DE69504383D1 - Bisulfit-Additionsverbindungen von Argininaldehyden und ihre Verwendung als Thrombininhibitoren und Antikoagulantien - Google Patents

Bisulfit-Additionsverbindungen von Argininaldehyden und ihre Verwendung als Thrombininhibitoren und Antikoagulantien

Info

Publication number
DE69504383D1
DE69504383D1 DE69504383T DE69504383T DE69504383D1 DE 69504383 D1 DE69504383 D1 DE 69504383D1 DE 69504383 T DE69504383 T DE 69504383T DE 69504383 T DE69504383 T DE 69504383T DE 69504383 D1 DE69504383 D1 DE 69504383D1
Authority
DE
Germany
Prior art keywords
anticoagulants
thrombin inhibitors
addition compounds
bisulfite addition
arginine aldehydes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69504383T
Other languages
English (en)
Other versions
DE69504383T2 (de
Inventor
Kenneth James Ruterbories
Robert Theodore Shuman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69504383D1 publication Critical patent/DE69504383D1/de
Application granted granted Critical
Publication of DE69504383T2 publication Critical patent/DE69504383T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69504383T 1994-03-04 1995-03-03 Bisulfit-Additionsverbindungen von Argininaldehyden und ihre Verwendung als Thrombininhibitoren und Antikoagulantien Expired - Fee Related DE69504383T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/206,579 US5436229A (en) 1994-03-04 1994-03-04 Bisulfite adducts of arginine aldehydes

Publications (2)

Publication Number Publication Date
DE69504383D1 true DE69504383D1 (de) 1998-10-08
DE69504383T2 DE69504383T2 (de) 1999-02-11

Family

ID=22767010

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69504383T Expired - Fee Related DE69504383T2 (de) 1994-03-04 1995-03-03 Bisulfit-Additionsverbindungen von Argininaldehyden und ihre Verwendung als Thrombininhibitoren und Antikoagulantien

Country Status (9)

Country Link
US (1) US5436229A (de)
EP (1) EP0670310B1 (de)
JP (1) JPH07278095A (de)
AT (1) ATE170508T1 (de)
CA (1) CA2143532A1 (de)
DE (1) DE69504383T2 (de)
DK (1) DK0670310T3 (de)
ES (1) ES2120132T3 (de)
SI (1) SI0670310T1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
CA2143533A1 (en) * 1994-03-04 1995-09-05 Kenneth D. Kurz Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
CA2238175A1 (en) * 1995-11-28 1997-06-19 Cephalon, Inc. D-amino acid derived inhibitors of cysteine and serine proteases
WO1997019919A1 (fr) * 1995-11-30 1997-06-05 C & C Research Laboratories Derives de sulfamides
US6001994A (en) * 1995-12-13 1999-12-14 Eli Lilly And Company Process for making gemcitabine hydrochloride
US5756775A (en) * 1995-12-13 1998-05-26 Eli Lilly And Company Process to make α,α-difluoro-β-hydroxyl thiol esters
DE69832268T2 (de) 1997-04-18 2006-07-13 Cephalon, Inc. Peptidyl2-amino-1hydroxyalkansulfonsäuren als zysteinprotease-inhibitoren
WO1998051684A1 (en) 1997-05-15 1998-11-19 Eli Lilly And Company Antithrombotic compound
SE9802973D0 (sv) * 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
DE10121003A1 (de) * 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
JP4230908B2 (ja) * 2001-08-21 2009-02-25 イヴァックス インスティテュート フォー ドラッグ リサーチ，リミテッド ペプチド・アルギナル類および播種性血管内血液凝固の治療方法
CN107858217B (zh) * 2011-07-01 2021-03-23 诺维信公司 稳定化的枯草杆菌蛋白酶组合物
CN112143570A (zh) 2011-07-01 2020-12-29 诺维信公司 液体洗涤剂组合物
CN105189724A (zh) 2013-03-14 2015-12-23 诺维信公司 含有酶和抑制剂的水溶性膜
JP7020778B2 (ja) 2013-05-03 2022-02-16 ノボザイムス アクティーゼルスカブ 洗剤酵素のマイクロカプセル化
WO2016001319A1 (en) 2014-07-03 2016-01-07 Novozymes A/S Improved stabilization of non-protease enzyme
WO2016097352A1 (en) 2014-12-19 2016-06-23 Novozymes A/S Protease variants and polynucleotides encoding same
EP3950939A3 (de) 2015-07-06 2022-06-08 Novozymes A/S Lipasevarianten und polynukleotide zur codierung davon
WO2017061871A1 (en) 2015-10-09 2017-04-13 Axichem Ab Bird feed and in particular poultry feed, comprising synthetic capsaicinoid derivatives and such feed for prohylactic use or treatment of salmonella infection
EP3619304A1 (de) 2017-05-05 2020-03-11 Novozymes A/S Lipase und sulfit enthaltende zusammensetzungen
CN111108183A (zh) 2017-06-30 2020-05-05 诺维信公司 酶浆液组合物
EP3704219B1 (de) 2017-11-01 2024-01-10 Novozymes A/S Polypeptide und zusammensetzungen mit solchen polypeptiden
EP3704240A1 (de) 2017-11-01 2020-09-09 Novozymes A/S Polypeptide und zusammensetzungen mit solchen polypeptiden
CN111770788B (zh) 2018-03-13 2023-07-25 诺维信公司 使用氨基糖低聚物进行微囊化
EP3647397A1 (de) 2018-10-31 2020-05-06 Henkel AG & Co. KGaA Reinigungsmittel mit dispersins iv
EP3647398B1 (de) 2018-10-31 2024-05-15 Henkel AG & Co. KGaA Reinigungszusammensetzungen mit dispersinen v
MX2021015894A (es) 2019-07-01 2022-02-03 Basf Se Peptidos acetales para estabilizar enzimas.
US20220411773A1 (en) 2019-12-20 2022-12-29 Novozymes A/S Polypeptides having proteolytic activity and use thereof
WO2021236475A1 (en) * 2020-05-18 2021-11-25 Asinex Corporation Compounds that inhibit asparagine synthetase and their methods of use
WO2022189521A1 (en) 2021-03-12 2022-09-15 Novozymes A/S Polypeptide variants
WO2024131880A2 (en) 2022-12-23 2024-06-27 Novozymes A/S Detergent composition comprising catalase and amylase

