HUP0101333A3 - Diazepan derivatives and their salts, pharmaceutical compositions containing the same - Google Patents
Diazepan derivatives and their salts, pharmaceutical compositions containing the sameInfo
- Publication number
- HUP0101333A3 HUP0101333A3 HU0101333A HUP0101333A HUP0101333A3 HU P0101333 A3 HUP0101333 A3 HU P0101333A3 HU 0101333 A HU0101333 A HU 0101333A HU P0101333 A HUP0101333 A HU P0101333A HU P0101333 A3 HUP0101333 A3 HU P0101333A3
- Authority
- HU
- Hungary
- Prior art keywords
- salts
- same
- pharmaceutical compositions
- compositions containing
- diazepan derivatives
- Prior art date
Links
- QPMLSUSACCOBDK-UHFFFAOYSA-N diazepane Chemical class C1CCNNCC1 QPMLSUSACCOBDK-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000096858 | 2000-03-31 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU0101333D0 HU0101333D0 (en) | 2001-06-28 |
| HUP0101333A2 HUP0101333A2 (hu) | 2002-02-28 |
| HUP0101333A3 true HUP0101333A3 (en) | 2002-12-28 |
Family
ID=18611560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0101333A HUP0101333A3 (en) | 2000-03-31 | 2001-03-30 | Diazepan derivatives and their salts, pharmaceutical compositions containing the same |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6642224B1 (hu) |
| EP (2) | EP1273575B1 (hu) |
| JP (1) | JP3788349B2 (hu) |
| KR (1) | KR100739359B1 (hu) |
| CN (1) | CN1226292C (hu) |
| AR (1) | AR027985A1 (hu) |
| AT (2) | ATE340166T1 (hu) |
| AU (2) | AU776053B2 (hu) |
| BR (1) | BR0101264A (hu) |
| CA (1) | CA2395846C (hu) |
| DE (2) | DE60103390T2 (hu) |
| DK (1) | DK1273575T3 (hu) |
| ES (2) | ES2217129T3 (hu) |
| HU (1) | HUP0101333A3 (hu) |
| MX (1) | MXPA01003279A (hu) |
| PL (1) | PL207651B1 (hu) |
| PT (1) | PT1273575E (hu) |
| RU (1) | RU2257381C2 (hu) |
| TR (1) | TR200401955T4 (hu) |
| TW (1) | TW575569B (hu) |
| WO (1) | WO2001074791A1 (hu) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1259485B1 (en) * | 2000-02-29 | 2005-11-30 | Millennium Pharmaceuticals, Inc. | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa |
| AU776053B2 (en) * | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| WO2002010154A2 (en) | 2000-07-27 | 2002-02-07 | Eli Lilly And Company | Substituted heterocyclic amides |
| CA2424522C (en) | 2000-11-22 | 2009-12-29 | Yamanouchi Pharmaceutical Co., Ltd. | Substituted benzene derivatives or salts thereof |
| US7163938B2 (en) | 2000-11-28 | 2007-01-16 | Eli Lilly And Company | Substituted carboxamides |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| AU2002350172A1 (en) | 2001-12-07 | 2003-06-23 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
| TWI319387B (en) * | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| AU2004246766B2 (en) * | 2003-06-18 | 2009-09-17 | Merck Patent Gmbh | Pyrrolidin-1, 2- dicarboxylic acid- 1- [(4- ethinyl- phenyl) - amid]- 2- [(phenyl)- amid] derivative as inhibitors of coagulation factor Xa and VIIa for the treatment of thrombosis |
| US7511066B2 (en) | 2003-09-30 | 2009-03-31 | Eli Lilly And Company | Antithrombotic aromatic ethers |
| ATE457302T1 (de) | 2004-11-24 | 2010-02-15 | Lilly Co Eli | Aromatische etherderivate als thrombin-hemmer |
| ES2330461T3 (es) | 2004-11-29 | 2009-12-10 | Eli Lilly And Company | Diamidas antitromboticas. |
| WO2006083003A1 (ja) | 2005-02-02 | 2006-08-10 | Ajinomoto Co., Inc. | 新規ベンズアミジン化合物 |
| GB0521244D0 (en) | 2005-10-19 | 2005-11-30 | Astrazeneca Ab | Benzamide compounds |
| TW200734304A (en) * | 2005-11-08 | 2007-09-16 | Astellas Pharma Inc | Benzene derivative or salt thereof |
| CN101595092B (zh) | 2006-11-02 | 2012-02-01 | 米伦纽姆医药公司 | 合成因子xa抑制剂的医药盐的方法 |
| JP2010120852A (ja) * | 2007-03-09 | 2010-06-03 | Daiichi Sankyo Co Ltd | 新規なジアミド誘導体 |
| EP2311810A4 (en) * | 2008-07-11 | 2012-04-04 | Ajinomoto Kk | AMIDINE DERIVATIVE |
| TW201021832A (en) * | 2008-09-30 | 2010-06-16 | Astellas Pharma Inc | Pharmaceutical composition for oral administration |
| EP2590965B1 (en) | 2010-07-07 | 2016-04-20 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| JP5827328B2 (ja) | 2010-07-07 | 2015-12-02 | アーデリクス，インコーポレーテッド | リン酸輸送を阻害する化合物及び方法 |
| WO2012006475A1 (en) * | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| WO2012054110A2 (en) | 2010-07-07 | 2012-04-26 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| WO2012006473A1 (en) | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| WO2012059442A2 (en) * | 2010-11-01 | 2012-05-10 | Neurotune Ag | Neurotrypsin inhibitors |
| WO2013161871A1 (ja) * | 2012-04-25 | 2013-10-31 | 興和株式会社 | Ｔｌｒ阻害作用を有するチオフェン誘導体 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5417200A (en) * | 1994-01-25 | 1995-05-23 | Wasielewski; John J. | Lantern cooker |
| ES2193202T3 (es) | 1994-12-02 | 2003-11-01 | Yamanouchi Pharma Co Ltd | Nuevo derivado de amidinonaftilo o sal de este. |
| JP2002506462A (ja) | 1997-06-26 | 2002-02-26 | イーライ・リリー・アンド・カンパニー | 抗血栓物質 |
| WO1999000121A1 (en) | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Antithrombotic agents |
| US6372759B1 (en) | 1997-06-26 | 2002-04-16 | Eli Lilly And Company | Antithrombotic agents |
| JP2002510313A (ja) | 1997-06-26 | 2002-04-02 | イーライ・リリー・アンド・カンパニー | 抗血栓物質 |
| US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| RU2226529C2 (ru) | 1997-12-19 | 2004-04-10 | Шеринг Акциенгезельшафт | Производные ортоантраниламида в качестве антикоагулянтов, фармацевтическая композиция и способ лечения |
| AU2074699A (en) | 1998-01-26 | 1999-08-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzene-fused heterocyclic derivatives or salts thereof |
| JP2002533453A (ja) | 1998-12-23 | 2002-10-08 | イーライ・リリー・アンド・カンパニー | Ｘａ因子のインヒビターとしてのヘテロ芳香族アミド |
| AU2054700A (en) | 1998-12-23 | 2000-07-31 | Eli Lilly And Company | Antithrombotic amides |
| ES2226485T3 (es) | 1998-12-23 | 2005-03-16 | Eli Lilly And Company | Amidas aromaticas. |
| JP4390024B2 (ja) | 1999-04-23 | 2009-12-24 | アステラス製薬株式会社 | 新規なジアゼパン誘導体又はその塩 |
| US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| EP1216228B1 (en) | 1999-09-17 | 2008-10-29 | Millennium Pharmaceuticals, Inc. | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa |
| TR200201413T2 (tr) | 1999-09-17 | 2003-02-21 | Millennium Pharmaceuticals, Inc. | Faktör Xa' nın inhibitörleri. |
| EP1259485B1 (en) | 2000-02-29 | 2005-11-30 | Millennium Pharmaceuticals, Inc. | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa |
| AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| WO2002010154A2 (en) * | 2000-07-27 | 2002-02-07 | Eli Lilly And Company | Substituted heterocyclic amides |
| US7163938B2 (en) * | 2000-11-28 | 2007-01-16 | Eli Lilly And Company | Substituted carboxamides |
-
2001
- 2001-03-22 AU AU29827/01A patent/AU776053B2/en not_active Ceased
- 2001-03-28 PL PL346731A patent/PL207651B1/pl not_active IP Right Cessation
- 2001-03-29 DE DE60103390T patent/DE60103390T2/de not_active Expired - Lifetime
- 2001-03-29 TR TR2004/01955T patent/TR200401955T4/xx unknown
- 2001-03-29 RU RU2001108494/04A patent/RU2257381C2/ru not_active IP Right Cessation
- 2001-03-29 PT PT01917634T patent/PT1273575E/pt unknown
- 2001-03-29 DK DK01917634T patent/DK1273575T3/da active
- 2001-03-29 JP JP2001572486A patent/JP3788349B2/ja not_active Expired - Fee Related
- 2001-03-29 AU AU2001244634A patent/AU2001244634A1/en not_active Abandoned
- 2001-03-29 MX MXPA01003279A patent/MXPA01003279A/es active IP Right Grant
- 2001-03-29 ES ES01917634T patent/ES2217129T3/es not_active Expired - Lifetime
- 2001-03-29 AT AT03029061T patent/ATE340166T1/de not_active IP Right Cessation
- 2001-03-29 EP EP01917634A patent/EP1273575B1/en not_active Expired - Lifetime
- 2001-03-29 AT AT01917634T patent/ATE267178T1/de active
- 2001-03-29 AR ARP010101497A patent/AR027985A1/es active IP Right Grant
- 2001-03-29 CA CA002395846A patent/CA2395846C/en not_active Expired - Fee Related
- 2001-03-29 WO PCT/JP2001/002673 patent/WO2001074791A1/ja active IP Right Grant
- 2001-03-29 US US10/148,544 patent/US6642224B1/en not_active Expired - Fee Related
- 2001-03-29 ES ES03029061T patent/ES2271464T3/es not_active Expired - Lifetime
- 2001-03-29 EP EP03029061A patent/EP1415990B1/en not_active Expired - Lifetime
- 2001-03-29 DE DE60123294T patent/DE60123294T2/de not_active Expired - Lifetime
- 2001-03-30 BR BR0101264-9A patent/BR0101264A/pt not_active IP Right Cessation
- 2001-03-30 CN CNB011121904A patent/CN1226292C/zh not_active Expired - Fee Related
- 2001-03-30 TW TW90107761A patent/TW575569B/zh not_active IP Right Cessation
- 2001-03-30 KR KR1020010016952A patent/KR100739359B1/ko not_active IP Right Cessation
- 2001-03-30 HU HU0101333A patent/HUP0101333A3/hu unknown
-
2003
- 2003-09-08 US US10/656,129 patent/US7307074B2/en not_active Ceased
-
2008
- 2008-09-03 US US12/203,640 patent/USRE43481E1/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |