CY1111850T1 - Παραγωγα κυκλικου αμιδιου, και η παραγωγη και χρηση τους ως αντιθρομβωτικοι παραγοντες - Google Patents
Παραγωγα κυκλικου αμιδιου, και η παραγωγη και χρηση τους ως αντιθρομβωτικοι παραγοντεςInfo
- Publication number
- CY1111850T1 CY1111850T1 CY20111100894T CY111100894T CY1111850T1 CY 1111850 T1 CY1111850 T1 CY 1111850T1 CY 20111100894 T CY20111100894 T CY 20111100894T CY 111100894 T CY111100894 T CY 111100894T CY 1111850 T1 CY1111850 T1 CY 1111850T1
- Authority
- CY
- Cyprus
- Prior art keywords
- optionally substituted
- thumpty
- bond
- agents
- products
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ένα παράγωγο κυκλικού αμιδίου χρήσιμο ως φάρμακο για την αγωγή της θρομβώσεως, που αναπαρίσταται από τον τύπο (I): όπου το R1 αντιπροσωπεύει μία προαιρετικά υποκατασταθείσα ομάδα κυκλικού υδρογονάνθρακα ή μία προαιρετικά υποκατασταθείσα ετεροκυκλική ομάδα, το W αντιπροσωπεύει ένα δεσμό ή μία προαιρετικά υποκατασταθείσα ομάδα υδρογονάνθρακα δισθενούς αλύσου, το a αντιπροσωπεύει 0, 1 ή 2, το Χ1 αντιπροσωπεύει ένα προαιρετικά υποκατασταθέν κατώτερο αλκυλένιο ή ένα προαιρετικά υποκατασταθέν κατώτερο αλκενυλένιο, το Υ1 αντιπροσωπεύει -C(O)-, -S(O)- ή -S(O)2-, το Α αντιπροσωπεύει ένα δακτύλιο πιπεραζίνης που μπορεί να υποκατασταθεί περαιτέρω ή ένα δακτύλιο πιπεριδίνης που μπορεί να υποκατασταθεί περαιτέρω, το Χ2 αντιπροσωπεύει ένα δεσμό ή ένα προαιρετικά υποκατασταθέν κατώτερο αλκυλένιο, το Υ2 αντιπροσωπεύει -C(O)-, -S(O)-, -S(O)2- ή -C(=NR7)-, το Χ3 αντιπροσωπεύει ένα προαιρετικά υποκατασταθέν αλκυλένιο με C1-4 ή ένα προαιρετικά υποκατασταθέν αλκενυλένιο με C2-4, το Ζ3 αντιπροσωπεύει -N(R4)-, -Ο- ή ένα δεσμό, το Ζ1 αντιπροσωπεύει -C(R2)(R2’)-, -N(R2)-, κ.λ.π., και το Ζ2 αντιπροσωπεύει -C(R3)(R3')-, -N(R3)-, κ.λ.π., ή ένα άλας αυτού.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004152000 | 2004-05-21 | ||
| EP05743594A EP1748985B1 (en) | 2004-05-21 | 2005-05-20 | Cyclic amide derivatives, and their production and use as antithrombotic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111850T1 true CY1111850T1 (el) | 2015-10-07 |
Family
ID=34968275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111100894T CY1111850T1 (el) | 2004-05-21 | 2011-09-15 | Παραγωγα κυκλικου αμιδιου, και η παραγωγη και χρηση τους ως αντιθρομβωτικοι παραγοντες |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US7745623B2 (el) |
| EP (2) | EP2208726B1 (el) |
| JP (2) | JP4129047B2 (el) |
| KR (1) | KR101248637B1 (el) |
| CN (2) | CN1989104B (el) |
| AT (1) | ATE513813T1 (el) |
| AU (1) | AU2005245298B2 (el) |
| BR (1) | BRPI0511186A (el) |
| CA (1) | CA2567506C (el) |
| CY (1) | CY1111850T1 (el) |
| DK (1) | DK1748985T3 (el) |
| ES (1) | ES2368155T3 (el) |
| HK (1) | HK1100666A1 (el) |
| HR (1) | HRP20110640T1 (el) |
| IL (1) | IL178896A (el) |
| MX (1) | MXPA06013243A (el) |
| MY (1) | MY154461A (el) |
| NO (1) | NO20065929L (el) |
| NZ (1) | NZ550985A (el) |
| PL (1) | PL1748985T3 (el) |
| PT (1) | PT1748985E (el) |
| RS (1) | RS51925B (el) |
| RU (1) | RU2361861C2 (el) |
| SI (1) | SI1748985T1 (el) |
| TW (1) | TWI396686B (el) |
| WO (1) | WO2005113504A1 (el) |
Families Citing this family (59)
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| TWI396686B (zh) * | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
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| JP5535931B2 (ja) | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | 二環性化合物 |
| JPWO2010076884A1 (ja) | 2008-12-29 | 2012-06-21 | 武田薬品工業株式会社 | 新規縮合環化合物およびその用途 |
| AR075158A1 (es) | 2009-01-27 | 2011-03-16 | Takeda Pharmaceutical | Derivados de pirrolopirimidinas, composiciones farmaceuticas y usos. |
| AU2010242308A1 (en) | 2009-04-30 | 2011-12-01 | Takeda Pharmaceutical Company Limited | Solid preparation |
| US20120172351A1 (en) | 2009-06-09 | 2012-07-05 | Nobuyuki Negoro | Novel fused cyclic compound and use thereof |
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| TWI511967B (zh) | 2010-06-16 | 2015-12-11 | Takeda Pharmaceutical | 醯胺化合物之結晶 |
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| US20130184272A1 (en) | 2010-09-17 | 2013-07-18 | Takeda Pharmaceutical Company Limited | Diabetes therapeutic agent |
| SG190925A1 (en) | 2010-11-30 | 2013-07-31 | Takeda Pharmaceutical | Bicyclic compound |
| JP5945545B2 (ja) | 2011-02-17 | 2016-07-05 | 武田薬品工業株式会社 | 光学活性なジヒドロベンゾフラン誘導体の製造法 |
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| BR112023023559A2 (pt) | 2021-05-13 | 2024-02-06 | Carmot Therapeutics Inc | Moduladores de receptores acoplados à proteína g |
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- 2005-05-20 MY MYPI20052298A patent/MY154461A/en unknown
- 2005-05-20 WO PCT/JP2005/009711 patent/WO2005113504A1/en active Application Filing
- 2005-05-20 RU RU2006145449/04A patent/RU2361861C2/ru not_active IP Right Cessation
- 2005-05-20 AU AU2005245298A patent/AU2005245298B2/en not_active Ceased
- 2005-05-20 BR BRPI0511186-2A patent/BRPI0511186A/pt not_active Application Discontinuation
- 2005-05-20 DK DK05743594.3T patent/DK1748985T3/da active
- 2005-05-20 CN CN2005800244522A patent/CN1989104B/zh not_active Expired - Fee Related
- 2005-05-20 NZ NZ550985A patent/NZ550985A/en not_active IP Right Cessation
- 2005-05-20 CN CN2010105739971A patent/CN102093285B/zh not_active Expired - Fee Related
- 2005-05-20 ES ES05743594T patent/ES2368155T3/es active Active
- 2005-05-20 SI SI200531321T patent/SI1748985T1/sl unknown
- 2005-05-20 PL PL05743594T patent/PL1748985T3/pl unknown
- 2005-05-20 US US11/596,089 patent/US7745623B2/en not_active Expired - Fee Related
- 2005-05-20 MX MXPA06013243A patent/MXPA06013243A/es active IP Right Grant
- 2005-05-20 KR KR1020067023942A patent/KR101248637B1/ko not_active IP Right Cessation
- 2005-05-20 EP EP10161428.7A patent/EP2208726B1/en active Active
- 2005-05-20 RS RS20110371A patent/RS51925B/en unknown
- 2005-05-20 CA CA2567506A patent/CA2567506C/en not_active Expired - Fee Related
- 2005-05-20 EP EP05743594A patent/EP1748985B1/en active Active
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- 2005-05-20 JP JP2007521014A patent/JP4129047B2/ja not_active Expired - Fee Related
- 2005-05-20 AT AT05743594T patent/ATE513813T1/de active
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- 2006-12-20 NO NO20065929A patent/NO20065929L/no not_active Application Discontinuation
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2007
- 2007-08-03 HK HK07108476.9A patent/HK1100666A1/xx not_active IP Right Cessation
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2008
- 2008-01-15 JP JP2008006003A patent/JP4362535B2/ja not_active Expired - Fee Related
- 2008-06-11 US US12/157,574 patent/US20080255352A1/en not_active Abandoned
- 2008-06-11 US US12/157,573 patent/US20080255362A1/en not_active Abandoned
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2010
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- 2011-09-15 CY CY20111100894T patent/CY1111850T1/el unknown
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