BR9802544A - Derivados de hexahidro-1,4-diazepina os seus sais. - Google Patents

Derivados de hexahidro-1,4-diazepina os seus sais.

Info

Publication number
BR9802544A
BR9802544A BR9802544-9A BR9802544A BR9802544A BR 9802544 A BR9802544 A BR 9802544A BR 9802544 A BR9802544 A BR 9802544A BR 9802544 A BR9802544 A BR 9802544A
Authority
BR
Brazil
Prior art keywords
hexahydro
diazepine
salts
derivatives
compounds
Prior art date
Application number
BR9802544-9A
Other languages
English (en)
Inventor
Hiroyuki Koshio
Fukushi Hirayama
Tsukasa Ishihara
Masashi Funatsu
Tomihisa Kawasaki
Yuzo Matsumoto
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of BR9802544A publication Critical patent/BR9802544A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção:<B>"DERIVADOS DE HEXAHIDRO-1,4-DIAZEPINA OU SEUS SAIS"<D>. São fornecidos compostos que têm uma atividade anticoagulante baseada na inibição do fator X de coagulação do sangue ativado, e são úteis como anticoagulantes ou como medicamentos para prevenir ou tratar distúrbios induzidos por trombos ou êmbolos. Os compostos são derivados de hexahidro-1,4-diazepina da fórmula geral (I) a seguir ou sais farmaceuticamente aceitáveis dos mesmos: (I) onde os símbolos têm os seguintes significados: A:um grupo fenileno ou piridileno, R^ 1^: um átomo de hidrogênio, um grupo -C(=NH)-alquila inferior, X: -CO- ou -SO~ 2~-, Y: uma ligação química ou um grupo alquileno inferior, R^ 2^: -COOH ou um grupo -COO-alquila inferior.
BR9802544-9A 1997-07-23 1998-07-21 Derivados de hexahidro-1,4-diazepina os seus sais. BR9802544A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19758797 1997-07-23

Publications (1)

Publication Number Publication Date
BR9802544A true BR9802544A (pt) 2000-02-08

Family

ID=16376978

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9802544-9A BR9802544A (pt) 1997-07-23 1998-07-21 Derivados de hexahidro-1,4-diazepina os seus sais.

Country Status (10)

Country Link
US (1) US6333320B1 (pt)
EP (1) EP1000936A1 (pt)
KR (1) KR19990014049A (pt)
AR (1) AR013366A1 (pt)
AU (2) AU735144B2 (pt)
BR (1) BR9802544A (pt)
CA (1) CA2289572A1 (pt)
HU (1) HUP9801671A3 (pt)
PL (1) PL327681A1 (pt)
WO (1) WO1999005124A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA986594B (en) * 1997-07-25 1999-01-27 Abbott Lab Urokinase inhibitors
US6258822B1 (en) 1997-08-06 2001-07-10 Abbott Laboratories Urokinase inhibitors
WO1999037643A1 (fr) * 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Nouveaux derives heterocycliques a fusion benzenique ou sels de ceux-ci
US6504031B1 (en) 1998-08-06 2003-01-07 Milan Bruncko Naphthamidine urokinase inhibitors
US6284796B1 (en) 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
EP1122242B1 (en) * 1998-09-22 2008-01-16 Astellas Pharma Inc. Cyanophenyl derivatives
EP1263754A1 (en) * 2000-02-01 2002-12-11 Millennium Pharmaceuticals, Inc. INDALONE AND BENZIMIDAZOLONE INHIBITORS OF FACTOR Xa
US6495562B1 (en) 2000-04-25 2002-12-17 Abbott Laboratories Naphthamidine urokinase inhibitors
AU2001280438A1 (en) * 2000-07-27 2002-02-13 Eli Lilly And Company Substituted heterocyclic amides
WO2002064567A2 (en) * 2000-11-28 2002-08-22 Eli Lilly And Company Substituted carboxamides as inhibitors of factor xa
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
GB0815781D0 (en) * 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59139357A (ja) 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
ZA928276B (en) 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
JP3079570B2 (ja) * 1992-07-15 2000-08-21 大正製薬株式会社 チアゾリン誘導体
US5478945A (en) 1992-07-15 1995-12-26 Taisho Pharmaceutical Co., Ltd. Thiazoline derivatives
JPH1017549A (ja) * 1996-07-02 1998-01-20 Banyu Pharmaceut Co Ltd 二環性芳香族アミジン誘導体

Also Published As

Publication number Publication date
HU9801671D0 (en) 1998-09-28
WO1999005124A1 (fr) 1999-02-04
PL327681A1 (en) 1999-02-01
AR013366A1 (es) 2000-12-27
HUP9801671A3 (en) 2000-04-28
US6333320B1 (en) 2001-12-25
AU8356098A (en) 1999-02-16
AU735144B2 (en) 2001-07-05
HUP9801671A2 (hu) 1999-03-29
KR19990014049A (ko) 1999-02-25
EP1000936A1 (en) 2000-05-17
CA2289572A1 (en) 1999-02-04
AU7730198A (en) 1999-02-04

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law