BR9814983A - Derivado de bifenil-amidina, pró-medicamento; inibidor de coagulação sanguìnea, e, agentes profilático e terapêutico para trombose ou êmbolo. - Google Patents

Derivado de bifenil-amidina, pró-medicamento; inibidor de coagulação sanguìnea, e, agentes profilático e terapêutico para trombose ou êmbolo.

Info

Publication number
BR9814983A
BR9814983A BR9814983-0A BR9814983A BR9814983A BR 9814983 A BR9814983 A BR 9814983A BR 9814983 A BR9814983 A BR 9814983A BR 9814983 A BR9814983 A BR 9814983A
Authority
BR
Brazil
Prior art keywords
thrombosis
prophylactic
biphenyl
therapeutic agents
embolus
Prior art date
Application number
BR9814983-0A
Other languages
English (en)
Inventor
Yoshiharu Takazawa
Takayuki Hara
Tomohisa Nakada
Yasunobu Takano
Satoshi Sugiura
Takaharu Tsutsumi
Reiko Takarada
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Publication of BR9814983A publication Critical patent/BR9814983A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/18—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"DERIVADO DE BIFENIL-AMIDINA, PRó-MEDICAMENTO, INIBIDOR DE COAGULAçãO SANGUìNEA, E, AGENTES PROFILáTICO E TERAPêUTICO PARA TROMBOSE OU êMBOLO". A presente invenção refere-se a um derivado de bifenilamidina de fórmula geral (1): ou um seu sal farmaceuticamente aceitável, que é um novo composto funcionando como um inibidor de FXa clinicamente aplicável.
BR9814983-0A 1997-11-20 1998-11-19 Derivado de bifenil-amidina, pró-medicamento; inibidor de coagulação sanguìnea, e, agentes profilático e terapêutico para trombose ou êmbolo. BR9814983A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP31969897 1997-11-20
JP12749898 1998-05-11
PCT/JP1998/005209 WO1999026918A1 (fr) 1997-11-20 1998-11-19 Derives de biphenylamidine

Publications (1)

Publication Number Publication Date
BR9814983A true BR9814983A (pt) 2000-10-03

Family

ID=26463455

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814983-0A BR9814983A (pt) 1997-11-20 1998-11-19 Derivado de bifenil-amidina, pró-medicamento; inibidor de coagulação sanguìnea, e, agentes profilático e terapêutico para trombose ou êmbolo.

Country Status (28)

Country Link
US (1) US6706745B1 (pt)
EP (1) EP1043310B1 (pt)
KR (1) KR100581506B1 (pt)
CN (1) CN1150162C (pt)
AT (1) ATE268751T1 (pt)
AU (1) AU744567B2 (pt)
BG (1) BG63536B1 (pt)
BR (1) BR9814983A (pt)
CA (1) CA2310331A1 (pt)
DE (1) DE69824450T2 (pt)
DK (1) DK1043310T3 (pt)
EE (1) EE04564B1 (pt)
ES (1) ES2218866T3 (pt)
HR (1) HRP20000304B1 (pt)
HU (1) HUP0100085A3 (pt)
ID (1) ID24846A (pt)
IL (1) IL136100A (pt)
IS (1) IS5497A (pt)
NO (1) NO20002589L (pt)
NZ (1) NZ504407A (pt)
PL (1) PL340658A1 (pt)
PT (1) PT1043310E (pt)
RU (1) RU2197478C2 (pt)
SK (1) SK7612000A3 (pt)
TR (1) TR200001452T2 (pt)
TW (1) TW523504B (pt)
UA (1) UA52797C2 (pt)
WO (1) WO1999026918A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6348478B1 (en) * 1997-11-20 2002-02-19 Teijin Limited Biphenylamidine derivatives
US6676968B1 (en) 1999-01-28 2004-01-13 Teijin Limited Release-regulating preparations comprising biphenyldiamine derivatives
US6538137B1 (en) * 1999-05-17 2003-03-25 Teijin Limited Cyanobiphenyl derivatives
WO2001056989A2 (en) * 2000-02-01 2001-08-09 Cor Therapeutics, Inc. Inhibitors of factor xa
US6316475B1 (en) * 2000-11-17 2001-11-13 Abbott Laboratories Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
WO2002059091A1 (fr) * 2001-01-26 2002-08-01 Teijin Limited Procede de preparation de derives d'acide cyanophenylbenzoique
HUP0302989A3 (en) * 2001-01-29 2007-06-28 Teijin Ltd Benzamidine derivatives and process for production thereof
US20040092480A1 (en) * 2001-01-30 2004-05-13 Kentaro Fujinaga Medicinal composition
AR035425A1 (es) * 2001-01-30 2004-05-26 Teijin Ltd Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo
WO2003040086A1 (fr) * 2001-11-09 2003-05-15 Kissei Pharmaceutical Co., Ltd. Derives de 5-amidino-2-hydroxybenzene-sulfonamide, composition medicinales les contenant, leur utilisation medicale et produits intermediaires utilises dans le cadre de leur production
WO2003048111A1 (en) 2001-11-30 2003-06-12 Teijin Limited Process for producing 5-(3-cyanophenyl)-3-formylbenzoic acid compound
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
EP1915988A4 (en) 2005-08-18 2012-07-25 Teijin Pharma Ltd COMPRESSOR COMPRISING MULTIPLE SEGMENTS CONTAINING MEDICAMENTS
CN101291656B (zh) 2005-08-18 2012-11-07 帝人制药株式会社 具有准确的用量分割功能的制剂
PE20070698A1 (es) 2005-11-14 2007-08-17 Teijin Pharma Ltd Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol
WO2016198691A1 (en) 2015-06-11 2016-12-15 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
KR940005271A (ko) * 1992-04-28 1994-03-21 디터 라우딘, 게르하르트 후버 표지된 피브리노겐 수용체 길항제, 이의 용도 및 이의 제조방법
DE4219158A1 (de) * 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JPH101467A (ja) * 1996-06-13 1998-01-06 Banyu Pharmaceut Co Ltd ビフェニルアミジン誘導体
US6348478B1 (en) * 1997-11-20 2002-02-19 Teijin Limited Biphenylamidine derivatives

Also Published As

Publication number Publication date
ID24846A (id) 2000-08-24
BG63536B1 (bg) 2002-04-30
US6706745B1 (en) 2004-03-16
ES2218866T3 (es) 2004-11-16
EP1043310A4 (en) 2001-03-21
PT1043310E (pt) 2004-10-29
HRP20000304A2 (en) 2002-02-28
KR20010032259A (ko) 2001-04-16
TW523504B (en) 2003-03-11
NO20002589D0 (no) 2000-05-19
DK1043310T3 (da) 2004-10-25
EP1043310A1 (en) 2000-10-11
SK7612000A3 (en) 2001-05-10
HUP0100085A3 (en) 2002-12-28
AU1174099A (en) 1999-06-15
TR200001452T2 (tr) 2004-12-21
NO20002589L (no) 2000-07-19
BG104447A (en) 2001-01-31
PL340658A1 (en) 2001-02-12
DE69824450D1 (de) 2004-07-15
EE04564B1 (et) 2005-12-15
NZ504407A (en) 2002-02-01
HRP20000304B1 (en) 2005-08-31
CA2310331A1 (en) 1999-06-03
RU2197478C2 (ru) 2003-01-27
HUP0100085A2 (hu) 2001-07-30
EE200000298A (et) 2001-08-15
CN1284059A (zh) 2001-02-14
DE69824450T2 (de) 2005-09-29
IL136100A (en) 2005-05-17
KR100581506B1 (ko) 2006-05-22
AU744567B2 (en) 2002-02-28
IS5497A (is) 2000-05-15
EP1043310B1 (en) 2004-06-09
IL136100A0 (en) 2001-05-20
UA52797C2 (uk) 2003-01-15
ATE268751T1 (de) 2004-06-15
WO1999026918A1 (fr) 1999-06-03
CN1150162C (zh) 2004-05-19

Similar Documents

Publication Publication Date Title
BR9814983A (pt) Derivado de bifenil-amidina, pró-medicamento; inibidor de coagulação sanguìnea, e, agentes profilático e terapêutico para trombose ou êmbolo.
BR0112395A (pt) Derivados de benzotiazol
BR0210532A (pt) Derivados de naftil benzofurano como inibidores do inibidor-1 de ativador de plasminogênio (pai-1)
BR0115411A (pt) Combinações sinergìsticas compreendendo um inibidor de renina para doenças cardiovasculares
AP1445A (en) Substituted 4-amino-thiazol-2-yl compounds as CDKs inhibitors.
BR0101264A (pt) Derivados de diazepan ou seus sais
EA200101085A1 (ru) Гидроксамовые кислоты, производные ароматических сульфонов, - ингибиторы металлопротеаз
BR0211810A (pt) Derivados ácido carboxìlico e agente farmacêutico compreendendo os mesmos como ingrediente ativo
BR9813360A (pt) Derivados de ácido hidroxâmico como inibidores de metaloprotease de matriz (mmp)
BRPI0407618A (pt) derivados de tiazole amino substituidos com cicloalquilo contendo n e composições farmacêuticas para inibição da proliferação celular e métodos para a sua utilização
NO20032208D0 (no) Benzodiazepinderivater som GABA A reseptormodulatorer
FI950309A (fi) Proliiniamidijohdannaisia
EA200100804A1 (ru) Сульфоароматические производные гидроксамовой кислоты как ингибиторы металлопротеаз
BR9814643A (pt) Inibidor de metaloprotease de ácido sulfona hidroxâmico aromático
BR0114391A (pt) Tiadiazóis e oxadiazóis e seu uso como inibidores de fosfodiesterase-7
BR9809062A (pt) Inibidores da metaloproteinase, composições farmacêuticas comtendo os mesmos e seus usos farmacêuticos
LV12291A (lv) Savienojums un farmaceitiskas kompozicijas ar triptazes aktivitates izmainam saistitu slimibu arstesanai
ATE330601T1 (de) Sulfonamide als matrix-metalloproteinase inhibitoren
GT199900015A (es) Procedimiento para tratar la insuficiencia cardiaca
BR0113389A (pt) Compostos que inibem a atividade do fator xa
EP1086946A4 (en) BENZAMIDINE DERIVATIVE
BR0014615A (pt) Derivado de ácido fosfÈnico que apresenta atividade inibidora contra carboxipeptidase b
BR0112338A (pt) Composto, composição farmacêutica, e, uso de um composto
BR0110871A (pt) Derivados de sulfonamida
BR0015082A (pt) Derivado de ácido hidroxâmico como inibidor da formação de cd 23 humano solúvel

Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements