HUP0100085A2 - Bifenilamidinszármazékok és ilyen vegyületeket tartalmazó gyógyászati készítmények - Google Patents

Bifenilamidinszármazékok és ilyen vegyületeket tartalmazó gyógyászati készítmények

Info

Publication number
HUP0100085A2
HUP0100085A2 HU0100085A HUP0100085A HUP0100085A2 HU P0100085 A2 HUP0100085 A2 HU P0100085A2 HU 0100085 A HU0100085 A HU 0100085A HU P0100085 A HUP0100085 A HU P0100085A HU P0100085 A2 HUP0100085 A2 HU P0100085A2
Authority
HU
Hungary
Prior art keywords
group
hydroxyl
alkoxy
alkyl
amino
Prior art date
Application number
HU0100085A
Other languages
English (en)
Inventor
Takayuki Hara
Tomohisa Nakada
Satoshi Sugiura
Yasunobu Takano
Reiko Takarada
Yoshiharu Takazawa
Takaharu Tsutsumi
Original Assignee
Teijin Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Limited filed Critical Teijin Limited
Publication of HUP0100085A2 publication Critical patent/HUP0100085A2/hu
Publication of HUP0100085A3 publication Critical patent/HUP0100085A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/18—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

A találmány az (1) általános képletű bifenilamidinszármazékokra,gyógyászati szempontból elfogadható sóikra, ezek előállítására, ilyenvegyületeket tartalmazó gyógyászati készítményekre és alkalmazásukravonatkozik. Az (1) képletben R1 jelentése hidrogénatom-, halogénatom,hidroxil-, alkil- vagy alkoxicsoport; L jelentése kémiai kötés vagyalkiléncsoport; R2 jelentése halogén, hidroxil-, amino-, alkoxi- vagykarboxilcsoport; továbbá alkoxikarbonilcsoport és annak analógjai;valamint alkilsziulfenil-, alkilszulfinil-, alkilszulfonilcsoport;vagy 5-tetrazolil-csoport; R3 jelentése hidrogén-, halogénatom;hidroxil-, amino-, alkil-, alkoxi-, vagy karboxilcsoport; X jelentése-O-, -S- és ennek oxidált analógjai, valamint -NH-CO-NH- képletűcsoport; vagy szulfonamidcsoportok és származékaik; Y jelentésecikloalkilcsoport vagy ennek karbonilcsoportot tartalmazó analógja,amelyek halogénatommal, hidroxil-, aminocsoporttal vagy alkil- ésalkoxicsoporttal szubsztituálva lehetnek; R6 jelentése hidrogén vagyhalogénatom, hidroxil- vagy alkoxi- csoport; W jelentése C-H vagynitrogénatom; Z jelentése hidrogén, alkil-, hidroxil-, amino-,alkoxicsoport vagy ezek analógjai. A találmány szerinti hatóanyagokszelektív módon gátolják az aktivált véralvadási Xa faktort (FXa-gátlóhatóanyagok), s ezért trombózisok és embóliák kezelésében, ígyszívizominfarktus, agytrombózis, perifériás artériatrombózis ésmélyvénás trombózis gyógyszeres kezelésében és megelőzésébenalkalmazhatók. Ó
HU0100085A 1997-11-20 1998-11-19 Biphenylamidine derivatives and pharmaceutical compositions containing them HUP0100085A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP31969897 1997-11-20
JP12749898 1998-05-11
PCT/JP1998/005209 WO1999026918A1 (fr) 1997-11-20 1998-11-19 Derives de biphenylamidine

Publications (2)

Publication Number Publication Date
HUP0100085A2 true HUP0100085A2 (hu) 2001-07-30
HUP0100085A3 HUP0100085A3 (en) 2002-12-28

Family

ID=26463455

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100085A HUP0100085A3 (en) 1997-11-20 1998-11-19 Biphenylamidine derivatives and pharmaceutical compositions containing them

Country Status (28)

Country Link
US (1) US6706745B1 (hu)
EP (1) EP1043310B1 (hu)
KR (1) KR100581506B1 (hu)
CN (1) CN1150162C (hu)
AT (1) ATE268751T1 (hu)
AU (1) AU744567B2 (hu)
BG (1) BG63536B1 (hu)
BR (1) BR9814983A (hu)
CA (1) CA2310331A1 (hu)
DE (1) DE69824450T2 (hu)
DK (1) DK1043310T3 (hu)
EE (1) EE04564B1 (hu)
ES (1) ES2218866T3 (hu)
HR (1) HRP20000304B1 (hu)
HU (1) HUP0100085A3 (hu)
ID (1) ID24846A (hu)
IL (1) IL136100A (hu)
IS (1) IS5497A (hu)
NO (1) NO20002589L (hu)
NZ (1) NZ504407A (hu)
PL (1) PL340658A1 (hu)
PT (1) PT1043310E (hu)
RU (1) RU2197478C2 (hu)
SK (1) SK7612000A3 (hu)
TR (1) TR200001452T2 (hu)
TW (1) TW523504B (hu)
UA (1) UA52797C2 (hu)
WO (1) WO1999026918A1 (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ504324A (en) * 1997-11-20 2002-02-01 Teijin Ltd Biphenylamidine derivatives and pharmaceutical compositions thereof; which can be useful as anticoagulant inhibitors, and thrombus or embolus preventing agents
AU773156B2 (en) * 1999-01-28 2004-05-20 Teijin Limited Release-regulating preparations
US6538137B1 (en) * 1999-05-17 2003-03-25 Teijin Limited Cyanobiphenyl derivatives
WO2001056989A2 (en) * 2000-02-01 2001-08-09 Cor Therapeutics, Inc. Inhibitors of factor xa
US6316475B1 (en) * 2000-11-17 2001-11-13 Abbott Laboratories Aminoalkoxybiphenylcarboxamides as histamine-3 receptor ligands and their therapeutic applications
EP1361213A4 (en) * 2001-01-26 2004-06-09 Teijin Ltd METHOD FOR THE PRODUCTION OF CYANOPHENYLBENEOIC ACID DERIVATIVES
CN1489575A (zh) * 2001-01-29 2004-04-14 ������������ʽ���� 苯甲脒衍生物及其制备方法
AR035425A1 (es) * 2001-01-30 2004-05-26 Teijin Ltd Cristal de diclorhidrato del acido 3-(3-amidinofenil)-5-[({[1-(iminoetil)-4-piperidil]metil}amino)metil]benzoico y proceso para prepararlo
JPWO2002060448A1 (ja) * 2001-01-30 2004-05-27 帝人株式会社 医薬組成物
JPWO2003040086A1 (ja) * 2001-11-09 2005-03-03 キッセイ薬品工業株式会社 ５−アミジノ−２−ヒドロキシベンゼンスルホンアミド誘導体、それを含有する医薬組成物、その医薬用途およびその製造中間体
EP1460059A4 (en) 2001-11-30 2005-01-05 Teijin Ltd PROCESS FOR PRODUCING 5- (3-CYANOPHENYL) -3-FORMYLBENZOIC ACID COMPOUND
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
US9028867B2 (en) 2005-08-18 2015-05-12 Teijin Pharma Limited Formulation having accurate dose-dividing function
CA2619745A1 (en) 2005-08-18 2007-02-22 Teijin Pharma Limited Tablet with multiple drug-containing sections
PE20070698A1 (es) 2005-11-14 2007-08-17 Teijin Pharma Ltd Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol
WO2016198691A1 (en) 2015-06-11 2016-12-15 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4102024A1 (de) 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE59303178D1 (de) 1992-04-28 1996-08-14 Thomae Gmbh Dr K Tritiumarkierte Fibrinogen-Rezeptor-Antagonisten, deren Verwendung und Verfahren zur ihrer Herstellung
DE4219158A1 (de) * 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JPH101467A (ja) * 1996-06-13 1998-01-06 Banyu Pharmaceut Co Ltd ビフェニルアミジン誘導体
NZ504324A (en) * 1997-11-20 2002-02-01 Teijin Ltd Biphenylamidine derivatives and pharmaceutical compositions thereof; which can be useful as anticoagulant inhibitors, and thrombus or embolus preventing agents

Also Published As

Publication number Publication date
ATE268751T1 (de) 2004-06-15
NZ504407A (en) 2002-02-01
NO20002589D0 (no) 2000-05-19
EP1043310A4 (en) 2001-03-21
CN1150162C (zh) 2004-05-19
ES2218866T3 (es) 2004-11-16
NO20002589L (no) 2000-07-19
EE200000298A (et) 2001-08-15
AU744567B2 (en) 2002-02-28
PT1043310E (pt) 2004-10-29
HUP0100085A3 (en) 2002-12-28
IL136100A0 (en) 2001-05-20
AU1174099A (en) 1999-06-15
SK7612000A3 (en) 2001-05-10
DE69824450D1 (de) 2004-07-15
HRP20000304B1 (en) 2005-08-31
WO1999026918A1 (fr) 1999-06-03
EP1043310B1 (en) 2004-06-09
IL136100A (en) 2005-05-17
ID24846A (id) 2000-08-24
TR200001452T2 (tr) 2004-12-21
KR20010032259A (ko) 2001-04-16
BG104447A (en) 2001-01-31
HRP20000304A2 (en) 2002-02-28
CN1284059A (zh) 2001-02-14
US6706745B1 (en) 2004-03-16
DE69824450T2 (de) 2005-09-29
DK1043310T3 (da) 2004-10-25
IS5497A (is) 2000-05-15
RU2197478C2 (ru) 2003-01-27
TW523504B (en) 2003-03-11
BG63536B1 (bg) 2002-04-30
BR9814983A (pt) 2000-10-03
CA2310331A1 (en) 1999-06-03
PL340658A1 (en) 2001-02-12
EP1043310A1 (en) 2000-10-11
KR100581506B1 (ko) 2006-05-22
UA52797C2 (uk) 2003-01-15
EE04564B1 (et) 2005-12-15

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