ATE267178T1 - Diazepinderivate oder deren salze - Google Patents

Diazepinderivate oder deren salze

Info

Publication number
ATE267178T1
ATE267178T1 AT01917634T AT01917634T ATE267178T1 AT E267178 T1 ATE267178 T1 AT E267178T1 AT 01917634 T AT01917634 T AT 01917634T AT 01917634 T AT01917634 T AT 01917634T AT E267178 T1 ATE267178 T1 AT E267178T1
Authority
AT
Austria
Prior art keywords
salts
diazepine derivatives
diazepine
derivatives
Prior art date
Application number
AT01917634T
Other languages
English (en)
Inventor
Fukushi Hirayama
Hiroyuki Koshio
Tsukasa Ishihara
Norio Seki
Shunichiro Hachiya
Keizo Sugasawa
Ryota Shiraki
Yuji Koga
Yuzo Matsumoto
Takeshi Shigenaga
Souichirou Kawazoe
Oaza Akahama Matsukubo
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18611560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE267178(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Application granted granted Critical
Publication of ATE267178T1 publication Critical patent/ATE267178T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01917634T 2000-03-31 2001-03-29 Diazepinderivate oder deren salze ATE267178T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000096858 2000-03-31
PCT/JP2001/002673 WO2001074791A1 (fr) 2000-03-31 2001-03-29 Derives de diazepane ou sels desdits composes

Publications (1)

Publication Number Publication Date
ATE267178T1 true ATE267178T1 (de) 2004-06-15

Family

ID=18611560

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01917634T ATE267178T1 (de) 2000-03-31 2001-03-29 Diazepinderivate oder deren salze
AT03029061T ATE340166T1 (de) 2000-03-31 2001-03-29 Diazepan derivate als faktor x inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03029061T ATE340166T1 (de) 2000-03-31 2001-03-29 Diazepan derivate als faktor x inhibitor

Country Status (21)

Country Link
US (3) US6642224B1 (de)
EP (2) EP1273575B1 (de)
JP (1) JP3788349B2 (de)
KR (1) KR100739359B1 (de)
CN (1) CN1226292C (de)
AR (1) AR027985A1 (de)
AT (2) ATE267178T1 (de)
AU (2) AU776053B2 (de)
BR (1) BR0101264A (de)
CA (1) CA2395846C (de)
DE (2) DE60123294T2 (de)
DK (1) DK1273575T3 (de)
ES (2) ES2217129T3 (de)
HU (1) HUP0101333A3 (de)
MX (1) MXPA01003279A (de)
PL (1) PL207651B1 (de)
PT (1) PT1273575E (de)
RU (1) RU2257381C2 (de)
TR (1) TR200401955T4 (de)
TW (1) TW575569B (de)
WO (1) WO2001074791A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1259485B1 (de) * 2000-02-29 2005-11-30 Millennium Pharmaceuticals, Inc. Benzamide und ähnliche inhibitoren vom faktor xa
AU776053B2 (en) * 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
DE60130771T2 (de) 2000-07-27 2008-07-17 Eli Lilly And Co., Indianapolis Substituierte heterocyclische amide
AU2406402A (en) * 2000-11-22 2002-06-03 Yamanouchi Pharma Co Ltd Substituted benzene derivatives or salts thereof
US7163938B2 (en) 2000-11-28 2007-01-16 Eli Lilly And Company Substituted carboxamides
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
EP1456175A1 (de) * 2001-12-07 2004-09-15 Eli Lilly And Company Substituierte heterozyklische karboxamide mit antithrombotischer aktivität
TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
KR20060023154A (ko) * 2003-06-18 2006-03-13 메르크 파텐트 게엠베하 혈전증 치료용 응고 인자 ｘａ 및 ｖｉｉａ의 저해제로서의피롤리딘-１,２-디카르복실산-１-[(４-에티닐-페닐)-아미드]-２-[(페닐)-아미드] 유도체
US7511066B2 (en) 2003-09-30 2009-03-31 Eli Lilly And Company Antithrombotic aromatic ethers
EP1817287B1 (de) 2004-11-24 2010-02-10 Eli Lilly And Company Aromatische etherderivate als thrombin-hemmer
WO2006057868A1 (en) 2004-11-29 2006-06-01 Eli Lilly And Company Antithrombotic diamides
EP1847527A4 (de) 2005-02-02 2009-04-08 Ajinomoto Kk Neue benzamidinverbindungen
GB0521244D0 (en) 2005-10-19 2005-11-30 Astrazeneca Ab Benzamide compounds
TW200734304A (en) * 2005-11-08 2007-09-16 Astellas Pharma Inc Benzene derivative or salt thereof
ES2382055T3 (es) * 2006-11-02 2012-06-04 Millennium Pharmaceuticals, Inc. Métodos para sintetizar sales farmacéuticas de un inhibidor del factor Xa
JP2010120852A (ja) * 2007-03-09 2010-06-03 Daiichi Sankyo Co Ltd 新規なジアミド誘導体
EP2311810A4 (de) 2008-07-11 2012-04-04 Ajinomoto Kk Amidderivate
TW201021832A (en) * 2008-09-30 2010-06-16 Astellas Pharma Inc Pharmaceutical composition for oral administration
JP5827326B2 (ja) 2010-07-07 2015-12-02 アーデリクス，インコーポレーテッド リン酸輸送を阻害する化合物及び方法
JP5827328B2 (ja) 2010-07-07 2015-12-02 アーデリクス，インコーポレーテッド リン酸輸送を阻害する化合物及び方法
JP5823514B2 (ja) 2010-07-07 2015-11-25 アーデリクス，インコーポレーテッド リン酸輸送を阻害する化合物及び方法
EP2591354B1 (de) * 2010-07-07 2016-09-07 Ardelyx, Inc. Verbindungen und verfahren zur hemmung eines phosphattransports
WO2012006474A2 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2012059442A2 (en) * 2010-11-01 2012-05-10 Neurotune Ag Neurotrypsin inhibitors
JPWO2013161871A1 (ja) * 2012-04-25 2015-12-24 興和株式会社 Ｔｌｒ阻害作用を有するチオフェン誘導体

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5417200A (en) * 1994-01-25 1995-05-23 Wasielewski; John J. Lantern cooker
ATE233240T1 (de) 1994-12-02 2003-03-15 Yamanouchi Pharma Co Ltd Neues amidinonaphthylderivat oder dessen salz
CA2295153A1 (en) 1997-06-26 1999-01-07 Gerald Floyd Smith Antithrombotic agents
WO1999000128A1 (en) 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
WO1999000121A1 (en) * 1997-06-26 1999-01-07 Eli Lilly And Company Antithrombotic agents
EP1007037A4 (de) 1997-06-26 2004-10-06 Lilly Co Eli Antithrombose mittel
US6140351A (en) 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
CA2315070A1 (en) 1997-12-17 1999-07-01 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
AU2074699A (en) * 1998-01-26 1999-08-09 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof
WO2000039111A1 (en) 1998-12-23 2000-07-06 Eli Lilly And Company Antithrombotic amides
US6635657B1 (en) 1998-12-23 2003-10-21 Eli Lilly And Company Aromatic amides
WO2000039117A1 (en) 1998-12-23 2000-07-06 Eli Lilly And Company HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa
JP4390024B2 (ja) * 1999-04-23 2009-12-24 アステラス製薬株式会社 新規なジアゼパン誘導体又はその塩
WO2001019788A2 (en) 1999-09-17 2001-03-22 Cor Therapeutics, Inc. BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa
NZ517828A (en) 1999-09-17 2003-10-31 Millennium Pharm Inc Inhibitors having activity against mammalian factor Xa
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
EP1259485B1 (de) 2000-02-29 2005-11-30 Millennium Pharmaceuticals, Inc. Benzamide und ähnliche inhibitoren vom faktor xa
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
DE60130771T2 (de) * 2000-07-27 2008-07-17 Eli Lilly And Co., Indianapolis Substituierte heterocyclische amide
US7163938B2 (en) * 2000-11-28 2007-01-16 Eli Lilly And Company Substituted carboxamides

Also Published As

Publication number Publication date
ES2271464T3 (es) 2007-04-16
DE60103390T2 (de) 2005-06-16
HUP0101333A2 (hu) 2002-02-28
AU2001244634A1 (en) 2001-10-15
RU2257381C2 (ru) 2005-07-27
HUP0101333A3 (en) 2002-12-28
DE60123294D1 (de) 2006-11-02
CA2395846C (en) 2009-08-11
US7307074B2 (en) 2007-12-11
USRE43481E1 (en) 2012-06-19
CN1319594A (zh) 2001-10-31
JP3788349B2 (ja) 2006-06-21
KR20010095174A (ko) 2001-11-03
PT1273575E (pt) 2004-09-30
AU776053B2 (en) 2004-08-26
MXPA01003279A (es) 2004-07-30
EP1415990B1 (de) 2006-09-20
DK1273575T3 (da) 2004-09-13
HU0101333D0 (en) 2001-06-28
ATE340166T1 (de) 2006-10-15
AR027985A1 (es) 2003-04-23
ES2217129T3 (es) 2004-11-01
CN1226292C (zh) 2005-11-09
EP1273575B1 (de) 2004-05-19
US20030195193A1 (en) 2003-10-16
EP1273575A4 (de) 2003-01-08
TR200401955T4 (tr) 2004-09-21
WO2001074791A1 (fr) 2001-10-11
DE60103390D1 (de) 2004-06-24
US6642224B1 (en) 2003-11-04
PL346731A1 (en) 2001-10-08
EP1415990A1 (de) 2004-05-06
BR0101264A (pt) 2001-11-06
PL207651B1 (pl) 2011-01-31
KR100739359B1 (ko) 2007-07-18
DE60123294T2 (de) 2007-04-05
EP1273575A1 (de) 2003-01-08
AU2982701A (en) 2001-10-04
US20040068109A1 (en) 2004-04-08
CA2395846A1 (en) 2001-10-11
TW575569B (en) 2004-02-11

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