ATE170508T1 - Bisulfit-additionsverbindungen von argininaldehyden und ihre verwendung als thrombininhibitoren und antikoagulantien - Google Patents
Bisulfit-additionsverbindungen von argininaldehyden und ihre verwendung als thrombininhibitoren und antikoagulantienInfo
- Publication number
- ATE170508T1 ATE170508T1 AT95301389T AT95301389T ATE170508T1 AT E170508 T1 ATE170508 T1 AT E170508T1 AT 95301389 T AT95301389 T AT 95301389T AT 95301389 T AT95301389 T AT 95301389T AT E170508 T1 ATE170508 T1 AT E170508T1
- Authority
- AT
- Austria
- Prior art keywords
- argininal
- dehydes
- anticoagulants
- thrombin inhibitors
- addition compounds
- Prior art date
Links
- 229940122388 Thrombin inhibitor Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003868 thrombin inhibitor Substances 0.000 title abstract 2
- QJYRUYURLPTHLR-YFKPBYRVSA-N 2-[(4s)-4-amino-5-oxopentyl]guanidine Chemical compound O=C[C@@H](N)CCCNC(N)=N QJYRUYURLPTHLR-YFKPBYRVSA-N 0.000 title 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 title 1
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 229940127219 anticoagulant drug Drugs 0.000 title 1
- 229930064664 L-arginine Natural products 0.000 abstract 1
- 235000014852 L-arginine Nutrition 0.000 abstract 1
- -1 L-arginine aldehyde Chemical class 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical class OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 abstract 1
- 239000003130 blood coagulation factor inhibitor Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/206,579 US5436229A (en) | 1994-03-04 | 1994-03-04 | Bisulfite adducts of arginine aldehydes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE170508T1 true ATE170508T1 (de) | 1998-09-15 |
Family
ID=22767010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95301389T ATE170508T1 (de) | 1994-03-04 | 1995-03-03 | Bisulfit-additionsverbindungen von argininaldehyden und ihre verwendung als thrombininhibitoren und antikoagulantien |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5436229A (de) |
| EP (1) | EP0670310B1 (de) |
| JP (1) | JPH07278095A (de) |
| AT (1) | ATE170508T1 (de) |
| CA (1) | CA2143532A1 (de) |
| DE (1) | DE69504383T2 (de) |
| DK (1) | DK0670310T3 (de) |
| ES (1) | ES2120132T3 (de) |
| SI (1) | SI0670310T1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA951618B (en) * | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
| CA2143533A1 (en) * | 1994-03-04 | 1995-09-05 | Kenneth D. Kurz | Antithrombotic agents |
| US5602101A (en) * | 1994-03-04 | 1997-02-11 | Eli Lilly And Company | Antithrombotic agents |
| US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| US5885967A (en) * | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
| US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
| US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
| US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
| US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
| ATE377006T1 (de) * | 1995-11-28 | 2007-11-15 | Cephalon Inc | Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer |
| WO1997019919A1 (en) * | 1995-11-30 | 1997-06-05 | C & C Research Laboratories | Sulfamide derivatives |
| US5756775A (en) * | 1995-12-13 | 1998-05-26 | Eli Lilly And Company | Process to make α,α-difluoro-β-hydroxyl thiol esters |
| US6001994A (en) * | 1995-12-13 | 1999-12-14 | Eli Lilly And Company | Process for making gemcitabine hydrochloride |
| JP4144811B2 (ja) | 1997-04-18 | 2008-09-03 | セフアロン・インコーポレーテツド | ペプチジル−２−アミノ−１−ヒドロキシアルカンスルホン酸システインプロテアーゼインヒビター |
| AU7292398A (en) | 1997-05-15 | 1998-12-08 | Eli Lilly And Company | Antithrombotic compound |
| SE9802973D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
| DE10121003A1 (de) * | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| CZ2004265A3 (cs) * | 2001-08-21 | 2004-08-18 | Ivaxáinstituteáforádrugáresearchźáltd | Peptidové arginaly a způsoby léčby diseminované intravaskulární koagulace |
| MX350874B (es) | 2011-07-01 | 2017-09-19 | Novozymes As | Composicion de detergente liquido. |
| RU2635355C2 (ru) * | 2011-07-01 | 2017-11-13 | Новозимс А/С | Композиция со стабилизированным субтилизином |
| CN105189724A (zh) | 2013-03-14 | 2015-12-23 | 诺维信公司 | 含有酶和抑制剂的水溶性膜 |
| CN105164244B (zh) | 2013-05-03 | 2019-08-20 | 诺维信公司 | 洗涤剂酶的微囊化 |
| WO2016001319A1 (en) | 2014-07-03 | 2016-01-07 | Novozymes A/S | Improved stabilization of non-protease enzyme |
| EP3741848A3 (de) | 2014-12-19 | 2021-02-17 | Novozymes A/S | Proteasevarianten und dafür codierende polynukleotide |
| US10822598B2 (en) | 2015-07-06 | 2020-11-03 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| MX377422B (es) | 2015-10-09 | 2025-03-10 | Axichem Ab | Alimento para pájaros y en particular alimento para aves, que comprende derivados sintéticos de capsaicinoides y alimento para uso profiláctico o tratamiento de infección por salmonela. |
| CN110651038B (zh) | 2017-05-05 | 2025-02-18 | 诺维信公司 | 包含脂肪酶和亚硫酸根的组合物 |
| EP3645692B1 (de) | 2017-06-30 | 2025-12-31 | Novozymes A/S | Enzymschlammzusammensetzung |
| EP3704219B1 (de) | 2017-11-01 | 2024-01-10 | Novozymes A/S | Polypeptide und zusammensetzungen mit solchen polypeptiden |
| CN111479919A (zh) | 2017-11-01 | 2020-07-31 | 诺维信公司 | 多肽以及包含此类多肽的组合物 |
| US20210002588A1 (en) | 2018-03-13 | 2021-01-07 | Novozymes A/S | Microencapsulation Using Amino Sugar Oligomers |
| EP3647397A1 (de) | 2018-10-31 | 2020-05-06 | Henkel AG & Co. KGaA | Reinigungsmittel mit dispersins iv |
| ES2981999T3 (es) | 2018-10-31 | 2024-10-14 | Henkel Ag & Co Kgaa | Composiciones limpiadoras que contienen dispersinas V |
| US12351780B2 (en) | 2019-07-01 | 2025-07-08 | Basf Se | Peptide acetals for stabilising enzymes |
| EP4077656A2 (de) | 2019-12-20 | 2022-10-26 | Novozymes A/S | Polypeptide mit proteolytischer aktivität und verwendung davon |
| WO2021236475A1 (en) * | 2020-05-18 | 2021-11-25 | Asinex Corporation | Compounds that inhibit asparagine synthetase and their methods of use |
| WO2022189521A1 (en) | 2021-03-12 | 2022-09-15 | Novozymes A/S | Polypeptide variants |
| KR20250130619A (ko) | 2022-12-23 | 2025-09-02 | 노보자임스 에이/에스 | 카탈라제 및 아밀라제를 포함하는 세제 조성물 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177098B (en) * | 1979-01-04 | 1981-07-28 | Gyogyszerkutato Intezet | Process for producing new peptidyl-n-carboxy-l-arginin-a |
| HU178398B (en) * | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| HU184368B (en) * | 1981-01-13 | 1984-08-28 | Gyogyszerkutato Intezet | Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate |
| EP0124317B1 (de) * | 1983-04-27 | 1990-04-11 | Ici Americas Inc. | Prolin-Derivate |
| HU192646B (en) * | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| DE3606480A1 (de) * | 1986-02-28 | 1987-09-03 | Behringwerke Ag | Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung |
| US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| DE3827415A1 (de) * | 1988-08-12 | 1990-02-15 | Behringwerke Ag | Peptidderivate, verfahren zu ihrer herstellung und ihre verwendung |
| US5204323B1 (en) * | 1988-10-06 | 1995-07-18 | Ciba Geigy Corp | Hirudin antidotal compositions and methods |
| CA2021660A1 (en) * | 1989-07-26 | 1991-01-27 | Philippe Bey | Peptidase inhibitors |
| US5053392A (en) * | 1989-12-01 | 1991-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors |
| IL99527A (en) * | 1990-09-28 | 1997-08-14 | Lilly Co Eli | Tripeptide antithrombotic agents |
| EP0503203A1 (de) * | 1991-03-15 | 1992-09-16 | Merrell Dow Pharmaceuticals Inc. | Neue Thrombin-Inhibitoren |
| CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
| AU655831B2 (en) * | 1991-08-22 | 1995-01-12 | Merrell Pharmaceuticals Inc. | Novel orally-active elastase inhibitors |
| SE9102462D0 (sv) * | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
| WO1993008211A1 (en) * | 1991-10-23 | 1993-04-29 | The Procter & Gamble Company | Tripeptide derivative anti-inflammatory agents |
| US5250660A (en) * | 1991-11-12 | 1993-10-05 | Eli Lilly And Company | Peptide purification process |
| CZ333492A3 (en) * | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
-
1994
- 1994-03-04 US US08/206,579 patent/US5436229A/en not_active Expired - Fee Related
-
1995
- 1995-02-28 CA CA002143532A patent/CA2143532A1/en not_active Abandoned
- 1995-03-03 JP JP7043919A patent/JPH07278095A/ja not_active Withdrawn
- 1995-03-03 SI SI9530171T patent/SI0670310T1/xx unknown
- 1995-03-03 DE DE69504383T patent/DE69504383T2/de not_active Expired - Fee Related
- 1995-03-03 ES ES95301389T patent/ES2120132T3/es not_active Expired - Lifetime
- 1995-03-03 EP EP95301389A patent/EP0670310B1/de not_active Expired - Lifetime
- 1995-03-03 AT AT95301389T patent/ATE170508T1/de not_active IP Right Cessation
- 1995-03-03 DK DK95301389T patent/DK0670310T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07278095A (ja) | 1995-10-24 |
| EP0670310A1 (de) | 1995-09-06 |
| CA2143532A1 (en) | 1995-09-05 |
| DE69504383D1 (de) | 1998-10-08 |
| DE69504383T2 (de) | 1999-02-11 |
| ES2120132T3 (es) | 1998-10-16 |
| EP0670310B1 (de) | 1998-09-02 |
| US5436229A (en) | 1995-07-25 |
| DK0670310T3 (da) | 1999-02-08 |
| SI0670310T1 (en) | 1999-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |