MX9704059A - Derivado de amidinonaftilo novedoso o sal del mismo. - Google Patents

Derivado de amidinonaftilo novedoso o sal del mismo.

Info

Publication number
MX9704059A
MX9704059A MX9704059A MX9704059A MX9704059A MX 9704059 A MX9704059 A MX 9704059A MX 9704059 A MX9704059 A MX 9704059A MX 9704059 A MX9704059 A MX 9704059A MX 9704059 A MX9704059 A MX 9704059A
Authority
MX
Mexico
Prior art keywords
group
formula
represented
hydrogen atom
group represented
Prior art date
Application number
MX9704059A
Other languages
English (en)
Spanish (es)
Inventor
Fukushi Hirayama
Hiroyuki Koshio
Yuzo Matsumoto
Tomihisa Kawasaki
Seiji Kaku
Isao Yanagisawa
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of MX9704059A publication Critical patent/MX9704059A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
MX9704059A 1994-12-02 1995-12-01 Derivado de amidinonaftilo novedoso o sal del mismo. MX9704059A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP29996394 1994-12-02
JP10520595 1995-04-28
JP19881695 1995-08-03
PCT/JP1995/002458 WO1996016940A1 (en) 1994-12-02 1995-12-01 Novel amidinonaphthyl derivative or salt thereof

Publications (1)

Publication Number Publication Date
MX9704059A true MX9704059A (es) 1997-08-30

Family

ID=27310425

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704059A MX9704059A (es) 1994-12-02 1995-12-01 Derivado de amidinonaftilo novedoso o sal del mismo.

Country Status (20)