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU177098B (en) * 1979-01-04 1981-07-28 Gyogyszerkutato Intezet Process for producing new peptidyl-n-carboxy-l-arginin-a
HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
DE3481913D1 (de) * 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
HU192646B (en) * 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
DE3606480A1 (de) * 1986-02-28 1987-09-03 Behringwerke Ag Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
DE3827415A1 (de) * 1988-08-12 1990-02-15 Behringwerke Ag Peptidderivate, verfahren zu ihrer herstellung und ihre verwendung
US5204323B1 (en) * 1988-10-06 1995-07-18 Ciba Geigy Corp Hirudin antidotal compositions and methods
CA2021660A1 (en) * 1989-07-26 1991-01-27 Philippe Bey Peptidase inhibitors
US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
IL99527A (en) * 1990-09-28 1997-08-14 Lilly Co Eli Tripeptide antithrombotic agents
EP0503203A1 (de) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Neue Thrombin-Inhibitoren
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
AU655831B2 (en) * 1991-08-22 1995-01-12 Merrell Pharmaceuticals Inc. Novel orally-active elastase inhibitors
SE9102462D0 (sv) * 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
AU2882792A (en) * 1991-10-23 1993-05-21 Procter & Gamble Company, The Tripeptide derivative anti-inflammatory agents
US5250660A (en) * 1991-11-12 1993-10-05 Eli Lilly And Company Peptide purification process
CZ333492A3 (en) * 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised

Also Published As

Publication number Publication date
SI0670310T1 (en) 1999-02-28
EP0670310A1 (de) 1995-09-06
ES2120132T3 (es) 1998-10-16
EP0670310B1 (de) 1998-09-02
DK0670310T3 (da) 1999-02-08
CA2143532A1 (en) 1995-09-05
ATE170508T1 (de) 1998-09-15
US5436229A (en) 1995-07-25
JPH07278095A (ja) 1995-10-24
DE69504383T2 (de) 1999-02-11

Similar Documents

Publication Publication Date Title
DE69504383D1 (de) Bisulfit-Additionsverbindungen von Argininaldehyden und ihre Verwendung als Thrombininhibitoren und Antikoagulantien
DE69507062D1 (de) Verbindungen zur Hemmung der Thrombin
BR9806752A (pt) Ftalazinonas.
PT672658E (pt) Agentes antitromboticos
DE60118774D1 (de) Substituierte phenolderivate und deren salze als hemmstoffe von koagulations faktor x
ATE547101T1 (de) Verfahren zur verwendung von diketopiperazinen und zusammensetzungen, die diese enthalten
DE69910831D1 (de) Epothilonderivate und ihre verwendung als antitumormittel
EA200500856A1 (ru) Новые химические соединения
EA200001133A1 (ru) Антипикорнавирусные композиции, их получение и применение
BR0209149A (pt) Ftalazinonas
PT1206484E (pt) Compostos e composicoes antipicornavirais, suas utilizacoes farmaceuticas e materiais para a sua sintese
EA200200625A1 (ru) Антипикорнавирусные соединения и композиции, их фармацевтическое применение и вещества для их синтеза
ATE403712T1 (de) Verwendung von polymerisaten, enthaltend thermoplastische polymere als filterhilfs- und/oder stabilisierungsmittel
WO2001079167A3 (en) Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
BR9904075A (pt) Cetonas
DE60131968D1 (de) PYRANOÄ2,3-cÜIMIDAZOÄ1,2-aÜPYRIDIN-DERIVATE ZUR BEHANDLUNG VON GASTROINTESTINALEN ERKRANKUNGEN
ATE302026T1 (de) Zusammensetzung enthaltend einen inhibitor der signaltransduktion von heterometrischen g proteinen in kombination mit einem antihypertensiven mittel zu einer therapeutischen verwendung in der behandlung von arterieller hypertonie
ATE348611T1 (de) Derivate des phenoxy-n-'4-(isothiazolidin-1,1- dioxid-2yl)pheny)-valerian-säureamids und andere verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen und tumoren
CY1106472T1 (el) Η χρηση των παραγωγων υδροξυπυριδονης στην επουλωση πληγων
EA200100151A1 (ru) Производные пиперазинона и их применение
EA200200321A1 (ru) Апоптин-ассоциированный белок
ATE244714T1 (de) 1-(3-aminoindazol-5-yl)-3-phenylmethyl cyclische harnstoffe und ihre verwendung als hiv protease inhibitoren
WO2001096297A3 (en) Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
EA199900257A1 (ru) Промежуточные соединения для получения ингибиторов вич-протеазы и способы получения ингибиторов вич-протеазы
DE59905355D1 (de) Verwendung von katecholderivaten als proteinaseinhibitoren

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee