en) 2008-03-13
EP2064213A1 (en) 2009-06-03
US20090318428A1 (en) 2009-12-24
CA2662031A1 (en) 2008-03-13
WO2008028617A1 (en) 2008-03-13
JP2010502660A (ja) 2010-01-28
IL196554A0 (en) 2009-11-18
KR20090038487A (ko) 2009-04-20
US8067599B2 (en) 2011-11-29

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