BR0101264A - Derivados de diazepan ou seus sais - Google Patents

Derivados de diazepan ou seus sais

Info

Publication number
BR0101264A
BR0101264A BR0101264-9A BR0101264A BR0101264A BR 0101264 A BR0101264 A BR 0101264A BR 0101264 A BR0101264 A BR 0101264A BR 0101264 A BR0101264 A BR 0101264A
Authority
BR
Brazil
Prior art keywords
diazepan
salts
derivatives
anticoagulant
emboli
Prior art date
Application number
BR0101264-9A
Other languages
English (en)
Inventor
Fukushi Hirayama
Hiroyuki Koshio
Tsukasa Ishihara
Norio Seki
Shunichiro Hachiya
Keizo Sugasawa
Ryota Shiraki
Yuji Koga
Takeshi Shigenaga
Yuzo Matsumoto
Souichirou Kawazoe
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18611560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0101264(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of BR0101264A publication Critical patent/BR0101264A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Patente de Invenção: "DERIVADOS DE DIAZEPAN OU SEUS SAIS". Para fornecer um composto que apresenta uma ação anticoagulante com base na inibição do fator X de coagulação sang³ínea ativada e que é útil como um anticoagulante ou como um agente para a prevenção e tratamento de doenças causadas por trombos ou êmbolos. Um derivado de diazepan, tal como a 3-hidróxi-4'-metóxí-2-{[4(4-metil-1,4-diazepan-1-il)benzoil]amino}benz anilida, ou um sal do mesmo é um ingrediente efetivo.
BR0101264-9A 2000-03-31 2001-03-30 Derivados de diazepan ou seus sais BR0101264A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000096858 2000-03-31

Publications (1)

Publication Number Publication Date
BR0101264A true BR0101264A (pt) 2001-11-06

Family

ID=18611560

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0101264-9A BR0101264A (pt) 2000-03-31 2001-03-30 Derivados de diazepan ou seus sais

Country Status (21)

Country Link
US (3) US6642224B1 (pt)
EP (2) EP1273575B1 (pt)
JP (1) JP3788349B2 (pt)
KR (1) KR100739359B1 (pt)
CN (1) CN1226292C (pt)
AR (1) AR027985A1 (pt)
AT (2) ATE267178T1 (pt)
AU (2) AU776053B2 (pt)
BR (1) BR0101264A (pt)
CA (1) CA2395846C (pt)
DE (2) DE60123294T2 (pt)
DK (1) DK1273575T3 (pt)
ES (2) ES2217129T3 (pt)
HU (1) HUP0101333A3 (pt)
MX (1) MXPA01003279A (pt)
PL (1) PL207651B1 (pt)
PT (1) PT1273575E (pt)
RU (1) RU2257381C2 (pt)
TR (1) TR200401955T4 (pt)
TW (1) TW575569B (pt)
WO (1) WO2001074791A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376515B2 (en) * 2000-02-29 2002-04-23 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor Xa
AU776053B2 (en) * 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
AU2001280438A1 (en) 2000-07-27 2002-02-13 Eli Lilly And Company Substituted heterocyclic amides
AU2002224064B2 (en) * 2000-11-22 2005-12-08 Astellas Pharma Inc. Substituted benzene derivatives or salts thereof
AU2001297648A1 (en) * 2000-11-28 2002-08-28 Eli Lilly And Company Substituted carboxamides as inhibitors of factor xa
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
EP1456175A1 (en) 2001-12-07 2004-09-15 Eli Lilly And Company Substituted heterocyclic carboxamides with antithrombotic activity
TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
WO2004110433A1 (de) * 2003-06-18 2004-12-23 Merck Patent Gmbh Pyrrolidin-1, 2- dicarbonsäure- 1- [(4- ethinyl- phenyl) - amid]- 2- [(phenyl)- amid] derivative als inhibitoren der koagulationsfaktoren xa und viia zur behandlung von thrombosen
EP1670783A2 (en) 2003-09-30 2006-06-21 Eli Lilly And Company Antithrombotic aromatic ethers
EP1817287B1 (en) 2004-11-24 2010-02-10 Eli Lilly And Company Aromatic ether derivatives useful as thrombin inhibitors
WO2006057868A1 (en) 2004-11-29 2006-06-01 Eli Lilly And Company Antithrombotic diamides
WO2006083003A1 (ja) 2005-02-02 2006-08-10 Ajinomoto Co., Inc. 新規ベンズアミジン化合物
GB0521244D0 (en) 2005-10-19 2005-11-30 Astrazeneca Ab Benzamide compounds
TW200734304A (en) 2005-11-08 2007-09-16 Astellas Pharma Inc Benzene derivative or salt thereof
PT2404906E (pt) 2006-11-02 2015-11-02 Millennium Pharm Inc Métodos de sintetizar sais farmacêuticos de um inibidor de fator xa
JP2010120852A (ja) * 2007-03-09 2010-06-03 Daiichi Sankyo Co Ltd 新規なジアミド誘導体
EP2311810A4 (en) * 2008-07-11 2012-04-04 Ajinomoto Kk AMIDINE DERIVATIVE
TW201021832A (en) * 2008-09-30 2010-06-16 Astellas Pharma Inc Pharmaceutical composition for oral administration
WO2012006477A1 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP2591354B1 (en) * 2010-07-07 2016-09-07 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2012054110A2 (en) 2010-07-07 2012-04-26 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP2590965B1 (en) 2010-07-07 2016-04-20 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2012006473A1 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2012059442A2 (en) * 2010-11-01 2012-05-10 Neurotune Ag Neurotrypsin inhibitors
WO2013161871A1 (ja) * 2012-04-25 2013-10-31 興和株式会社 Ｔｌｒ阻害作用を有するチオフェン誘導体

