CY1111850T1 - Παραγωγα κυκλικου αμιδιου, και η παραγωγη και χρηση τους ως αντιθρομβωτικοι παραγοντες - Google Patents
Παραγωγα κυκλικου αμιδιου, και η παραγωγη και χρηση τους ως αντιθρομβωτικοι παραγοντεςInfo
- Publication number
- CY1111850T1 CY1111850T1 CY20111100894T CY111100894T CY1111850T1 CY 1111850 T1 CY1111850 T1 CY 1111850T1 CY 20111100894 T CY20111100894 T CY 20111100894T CY 111100894 T CY111100894 T CY 111100894T CY 1111850 T1 CY1111850 T1 CY 1111850T1
- Authority
- CY
- Cyprus
- Prior art keywords
- optionally substituted
- thumpty
- agents
- products
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004152000 | 2004-05-21 | ||
| EP05743594A EP1748985B1 (en) | 2004-05-21 | 2005-05-20 | Cyclic amide derivatives, and their production and use as antithrombotic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111850T1 true CY1111850T1 (el) | 2015-10-07 |
Family
ID=34968275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111100894T CY1111850T1 (el) | 2004-05-21 | 2011-09-15 | Παραγωγα κυκλικου αμιδιου, και η παραγωγη και χρηση τους ως αντιθρομβωτικοι παραγοντες |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US7745623B2 (OSRAM) |
| EP (2) | EP2208726B1 (OSRAM) |
| JP (2) | JP4129047B2 (OSRAM) |
| KR (1) | KR101248637B1 (OSRAM) |
| CN (2) | CN1989104B (OSRAM) |
| AT (1) | ATE513813T1 (OSRAM) |
| AU (1) | AU2005245298B2 (OSRAM) |
| BR (1) | BRPI0511186A (OSRAM) |
| CA (1) | CA2567506C (OSRAM) |
| CY (1) | CY1111850T1 (OSRAM) |
| DK (1) | DK1748985T3 (OSRAM) |
| ES (1) | ES2368155T3 (OSRAM) |
| HR (1) | HRP20110640T1 (OSRAM) |
| IL (1) | IL178896A (OSRAM) |
| MX (1) | MXPA06013243A (OSRAM) |
| MY (1) | MY154461A (OSRAM) |
| NO (1) | NO20065929L (OSRAM) |
| NZ (1) | NZ550985A (OSRAM) |
| PH (1) | PH12012501331A1 (OSRAM) |
| PL (1) | PL1748985T3 (OSRAM) |
| PT (1) | PT1748985E (OSRAM) |
| RS (1) | RS51925B (OSRAM) |
| RU (1) | RU2361861C2 (OSRAM) |
| SI (1) | SI1748985T1 (OSRAM) |
| TW (1) | TWI396686B (OSRAM) |
| WO (1) | WO2005113504A1 (OSRAM) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2416384A1 (en) * | 2000-07-17 | 2003-01-16 | Takeda Chemical Industries, Ltd. | Sulfone derivatives, their production and use |
| WO2004048363A1 (ja) * | 2002-11-22 | 2004-06-10 | Takeda Pharmaceutical Company Limited | イミダゾール誘導体、その製造法および用途 |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| CA2632218A1 (en) * | 2005-11-28 | 2007-10-11 | Zymogenetics, Inc. | Il-21 receptor antagonists |
| EP2090300A4 (en) * | 2006-11-30 | 2010-02-10 | Takeda Pharmaceutical | PREPARATION WITH DELAYED RELEASE |
| UY32126A (es) | 2008-09-25 | 2010-04-30 | Takeda Pharmaceutical | Composición farmacéutica sólida |
| WO2010050445A1 (ja) | 2008-10-27 | 2010-05-06 | 武田薬品工業株式会社 | 二環性化合物 |
| JPWO2010076884A1 (ja) | 2008-12-29 | 2012-06-21 | 武田薬品工業株式会社 | 新規縮合環化合物およびその用途 |
| UY32395A (es) | 2009-01-27 | 2010-08-31 | Takeda Pharmaceutical | Compuesto con anillo fusionado y su uso |
| JP5666471B2 (ja) | 2009-04-30 | 2015-02-12 | 武田薬品工業株式会社 | 固形製剤 |
| WO2010143733A1 (en) | 2009-06-09 | 2010-12-16 | Takeda Pharmaceutical Company Limited | Novel fused cyclic compound and use thereof |
| US20120129878A1 (en) | 2009-07-28 | 2012-05-24 | Takeda Pharmaceutical Company Limited | Tablet |
| US8221489B2 (en) * | 2009-08-20 | 2012-07-17 | Stentys | Device and method for treating a body lumen |
| KR20130094211A (ko) | 2010-04-27 | 2013-08-23 | 다케다 야쿠힌 고교 가부시키가이샤 | 바이시클릭 화합물 유도체 및 이의 ａｃｃ 저해제로서의 용도 |
| US9018374B2 (en) | 2010-06-16 | 2015-04-28 | Takeda Pharmaceutical Company Limited | Crystal of amide compound |
| JPWO2012011591A1 (ja) | 2010-07-23 | 2013-09-09 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
| EP2617726A4 (en) | 2010-09-17 | 2014-05-14 | Takeda Pharmaceutical | DIABETES THERAPEUTIC |
