ES2120132T3 - Aductos de bisulfito de argininaldehidos utiles como inhibidores de la trombina y anticoagulantes. - Google Patents

Aductos de bisulfito de argininaldehidos utiles como inhibidores de la trombina y anticoagulantes.

Info

Publication number
ES2120132T3
ES2120132T3 ES95301389T ES95301389T ES2120132T3 ES 2120132 T3 ES2120132 T3 ES 2120132T3 ES 95301389 T ES95301389 T ES 95301389T ES 95301389 T ES95301389 T ES 95301389T ES 2120132 T3 ES2120132 T3 ES 2120132T3
Authority
ES
Spain
Prior art keywords
argininaldehyde
addicts
bisulphite
anticoagulants
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95301389T
Other languages
English (en)
Inventor
Kenneth James Ruterbories
Robert Theodore Shuman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2120132T3 publication Critical patent/ES2120132T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

ESTA INVENCION SE REFIERE A ADUCTOS DE BISULFITO DE DERIVADOS DE ALDEHIDOS DE L-ARGININA, TENIENDO LOS ADUCTOS LA FORMULA (I) DONDE M, X E Y TIENEN LOS VALORES DEFINIDOS EN LA DESCRIPCION, ASI COMO FORMULACIONES FARMACEUTICAS QUE CONTIENEN ESTOS COMPUESTOS Y METODOS PARA SU USO COMO INHIBIDORES DE TROMBINA, INHIBIDORES DE COAGULACION Y AGENTES DE TRASTORNOS TROMOEMBOLICOS.
ES95301389T 1994-03-04 1995-03-03 Aductos de bisulfito de argininaldehidos utiles como inhibidores de la trombina y anticoagulantes. Expired - Lifetime ES2120132T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/206,579 US5436229A (en) 1994-03-04 1994-03-04 Bisulfite adducts of arginine aldehydes

Publications (1)

Publication Number Publication Date
ES2120132T3 true ES2120132T3 (es) 1998-10-16

Family

ID=22767010

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95301389T Expired - Lifetime ES2120132T3 (es) 1994-03-04 1995-03-03 Aductos de bisulfito de argininaldehidos utiles como inhibidores de la trombina y anticoagulantes.

Country Status (9)

Country Link
US (1) US5436229A (es)
EP (1) EP0670310B1 (es)
JP (1) JPH07278095A (es)
AT (1) ATE170508T1 (es)
CA (1) CA2143532A1 (es)
DE (1) DE69504383T2 (es)
DK (1) DK0670310T3 (es)
ES (1) ES2120132T3 (es)
SI (1) SI0670310T1 (es)

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US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
ES2293651T3 (es) * 1995-11-28 2008-03-16 Cephalon, Inc. Inhibidores de cisteina y serina proteasas derivados de aminoacidos d.
KR19990071666A (ko) * 1995-11-30 1999-09-27 이경하 술파미드 유도체
US6001994A (en) * 1995-12-13 1999-12-14 Eli Lilly And Company Process for making gemcitabine hydrochloride
US5756775A (en) * 1995-12-13 1998-05-26 Eli Lilly And Company Process to make α,α-difluoro-β-hydroxyl thiol esters
EP0975353B1 (en) 1997-04-18 2005-11-09 Cephalon, Inc. Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors
US6214841B1 (en) 1997-05-15 2001-04-10 Eli Lilly And Company Antithrombotic compound
SE9802973D0 (sv) * 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
DE10121003A1 (de) * 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
WO2003016273A2 (en) * 2001-08-21 2003-02-27 Ivax Corporation Peptide arginals and methods for treating disseminated intravascular coagulation
BR112013033816A2 (pt) 2011-07-01 2017-02-14 Novozymes A / S composição de detergente líquido sem boro
IN2014CN00700A (es) * 2011-07-01 2015-04-03 Novozymes As
US20160024440A1 (en) 2013-03-14 2016-01-28 Novozymes A/S Enzyme and Inhibitor Containing Water-Soluble Films
WO2014177709A1 (en) 2013-05-03 2014-11-06 Novozymes A/S Microencapsulation of detergent enzymes
US20170121646A1 (en) 2014-07-03 2017-05-04 Novozymes A/S Improved Stabilization of Non-Protease Enzyme
DK3234093T3 (da) 2014-12-19 2020-08-17 Novozymes As Proteasevarianter og polynukleotider, som koder for dem
EP3320089B1 (en) 2015-07-06 2021-06-16 Novozymes A/S Lipase variants and polynucleotides encoding same
ES2759360T3 (es) 2015-10-09 2020-05-08 Axichem Ab Pienso para aves y, en particular, pienso para aves de corral, que comprende derivados capsaicinoides sintéticos y piensos de este tipo para un uso o tratamiento profiláctico de infección de salmonella
CN110651038A (zh) 2017-05-05 2020-01-03 诺维信公司 包含脂肪酶和亚硫酸盐的组合物
CN111108183A (zh) 2017-06-30 2020-05-05 诺维信公司 酶浆液组合物
WO2019086528A1 (en) 2017-11-01 2019-05-09 Novozymes A/S Polypeptides and compositions comprising such polypeptides
US11767492B2 (en) 2017-11-01 2023-09-26 Novozymes A/S Methods of treating fabric using a Lactobacillus hexosaminidase
WO2019175240A1 (en) 2018-03-13 2019-09-19 Novozymes A/S Microencapsulation using amino sugar oligomers
EP3647397A1 (en) 2018-10-31 2020-05-06 Henkel AG & Co. KGaA Cleaning compositions containing dispersins iv
EP3647398B1 (en) 2018-10-31 2024-05-15 Henkel AG & Co. KGaA Cleaning compositions containing dispersins v
JP2022538360A (ja) 2019-07-01 2022-09-01 ビーエーエスエフ ソシエタス・ヨーロピア 酵素を安定化するためのペプチドアセタール
WO2021123307A2 (en) 2019-12-20 2021-06-24 Novozymes A/S Polypeptides having proteolytic activity and use thereof
WO2021236475A1 (en) * 2020-05-18 2021-11-25 Asinex Corporation Compounds that inhibit asparagine synthetase and their methods of use
WO2022189521A1 (en) 2021-03-12 2022-09-15 Novozymes A/S Polypeptide variants

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HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a
HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
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HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
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US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
DE3827415A1 (de) * 1988-08-12 1990-02-15 Behringwerke Ag Peptidderivate, verfahren zu ihrer herstellung und ihre verwendung
US5204323B1 (en) * 1988-10-06 1995-07-18 Ciba Geigy Corp Hirudin antidotal compositions and methods
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US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
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EP0503203A1 (en) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
AU655831B2 (en) * 1991-08-22 1995-01-12 Merrell Pharmaceuticals Inc. Novel orally-active elastase inhibitors
SE9102462D0 (sv) * 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
WO1993008211A1 (en) * 1991-10-23 1993-04-29 The Procter & Gamble Company Tripeptide derivative anti-inflammatory agents
ZA928581B (en) * 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
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Also Published As

Publication number Publication date
ATE170508T1 (de) 1998-09-15
DE69504383T2 (de) 1999-02-11
EP0670310A1 (en) 1995-09-06
JPH07278095A (ja) 1995-10-24
DE69504383D1 (de) 1998-10-08
SI0670310T1 (en) 1999-02-28
US5436229A (en) 1995-07-25
CA2143532A1 (en) 1995-09-05
EP0670310B1 (en) 1998-09-02
DK0670310T3 (da) 1999-02-08

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