ATE233240T1 - Neues amidinonaphthylderivat oder dessen salz - Google Patents
Neues amidinonaphthylderivat oder dessen salzInfo
- Publication number
- ATE233240T1 ATE233240T1 AT95938625T AT95938625T ATE233240T1 AT E233240 T1 ATE233240 T1 AT E233240T1 AT 95938625 T AT95938625 T AT 95938625T AT 95938625 T AT95938625 T AT 95938625T AT E233240 T1 ATE233240 T1 AT E233240T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- formula
- represented
- chem
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP29996394 | 1994-12-02 | ||
JP10520595 | 1995-04-28 | ||
JP19881695 | 1995-08-03 | ||
PCT/JP1995/002458 WO1996016940A1 (fr) | 1994-12-02 | 1995-12-01 | Nouveau derive d'amidinonaphtyle ou sel de celui-ci |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE233240T1 true ATE233240T1 (de) | 2003-03-15 |
Family
ID=27310425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95938625T ATE233240T1 (de) | 1994-12-02 | 1995-12-01 | Neues amidinonaphthylderivat oder dessen salz |
Country Status (20)
Country | Link |
---|---|
US (1) | US5869501A (de) |
EP (1) | EP0798295B1 (de) |
JP (1) | JP3004362B2 (de) |
KR (1) | KR100383161B1 (de) |
CN (1) | CN1087736C (de) |
AT (1) | ATE233240T1 (de) |
AU (1) | AU688628B2 (de) |
CA (1) | CA2206532C (de) |
DE (1) | DE69529770T2 (de) |
ES (1) | ES2193202T3 (de) |
FI (1) | FI115051B (de) |
HU (1) | HUT77313A (de) |
MX (1) | MX9704059A (de) |
NO (1) | NO309566B1 (de) |
NZ (1) | NZ296210A (de) |
PL (1) | PL184824B1 (de) |
PT (1) | PT798295E (de) |
RU (1) | RU2154633C2 (de) |
TW (1) | TW300888B (de) |
WO (1) | WO1996016940A1 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0813525T3 (da) | 1995-03-10 | 2004-02-16 | Berlex Lab | Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter |
SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
EP0842941A1 (de) * | 1996-11-16 | 1998-05-20 | Roche Diagnostics GmbH | Neue Phosphonate, Verfahren zu ihrer Herstellung und Arzneimittel |
AU7808198A (en) | 1997-06-03 | 1998-12-21 | Biocryst Pharmaceuticals, Inc. | Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation |
AU7976998A (en) * | 1997-06-19 | 1999-01-04 | Du Pont Merck Pharmaceutical Company, The | (amidino)6-membered aromatics as factor xa inhibitors |
US6060491A (en) * | 1997-06-19 | 2000-05-09 | Dupont Pharmaceuticals | 6-membered aromatics as factor Xa inhibitors |
ZA986594B (en) * | 1997-07-25 | 1999-01-27 | Abbott Lab | Urokinase inhibitors |
US6258822B1 (en) | 1997-08-06 | 2001-07-10 | Abbott Laboratories | Urokinase inhibitors |
WO1999011617A1 (fr) * | 1997-09-01 | 1999-03-11 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveaux derives de naphtamide et sels de ces derives |
US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
DE19754490A1 (de) * | 1997-12-09 | 1999-06-10 | Boehringer Ingelheim Pharma | Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
AU1692399A (en) * | 1997-12-26 | 1999-07-19 | Mochida Pharmaceutical Co., Ltd. | Aromatic compounds having cyclic amino or salts thereof |
AU2074699A (en) * | 1998-01-26 | 1999-08-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzene-fused heterocyclic derivatives or salts thereof |
EP0937723A1 (de) * | 1998-02-18 | 1999-08-25 | Roche Diagnostics GmbH | Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
EP1066272A4 (de) * | 1998-03-27 | 2002-03-13 | Biocryst Pharm Inc | Neue verbindungen, die im komplement-, koagulat- und kallikrein-reaktionsweg nützlich sind und verfahren zu ihrer herstellung |
IL138899A0 (en) | 1998-04-10 | 2001-11-25 | Japan Tobacco Inc | Amidene derivatives and pharmaceutical compositions containing the same |
US6504031B1 (en) | 1998-08-06 | 2003-01-07 | Milan Bruncko | Naphthamidine urokinase inhibitors |
US6284796B1 (en) | 1998-08-06 | 2001-09-04 | Abbott Laboratories | Ukokinase inhibitors |
US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
CA2320730A1 (en) | 1998-12-23 | 2000-07-06 | Renhua Li | Thrombin or factor xa inhibitors |
PL350042A1 (en) | 1999-01-13 | 2002-10-21 | Genentech Inc | Serine protease inhibitors |
AU3074700A (en) * | 1999-01-22 | 2000-08-07 | Yamanouchi Pharmaceutical Co., Ltd. | Medicinal compositions with improved oral absorption |
CA2360740A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
FR2793247B1 (fr) * | 1999-05-04 | 2001-06-22 | Synthelabo | Derives de 6-[[(aryl et heteroaryl)oxy]methyl]naphtalene-2- carboximidamide, leur preparation et leur application en therapeutique |
US6858599B2 (en) | 1999-06-30 | 2005-02-22 | Mochida Pharmaceutical Co., Ltd. | Tricyclic compound having spiro union |
WO2001002356A1 (fr) * | 1999-07-01 | 2001-01-11 | Sankyo Company, Limited | Dérivés d'indoline ou tétrahydroquinoline |
US6350761B1 (en) * | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
CN1572882A (zh) | 1999-10-28 | 2005-02-02 | 三共株式会社 | 苯甲脒衍生物 |
EP1095933A1 (de) * | 1999-10-30 | 2001-05-02 | Aventis Pharma Deutschland GmbH | N-Guanidinoalkylamide, Verfahren zu ihrer Herstellung, ihre Verwendung und pharmazeutische Zusammensetzungen, die sie enthalten |
US20020065303A1 (en) * | 2000-02-01 | 2002-05-30 | Bing-Yan Zhu | Bivalent phenylene inhibitors of factor Xa |
ES2254385T3 (es) | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
WO2001072708A2 (en) * | 2000-03-24 | 2001-10-04 | Cor Therapeutics, Inc. | OXINDOLE INHIBITORS OF FACTOR Xa |
AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
US6495562B1 (en) | 2000-04-25 | 2002-12-17 | Abbott Laboratories | Naphthamidine urokinase inhibitors |
US6410733B1 (en) | 2000-09-11 | 2002-06-25 | Genentech, Inc. | Amidine inhibitors of serine proteases |
MXPA03003572A (es) | 2000-11-22 | 2003-07-14 | Yamanouchi Pharma Co Ltd | Derivados de benceno sustituidos o sales de los mismos. |
US6710061B2 (en) | 2001-03-09 | 2004-03-23 | Ortho-Mcneil Pharamceutical, Inc. | Aminopyrrolidine sulfonamides as serine protease inhibitors |
JP2004520438A (ja) | 2001-03-09 | 2004-07-08 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | セリンプロテアーゼインヒビターとしてのアミノピロリジンスルホンアミド |
US7312235B2 (en) | 2001-03-30 | 2007-12-25 | Millennium Pharmaceuticals, Inc. | Benzamide inhibitors of factor Xa |
HUP0400384A3 (en) | 2001-04-05 | 2008-08-28 | Sankyo Co | Benzamidine derivative and pharmaceutical compositions containing them and their use |
RS51865B (sr) | 2002-01-29 | 2012-02-29 | Laboratoires Serono Sa. | Supstituisani derivati metilen amida kao modulatori protein tirozin fosfataze (ptp) |
AU2003284596A1 (en) | 2002-11-22 | 2004-06-18 | Takeda Pharmaceutical Company Limited | Imidazole derivative, process for producing the same, and use |
ES2543588T3 (es) | 2002-12-03 | 2015-08-20 | Pharmacyclics Llc | Derivados de 2-(2-hidroxibifenil-3-il)-1H-benzoimidazol-5-carboxamidina como inhibidores del factor VIIa |
WO2004058728A1 (ja) * | 2002-12-24 | 2004-07-15 | Daiichi Pharmaceutical Co., Ltd. | 新規なエチレンジアミン誘導体 |
AU2004249670A1 (en) | 2003-05-20 | 2004-12-29 | Genentech, Inc. | Acylsulfamide inhibitors of factor VIIa |
AU2004249671A1 (en) | 2003-05-20 | 2004-12-29 | Genentech, Inc. | Benzofuran inhibitors of factor VIIa |
US7022695B2 (en) | 2003-10-09 | 2006-04-04 | Millennium Pharmaceuticals, Inc. | Thioether-substituted benzamides as inhibitors of Factor Xa |
TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
CA2565437A1 (en) | 2004-06-18 | 2006-01-05 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
WO2006055951A2 (en) | 2004-11-19 | 2006-05-26 | Portola Pharmaceuticals, Inc. | Tetrahydroisoquinolines as factor xa inhibitors |
US20060160790A1 (en) * | 2004-12-07 | 2006-07-20 | Portola Pharmaceuticals, Inc. | Thioureas as factor Xa inhibitors |
US7678913B2 (en) | 2004-12-07 | 2010-03-16 | Portola Pharmaceuticals, Inc. | Ureas as factor Xa inhibitors |
WO2006083003A1 (ja) | 2005-02-02 | 2006-08-10 | Ajinomoto Co., Inc. | 新規ベンズアミジン化合物 |
AU2006311544B2 (en) | 2005-11-08 | 2012-03-08 | Millennium Pharmaceuticals, Inc. | Pharmaceutical salts and polymorphs of N- (5-CHLORO-2-PYRIDINYL) -2- [ [4- [ (DIMETHYLAMINO) IMINOMETHYL] BENZOYL] AMINO] -5-METH OXY-BENZAMIDE, a factor XA inhibitor |