| JP5824517B2 (ja) | 2010-11-30 | 2015-11-25 | 武田薬品工業株式会社 | 二環性化合物 |
| PH12013501718A1 (en) | 2011-02-17 | 2013-10-07 | Takeda Pharmaceuticals Co | Production method of optically active dihydrobenzofuran derivative |
| US9133129B2 (en) | 2011-10-24 | 2015-09-15 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| EP2802571A1 (en) | 2012-01-12 | 2014-11-19 | Takeda Pharmaceutical Company Limited | Benzimidazole derivatives as mch receptor antagonists |
| US9382188B2 (en) | 2012-02-13 | 2016-07-05 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| EP2816032A4 (en) | 2012-02-13 | 2015-09-30 | Takeda Pharmaceutical | AROMATIC RING CONNECTION |
| CA2864068A1 (en) | 2012-02-15 | 2013-08-22 | Takeda Pharmaceutical Company Limited | Tablet comprising 1-(4-methoxybutyl)-n-(2-methylpropyl)-n-[(3s,5r)-5-(morpholin-4-ylcarbonyl)piperidin-3-yl]-1h-benzimidazole-2-carboxamide or a salt thereof |
| JP6106179B2 (ja) | 2012-02-24 | 2017-03-29 | 武田薬品工業株式会社 | 芳香環化合物 |
| WO2013147026A1 (ja) | 2012-03-29 | 2013-10-03 | 武田薬品工業株式会社 | 芳香環化合物 |
| JPWO2013168759A1 (ja) | 2012-05-10 | 2016-01-07 | 武田薬品工業株式会社 | 芳香環化合物 |
| US9505772B2 (en) | 2012-05-10 | 2016-11-29 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| US9486411B2 (en) | 2012-06-05 | 2016-11-08 | Takeda Pharmaceutical Company Limited | Solid preparation |
| JP2015127299A (ja) | 2012-07-19 | 2015-07-09 | 武田薬品工業株式会社 | 固形製剤 |
| EP2889291A4 (en) | 2012-08-24 | 2015-10-14 | Takeda Pharmaceutical | HETEROCYCLIC CONNECTION |
| CN103936763B (zh) * | 2013-01-18 | 2017-10-31 | 中国科学院上海药物研究所 | 噁唑烷酮类化合物及其制备方法和用途 |
| ES2629729T3 (es) | 2013-03-14 | 2017-08-14 | Takeda Pharmaceutical Company Limited | Derivados de espiro azetidina asoxazol y uso de los mismos como antagonistas de sstr5 |
| WO2014165816A1 (en) | 2013-04-05 | 2014-10-09 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
| CN105358544A (zh) | 2013-07-09 | 2016-02-24 | 武田药品工业株式会社 | 杂环化合物 |
| PL3031799T3 (pl) | 2013-08-09 | 2018-09-28 | Takeda Pharmaceutical Company Limited | Związek aromatyczny |
| JO3442B1 (ar) | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
| US9428470B2 (en) | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
| BR112017006117A2 (pt) * | 2014-09-26 | 2017-12-19 | Changzhou Yinsheng Pharmaceutical Co Ltd | análogo de benzofurano como inibidor de ns4b |
| WO2016103185A2 (en) | 2014-12-23 | 2016-06-30 | Crossing Srl | Method for the industrial production of 2-halo -4,6-dialkoxy-1,3,5-triazines and their use in the presence of amines |
| AR111199A1 (es) | 2017-03-31 | 2019-06-12 | Takeda Pharmaceuticals Co | Compuesto aromático agonista de gpr40 |
| JPWO2018181847A1 (ja) | 2017-03-31 | 2020-03-05 | 武田薬品工業株式会社 | 芳香環化合物 |
| JOP20180028A1 (ar) | 2017-03-31 | 2019-01-30 | Takeda Pharmaceuticals Co | مركب ببتيد |
| WO2019018186A1 (en) | 2017-07-17 | 2019-01-24 | Merck Sharp & Dohme Corp. | Metallo-beta-lactamase inhibitors and methods of use thereof |
| MX2020009950A (es) | 2018-03-23 | 2021-04-28 | Carmot Therapeutics Inc | Moduladores de receptores acoplados a proteina g. |
| EP3650440A4 (en) | 2018-08-27 | 2020-11-25 | Scohia Pharma, Inc. | BENZOIC ESTER COMPOUND |
| WO2020067575A1 (en) | 2018-09-24 | 2020-04-02 | Takeda Pharmaceutical Company Limited | Gip receptor agonist peptide compounds and uses thereof |
| JP2022503793A (ja) | 2018-09-24 | 2022-01-12 | 武田薬品工業株式会社 | Ｇｉｐ受容体アゴニストペプチド化合物及びその使用 |
| DK4097099T3 (da) | 2020-02-07 | 2024-07-15 | Gasherbrum Bio Inc | Heterocyckliske GLP1-agonister |
| PE20221727A1 (es) | 2020-03-25 | 2022-11-04 | Takeda Pharmaceuticals Co | Dosificacion qw de compuestos peptidicos agonistas del receptor de gip y sus usos |
| AU2021241257A1 (en) | 2020-03-25 | 2022-10-13 | Takeda Pharmaceutical Company Limited | QD dosing of GIP receptor agonist peptide compounds and uses thereof |
| US12281149B2 (en) | 2021-05-13 | 2025-04-22 | Carmot Therapeutics, Inc. | Modulators of G-protein coupled receptors |
| US20250188103A1 (en) | 2022-03-09 | 2025-06-12 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| US20250206757A1 (en) | 2022-03-21 | 2025-06-26 | Gasherbrum Bio, Inc. | 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes |
| JP2025513071A (ja) | 2022-04-14 | 2025-04-22 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環式ｇｌｐ－１アゴニスト |
| CN121002014A (zh) | 2022-12-15 | 2025-11-21 | 加舒布鲁姆生物公司 | 具有glp-1激动剂活性的化合物的盐和固体形式 |
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| CN120693338A (zh) | 2022-12-22 | 2025-09-23 | 加舒布鲁姆生物公司 | 杂环的glp-1激动剂 |
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| TW202519220A (zh) | 2023-07-13 | 2025-05-16 | 美商雅空嘉閣生物公司 | 化合物、組合物及方法 |
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| WO2025154020A1 (en) | 2024-01-19 | 2025-07-24 | Takeda Pharmaceutical Company Limited | Improved gip receptor agonist peptide compounds and uses thereof |
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| WO2025189141A1 (en) | 2024-03-08 | 2025-09-12 | Annapurna Bio, Inc. | Methods for treating obesity and increasing weight loss |
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-
2005
- 2005-05-19 TW TW094116243A patent/TWI396686B/zh not_active IP Right Cessation
- 2005-05-20 MY MYPI20052298A patent/MY154461A/en unknown
- 2005-05-20 PT PT05743594T patent/PT1748985E/pt unknown
- 2005-05-20 PL PL05743594T patent/PL1748985T3/pl unknown
- 2005-05-20 AU AU2005245298A patent/AU2005245298B2/en not_active Ceased
- 2005-05-20 DK DK05743594.3T patent/DK1748985T3/da active
- 2005-05-20 EP EP10161428.7A patent/EP2208726B1/en not_active Expired - Lifetime
- 2005-05-20 HR HR20110640T patent/HRP20110640T1/hr unknown
- 2005-05-20 RS RS20110371A patent/RS51925B/sr unknown
- 2005-05-20 CN CN2005800244522A patent/CN1989104B/zh not_active Expired - Fee Related
- 2005-05-20 MX MXPA06013243A patent/MXPA06013243A/es active IP Right Grant
- 2005-05-20 BR BRPI0511186-2A patent/BRPI0511186A/pt not_active Application Discontinuation
- 2005-05-20 US US11/596,089 patent/US7745623B2/en not_active Expired - Fee Related
- 2005-05-20 AT AT05743594T patent/ATE513813T1/de active
- 2005-05-20 RU RU2006145449/04A patent/RU2361861C2/ru not_active IP Right Cessation
- 2005-05-20 KR KR1020067023942A patent/KR101248637B1/ko not_active Expired - Fee Related
- 2005-05-20 EP EP05743594A patent/EP1748985B1/en not_active Expired - Lifetime
- 2005-05-20 CN CN2010105739971A patent/CN102093285B/zh not_active Expired - Fee Related
- 2005-05-20 WO PCT/JP2005/009711 patent/WO2005113504A1/en not_active Ceased
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- 2005-05-20 PH PH1/2012/501331A patent/PH12012501331A1/en unknown
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- 2005-05-20 NZ NZ550985A patent/NZ550985A/en not_active IP Right Cessation
- 2005-05-20 SI SI200531321T patent/SI1748985T1/sl unknown
- 2005-05-20 JP JP2007521014A patent/JP4129047B2/ja not_active Expired - Fee Related
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- 2006-10-26 IL IL178896A patent/IL178896A/en not_active IP Right Cessation
- 2006-12-20 NO NO20065929A patent/NO20065929L/no not_active Application Discontinuation
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- 2008-01-15 JP JP2008006003A patent/JP4362535B2/ja not_active Expired - Fee Related
- 2008-06-11 US US12/157,574 patent/US20080255352A1/en not_active Abandoned
- 2008-06-11 US US12/157,573 patent/US20080255362A1/en not_active Abandoned
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