AR040788A1 - 2,3- dihidro -isoindol-1-onas - Google Patents
2,3- dihidro -isoindol-1-onasInfo
- Publication number
- AR040788A1 AR040788A1 AR20030102801A ARP030102801A AR040788A1 AR 040788 A1 AR040788 A1 AR 040788A1 AR 20030102801 A AR20030102801 A AR 20030102801A AR P030102801 A ARP030102801 A AR P030102801A AR 040788 A1 AR040788 A1 AR 040788A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- halogen
- dihidro
- onas
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Derivados de 2,3-dihidro-isoindol-1-ona, procesos para su producción, su uso como composiciones farmacéuticas y medicamentos que las comprenden, para la prevención y tratamiento de enfermedades que son mediadas por inhibidores de la monoaminoxidasa B. Reivindicación 1: Un compuesto de grupo de fórmula (1) en donde: X es -N= o -CH=; R1 es -(CH2)n-CO-NR5R6, -(CH2)n-NR5R6, -(CH2)n-COOR7; -(CH2)n-CN; -(CH2)n-isoindol-1,3-dionilo; o -(CH2)p-OR8; R2 es hidrógeno, alquilo C1-6 o OH; R3 es hidrógeno o alquilo C1-6; R4 es halógeno, halógeno-alquilo (C1-6), alcoxilo C1-6 o halógeno-alcoxilo (C1-6); R5 y R6 son independientes el uno del otro hidrógeno o alquilo C1-3; R7 es alquilo C1-6; R8 es hidrógeno o alquilo C1-6; m es 1, 2 ó 3; n es 0, 1 ó 2; y p es 0 ó 2; y sales farmacéuticamente aceptables de las mismas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02017676 | 2002-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR040788A1 true AR040788A1 (es) | 2005-04-20 |
Family
ID=31502695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20030102801A AR040788A1 (es) | 2002-08-07 | 2003-08-05 | 2,3- dihidro -isoindol-1-onas |
Country Status (16)
Country | Link |
---|---|
US (1) | US6846832B2 (es) |
EP (1) | EP1539694A1 (es) |
JP (1) | JP4322805B2 (es) |
KR (1) | KR20050059062A (es) |
CN (1) | CN1305848C (es) |
AR (1) | AR040788A1 (es) |
BR (1) | BR0313543A (es) |
CA (1) | CA2493143A1 (es) |
GT (1) | GT200300165A (es) |
MX (1) | MXPA05001327A (es) |
PA (1) | PA8579401A1 (es) |
PE (1) | PE20040753A1 (es) |
PL (1) | PL375417A1 (es) |
RU (1) | RU2322437C2 (es) |
TW (1) | TW200413315A (es) |
WO (1) | WO2004014856A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
WO2004113330A1 (en) * | 2003-05-19 | 2004-12-29 | Irm Llc | Immunosuppressant compounds and compositions |
BRPI0606187A2 (pt) | 2005-02-25 | 2009-06-09 | Hoffmann La Roche | comprimidos com capacidade de dispersão da substáncia do fármaco melhorada |
CN102190616B (zh) * | 2010-03-18 | 2015-07-29 | 苏州泽璟生物制药有限公司 | 一种氘代的ω-二苯基脲的合成及生产的方法和工艺 |
EP2821404B1 (en) * | 2012-03-02 | 2019-07-31 | TMS Co. Ltd. | Chroman derivative |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3834861A1 (de) | 1988-10-13 | 1990-04-19 | Basf Ag | Arylalkoxycumarine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel |
TW219935B (es) * | 1991-12-25 | 1994-02-01 | Mitsubishi Chemicals Co Ltd | |
US5326760A (en) * | 1992-06-29 | 1994-07-05 | Glaxo, Inc. | Aminobutanoic acid compounds having metalloprotease inhibiting properties |
ES2098186B1 (es) | 1995-02-09 | 1998-02-01 | Consejo Superior Investigacion | Composiciones farmaceuticas a base de aminometilindoles para su aplicacion terapeutica como neuroprotectores en las enfermedades de parkinson y alzheimer. |
US5679715A (en) | 1995-06-07 | 1997-10-21 | Harris; Richard Y. | Method for treating multiple sclerosis |
JP3258027B2 (ja) | 1996-03-15 | 2002-02-18 | サマーセット・ファーマシューティカルズ・インコーポレイテッド | セレジリン投与による末梢ニューロパシーの予防および治療方法 |
AU1359801A (en) | 1999-11-05 | 2001-06-06 | Vela Pharmaceuticals Inc. | Methods and compositions for treating reward deficiency syndrome |
US6660736B2 (en) | 2002-03-27 | 2003-12-09 | Hoffmann-La Roche Inc. | Phthalimido derivatives and a process for their preparation |
-
2003
- 2003-07-22 US US10/625,116 patent/US6846832B2/en not_active Expired - Fee Related
- 2003-07-31 BR BR0313543-8A patent/BR0313543A/pt not_active IP Right Cessation
- 2003-07-31 CN CNB038189747A patent/CN1305848C/zh not_active Expired - Fee Related
- 2003-07-31 RU RU2005106200/04A patent/RU2322437C2/ru not_active IP Right Cessation
- 2003-07-31 MX MXPA05001327A patent/MXPA05001327A/es active IP Right Grant
- 2003-07-31 KR KR1020057002233A patent/KR20050059062A/ko not_active Application Discontinuation
- 2003-07-31 WO PCT/EP2003/008456 patent/WO2004014856A1/en active Application Filing
- 2003-07-31 CA CA002493143A patent/CA2493143A1/en not_active Abandoned
- 2003-07-31 PL PL03375417A patent/PL375417A1/xx not_active Application Discontinuation
- 2003-07-31 JP JP2004526827A patent/JP4322805B2/ja not_active Expired - Fee Related
- 2003-07-31 EP EP03784117A patent/EP1539694A1/en not_active Withdrawn
- 2003-08-04 PA PA20038579401A patent/PA8579401A1/es unknown
- 2003-08-04 TW TW092121280A patent/TW200413315A/zh unknown
- 2003-08-04 PE PE2003000766A patent/PE20040753A1/es not_active Application Discontinuation
- 2003-08-05 GT GT200300165A patent/GT200300165A/es unknown
- 2003-08-05 AR AR20030102801A patent/AR040788A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2005539015A (ja) | 2005-12-22 |
PE20040753A1 (es) | 2004-11-20 |
RU2322437C2 (ru) | 2008-04-20 |
US6846832B2 (en) | 2005-01-25 |
AU2003255334A1 (en) | 2004-02-25 |
PL375417A1 (en) | 2005-11-28 |
PA8579401A1 (es) | 2004-02-16 |
MXPA05001327A (es) | 2005-04-28 |
WO2004014856A1 (en) | 2004-02-19 |
BR0313543A (pt) | 2005-06-21 |
JP4322805B2 (ja) | 2009-09-02 |
CA2493143A1 (en) | 2004-02-19 |
RU2005106200A (ru) | 2005-10-20 |
KR20050059062A (ko) | 2005-06-17 |
GT200300165A (es) | 2004-03-16 |
US20040082603A1 (en) | 2004-04-29 |
CN1305848C (zh) | 2007-03-21 |
TW200413315A (en) | 2004-08-01 |
CN1675181A (zh) | 2005-09-28 |
EP1539694A1 (en) | 2005-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |