BRPI0511186A - composto, pró-droga do composto, composição farmacêutica, uso do composto, e, processo para preparar o composto - Google Patents
composto, pró-droga do composto, composição farmacêutica, uso do composto, e, processo para preparar o compostoInfo
- Publication number
- BRPI0511186A BRPI0511186A BRPI0511186-2A BRPI0511186A BRPI0511186A BR PI0511186 A BRPI0511186 A BR PI0511186A BR PI0511186 A BRPI0511186 A BR PI0511186A BR PI0511186 A BRPI0511186 A BR PI0511186A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- optionally substituted
- bond
- prodrug
- pharmaceutical composition
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Abstract
COMPOSTO, PRó-DROGA DO COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DO COMPOSTO, E , PROCESSO PARA PREPARAR O COMPOSTO A presente invenção fornece um derivado de amida cíclica útil como um medicamento para tratar fórmula (I): em que R¬ 1¬ representa um grupo hidrocarboneto cíclico opcionalmente substituído ou um grupo heterocíclico opcionalmente substituído. W representa uma ligação ou um grupo hidrocarboneto de cadeia divalente opcionalmente substituído, a representa 0,1 ou 2, X¬ 1¬ representa um alquileno inferior opcionalmente substituído ou um alquenileno inferior opcionalmente substituído, Y¬ 1¬ representa -C(O)-, -S(O)- ou -S(O)~ 2~-, A representa um anel piperazina que pode ser ainda substituído ou um anel piperidina que pode ser ainda substituído, X¬ 2¬ representa uma ligação ou um alquileno inferior opcionalmente substituído, Y¬ 2¬ representa -C(O)-, -S(O)-, -S(O~ 2~- ou -C(=NR¬ 7¬)-, X¬ 3¬ representa um alquileno C~ 1~-~ 4~ opcionalmente substituído ou um alquenileno C~ 2~-~ 4~ opcionalmente substituído, Z¬ 3¬ representa - N(R¬ 4¬)-, -O- ou uma ligação, Z¬ 1¬ representa -C(R¬ 2¬) (R¬ 2¬)-, -N(R¬ 2¬)-, etc., e Z¬ 2¬ representa -C(R¬ 3¬)(R¬ 3¬)-, -N(R¬ 3¬)-, etc., ou um sal destes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004152000 | 2004-05-21 | ||
PCT/JP2005/009711 WO2005113504A1 (en) | 2004-05-21 | 2005-05-20 | Cyclic amide derivatives, and their production and use as antithrombotic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0511186A true BRPI0511186A (pt) | 2007-12-04 |
Family
ID=34968275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0511186-2A BRPI0511186A (pt) | 2004-05-21 | 2005-05-20 | composto, pró-droga do composto, composição farmacêutica, uso do composto, e, processo para preparar o composto |
Country Status (26)
Country | Link |
---|---|
US (4) | US7745623B2 (pt) |
EP (2) | EP2208726B1 (pt) |
JP (2) | JP4129047B2 (pt) |
KR (1) | KR101248637B1 (pt) |
CN (2) | CN1989104B (pt) |
AT (1) | ATE513813T1 (pt) |
AU (1) | AU2005245298B2 (pt) |
BR (1) | BRPI0511186A (pt) |
CA (1) | CA2567506C (pt) |
CY (1) | CY1111850T1 (pt) |
DK (1) | DK1748985T3 (pt) |
ES (1) | ES2368155T3 (pt) |
HK (1) | HK1100666A1 (pt) |
HR (1) | HRP20110640T1 (pt) |
IL (1) | IL178896A (pt) |
MX (1) | MXPA06013243A (pt) |
MY (1) | MY154461A (pt) |
NO (1) | NO20065929L (pt) |
NZ (1) | NZ550985A (pt) |
PL (1) | PL1748985T3 (pt) |
PT (1) | PT1748985E (pt) |
RS (1) | RS51925B (pt) |
RU (1) | RU2361861C2 (pt) |
SI (1) | SI1748985T1 (pt) |
TW (1) | TWI396686B (pt) |
WO (1) | WO2005113504A1 (pt) |
Families Citing this family (55)
