PT798295E - Novo derivado de amidinonaftilo ou sal deste - Google Patents
Novo derivado de amidinonaftilo ou sal desteInfo
- Publication number
- PT798295E PT798295E PT95938625T PT95938625T PT798295E PT 798295 E PT798295 E PT 798295E PT 95938625 T PT95938625 T PT 95938625T PT 95938625 T PT95938625 T PT 95938625T PT 798295 E PT798295 E PT 798295E
- Authority
- PT
- Portugal
- Prior art keywords
- group
- formula
- represented
- chem
- hydrogen atom
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- -1 amidinonaphthyl Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29996394 | 1994-12-02 | ||
| JP10520595 | 1995-04-28 | ||
| JP19881695 | 1995-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT798295E true PT798295E (pt) | 2003-07-31 |
Family
ID=27310425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95938625T PT798295E (pt) | 1994-12-02 | 1995-12-01 | Novo derivado de amidinonaftilo ou sal deste |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5869501A (pt) |
| EP (1) | EP0798295B1 (pt) |
| JP (1) | JP3004362B2 (pt) |
| KR (1) | KR100383161B1 (pt) |
| CN (1) | CN1087736C (pt) |
| AT (1) | ATE233240T1 (pt) |
| AU (1) | AU688628B2 (pt) |
| CA (1) | CA2206532C (pt) |
| DE (1) | DE69529770T2 (pt) |
| ES (1) | ES2193202T3 (pt) |
| FI (1) | FI115051B (pt) |
| HU (1) | HUT77313A (pt) |
| MX (1) | MX9704059A (pt) |
| NO (1) | NO309566B1 (pt) |
| NZ (1) | NZ296210A (pt) |
| PL (1) | PL184824B1 (pt) |
| PT (1) | PT798295E (pt) |
| RU (1) | RU2154633C2 (pt) |
| TW (1) | TW300888B (pt) |
| WO (1) | WO1996016940A1 (pt) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2208737T3 (es) | 1995-03-10 | 2004-06-16 | Berlex Laboratories, Inc. | Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes. |
| SE9602646D0 (sv) * | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| CZ43399A3 (cs) | 1996-08-15 | 1999-07-14 | Schering Corporation | Etheroví muskarinní antagonisté |
| EP0842941A1 (de) * | 1996-11-16 | 1998-05-20 | Roche Diagnostics GmbH | Neue Phosphonate, Verfahren zu ihrer Herstellung und Arzneimittel |
| US6653340B1 (en) | 1997-06-03 | 2003-11-25 | Biocryst Pharmaceuticals, Inc. | Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation |
| US6060491A (en) * | 1997-06-19 | 2000-05-09 | Dupont Pharmaceuticals | 6-membered aromatics as factor Xa inhibitors |
| EP0993448A1 (en) * | 1997-06-19 | 2000-04-19 | The Du Pont Merck Pharmaceutical Company | (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS |
| ZA986594B (en) * | 1997-07-25 | 1999-01-27 | Abbott Lab | Urokinase inhibitors |
| US6258822B1 (en) | 1997-08-06 | 2001-07-10 | Abbott Laboratories | Urokinase inhibitors |
| WO1999011617A1 (en) * | 1997-09-01 | 1999-03-11 | Yamanouchi Pharmaceutical Co., Ltd. | Novel naphthamide derivatives or salts thereof |
| US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| DE19754490A1 (de) * | 1997-12-09 | 1999-06-10 | Boehringer Ingelheim Pharma | Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
| AU1692399A (en) * | 1997-12-26 | 1999-07-19 | Mochida Pharmaceutical Co., Ltd. | Aromatic compounds having cyclic amino or salts thereof |
| AU2074699A (en) * | 1998-01-26 | 1999-08-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzene-fused heterocyclic derivatives or salts thereof |
| EP0937723A1 (de) * | 1998-02-18 | 1999-08-25 | Roche Diagnostics GmbH | Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
| EP1066272A4 (en) * | 1998-03-27 | 2002-03-13 | Biocryst Pharm Inc | NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION |
| NZ508101A (en) | 1998-04-10 | 2002-12-20 | Japan Tobacco Inc | Amidine compounds useful as factor Xa inhibitors and as anticoagulants |
| US6284796B1 (en) | 1998-08-06 | 2001-09-04 | Abbott Laboratories | Ukokinase inhibitors |
| US6504031B1 (en) | 1998-08-06 | 2003-01-07 | Milan Bruncko | Naphthamidine urokinase inhibitors |
| US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
| EP1058549A4 (en) | 1998-12-23 | 2003-11-12 | Bristol Myers Squibb Pharma Co | FACTOR Xa OR THROMBIN INHIBITORS |
| AU771776B2 (en) | 1999-01-13 | 2004-04-01 | Genentech Inc. | Serine protease inhibitors |
| WO2000043041A1 (fr) * | 1999-01-22 | 2000-07-27 | Yamanouchi Pharmaceutical Co., Ltd. | Compositions medicamenteuses presentant une meilleure absorption orale |
| JP2002538151A (ja) | 1999-03-02 | 2002-11-12 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | カテプシンの可逆的インヒビターとして有用な化合物 |
| FR2793247B1 (fr) * | 1999-05-04 | 2001-06-22 | Synthelabo | Derives de 6-[[(aryl et heteroaryl)oxy]methyl]naphtalene-2- carboximidamide, leur preparation et leur application en therapeutique |
| US6858599B2 (en) * | 1999-06-30 | 2005-02-22 | Mochida Pharmaceutical Co., Ltd. | Tricyclic compound having spiro union |
| WO2001002356A1 (en) * | 1999-07-01 | 2001-01-11 | Sankyo Company, Limited | Indoline or tetrahydroquinoline derivatives |
| US6350761B1 (en) | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| TR200201654T2 (tr) * | 1999-10-28 | 2002-12-23 | Sankyo Company Limited | Benzamidin türevleri. |
| EP1095933A1 (en) * | 1999-10-30 | 2001-05-02 | Aventis Pharma Deutschland GmbH | Novel N-guanidinoalkylamides, their preparation, their use, and pharmaceutical preparations comprising them |
| WO2001056989A2 (en) * | 2000-02-01 | 2001-08-09 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
| ATE311366T1 (de) | 2000-02-29 | 2005-12-15 | Millennium Pharm Inc | Benzamide und ähnliche inhibitoren vom faktor xa |
| EP1272483A2 (en) * | 2000-03-24 | 2003-01-08 | Millenium Pharmaceuticals, Inc. | OXINDOLE INHIBITORS OF FACTOR Xa |
| AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| US6495562B1 (en) | 2000-04-25 | 2002-12-17 | Abbott Laboratories | Naphthamidine urokinase inhibitors |
| ATE338030T1 (de) | 2000-09-11 | 2006-09-15 | Genentech Inc | Amidine-inhibitoren der serine-proteasen |
| DE60118774T2 (de) | 2000-11-22 | 2007-03-15 | Astellas Pharma Inc. | Substituierte phenolderivate und deren salze als hemmstoffe von koagulations faktor x |
| US6710061B2 (en) | 2001-03-09 | 2004-03-23 | Ortho-Mcneil Pharamceutical, Inc. | Aminopyrrolidine sulfonamides as serine protease inhibitors |
| JP2004520438A (ja) | 2001-03-09 | 2004-07-08 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | セリンプロテアーゼインヒビターとしてのアミノピロリジンスルホンアミド |
| US7312235B2 (en) | 2001-03-30 | 2007-12-25 | Millennium Pharmaceuticals, Inc. | Benzamide inhibitors of factor Xa |
| BR0208678A (pt) | 2001-04-05 | 2004-03-30 | Sankyo Co | Composto, composição farmacêutica, uso de um composto |
| EP1470102B1 (en) | 2002-01-29 | 2011-05-25 | Merck Serono SA | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases (ptps) |
| RU2226392C1 (ru) * | 2002-10-23 | 2004-04-10 | Биологический факультет Московского государственного университета им. М.В. Ломоносова | Способ ингибирования агрегации тромбоцитов |
| US20070004736A1 (en) | 2002-11-22 | 2007-01-04 | Keiji Kubo | Imidazole derivative, process for producing the same, and use |
| PT1569912E (pt) | 2002-12-03 | 2015-09-15 | Pharmacyclics Llc | Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia |
| US20070129371A1 (en) * | 2002-12-24 | 2007-06-07 | Daiichi Pharmaceutical Co., Ltd. | Novel ethylenediamine derivatives |
| JP2007500221A (ja) | 2003-05-20 | 2007-01-11 | ジェネンテック・インコーポレーテッド | 第ＶＩＩａ因子のベンゾフラン阻害剤 |
| EP1628954A2 (en) | 2003-05-20 | 2006-03-01 | Genentech, Inc. | Acylsulfamide inhibitors of factor viia |
| ES2338881T3 (es) | 2003-10-09 | 2010-05-13 | Millennium Pharmaceuticals, Inc. | Benzamidas sustituidas con tioeter como inhibidores del factor xa. |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| CA2565437A1 (en) | 2004-06-18 | 2006-01-05 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
| US7612089B2 (en) | 2004-11-19 | 2009-11-03 | Portola Pharmaceuticals, Inc. | Tetrahydroisoquinolines as factor Xa inhibitors |
| US20060160790A1 (en) * | 2004-12-07 | 2006-07-20 | Portola Pharmaceuticals, Inc. | Thioureas as factor Xa inhibitors |
| WO2006063113A2 (en) | 2004-12-07 | 2006-06-15 | Portola Pharmaceuticals, Inc. | Ureas as factor xa inhibitors |
| EP1847527A4 (en) | 2005-02-02 | 2009-04-08 | Ajinomoto Kk | NEW BENZAMIDINE DERIVATIVE |
| RU2440986C2 (ru) | 2005-11-08 | 2012-01-27 | Милленниум Фамэсьютикэлс, Инк. | СОЛЬ ИНГИБИТОРА ФАКТОРА Ха, СПОСОБ ЕЕ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЕ ОСНОВЕ, СОСТОЯЩИЕ ИЗ НАЗВАННОЙ КОМПОЗИЦИИ ТАБЛЕТКА, КАПСУЛА И ЛЕПЕШКА, СПОСОБ ЛЕЧЕНИЯ ТРОМБОЗА И СПОСОБ ИНГИБИРОВАНИЯ КОАГУЛЯЦИИ ОБРАЗЦОВ КРОВИ |
| US20100261758A1 (en) * | 2006-03-28 | 2010-10-14 | Novartis Ag | Heterocyclic amides for use as pharmaceuticals |
| US7884234B2 (en) * | 2006-10-12 | 2011-02-08 | Institute Of Medicinal Molecular Design, Inc. | N-phenyloxamide derivatives |
| ES2550057T3 (es) | 2006-11-02 | 2015-11-04 | Millennium Pharmaceuticals, Inc. | Métodos para sintetizar sales farmacéuticas de un inhibidor del Factor Xa |
| US20110045028A1 (en) | 2006-11-30 | 2011-02-24 | Takeda Pharmaceutical Company Limited | Sustained release preparation |
| US8633245B2 (en) * | 2008-04-11 | 2014-01-21 | Institute Of Medicinal Molecular Design, Inc. | PAI-1 inhibitor |
| WO2010005087A1 (ja) | 2008-07-11 | 2010-01-14 | 味の素株式会社 | アミジン誘導体 |
| EA015918B1 (ru) | 2010-03-03 | 2011-12-30 | Дмитрий Геннадьевич ТОВБИН | УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa |
| WO2019241213A1 (en) * | 2018-06-11 | 2019-12-19 | The Regents Of The University Of Colorado, A Body Corporate | 2-naphthimidamides, analogues thereof, and methods of treatment using same |
| CN117304076B (zh) * | 2023-11-28 | 2024-02-20 | 苏州大学 | 一种n-磺酰基脒化合物的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443462A (en) * | 1979-08-06 | 1984-04-17 | Merrell Dow Pharmaceuticals Inc. | Antipsychotic 4-(naphthalenyloxy)piperidine derivatives |
| AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
| JPS59139357A (ja) * | 1983-01-28 | 1984-08-10 | Torii Yakuhin Kk | アミジン誘導体 |
| US4563527A (en) * | 1984-07-19 | 1986-01-07 | Torii & Co., Ltd. | Amidine compounds |
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
-
1995
- 1995-12-01 PT PT95938625T patent/PT798295E/pt unknown
- 1995-12-01 DE DE69529770T patent/DE69529770T2/de not_active Expired - Fee Related
- 1995-12-01 RU RU97108576/04A patent/RU2154633C2/ru not_active IP Right Cessation
- 1995-12-01 ES ES95938625T patent/ES2193202T3/es not_active Expired - Lifetime
- 1995-12-01 KR KR1019970703620A patent/KR100383161B1/ko not_active Expired - Fee Related
- 1995-12-01 CN CN95196546A patent/CN1087736C/zh not_active Expired - Fee Related
- 1995-12-01 MX MX9704059A patent/MX9704059A/es not_active IP Right Cessation
- 1995-12-01 AU AU39942/95A patent/AU688628B2/en not_active Ceased
- 1995-12-01 EP EP95938625A patent/EP0798295B1/en not_active Expired - Lifetime
- 1995-12-01 PL PL95320486A patent/PL184824B1/pl not_active IP Right Cessation
- 1995-12-01 AT AT95938625T patent/ATE233240T1/de not_active IP Right Cessation
- 1995-12-01 JP JP8518590A patent/JP3004362B2/ja not_active Expired - Fee Related
- 1995-12-01 NZ NZ296210A patent/NZ296210A/en unknown
- 1995-12-01 HU HU9702028A patent/HUT77313A/hu unknown
- 1995-12-01 WO PCT/JP1995/002458 patent/WO1996016940A1/ja not_active Ceased
- 1995-12-01 US US08/849,391 patent/US5869501A/en not_active Expired - Fee Related
- 1995-12-01 TW TW084112820A patent/TW300888B/zh active
- 1995-12-01 CA CA002206532A patent/CA2206532C/en not_active Expired - Fee Related
-
1997
- 1997-05-30 NO NO972482A patent/NO309566B1/no not_active IP Right Cessation
- 1997-06-02 FI FI972326A patent/FI115051B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69529770D1 (de) | 2003-04-03 |
| ES2193202T3 (es) | 2003-11-01 |
| FI115051B (fi) | 2005-02-28 |
| US5869501A (en) | 1999-02-09 |
| CA2206532C (en) | 2006-07-11 |
| MX9704059A (es) | 1997-08-30 |
| FI972326A7 (fi) | 1997-06-02 |
| RU2154633C2 (ru) | 2000-08-20 |
| CN1167484A (zh) | 1997-12-10 |
| NZ296210A (en) | 1998-05-27 |
| TW300888B (pt) | 1997-03-21 |
| AU3994295A (en) | 1996-06-19 |
| JP3004362B2 (ja) | 2000-01-31 |
| PL320486A1 (en) | 1997-09-29 |
| EP0798295A4 (en) | 1998-03-04 |
| NO309566B1 (no) | 2001-02-19 |
| CA2206532A1 (en) | 1996-06-06 |
| DE69529770T2 (de) | 2003-12-24 |
| CN1087736C (zh) | 2002-07-17 |
| KR100383161B1 (ko) | 2003-12-24 |
| NO972482D0 (no) | 1997-05-30 |
| FI972326A0 (fi) | 1997-06-02 |
| HUT77313A (hu) | 1998-03-30 |
| EP0798295B1 (en) | 2003-02-26 |
| EP0798295A1 (en) | 1997-10-01 |
| ATE233240T1 (de) | 2003-03-15 |
| PL184824B1 (pl) | 2002-12-31 |
| AU688628B2 (en) | 1998-03-12 |
| WO1996016940A1 (en) | 1996-06-06 |
| NO972482L (no) | 1997-08-01 |
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