BR0012791A - Derivados de oxazino-carbazóis - Google Patents

Derivados de oxazino-carbazóis

Info

Publication number
BR0012791A
BR0012791A BR0012791-4A BR0012791A BR0012791A BR 0012791 A BR0012791 A BR 0012791A BR 0012791 A BR0012791 A BR 0012791A BR 0012791 A BR0012791 A BR 0012791A
Authority
BR
Brazil
Prior art keywords
oxazino
carbazole derivatives
derivatives
compounds
proposes
Prior art date
Application number
BR0012791-4A
Other languages
English (en)
Inventor
Ruth E Tenbrink
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BR0012791A publication Critical patent/BR0012791A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"DERIVADOS DE OXAZINO-CARBAZóIS". A presente invenção propõe derivados de oxazinocarbazóis tendo um anel conectando a posição 8 ( C-8 ) e posição 9 ( N-9 ), e mais especificamente, propõe compostos da fórmula ( I ) em que R~ 1~, R~ 2~, R~ 3~ e R~ 4~ são conforme descrito no presente Estes compostos são ligantes de 5-HT, e são úteis para o tratamento de doenças em que é desejada a modulação da atividade de 5-HT.
BR0012791-4A 1999-07-28 2000-07-20 Derivados de oxazino-carbazóis BR0012791A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14601399P 1999-07-28 1999-07-28
PCT/US2000/019532 WO2001009142A1 (en) 1999-07-28 2000-07-20 Oxazinocarbazoles for the treatment of cns diseases

Publications (1)

Publication Number Publication Date
BR0012791A true BR0012791A (pt) 2002-06-18

Family

ID=22515535

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012791-4A BR0012791A (pt) 1999-07-28 2000-07-20 Derivados de oxazino-carbazóis

Country Status (20)

Country Link
US (2) US6448397B1 (pt)
EP (1) EP1200447B1 (pt)
JP (1) JP2003506328A (pt)
KR (1) KR20020015079A (pt)
CN (1) CN1165539C (pt)
AR (1) AR024963A1 (pt)
AT (1) ATE251167T1 (pt)
AU (1) AU767282B2 (pt)
BR (1) BR0012791A (pt)
CA (1) CA2376927A1 (pt)
CO (1) CO5031298A1 (pt)
DE (1) DE60005685T2 (pt)
DK (1) DK1200447T3 (pt)
ES (1) ES2208371T3 (pt)
MX (1) MXPA02000984A (pt)
PE (1) PE20010548A1 (pt)
PT (1) PT1200447E (pt)
TW (1) TWI222450B (pt)
WO (1) WO2001009142A1 (pt)
ZA (1) ZA200110539B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100497122B1 (ko) * 2001-08-30 2005-06-29 주식회사 삼양제넥스 페놀옥시다제 시스템을 구성하는 단백질 및 그것의 유전자
SE0103539D0 (sv) * 2001-10-23 2001-10-23 Biovitrum Ab New Use
DE60232173D1 (de) * 2001-11-09 2009-06-10 Biovitrum Ab Publ Verwendung von sulfonamid-derivaten bei der behandlung von adipositas oder zur verringerung der nahrungsaufnahme
JP2005537226A (ja) * 2002-04-16 2005-12-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 診断薬としての標識オキサジノカルバゾール
US6932961B1 (en) 2002-04-16 2005-08-23 Pharmacia & Upjohn Company Oxazinocarbazoles for the treatment of CNS diseases
TWI284124B (en) * 2002-12-03 2007-07-21 Hoffmann La Roche Aminoalkoxyindoles
MX2008013053A (es) 2006-04-12 2008-10-17 Wyeth Corp Derivados de dihidri[1,4]oxazino[2,3,4-hi]indazol-sustituidos como ligandos de 5-hidroxitriptamina-6.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2059491T3 (es) * 1987-06-29 1994-11-16 Duphar Int Res Derivados de indol con anillos condensados.
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
CA2174543A1 (en) 1993-10-20 1995-04-27 Nobuyuki Yasuda Indole derivative
WO1997045427A1 (fr) 1996-05-31 1997-12-04 Mochida Pharmaceutical Co., Ltd. DERIVES DE PYRIDOCARBAZOLE AYANT UN EFFET INHIBITEUR DE cGMP-PDE

Also Published As

Publication number Publication date
AR024963A1 (es) 2002-10-30
EP1200447B1 (en) 2003-10-01
ATE251167T1 (de) 2003-10-15
US20020169317A1 (en) 2002-11-14
CA2376927A1 (en) 2001-02-08
WO2001009142A1 (en) 2001-02-08
AU6219700A (en) 2001-02-19
DE60005685D1 (de) 2003-11-06
KR20020015079A (ko) 2002-02-27
US6821970B2 (en) 2004-11-23
DK1200447T3 (da) 2004-02-02
EP1200447A1 (en) 2002-05-02
PT1200447E (pt) 2004-02-27
PE20010548A1 (es) 2001-05-13
CN1165539C (zh) 2004-09-08
DE60005685T2 (de) 2004-08-12
MXPA02000984A (es) 2002-07-30
US6448397B1 (en) 2002-09-10
JP2003506328A (ja) 2003-02-18
TWI222450B (en) 2004-10-21
ES2208371T3 (es) 2004-06-16
CO5031298A1 (es) 2001-04-27
AU767282B2 (en) 2003-11-06
CN1361781A (zh) 2002-07-31
ZA200110539B (en) 2003-03-24

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A E 9A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.