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CA2416384A1 (en) * | 2000-07-17 | 2003-01-16 | Takeda Chemical Industries, Ltd. | Sulfone derivatives, their production and use |
CA2507026A1 (en) * | 2002-11-22 | 2004-06-10 | Takeda Pharmaceutical Company Limited | Imidazole derivatives, their production and use |
TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
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WO2008066102A1 (fr) * | 2006-11-30 | 2008-06-05 | Takeda Pharmaceutical Company Limited | Préparation à libération prolongée |
TW201014850A (en) | 2008-09-25 | 2010-04-16 | Takeda Pharmaceutical | Solid pharmaceutical composition |
EP2351743A4 (en) | 2008-10-27 | 2012-05-09 | Takeda Pharmaceutical | BICYCLIC CONNECTION |
EP2371826A4 (en) | 2008-12-29 | 2012-06-27 | Takeda Pharmaceutical | NEW CONNECTION WITH CONDENSED RINGS AND ITS USE |
UY32395A (es) | 2009-01-27 | 2010-08-31 | Takeda Pharmaceutical | Compuesto con anillo fusionado y su uso |
NZ596395A (en) | 2009-04-30 | 2013-06-28 | Takeda Pharmaceutical | Stable solid benzimidazole derivative preparation having optimized dissolution property |
US20120172351A1 (en) | 2009-06-09 | 2012-07-05 | Nobuyuki Negoro | Novel fused cyclic compound and use thereof |
JP5732394B2 (ja) | 2009-07-28 | 2015-06-10 | 武田薬品工業株式会社 | 錠剤 |
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BR112012027648A2 (pt) | 2010-04-27 | 2019-09-24 | Takeda Pharmaceuticals Co | composto medicamento, método para profilaxia ou tratamento de doença, e, uso de composto |
BR112012032055B8 (pt) | 2010-06-16 | 2019-11-12 | Takeda Pharmaceuticals Co | cristal de cloridrato de 1-(4-metoxibutil)-n-(2-metilpropil)-n-[(3s,5r)-5-(morfolin-4-ilcarbonil)piperidin-3-il]-1h-benzimidazol-2-carboxamida, medicamento, e, uso do cristal |
CA2806258A1 (en) | 2010-07-23 | 2012-01-26 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and application thereof |
US20130184272A1 (en) | 2010-09-17 | 2013-07-18 | Takeda Pharmaceutical Company Limited | Diabetes therapeutic agent |
US8729102B2 (en) | 2010-11-30 | 2014-05-20 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
MX2013009526A (es) | 2011-02-17 | 2013-10-01 | Takeda Pharmaceutical | Metodo de produccion de derivado de dihidrobenzofurano opticamente activo. |
EP2772485A4 (en) | 2011-10-24 | 2015-06-10 | Takeda Pharmaceutical | BICYCLIC CONNECTION |
JP6129850B2 (ja) | 2012-01-12 | 2017-05-17 | 武田薬品工業株式会社 | Mch受容体拮抗剤としてのベンゾイミダゾール誘導体 |
US9181186B2 (en) | 2012-02-13 | 2015-11-10 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
JP6095580B2 (ja) | 2012-02-13 | 2017-03-15 | 武田薬品工業株式会社 | 芳香環化合物 |
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US9238639B2 (en) | 2012-02-24 | 2016-01-19 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
JPWO2013147026A1 (ja) | 2012-03-29 | 2015-12-14 | 武田薬品工業株式会社 | 芳香環化合物 |
US9440987B2 (en) | 2012-05-10 | 2016-09-13 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
US9505772B2 (en) | 2012-05-10 | 2016-11-29 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
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JP2015127299A (ja) | 2012-07-19 | 2015-07-09 | 武田薬品工業株式会社 | 固形製剤 |
JPWO2014030743A1 (ja) | 2012-08-24 | 2016-08-08 | 武田薬品工業株式会社 | 複素環化合物 |
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JP2022503793A (ja) | 2018-09-24 | 2022-01-12 | 武田薬品工業株式会社 | Gip受容体アゴニストペプチド化合物及びその使用 |
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