WO2007110237A2 (en) * | 2006-03-28 | 2007-10-04 | Novartis Ag | Amide derivatives and their application for the treatment of g protein related diseases |
US7884234B2 (en) * | 2006-10-12 | 2011-02-08 | Institute Of Medicinal Molecular Design, Inc. | N-phenyloxamide derivatives |
ATE544749T1 (de) | 2006-11-02 | 2012-02-15 | Millennium Pharm Inc | Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer |
JPWO2008066102A1 (ja) * | 2006-11-30 | 2010-03-11 | 武田薬品工業株式会社 | 徐放性製剤 |
US8633245B2 (en) * | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
KR20110036833A (ko) | 2008-07-11 | 2011-04-11 | 아지노모토 가부시키가이샤 | 아미딘 유도체 |
EA015918B1 (ru) | 2010-03-03 | 2011-12-30 | Дмитрий Геннадьевич ТОВБИН | УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa |
US11679093B2 (en) | 2018-06-11 | 2023-06-20 | The Regents Of The University Of Colorado, A Body Corporate | 2-naphthimidamides, analogues thereof, and methods of treatment using same |
CN117304076B (zh) * | 2023-11-28 | 2024-02-20 | 苏州大学 | 一种n-磺酰基脒化合物的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
JPS59139357A (ja) * | 1983-01-28 | 1984-08-10 | Torii Yakuhin Kk | アミジン誘導体 |
US4563527A (en) * | 1984-07-19 | 1986-01-07 | Torii & Co., Ltd. | Amidine compounds |
ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
-
1995
- 1995-12-01 PL PL95320486A patent/PL184824B1/pl not_active IP Right Cessation
- 1995-12-01 NZ NZ296210A patent/NZ296210A/en unknown
- 1995-12-01 CA CA002206532A patent/CA2206532C/en not_active Expired - Fee Related
- 1995-12-01 PT PT95938625T patent/PT798295E/pt unknown
- 1995-12-01 ES ES95938625T patent/ES2193202T3/es not_active Expired - Lifetime
- 1995-12-01 WO PCT/JP1995/002458 patent/WO1996016940A1/ja active IP Right Grant
- 1995-12-01 AU AU39942/95A patent/AU688628B2/en not_active Ceased
- 1995-12-01 DE DE69529770T patent/DE69529770T2/de not_active Expired - Fee Related
- 1995-12-01 EP EP95938625A patent/EP0798295B1/de not_active Expired - Lifetime
- 1995-12-01 AT AT95938625T patent/ATE233240T1/de not_active IP Right Cessation
- 1995-12-01 KR KR1019970703620A patent/KR100383161B1/ko not_active IP Right Cessation
- 1995-12-01 HU HU9702028A patent/HUT77313A/hu unknown
- 1995-12-01 RU RU97108576/04A patent/RU2154633C2/ru not_active IP Right Cessation
- 1995-12-01 US US08/849,391 patent/US5869501A/en not_active Expired - Fee Related
- 1995-12-01 CN CN95196546A patent/CN1087736C/zh not_active Expired - Fee Related
- 1995-12-01 JP JP8518590A patent/JP3004362B2/ja not_active Expired - Fee Related
- 1995-12-01 TW TW084112820A patent/TW300888B/zh active
- 1995-12-01 MX MX9704059A patent/MX9704059A/es not_active IP Right Cessation
-
1997
- 1997-05-30 NO NO972482A patent/NO309566B1/no not_active IP Right Cessation
- 1997-06-02 FI FI972326A patent/FI115051B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN1167484A (zh) | 1997-12-10 |
FI972326A0 (fi) | 1997-06-02 |
EP0798295A4 (de) | 1998-03-04 |
US5869501A (en) | 1999-02-09 |
EP0798295B1 (de) | 2003-02-26 |
CA2206532C (en) | 2006-07-11 |
AU688628B2 (en) | 1998-03-12 |
ES2193202T3 (es) | 2003-11-01 |
RU2154633C2 (ru) | 2000-08-20 |
CN1087736C (zh) | 2002-07-17 |
JP3004362B2 (ja) | 2000-01-31 |
KR100383161B1 (ko) | 2003-12-24 |
FI972326A (fi) | 1997-06-02 |
PL184824B1 (pl) | 2002-12-31 |
FI115051B (fi) | 2005-02-28 |
DE69529770T2 (de) | 2003-12-24 |
WO1996016940A1 (fr) | 1996-06-06 |
NO972482L (no) | 1997-08-01 |
PL320486A1 (en) | 1997-09-29 |
PT798295E (pt) | 2003-07-31 |
CA2206532A1 (en) | 1996-06-06 |
TW300888B (de) | 1997-03-21 |
HUT77313A (hu) | 1998-03-30 |
DE69529770D1 (de) | 2003-04-03 |
MX9704059A (es) | 1997-08-30 |
NO309566B1 (no) | 2001-02-19 |
AU3994295A (en) | 1996-06-19 |
NO972482D0 (no) | 1997-05-30 |
EP0798295A1 (de) | 1997-10-01 |
NZ296210A (en) | 1998-05-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0798295 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |