BR0308796A - Derivados de benzofurano - Google Patents

Derivados de benzofurano

Info

Publication number
BR0308796A
BR0308796A BR0308796-4A BR0308796A BR0308796A BR 0308796 A BR0308796 A BR 0308796A BR 0308796 A BR0308796 A BR 0308796A BR 0308796 A BR0308796 A BR 0308796A
Authority
BR
Brazil
Prior art keywords
optionally substituted
group
formula
hydrogen atom
benzofuran derivatives
Prior art date
Application number
BR0308796-4A
Other languages
English (en)
Inventor
Takayuki Kawaguchi
Hidenori Akatsuka
Toru Iijima
Yasunori Tsuboi
Takashi Mitsui
Jun Mirakami
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of BR0308796A publication Critical patent/BR0308796A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

"DERIVADOS DE BENZOFURANO". A presente invenção refere-se a um derivado de benzofurano da fórmula [1]: em que x é um grupo da fórmula: -N= ou -CH=; Y é um grupo de amino opcionalmente substituído, um grupo de cicloalquila opcionalmente substituído ou um grupo heterocíclico saturado opcionalmente substituído; A é uma ligação única, uma cadeia de carbono opcionalmente tendo uma ligação dupla dentro ou na(s) extremidade(s) da cadeia, ou um átomo de oxigênio; R^ 1^ é um átomo de hidrogênio ou um átomo de halogeno; o Anel B é um anel de benzeno opcionalmente substituído; e R^ 3^ é um átomo de hidrogênio ou um sal farmaceuticamente aceitável deste, que é útil como um medicamento, especialmente como um inibidor do fator X da coagulação sang³ínea ativada.
BR0308796-4A 2002-03-28 2003-03-27 Derivados de benzofurano BR0308796A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002091686 2002-03-28
JP2002376158 2002-12-26
PCT/JP2003/003807 WO2003082847A1 (fr) 2002-03-28 2003-03-27 Derive de benzofurane

Publications (1)

Publication Number Publication Date
BR0308796A true BR0308796A (pt) 2005-01-11

Family

ID=28677558

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308796-4A BR0308796A (pt) 2002-03-28 2003-03-27 Derivados de benzofurano

Country Status (23)

Country Link
US (2) US7531537B2 (pt)
EP (1) EP1489078B1 (pt)
KR (1) KR100702889B1 (pt)
CN (1) CN100439351C (pt)
AR (1) AR039190A1 (pt)
AT (1) ATE454381T1 (pt)
AU (1) AU2003221178B2 (pt)
BR (1) BR0308796A (pt)
CA (1) CA2479831C (pt)
DE (1) DE60330847D1 (pt)
DK (1) DK1489078T3 (pt)
ES (1) ES2336905T3 (pt)
HK (1) HK1069396A1 (pt)
IL (1) IL163923A0 (pt)
MX (1) MXPA04009477A (pt)
MY (1) MY144928A (pt)
NO (1) NO331281B1 (pt)
NZ (1) NZ535267A (pt)
PL (1) PL372548A1 (pt)
PT (1) PT1489078E (pt)
RU (1) RU2286344C2 (pt)
TW (1) TWI277416B (pt)
WO (1) WO2003082847A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1564213A4 (en) * 2002-11-22 2009-05-27 Takeda Pharmaceutical IMIDAZOLE DERIVATIVES, PROCESS FOR THE PRODUCTION AND USE THEREOF
JP2005104838A (ja) * 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物
TWI312345B (en) 2003-06-30 2009-07-21 Mitsubishi Tanabe Pharma Corp Process of preparating 3-acylaminobenzofuran-2-carboxylic acid derivatives
US7265148B2 (en) * 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
TW200524915A (en) * 2003-09-26 2005-08-01 Tanabe Seiyaku Co Carbamoyl-type benzofuran derivatives
TW200512181A (en) * 2003-09-26 2005-04-01 Tanabe Seiyaku Co Amide-type carboxamide derivatives
FR2862965B1 (fr) * 2003-11-27 2007-09-07 Merck Sante Sas Nouveaux derives de phenoxyacetamides et leur utilisation pour la preparation de diphenylamides.
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
TWI396686B (zh) * 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
JP4710445B2 (ja) * 2004-07-08 2011-06-29 田辺三菱製薬株式会社 医薬組成物
JP2006298909A (ja) * 2005-03-25 2006-11-02 Tanabe Seiyaku Co Ltd 医薬組成物
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
WO2010101247A1 (ja) 2009-03-05 2010-09-10 塩野義製薬株式会社 Ｎｐｙ ｙ５受容体拮抗作用を有するシクロヘキサン誘導体
UY34295A (es) * 2011-09-08 2013-04-30 Servier Lab Nuevo esquema de administración de la n-hidroxi -4- {2-[3- (n,ndimetilaminometil)benzofuran -2- ilcarbonilamino]etoxi}benzamida
CN106831541B (zh) * 2011-11-18 2019-09-06 赫普泰雅治疗有限公司 毒蕈碱性m1受体激动剂
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
UA126589C2 (uk) 2017-09-14 2022-11-02 Даїті Санкіо Компані, Лімітед Сполука, яка має циклічну структуру
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0937711A1 (de) 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
ATE272633T1 (de) * 1998-12-23 2004-08-15 Lilly Co Eli Aromatische amiden
US7112594B2 (en) * 2000-08-09 2006-09-26 Mitsubishi Pharma Corporation Fused bicyclic amide compounds and medicinal use thereof
TW200524915A (en) * 2003-09-26 2005-08-01 Tanabe Seiyaku Co Carbamoyl-type benzofuran derivatives

Also Published As

Publication number Publication date
ATE454381T1 (de) 2010-01-15
AR039190A1 (es) 2005-02-09
KR100702889B1 (ko) 2007-04-04
MXPA04009477A (es) 2005-01-25
CN100439351C (zh) 2008-12-03
IL163923A0 (en) 2005-12-18
DK1489078T3 (da) 2010-03-15
WO2003082847A1 (fr) 2003-10-09
ES2336905T3 (es) 2010-04-19
PL372548A1 (en) 2005-07-25
RU2004131680A (ru) 2005-06-27
AU2003221178B2 (en) 2006-06-15
US7531537B2 (en) 2009-05-12
CN1656086A (zh) 2005-08-17
TW200306812A (en) 2003-12-01
DE60330847D1 (de) 2010-02-25
MY144928A (en) 2011-11-30
AU2003221178A1 (en) 2003-10-13
NO331281B1 (no) 2011-11-14
CA2479831A1 (en) 2003-10-09
US20050282808A1 (en) 2005-12-22
KR20040111442A (ko) 2004-12-31
US20090209511A1 (en) 2009-08-20
CA2479831C (en) 2010-06-08
TWI277416B (en) 2007-04-01
HK1069396A1 (en) 2005-05-20
EP1489078B1 (en) 2010-01-06
NZ535267A (en) 2006-03-31
PT1489078E (pt) 2010-02-24
RU2286344C2 (ru) 2006-10-27
NO20044644L (no) 2004-12-16
EP1489078A4 (en) 2006-01-04
EP1489078A1 (en) 2004-12-22

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: MITSUBISHI TANABE PHARMA CORPORATION (JP)

Free format text: ALTERADO DE: TANABE SEIYAKU CO., LTD.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 10A E 11A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2258 DE 15/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 10A, 11A, 12A, 13A, 14A, 15A, 16A E 17A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.