Country Link
US (1) US5869501A (de)
EP (1) EP0798295B1 (de)
JP (1) JP3004362B2 (de)
KR (1) KR100383161B1 (de)
CN (1) CN1087736C (de)
AT (1) ATE233240T1 (de)
AU (1) AU688628B2 (de)
CA (1) CA2206532C (de)
DE (1) DE69529770T2 (de)
ES (1) ES2193202T3 (de)
FI (1) FI115051B (de)
HU (1) HUT77313A (de)
MX (1) MX9704059A (de)
NO (1) NO309566B1 (de)
NZ (1) NZ296210A (de)
PL (1) PL184824B1 (de)
PT (1) PT798295E (de)
RU (1) RU2154633C2 (de)
TW (1) TW300888B (de)
WO (1) WO1996016940A1 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69630214T2 (de) 1995-03-10 2004-07-15 Berlex Laboratories, Inc., Richmond Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
CZ43399A3 (cs) 1996-08-15 1999-07-14 Schering Corporation Etheroví muskarinní antagonisté
EP0842941A1 (de) 1996-11-16 1998-05-20 Roche Diagnostics GmbH Neue Phosphonate, Verfahren zu ihrer Herstellung und Arzneimittel
US6653340B1 (en) 1997-06-03 2003-11-25 Biocryst Pharmaceuticals, Inc. Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
EP0993448A1 (de) * 1997-06-19 2000-04-19 The Du Pont Merck Pharmaceutical Company (amidino)6-gliedrige aromaten als factor xa inhibitoren
US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
ZA986594B (en) * 1997-07-25 1999-01-27 Abbott Lab Urokinase inhibitors
US6258822B1 (en) 1997-08-06 2001-07-10 Abbott Laboratories Urokinase inhibitors
AU8886698A (en) * 1997-09-01 1999-03-22 Yamanouchi Pharmaceutical Co., Ltd. Novel naphthamide derivatives or salts thereof
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
DE19754490A1 (de) * 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
CA2318351A1 (en) * 1997-12-26 1999-07-08 Hidemitsu Nishida Aromatic compounds having cyclic amino or salts thereof
WO1999037643A1 (en) * 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof
EP0937723A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP1066272A4 (de) * 1998-03-27 2002-03-13 Biocryst Pharm Inc Neue verbindungen, die im komplement-, koagulat- und kallikrein-reaktionsweg nützlich sind und verfahren zu ihrer herstellung
TR200002904T2 (tr) * 1998-04-10 2001-02-21 Japan Tobacco Inc. Amidin bileşikleri
US6284796B1 (en) 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
US6504031B1 (en) 1998-08-06 2003-01-07 Milan Bruncko Naphthamidine urokinase inhibitors
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
CA2348740A1 (en) 1998-12-23 2000-07-06 Ruth R. Wexler Thrombin or factor xa inhibitors
CN100488947C (zh) 1999-01-13 2009-05-20 杰南技术公司 丝氨酸蛋白酶抑制剂
WO2000043041A1 (fr) * 1999-01-22 2000-07-27 Yamanouchi Pharmaceutical Co., Ltd. Compositions medicamenteuses presentant une meilleure absorption orale
WO2000051998A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
FR2793247B1 (fr) * 1999-05-04 2001-06-22 Synthelabo Derives de 6-[[(aryl et heteroaryl)oxy]methyl]naphtalene-2- carboximidamide, leur preparation et leur application en therapeutique
US6858599B2 (en) * 1999-06-30 2005-02-22 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having spiro union
AU5570900A (en) * 1999-07-01 2001-01-22 Sankyo Company Limited Indoline or tetrahydroquinoline derivatives
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
DE60027204T2 (de) 1999-10-28 2006-11-23 Sankyo Co., Ltd. Benzamidinderivate
EP1095933A1 (de) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH N-Guanidinoalkylamide, Verfahren zu ihrer Herstellung, ihre Verwendung und pharmazeutische Zusammensetzungen, die sie enthalten
AU2001234689A1 (en) * 2000-02-01 2001-08-14 Cor Therapeutics, Inc. Bivalent phenylene inhibitors of factor xa
ES2254385T3 (es) 2000-02-29 2006-06-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
AU2001249397A1 (en) * 2000-03-24 2001-10-08 Cor Therapeutics, Inc. Oxindole inhibitors of factor xa
AU776053B2 (en) * 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
US6495562B1 (en) 2000-04-25 2002-12-17 Abbott Laboratories Naphthamidine urokinase inhibitors
US6410733B1 (en) 2000-09-11 2002-06-25 Genentech, Inc. Amidine inhibitors of serine proteases
RU2276137C2 (ru) * 2000-11-22 2006-05-10 Астеллас Фарма Инк. Замещенные производные бензола или их соли, фармацевтическая композиция на их основе
CA2440389A1 (en) 2001-03-09 2002-10-03 Ortho-Mcneil Pharmaceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US6710061B2 (en) 2001-03-09 2004-03-23 Ortho-Mcneil Pharamceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
RU2256652C1 (ru) 2001-04-05 2005-07-20 Санкио Компани, Лимитед Соединение, фармацевтическая композиция, применение, способ предупреждения или лечения заболеваний
EP1569912B1 (de) 2002-12-03 2015-04-29 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidinderivate als faktor vii-a hemmer
ATE510817T1 (de) 2002-01-29 2011-06-15 Merck Serono Sa Substituierte methylenamidderivate als modulatoren von proteintyrosinphosphatasen (ptps)
RU2226392C1 (ru) * 2002-10-23 2004-04-10 Биологический факультет Московского государственного университета им. М.В. Ломоносова Способ ингибирования агрегации тромбоцитов
WO2004048363A1 (ja) 2002-11-22 2004-06-10 Takeda Pharmaceutical Company Limited イミダゾール誘導体、その製造法および用途
KR20050092373A (ko) * 2002-12-24 2005-09-21 다이이찌 세이야꾸 가부시기가이샤 신규한 에틸렌디아민 유도체
WO2004113316A1 (en) 2003-05-20 2004-12-29 Genentech, Inc. Benzofuran inhibitors of factor viia
US7250447B2 (en) 2003-05-20 2007-07-31 Genentech, Inc. Acylsulfamide inhibitors of factor VIIa
CN1886398A (zh) 2003-10-09 2006-12-27 米伦纽姆医药公司 作为Xa因子抑制剂的经硫醚取代的苯甲酰胺
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
JP5020073B2 (ja) 2004-06-18 2012-09-05 ミレニアム ファーマシューティカルズ インク. 第Xa因子阻害剤
US7612089B2 (en) 2004-11-19 2009-11-03 Portola Pharmaceuticals, Inc. Tetrahydroisoquinolines as factor Xa inhibitors
US7678913B2 (en) 2004-12-07 2010-03-16 Portola Pharmaceuticals, Inc. Ureas as factor Xa inhibitors
WO2006063293A2 (en) * 2004-12-07 2006-06-15 Portola Pharmaceuticals, Inc. THIOUREAS AS FACTOR Xa INHIBITORS
JP4900238B2 (ja) 2005-02-02 2012-03-21 味の素株式会社 新規ベンズアミジン化合物
RU2440986C2 (ru) 2005-11-08 2012-01-27 Милленниум Фамэсьютикэлс, Инк. СОЛЬ ИНГИБИТОРА ФАКТОРА Ха, СПОСОБ ЕЕ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЕ ОСНОВЕ, СОСТОЯЩИЕ ИЗ НАЗВАННОЙ КОМПОЗИЦИИ ТАБЛЕТКА, КАПСУЛА И ЛЕПЕШКА, СПОСОБ ЛЕЧЕНИЯ ТРОМБОЗА И СПОСОБ ИНГИБИРОВАНИЯ КОАГУЛЯЦИИ ОБРАЗЦОВ КРОВИ
US20100261758A1 (en) * 2006-03-28 2010-10-14 Novartis Ag Heterocyclic amides for use as pharmaceuticals
AU2007307599A1 (en) * 2006-10-12 2008-04-17 Institute Of Medicinal Molecular Design. Inc. N-phenyloxamic acid derivatives
PT2077995E (pt) 2006-11-02 2012-05-10 Millennium Pharm Inc Métodos de sintetizar sais farmacêuticos de um inibidor de fator xa
US20110045028A1 (en) 2006-11-30 2011-02-24 Takeda Pharmaceutical Company Limited Sustained release preparation
US8633245B2 (en) * 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor
KR20110036833A (ko) 2008-07-11 2011-04-11 아지노모토 가부시키가이샤 아미딘 유도체
EA015918B1 (ru) 2010-03-03 2011-12-30 Дмитрий Геннадьевич ТОВБИН УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa
WO2019241213A1 (en) * 2018-06-11 2019-12-19 The Regents Of The University Of Colorado, A Body Corporate 2-naphthimidamides, analogues thereof, and methods of treatment using same
CN117304076B (zh) * 2023-11-28 2024-02-20 苏州大学 一种n-磺酰基脒化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443462A (en) * 1979-08-06 1984-04-17 Merrell Dow Pharmaceuticals Inc. Antipsychotic 4-(naphthalenyloxy)piperidine derivatives
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
US4563527A (en) * 1984-07-19 1986-01-07 Torii & Co., Ltd. Amidine compounds
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.

Also Published As

Publication number Publication date
CA2206532C (en) 2006-07-11
FI972326A0 (fi) 1997-06-02
ATE233240T1 (de) 2003-03-15
DE69529770D1 (de) 2003-04-03
US5869501A (en) 1999-02-09
EP0798295A4 (de) 1998-03-04
CA2206532A1 (en) 1996-06-06
PL184824B1 (pl) 2002-12-31
FI115051B (fi) 2005-02-28
JP3004362B2 (ja) 2000-01-31
RU2154633C2 (ru) 2000-08-20
AU688628B2 (en) 1998-03-12
NZ296210A (en) 1998-05-27
ES2193202T3 (es) 2003-11-01
KR100383161B1 (ko) 2003-12-24
TW300888B (de) 1997-03-21
PT798295E (pt) 2003-07-31
AU3994295A (en) 1996-06-19
HUT77313A (hu) 1998-03-30
NO972482D0 (no) 1997-05-30
EP0798295B1 (de) 2003-02-26
WO1996016940A1 (en) 1996-06-06
FI972326A7 (fi) 1997-06-02
CN1087736C (zh) 2002-07-17
CN1167484A (zh) 1997-12-10
PL320486A1 (en) 1997-09-29
EP0798295A1 (de) 1997-10-01
DE69529770T2 (de) 2003-12-24
NO972482L (no) 1997-08-01
NO309566B1 (no) 2001-02-19

Similar Documents

Publication Publication Date Title
FI972326A0 (fi) Uusi amidinonaftyylijohdannainen tai sen suola
BR0114257A (pt) Ligandos de receptores de melanocortina
ATE170508T1 (de) Bisulfit-additionsverbindungen von argininaldehyden und ihre verwendung als thrombininhibitoren und antikoagulantien
MY121967A (en) New 4-(oxyalkoxyphenyl)-3-oxy-piperidines for treating heart and kidney insufficiency
DE50311008D1 (de) Mikroemulsion enthaltend uv-lichtschutzfilter und/oder antischuppenmittel
BR9916111A (pt) Derivados de fenilglicina
DK1158973T3 (da) Anvendelse af sulfamatderivater til behandling af impulskontrolafvigelser
NO2016007I1 (no) Susoktokog
FR2805817B1 (fr) Compositions pharmaceutiques contenant des derives d'azetidine, les nouveaux derives d'azetidine et leur preparation
BR0001468A (pt) ácidos dioxiciclopentil hidroxânicos
ES2151110T3 (es) Derivados de piridazinona y procedimiento de preparacion.
DK0672659T3 (da) Antitrombotiske midler
ATE302587T1 (de) Gebissreinigungsmittel
BR9802544A (pt) Derivados de hexahidro-1,4-diazepina os seus sais.
DE60135001D1 (de) Verwendung von polyethylenglycol ( peg ) zur herstellung eines medikamentes zur behandlung von verstopfung
FR2790953B1 (fr) Composition a phase aqueuse continue renfermant de l'acide l-2-oxothiazolidine 4-carboxylique
FR2687154B1 (fr) Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent.
DE59303894D1 (de) Flüssige zahnreinigungsmittel
ES2103615T3 (es) Nuevo compuesto de triazol fungicida, preparacion y utilizacion del mismo.
ES2101738T3 (es) Tintes de benzoxacina.
EP0790247A4 (de) Tetrahydroisochinolin-derivate und diese enthaltende arzneimittel
ATE299027T1 (de) Verwendung von übersulfatierten polysacchariden als hiv-hemmer
DE69701381D1 (de) Peptid-aldehydderivate als antikoagulierende mittel
ES2108832T3 (es) Agente que mejora la circulacion periferica.
ATE269088T1 (de) Tixocortolpivalathaltige pharmazeutische suspension,daraus hergestelltes mundwasser und diese suspension enthaltende verpackung

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees