CO5031298A1 - Oxazincarbazoles en el tratamiento de enfermedades del snc - Google Patents
Oxazincarbazoles en el tratamiento de enfermedades del sncInfo
- Publication number
- CO5031298A1 CO5031298A1 CO00056117A CO00056117A CO5031298A1 CO 5031298 A1 CO5031298 A1 CO 5031298A1 CO 00056117 A CO00056117 A CO 00056117A CO 00056117 A CO00056117 A CO 00056117A CO 5031298 A1 CO5031298 A1 CO 5031298A1
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- heteroaryl
- halogen
- cycloalkyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un compuesto de la fórmula (I) O una sal farmacéuticamente aceptable del mismo, en dondeR1 es(a) H,(b) halógeno o(c) C1-6 alquiloR2 es(a) H,(b) halógeno,(c) -OH,(d) -CN,(e) -CF3 ,(f) O (C1-6 )alquilo,(g) C1-6 alquilo(h) C3-6 cicloalquilo,(i) -NR5 R6 ,(j) -CONR5 R6 ,(k) SO2 NR5 R6 ,(l) -COOR7 ó (m) fenilo, opcionalmente substituido con halógeno, OH, O(C1-4 ) alquilo o C1-6 alquilo;R3 es(a) -(CH2 )m -NR8 R9 , en donde la cadena -(CH2 )m - puede estar sustituida con uno o dos C1-6 alquilo C3-6 cicloalquilo;R4 es(a) arilo o(b) heteroarilo;arilo es fenilo o naftilo, opcionalmente sustituido con uno o más R10 ; heteroarilo es un radical deun anillo aromático monocíclico de cinco o seis miembros que tiene uno o dos heteroátomos escogidos cada uno del grupo constituido de oxígeno, azufre y N(X), o un radical de un anillo aromático bicíclico fusionado en orto de nueve o diez miembros que tiene uno, dos o tres heteroátomos escogidos cada uno del grupo constituido de oxígeno, azufre y n (X); en donde X significa ausente, H o C1-4 alquilo; en donde los átomos de carbono del heteroarilo pueden estar substituidos con uno o más R10 ;R5 y R6 son independientemente(a) H,(b) C1-6 alquilo o (c) C3-6 cicloalquilo;R7 es(a) H,(b) C1-6 alquilo o ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14601399P | 1999-07-28 | 1999-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5031298A1 true CO5031298A1 (es) | 2001-04-27 |
Family
ID=22515535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00056117A CO5031298A1 (es) | 1999-07-28 | 2000-07-26 | Oxazincarbazoles en el tratamiento de enfermedades del snc |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6448397B1 (es) |
| EP (1) | EP1200447B1 (es) |
| JP (1) | JP2003506328A (es) |
| KR (1) | KR20020015079A (es) |
| CN (1) | CN1165539C (es) |
| AR (1) | AR024963A1 (es) |
| AT (1) | ATE251167T1 (es) |
| AU (1) | AU767282B2 (es) |
| BR (1) | BR0012791A (es) |
| CA (1) | CA2376927A1 (es) |
| CO (1) | CO5031298A1 (es) |
| DE (1) | DE60005685T2 (es) |
| DK (1) | DK1200447T3 (es) |
| ES (1) | ES2208371T3 (es) |
| MX (1) | MXPA02000984A (es) |
| PE (1) | PE20010548A1 (es) |
| PT (1) | PT1200447E (es) |
| TW (1) | TWI222450B (es) |
| WO (1) | WO2001009142A1 (es) |
| ZA (1) | ZA200110539B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100497122B1 (ko) * | 2001-08-30 | 2005-06-29 | 주식회사 삼양제넥스 | 페놀옥시다제 시스템을 구성하는 단백질 및 그것의 유전자 |
| SE0103539D0 (sv) * | 2001-10-23 | 2001-10-23 | Biovitrum Ab | New Use |
| WO2003039547A1 (en) * | 2001-11-09 | 2003-05-15 | Biovitrum Ab | Use of sulfonamide derivatives in the treatment of obesity or for the reduction of food intake |
| EP1495031A1 (en) * | 2002-04-16 | 2005-01-12 | Pharmacia & Upjohn Company LLC | Labeled oxazinocarbazoles as diagnostic agents |
| US6932961B1 (en) | 2002-04-16 | 2005-08-23 | Pharmacia & Upjohn Company | Oxazinocarbazoles for the treatment of CNS diseases |
| TWI284124B (en) * | 2002-12-03 | 2007-07-21 | Hoffmann La Roche | Aminoalkoxyindoles |
| MX2008013053A (es) * | 2006-04-12 | 2008-10-17 | Wyeth Corp | Derivados de dihidri[1,4]oxazino[2,3,4-hi]indazol-sustituidos como ligandos de 5-hidroxitriptamina-6. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3885357T2 (de) * | 1987-06-29 | 1994-03-24 | Duphar Int Res | Anellierte Indolderivate. |
| GB8812636D0 (en) * | 1988-05-27 | 1988-06-29 | Glaxo Group Ltd | Chemical compounds |
| EP0377238A1 (en) * | 1988-12-22 | 1990-07-11 | Duphar International Research B.V | New annelated indolo (3,2-c)-lactams |
| AU7949694A (en) | 1993-10-20 | 1995-05-08 | Tokyo Tanabe Company Limited | Indole derivative |
| EP0985671B1 (en) | 1996-05-31 | 2003-04-02 | Mochida Pharmaceutical Co., Ltd. | PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT |
-
2000
- 2000-07-19 TW TW089114437A patent/TWI222450B/zh active
- 2000-07-20 EP EP00948738A patent/EP1200447B1/en not_active Expired - Lifetime
- 2000-07-20 ES ES00948738T patent/ES2208371T3/es not_active Expired - Lifetime
- 2000-07-20 MX MXPA02000984A patent/MXPA02000984A/es active IP Right Grant
- 2000-07-20 DE DE60005685T patent/DE60005685T2/de not_active Expired - Fee Related
- 2000-07-20 DK DK00948738T patent/DK1200447T3/da active
- 2000-07-20 BR BR0012791-4A patent/BR0012791A/pt not_active IP Right Cessation
- 2000-07-20 AU AU62197/00A patent/AU767282B2/en not_active Ceased
- 2000-07-20 KR KR1020027001118A patent/KR20020015079A/ko not_active Application Discontinuation
- 2000-07-20 CA CA002376927A patent/CA2376927A1/en not_active Abandoned
- 2000-07-20 AT AT00948738T patent/ATE251167T1/de not_active IP Right Cessation
- 2000-07-20 PT PT00948738T patent/PT1200447E/pt unknown
- 2000-07-20 JP JP2001513949A patent/JP2003506328A/ja active Pending
- 2000-07-20 WO PCT/US2000/019532 patent/WO2001009142A1/en not_active Application Discontinuation
- 2000-07-20 US US09/620,493 patent/US6448397B1/en not_active Expired - Fee Related
- 2000-07-20 CN CNB008104573A patent/CN1165539C/zh not_active Expired - Fee Related
- 2000-07-25 PE PE2000000747A patent/PE20010548A1/es not_active Application Discontinuation
- 2000-07-26 CO CO00056117A patent/CO5031298A1/es unknown
- 2000-07-27 AR ARP000103887A patent/AR024963A1/es unknown
-
2001
- 2001-12-21 ZA ZA200110539A patent/ZA200110539B/xx unknown
-
2002
- 2002-05-16 US US10/146,970 patent/US6821970B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003506328A (ja) | 2003-02-18 |
| ZA200110539B (en) | 2003-03-24 |
| MXPA02000984A (es) | 2002-07-30 |
| CA2376927A1 (en) | 2001-02-08 |
| PT1200447E (pt) | 2004-02-27 |
| BR0012791A (pt) | 2002-06-18 |
| US6448397B1 (en) | 2002-09-10 |
| ATE251167T1 (de) | 2003-10-15 |
| US6821970B2 (en) | 2004-11-23 |
| TWI222450B (en) | 2004-10-21 |
| KR20020015079A (ko) | 2002-02-27 |
| AU767282B2 (en) | 2003-11-06 |
| DK1200447T3 (da) | 2004-02-02 |
| EP1200447B1 (en) | 2003-10-01 |
| US20020169317A1 (en) | 2002-11-14 |
| EP1200447A1 (en) | 2002-05-02 |
| WO2001009142A1 (en) | 2001-02-08 |
| AR024963A1 (es) | 2002-10-30 |
| DE60005685T2 (de) | 2004-08-12 |
| ES2208371T3 (es) | 2004-06-16 |
| AU6219700A (en) | 2001-02-19 |
| DE60005685D1 (de) | 2003-11-06 |
| CN1361781A (zh) | 2002-07-31 |
| PE20010548A1 (es) | 2001-05-13 |
| CN1165539C (zh) | 2004-09-08 |
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