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5417200A (en) * 1994-01-25 1995-05-23 Wasielewski; John J. Lantern cooker
ATE233240T1 (de) 1994-12-02 2003-03-15 Yamanouchi Pharma Co Ltd Neues amidinonaphthylderivat oder dessen salz
AU8269398A (en) 1997-06-26 1999-01-19 Eli Lilly And Company Antithrombotic agents
US6417200B1 (en) 1997-06-26 2002-07-09 Eli Lilly And Company Antithrombotic agents
DE69830504T2 (de) 1997-06-26 2006-03-16 Eli Lilly And Co., Indianapolis Antithrombotische mitteln
IL133621A0 (en) * 1997-06-26 2001-04-30 Lilly Co Eli Antithrombotic agents
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
NZ503809A (en) 1997-12-19 2002-04-26 Schering Ag Ortho-anthranilamide derivatives as anti-coagulants
AU2074699A (en) 1998-01-26 1999-08-09 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof
JP2002533453A (ja) 1998-12-23 2002-10-08 イーライ・リリー・アンド・カンパニー Ｘａ因子のインヒビターとしてのヘテロ芳香族アミド
EP1140881B1 (en) 1998-12-23 2006-05-17 Eli Lilly And Company Antithrombotic amides
ATE272633T1 (de) 1998-12-23 2004-08-15 Lilly Co Eli Aromatische amiden
JP4390024B2 (ja) * 1999-04-23 2009-12-24 アステラス製薬株式会社 新規なジアゼパン誘導体又はその塩
IL148698A0 (en) 1999-09-17 2002-09-12 Cor Therapeutics Inc INHIBITORS OF FACTOR Xa
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
MX226123B (es) 1999-09-17 2005-02-07 Millennium Pharm Inc Benzamidas e inhibidores del factor xa relacionadas.
US6376515B2 (en) 2000-02-29 2002-04-23 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor Xa
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
AU2001280438A1 (en) * 2000-07-27 2002-02-13 Eli Lilly And Company Substituted heterocyclic amides
AU2001297648A1 (en) * 2000-11-28 2002-08-28 Eli Lilly And Company Substituted carboxamides as inhibitors of factor xa

Also Published As

Publication number Publication date
AU2982701A (en) 2001-10-04
ES2271464T3 (es) 2007-04-16
CN1319594A (zh) 2001-10-31
USRE43481E1 (en) 2012-06-19
CA2395846C (en) 2009-08-11
TR200401955T4 (tr) 2004-09-21
KR20010095174A (ko) 2001-11-03
EP1415990B1 (en) 2006-09-20
HU0101333D0 (en) 2001-06-28
KR100739359B1 (ko) 2007-07-18
EP1415990A1 (en) 2004-05-06
DE60103390D1 (de) 2004-06-24
US7307074B2 (en) 2007-12-11
US20040068109A1 (en) 2004-04-08
US20030195193A1 (en) 2003-10-16
AU776053B2 (en) 2004-08-26
WO2001074791A1 (fr) 2001-10-11
ATE267178T1 (de) 2004-06-15
PL207651B1 (pl) 2011-01-31
EP1273575B1 (en) 2004-05-19
HUP0101333A3 (en) 2002-12-28
JP3788349B2 (ja) 2006-06-21
DK1273575T3 (da) 2004-09-13
DE60103390T2 (de) 2005-06-16
EP1273575A4 (en) 2003-01-08
AR027985A1 (es) 2003-04-23
CA2395846A1 (en) 2001-10-11
MXPA01003279A (es) 2004-07-30
HUP0101333A2 (hu) 2002-02-28
DE60123294T2 (de) 2007-04-05
US6642224B1 (en) 2003-11-04
ATE340166T1 (de) 2006-10-15
EP1273575A1 (en) 2003-01-08
PT1273575E (pt) 2004-09-30
TW575569B (en) 2004-02-11
AU2001244634A1 (en) 2001-10-15
RU2257381C2 (ru) 2005-07-27
PL346731A1 (en) 2001-10-08
ES2217129T3 (es) 2004-11-01
DE60123294D1 (de) 2006-11-02
CN1226292C (zh) 2005-11-09

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: ASTELLAS PHARMA INC. (JP)

Free format text: ALTERADO DE: YAMANOUCHI PHARMACEUTICAL CO., LTD.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 14A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2308 DE 31/03/2015.